Asacol®-induced neutropenia resolution without the use of granulocyte colony-stimulating factor.

Abstract:

:We report a case of neutropenia and gram-negative septicemia in a 73-year-old male with ulcerative colitis. During the hospital course, medications were adjusted according to rare accounts of drug-induced neutropenia. While the substitution of propafenone for another antiarrhythmic brought about no change in the patient's absolute neutrophil count, the cessation of Asacol® (Warner Chilcott, Rockaway, NJ) was followed by a significant improvement in the neutropenic state. In fact, this neutrophil count continued to trend upward for months following. We thereby conclude that Asacol® carries the potential to induce neutropenia and that this reaction may be reversed in some patients solely by discontinuing the medication and without the aid of stimulating factors such as filgrastim.

journal_name

South Med J

journal_title

Southern medical journal

authors

Fowler BT,Gupta T,Bilal M

doi

10.1097/SMJ.0b013e3181f46647

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

1167-9

issue

11

eissn

0038-4348

issn

1541-8243

journal_volume

103

pub_type

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