Abstract:
OBJECTIVE:No standard therapeutic option exists for men with prostate cancer who have failed local therapy, have no gross metastatic disease, and whose only manifestation of disease is a rising prostate-specific antigen (PSA) level. Soy products are able to affect PSA kinetics in some men with prostate cancer, and this effect has been attributed to the decreased expression of the androgen receptor and other mechanisms. METHODS:We treated 10 men with rising PSA levels after radical prostatectomy and salvage radiotherapy with commercially available soy products. Scans revealed no gross metastatic disease. Three men also had been receiving androgen-deprivation therapy (ADT) and had rising PSA levels that were consistent with castration-resistant (CR) disease. We reported the results of this modality on PSA levels, PSA kinetics, and the duration of PSA response. RESULTS:Responses occurred in 4 of 7 (57%) patients with ADT-naïve disease and 1 of 3 (33%) patients with CR disease. The median duration of treatment response was 24 months. The overall clinical benefit, therefore, was noted in 5 of 10 (50%) patients. Therapy was well tolerated. CONCLUSIONS:Our findings are fairly congruent with what has been described in the literature on the use of this modality in prostate cancer. We used commercially available soy products. We also show that soy can provide benefit in CR prostate cancer. Our clinical experience suggests that soy supplementation using commercially available soy products can have durable beneficial effects on PSA levels and PSA kinetics in some men with prostate cancer.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Joshi M,Agostino NM,Gingrich R,Drabick JJdoi
10.1097/SMJ.0b013e3182335151subject
Has Abstractpub_date
2011-11-01 00:00:00pages
736-40issue
11eissn
0038-4348issn
1541-8243pii
00007611-201111000-00006journal_volume
104pub_type
杂志文章abstract::Seven adults with acute leukemia had a clinical and radiologic diagnosis of neutropenic enterocolitis. Six of the seven patients had granulocyte counts less than 500/microliter. All seven patients responded to intensive medical therapy, including bowel rest, broad spectrum antibiotics, and white blood cell transfusion...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198710000-00008
更新日期:1987-10-01 00:00:00
abstract::Fifty-four residents in internal medicine and primary care medicine were surveyed before and after receiving a prescription drugs price guide booklet to determine whether providing written price information to the residents would improve their knowledge of drug costs. Results indicated that the pricing information did...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198303000-00015
更新日期:1983-03-01 00:00:00
abstract::We retrospectively analyzed experience with total gastrectomy (TG) for gastric carcinoma in 23 patients. The TNM stage was I in one patient, II in one patient, III in eight patients, and IV in 13. Linitis plastica was found in ten patients. The operation was considered curative in only eight patients (35%). There were...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198908000-00011
更新日期:1989-08-01 00:00:00
abstract::Hypokalemic periodic paralysis is an unusual disease that may begin dramatically. Although terrifying to the patient, the attacks can usually be controlled if the proper diagnosis is made. Although much has been done to determine the pathogenesis, many questions remain unanswered. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198409000-00046
更新日期:1984-09-01 00:00:00
abstract::Although recent increases in the incidence of syphilis are well known to public health officials, the general medical community is less well informed regarding the dramatic rise in cases. We present trend data from Nashville and Tennessee over the past decade. These statistics emphasize specific factors, such as drug ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199208000-00002
更新日期:1992-08-01 00:00:00
abstract::Although d-penicillamine has a wide range of benefits in many clinical conditions, various side effects have also been reported and preclude its further use in certain patients. In this case, d-penicillamine-induced reversible airway obstruction developed, despite the "go slow--go low" regimen as suggested to reduce t...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198006000-00032
更新日期:1980-06-01 00:00:00
abstract:OBJECTIVES:Gas exchange measurements obtained during submaximal exercise have been shown to provide prognostic and diagnostic information in patients with heart failure (HF) and to differentiate heart versus lung limitations in patients with unexplained dyspnea. The aim of our study was to assess the clinical utility o...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0000000000000066
更新日期:2014-03-01 00:00:00
abstract::A combined patient flow and work sampling study was done at the Ambulatory Pediatric Service of the Medical University of South Carolina. The biggest problem was that almost two thirds of the patient's time was spent waiting to see the doctor. Reasons for delay included too few examining rooms, the single block appoin...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197706000-00004
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:Patient comfort is an important part of laceration repair. METHODS:The study was a randomized single-blind cross-over trial in which each participant received 250 ml warmed and 250 ml room temperature saline irrigation in simple linear wounds after a local anesthetic was instilled. The solutions and the ord...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.SMJ.0000056657.63336.6C
更新日期:2003-05-01 00:00:00
abstract::We report four cases of group A streptococcal vulvovaginitis in prepubertal children. All cases were acute in onset. This illness presents with nonspecific signs and symptoms of labial inflammation. In a suburban community, streptococcal vulvovaginitis in prepubescent girls may be more common then genital infections d...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198204000-00017
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Conventional magnetic resonance imaging (MRI) of complex cervical spine disorders may underestimate the magnitude of structural disease because imaging is performed in a nondynamic non-weight-bearing manner. Myelography provides additional information but requires an invasive procedure. METHODS:This was a p...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-200405000-00008
更新日期:2004-05-01 00:00:00
abstract::A cross-sectional survey of a total semirural biracial population of children was conducted to determine the prevalence and types of cardiac disease. Of 4,074 children examined, 146 were thought to have significant cardiac murmurs. One hundred thirteen of these participated in a follow-up study in which they received ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198210000-00006
更新日期:1982-10-01 00:00:00
abstract::This study was undertaken to determine what factors would be useful in making a decision to do bronchoscopy to look for an obstructing carcinoma in cases of pneumonia. The study showed that in pneumonia limited to one lobe of the lung, which occurs in a heavy smoker over 50 years of age, and which does not have comple...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198006000-00024
更新日期:1980-06-01 00:00:00
abstract:BACKGROUND:Tobacco-growing states have few tobacco control laws, which are relatively weak compared with those in non-tobacco-growing states. Region of the country has been shown to be a predictor of legislators' intentions to vote for cigarette tax increases. METHODS:A total of 116 lawmakers (84%) participated in fac...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::This study was done to ascertain whether there was an increased incidence of acute rheumatic fever (ARF) in west Alabama, similar to that reported elsewhere within the United States. Hospital records for the previous 10 years were reviewed and 5-year intervals were compared (1980 through 1984 vs 1985 through 1989). A ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199203000-00007
更新日期:1992-03-01 00:00:00
abstract::We have described a case of hypophosphatasia with a mild progressive course. This condition and its familial propensity may be more prevalent than recognized. Thus, family members of a patient with hypophosphatasia should be screened for this disorder. Enthusiastic pharmacologic, hormonal, and/or dietary supplemental ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198312000-00030
更新日期:1983-12-01 00:00:00
abstract::We report a case of neutropenia and gram-negative septicemia in a 73-year-old male with ulcerative colitis. During the hospital course, medications were adjusted according to rare accounts of drug-induced neutropenia. While the substitution of propafenone for another antiarrhythmic brought about no change in the patie...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181f46647
更新日期:2010-11-01 00:00:00
abstract::We studied the prevalence of non-group-A beta-hemolytic streptococci (NGAS) in the pharyngeal cultures of symptomatic and asymptomatic children. Throat cultures were obtained by house officers in the Emergency Department at Children's Hospital of Pittsburgh to aid in the evaluation of children with symptoms or signs o...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198803000-00011
更新日期:1988-03-01 00:00:00
abstract::A 32-year-old farmer had signs and symptoms of dinitrophenol poisoning after crop spraying with a herbicide containing derivatives of 2,4-dinitrophenol. Dinitrophenol causes toxicity by the uncoupling of oxidative phosphorylation in the mitochondria of cells throughout the body. In man the classic syndrome consists of...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1982-02-01 00:00:00
abstract::To determine the prevalence of frequently occurring neurologic disorders in a biracial population, a survey of households and chronic care institutions was carried out for all residents of Copiah County, Mississippi. Along with a complete census, interviews were held using extensive questions about diagnoses, signs, a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198703000-00016
更新日期:1987-03-01 00:00:00
abstract::I reviewed the cases of 50 consecutive patients who had a total of 75 plastic surgery procedures after weight reduction. The average weight loss was 126 lb. There were 28 women and 22 men. The 75 operations were abdominoplasty (24), face-lift (18), reduction mammaplasty (ten), blepharoplasty (eight), mastopexy (eight)...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198711000-00011
更新日期:1987-11-01 00:00:00
abstract::In a ten-year period 139 patients with epidermoid carcinoma of the esophagus were treated by palliative feeding procedures, palliative radiation therapy, radiation therapy for cure, or resection. Analysis of the results of these modes of therapy indicates that long-term palliation is best achieved when resection is th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197606000-00016
更新日期:1976-06-01 00:00:00
abstract::We evaluated an incentive spirometer (IS) for monitoring changes in lung function in hospitalized patients. Accuracy and reproducibility of IS measurements of known volumes were adequate (r = 0.87). Flow dependency was demonstrated but was not significant in the clinically useful range. Reproducibility of IS measureme...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198206000-00013
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:The blood gas analyzer (BGA) has been considered the "gold standard" for pleural fluid pH determination. METHODS:We report the various methods used to measure pleural fluid pH by 277 acute care institutions who responded to a mailed questionnaire. The techniques used included the BGA (32%), dip stick or pH ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199902000-00010
更新日期:1999-02-01 00:00:00
abstract::A 54-year-old man deliberately drank a potassium-gold cyanide solution that contained approximately 1,650 mg of potassium cyanide. He survived after treatment with the Lilly antidote kit and hyperbaric oxygen. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199408000-00010
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of overweight in a cardiac stress testing population, and the percentage of subjects who indicate a history of overweight. METHODS:A total of 251 consecutive subjects presenting for cardiac stress testing in a 450-bed community hospital from June to September 2010 were asked to c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31821e9359
更新日期:2011-07-01 00:00:00
abstract::Recommendations concerning postoperative extubation after thymectomy for myasthenia gravis are presently based upon retrospective chart reviews. We present the results of a prospective investigation of time to extubation after thymectomy for 14 patients over a 12-month period based upon a protocol that included preope...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199106000-00007
更新日期:1991-06-01 00:00:00
abstract::A case of unilateral primary adrenal hyperplasia, without concomitant hypokalemia, is presented. After surgical removal of the gland, a complete remission occurred. This rare condition may, in fact, be more frequent than thought as it can coexist with normokalemia. We postulate that it is probably a new phase of the t...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199406000-00017
更新日期:1994-06-01 00:00:00
abstract::A patient with typical classic migraine, including clear-cut visual auras, who had been followed up clinically for more than 15 years developed permanent right homonymous hemianopia. The underlying cause of this clinical syndrome was established by computerized axial tomography as vascular infarction or ischemia, invo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197907000-00017
更新日期:1979-07-01 00:00:00
abstract::Bile acid sequestrants (BAS) continue to command a position in the treatment of dyslipidemias 25 years after their introduction. Partial diversion of the enterohepatic circulation using BAS depletes the endogenous bile acid pool by approximately 40%, thus stimulating an increase in bile acid synthesis from cholesterol...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000208120.73327.db
更新日期:2006-03-01 00:00:00