Abstract:
:Patients with sickle cell disease are predisposed to infection caused by Streptococcus pneumoniae. However, there has been only one published case of bacteremic pneumococcal meningitis in an adult with sickle cell anemia. We report here the cases of six adults with sickle cell disease, pneumococcal sepsis, and meningitis. Five patients were male and one was female. Their ages ranged from 18 to 34 years (mean, 25.7 years). Five patients had the SS and one had the SC hemoglobin phenotype. Only one patient had received pneumococcal vaccine (14 valent). This vaccine did not protect against the pneumococcal serotype causing his infection. All patients had high fever (mean, 39.8 degrees C [103.7 degrees F]) on admission; five had generalized weakness and four had neck stiffness. Leukocyte counts were greater than 30,000/mm3 in all patients. Streptococcus pneumoniae was isolated from the blood and the cerebrospinal fluid in all patients. The cerebrospinal fluid showed pleocytosis in six patients, an elevated protein level in five, and hypoglycorrhachia in two. Complications included renal failure in four patients, disseminated intravascular coagulation in one, and seizures in another. Two patients died. Pneumococcal sepsis and meningitis are uncommon in adults with sickle cell disease, but they carry a high morbidity and mortality. Wider use of the new 23-valent polysaccharide vaccine in these patients is recommended.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Olopoenia L,Frederick W,Greaves W,Adams R,Addo FE,Castro Odoi
10.1097/00007611-199009000-00005subject
Has Abstractpub_date
1990-09-01 00:00:00pages
1002-4issue
9eissn
0038-4348issn
1541-8243journal_volume
83pub_type
杂志文章abstract:BACKGROUND:: Bronchus-associated Lymphoid Tissue (BALT) lymphomas are a rare type of extranodal marginal zone lymphomas. They comprise 1% of lymphomas and more than two-thirds of all primary non-Hodgkin lymphoma (NHL) of the lung. BALT lymphomas arise from the bronchus-associated lymphoid tissue. METHODS:This report d...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181bfdd2d
更新日期:2009-12-01 00:00:00
abstract::Pyridium (phenazopyridine hydrochloride) is often prescribed as an analgesic in patients following trauma, surgery, or infections of the urinary tract. Pyridium toxicity has been previously reported, however, most cases result in a single adverse effect. Herein the authors describe an elderly patient who presented wit...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000197299.77949.16
更新日期:2006-01-01 00:00:00
abstract::This review of the basic purposes and principles of tables is oriented toward their preparation by physician-authors for use in medical manuscripts. The guidelines suggested are consistent with the general format and style current in scientific and medical writing, with emphasis upon the latter. Style and usage do evo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197612000-00035
更新日期:1976-12-01 00:00:00
abstract::Premalignant lesions of the anal margin include Bowen's disease (intraepithelial squamous cell carcinoma) and Paget's disease (intraepithelial adenocarcinoma). Our experience includes 11 patients with perianal Paget's disease and 37 patients with perianal Bowen's disease treated from 1957 to 1986. The patients with pe...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198904000-00016
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Hyponatremia is a frequent condition in elderly patients. In diagnostic workup, a 24-hour urine sample is used to measure urinary osmolality and urinary sodium concentration necessary to confirm the diagnosis of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). This study was undertake...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31819b0e06
更新日期:2009-04-01 00:00:00
abstract::Chronic mucocutaneous candidiasis is a heterogeneous group of immunodeficiencies associated with persistent candidal infections. Patients with chronic mucocutaneous candidiasis are rarely associated with systemic infections caused by other fungi, but almost never by Candida. The authors report a case of a 16-year-old ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-200408000-00024
更新日期:2004-08-01 00:00:00
abstract::Dysphagia is a commonly encountered patient complaint. The differential diagnosis for dysphagia is extensive. One long-recognized etiology of dysphagia is cervical osteophytosis. Degenerative joint disease, ankylosing spondylosis, and diffuse idiopathic skeletal hyperostosis (DISH) can all cause cervical osteophyte fo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199708000-00020
更新日期:1997-08-01 00:00:00
abstract::Transfusion in the pediatric age group requires careful consideration of the patient's weight and age because of potential problems with intravascular volume and difficulty with administration of the blood product. Different age groups have varied disease processes that require specific blood components. A correct dia...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
abstract:OBJECTIVE:To perform a needs assessment to determine the extent to which hospitalist providers recognize and intervene upon obese patients in the hospital setting. METHODS:A chart review was performed for patients admitted to the hospitalist service at Johns Hopkins Bayview Medical Center between September 1 and Octob...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181dfd715
更新日期:2010-06-01 00:00:00
abstract::A 74-year-old man was admitted with rhabdomyolysis after undergoing initial treatment for gastrointestinal cancer with irinotecan. The syndrome partially resolved after the discontinuation of all of his usual medications, including his chronic selective serotonin reuptake inhibitor (SSRI). The rhabdomyolysis was exace...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000084311.35864.D6
更新日期:2003-10-01 00:00:00
abstract::Myxoma is the most common primary tumor of the heart. The typical presentations include a triad of embolic phenomena, intracardiac flow obstruction, and constitutional symptoms. We report a case of cardiac myxoma presenting as prolonged fever. Leukocytosis with a left shift, anemia, and elevated C-reactive protein wer...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3182142bbd
更新日期:2011-05-01 00:00:00
abstract::The diagnoses of complete obstruction in a duplicated renal collecting system and ureterocele can be made with a high degree of confidence by ultrasound. Two children presenting with abdominal masses were examined by gray scale ultrasonography which demonstrated large cystic masses dorsal to and displacing the lower p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198008000-00018
更新日期:1980-08-01 00:00:00
abstract::Considerable controversy exists with regard to therapeutic efficacy of plasmapheresis in the immune-mediated demyelinating disorders of the peripheral and central nervous system: acute inflammatory polyneuropathy (Guillain-Barré syndrome), chronic inflammatory demyelinating polyneuropathy, and multiple sclerosis. In a...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198608000-00018
更新日期:1986-08-01 00:00:00
abstract::Perioperative consultations may play a major role in the care of surgical patients in an era of prospective payments. Since insurance reimbursement policy favors limitations in the number of consultants on a case, general medicine ("holistic") consultation services may become preferred perioperative consultants in the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198903000-00004
更新日期:1989-03-01 00:00:00
abstract::To make informed career decisions, physicians must acquire a basic knowledge in medical management and health care economics as they evaluate the potential survival and growth of a primary care practice. Health care providers considering a specific community and local leaders and hospital administrators attempting to ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199404000-00006
更新日期:1994-04-01 00:00:00
abstract::Autoimmune neutropenia (AIN) is defined as a neutrophil count <1.5 × 109/L caused by increased peripheral destruction of neutrophils from an underlying autoimmune mechanism in which autoantibodies are directed against a patient's own neutrophils. AIN has a multifactorial etiology ranging from an idiopathic primary phe...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.14423/SMJ.0000000000000637
更新日期:2017-04-01 00:00:00
abstract::AIDS-related Kaposi's sarcoma rarely involves bone or bone marrow. Computed tomography of the abdomen and pelvis of an AIDS patient with lower back pain and bilateral limb edema revealed multiple lesions involving liver, spleen, and axial skeleton. Bone marrow examination of the involved iliac crest revealed Kaposi's ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199901000-00012
更新日期:1999-01-01 00:00:00
abstract::The importance of considering organic diseases when evaluating catatonic patients is illustrated by two cases of akinetic parkinsonism in which the patients became catatonic, with waxy flexibility. The catatonic syndrome occurs in association with a variety of lesions that may affect any level of the central nervous s...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198606000-00008
更新日期:1986-06-01 00:00:00
abstract::The aim of this project was to review the course of infants referred for consideration of extracorporeal membrane oxygenation (ECMO) to identify maximal ventilator settings that, when exceeded, did not provide clinical benefit to the patient. These settings might then be used in defining failure of conventional mechan...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199706000-00009
更新日期:1997-06-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a cholestatic liver disease that usually presents in middle-aged women. Women are about ten times more commonly affected than men. The case of a 78-year-old man with PBC who presented with pruritus is discussed. Liver biopsy and antimitochondrial antibody serology were diagnostic of ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181c041bd
更新日期:2009-12-01 00:00:00
abstract::Poisoning by antimony led to the death of a great individual in English literature. This case report gives as much of the history of the illness as can be found and tells a little about the individual. ...
journal_title:Southern medical journal
pub_type: 传,历史文章,杂志文章
doi:10.1097/00007611-198205000-00021
更新日期:1982-05-01 00:00:00
abstract::An increased risk of skin and lymphoreticular malignancies is well documented in renal transplant patients receiving long-term immunosuppressive therapy, but squamous cell carcinoma of the esophagus is rare. We have reported the first case in the English literature in which there is a strong association between long-t...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198712000-00025
更新日期:1987-12-01 00:00:00
abstract::We report the case of a term newborn with vein of Galen aneurysm. No antenatal diagnosis was done. The infant was admitted secondary to cardiac failure, with cardiomegaly and pulmonary hypertension. Physical examination was remarkable for acrocyanosis, microcephaly, cranial bruit, bilateral neck swelling, coarse breat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-200405000-00020
更新日期:2004-05-01 00:00:00
abstract::Although alpha 1-antitrypsin deficiency has been associated with obstructive lung disease in individuals possessing a homozygous phenotype (PiZZ), this association has not been as clearly documented in heterozygous individuals (PiMZ, PiMS, and PiSZ phenotypes). Information regarding the heterozygous adolescent populat...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199610000-00018
更新日期:1996-10-01 00:00:00
abstract::In an attempt to prevent morbidity and mortality in carotid endarterectomy, we monitored 47 operations with intraoperative EEG to determine which patients should have a shunt during endarterectomy. The EEG was recorded for up to five minutes during test carotid cross-clamping. When EEG asymmetry between the cerebral h...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197908000-00018
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) is one of the most frequent infections in intensive care units (ICUs), and nearly 50% of patients with VAP develop septic shock. Septic shock is an independent predictor for mortality in these patients. OBJECTIVE:To investigate the predictors for septic shock in VAP pat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181827891
更新日期:2008-12-01 00:00:00
abstract::The sleep apnea syndromes have been recognized clinically in the United States only within the past ten years. The true extent of the problem is not known, but it seems certain that these syndromes are much more common than was generally assumed five years ago. Every clinician should be aware of the signs and symptoms...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198201000-00011
更新日期:1982-01-01 00:00:00
abstract::A retrospective study of 45 patients hospitalized with blastomycosis of bones or joints revealed 41 cases of osteomyelitis and 12 cases of septic arthritis. The majority were men (35 [78%] patients) and non-Aboriginal (32 [71%] patients). Median time from the onset of symptoms to hospitalization was shorter in women t...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3180487a92
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To determine vitamin D status in children with spina bifida (SB). METHODS:Charts of all patients with SB at the Shriners Hospital for Children in Houston, Texas, seen between July 2011 and June 2013 were retrospectively reviewed. Daily intake of milk, vitamins, amount of screen time, and time spent outdoors ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000397
更新日期:2016-01-01 00:00:00
abstract::The empirical use of amphotericin B in febrile leukemic patients not responding to antimicrobial agents has previously led to a significant decrease in fatal fungal infections and a significant increase in complete remissions. In this series of 66 patients receiving induction therapy for acute myelogenous leukemia (AM...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198607000-00020
更新日期:1986-07-01 00:00:00