Abstract:
:As our population ages, the incidence and prevalence of Alzheimer disease (AD) will increase dramatically. A number of therapies have been investigated for the treatment and prevention of AD. Clinicians should be prepared to provide evidence-based answers to inquiries regarding AD treatment. There is insufficient evidence to recommend ginkgo biloba, estrogen, statins, or nonsteroidal anti-inflammatory drugs for the prevention or treatment of AD. The use of vitamin E is supported by a single randomized controlled trial, while data on other antioxidants is mixed. There is good evidence that cholinesterase inhibitors and memantine are modestly effective in the treatment of AD. Cholinesterase inhibitors appear to be effective throughout the spectrum of AD, while memantine, alone or in combination with cholinesterase inhibitors, is effective in late stage disease. There is insufficient evidence to suggest superiority of one cholinesterase over another.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Potyk Ddoi
10.1097/01.SMJ.0000166671.86815.C1subject
Has Abstractpub_date
2005-06-01 00:00:00pages
628-35issue
6eissn
0038-4348issn
1541-8243journal_volume
98pub_type
杂志文章,评审abstract::We evaluated the indices of arterial distensibility in a group (N = 40) of normotensive subjects and patients with borderline or established hypertension by measuring intra-arterial pressure, pulse wave velocity, and a mathematical modification of MOEN's formula to calculate arterial distensibility. Multiple linear re...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198401000-00015
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:The objectives of the study were to determine the percentage of osteopathic emergency medicine (EM) residencies that require an original research project to meet the American Osteopathic Association requirement, describe the resources available to the residents and faculty members to complete their projects,...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000967
更新日期:2019-05-01 00:00:00
abstract::We have presented a case of tracheobronchitis due to C pseudodiphtheriticum in a patient with COPD who was treated with prednisone and apparently was not otherwise immunocompromised. Chronic lung disease seems to predispose to infection with C pseudodiphtheriticum; it can also occur in the immunocompetent host. This o...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199104000-00026
更新日期:1991-04-01 00:00:00
abstract::The incidence of acute rheumatic fever in Mississippi was estimated by reviewing the hospital charts of Mississippi residents with a discharge diagnosis of acute rheumatic fever from 1964 through 1973. The average annual incidence was 1.5 cases/100,000 population for primary attacks and 0.4 cases/100,000 population fo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198105000-00013
更新日期:1981-05-01 00:00:00
abstract:: Acute pulmonary embolism (PE) is a common clinical condition with presentations that may vary from asymptomatic subsegmental emboli to massive vascular obstruction and shock with high risk of death. Identifying patients at highest risk for death is critical to select those who would benefit most from thrombolytic the...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e318268dbca
更新日期:2012-10-01 00:00:00
abstract::Diagnostic peritoneal lavage (DPL) is an established procedure in evaluation of trauma victims but is less well established for use in patients suspected of having acute intra-abdominal disease. Twenty-six seriously ill patients at our institution who had DPL for acute intra-abdominal disease form the basis of this re...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199004000-00015
更新日期:1990-04-01 00:00:00
abstract::Two premature infants were infected with HIV via blood transfusions during the neonatal period. Although neither patient had serum antibody to HIV owing to severe hypogammaglobulinemia, HIV infection was confirmed by finding HIV antigen in the sera of both patients. These cases show that HIV infection can produce seve...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198904000-00005
更新日期:1989-04-01 00:00:00
abstract::Lactulose is a poorly absorbed synthetic disaccharide frequently used in the treatment of portasystemic encephalopathy. Because lactulose syrup contains small amounts of absorbable sugars, it may cause hyperglycemia in diabetic individuals, but is usually well tolerated. We report the case of a patient with diet-contr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199504000-00025
更新日期:1995-04-01 00:00:00
abstract::Abscess of the spleen is uncommon and potentially lethal, but until recently it was rarely diagnosed except by exploratory celiotomy or at autopsy. Now, with the advent of radionuclide scanning, ultrasonography, and selective angiography, earlier diagnosis is possible in most cases. We report a case of traumatic absce...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197905000-00019
更新日期:1979-05-01 00:00:00
abstract::Two cases are reviewed which presented findings strongly suggesting congenital synostosis between the third metatarsal and third cuneiform bones. Supplementary x-ray films proved these joints to be present and intact. This point, though well known to skeletal radiologists, is worthy of emphasis to nonskeletal radiolog...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::When patient records are to be auditied in a program designed to assess the quality of medical care rendered, careful consideration must be given to the cost of the system implemented. Structured data collection and a defined treatment plan are advantageous in facilitating the use of nonphysicians for the majority of ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197610000-00022
更新日期:1976-10-01 00:00:00
abstract::Amiodarone, a widely used antiarrhythmic drug, is associated with pulmonary toxicity, with an estimated mortality of 1% to 33%. Standard treatment for amiodarone pulmonary toxicity (APT) has been discontinuance of the drug and steroid therapy. We report a case of APT that recurred after withdrawal of steroids and fail...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199601000-00016
更新日期:1996-01-01 00:00:00
abstract::A technic of combined split-thickness and full-thickness skin grafts and local flap closure for extensive deep cicatricial neck contractures is presented. The head and neck are mobilized by excision of limiting tissues. The lateral neck skin is mobilized to be rotated anteriorly as flaps, and a full-thickness skin gra...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197606000-00023
更新日期:1976-06-01 00:00:00
abstract::Coagulopathy due to tuberculosis is rare. We believe ours is only the second reported case of cavitary tuberculosis associated with disseminated intravascular coagulation. Our review of all 13 cases to date shows that the patients are generally black, middle-aged, male, alcoholic, and febrile. The tuberculosis is gene...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199001000-00019
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:To characterize pain and exposure after Prolift placement and identify risk factors. METHODS:A case series of women who underwent Prolift vaginal mesh were surveyed. Pain was assessed using a visual analog scale. Exposure was evaluated clinically. RESULTS:Of 183 eligible patients, 160 completed the survey,...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000377
更新日期:2015-12-01 00:00:00
abstract::We have used the island gluteus maximus musculocutaneous flap to cover sacral pressure sores. In this report, we describe the surgical anatomy, cadaveric dissections (n = 25), and postoperative follow-up (one to 40 months) in 13 clinical cases. Our results compare favorably with those of other previously reported seri...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:
更新日期:1985-10-01 00:00:00
abstract::Pressure modes of invasive mechanical ventilation generate a tidal breath by delivering pressure over time. Pressure control ventilation (PC) is the prototypical pressure mode and is patient- or time-triggered, pressure-limited, and time-cycled. Other pressure modes include pressure support ventilation (PSV), pressure...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e31822da7fa
更新日期:2011-10-01 00:00:00
abstract::With the intent of cost containment, we conducted a survey of cimetidine usage in the Ambulatory Care Service of our Veterans Administration Medical Center. During a period of six months, this drug was prescribed for 132 patients. Only about 20% received cimetidine for FDA approved conditions. Treated conditions not a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198410000-00019
更新日期:1984-10-01 00:00:00
abstract::We present the first two known cases of infantile botulism in Oklahoma. The first case was due to type B toxin; the second was due to type A toxin. Both cases demonstrate most of the classic features of what now appears to be the most common form of botulism. Infantile botulism is an underrecognized but reversible cau...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198804000-00012
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVES:In 2014, 726 bicyclists were killed and an additional 50,000 were injured in crashes with motor vehicles. The number of cyclists in the United States is increasing, and as a result there has been a call for more bike lanes. We examined the difference in the severity of injury of bicyclists involved in motor ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000665
更新日期:2017-07-01 00:00:00
abstract::We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving "standard" doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and cl...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199701000-00007
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the statewide experience in mode of delivery for pregnancies complicated by stillbirth by annual delivery volume and presence of graduate medical education programs. METHODS:This is a descriptive study of all stillbirths without known congenital anomalies or aneuploidy born in our state from Jul...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000001180
更新日期:2020-12-01 00:00:00
abstract::Clinicians should be on the alert for the possibility of underlying thyrotoxicosis in patients having an affective disturbance. An initial detailed medical history and complete physical examination is essential even in severely agitated, threatening patients. The danger of inappropriate diagnosis and treatment of thes...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198811000-00032
更新日期:1988-11-01 00:00:00
abstract::Seven adults with acute leukemia had a clinical and radiologic diagnosis of neutropenic enterocolitis. Six of the seven patients had granulocyte counts less than 500/microliter. All seven patients responded to intensive medical therapy, including bowel rest, broad spectrum antibiotics, and white blood cell transfusion...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198710000-00008
更新日期:1987-10-01 00:00:00
abstract::This paper explores the possibility that bed sharing may carry particular risks for children with special healthcare needs (CSHCN). Two cases of CSHCN who may have sustained adverse health effects from bed sharing are described. These two case reports indicate that CSHCN may be particularly susceptible to risks associ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000220843.75686.cb
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Pulmonary contusion (PC) is the most common injury identified in pediatric blunt chest trauma. The disagreement over management principles of children with PC may complicate care of these patients. METHODS:We reviewed the literature and our institutional experience. RESULTS:Pulmonary contusion is most ofte...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199812000-00002
更新日期:1998-12-01 00:00:00
abstract::Prognosis of angiosarcoma, the most common primary malignant cardiac tumor, is very poor. An early detection and treatment may extend survival beyond one year. Newer imaging modalities, including magnetic resonance imaging (MRI), play an important role in the evaluation of cardiac masses. The case of a man admitted to...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181ecfb64
更新日期:2010-10-01 00:00:00
abstract::We have reported a case of spontaneous dissection of the internal carotid artery, with MRI and angiographic findings. We conclude that MRI is a beneficial noninvasive test for the detection and study of carotid artery dissection. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199109000-00021
更新日期:1991-09-01 00:00:00
abstract::Patients with blunt hepatic injury can safely be managed nonoperatively if they show hemodynamic stability. Transcatheter arterial embolization (TAE) is a useful adjunct in the treatment of patients who show evidence of continued hemorrhage or who have pooling of contrast material on computed tomography (CT). In these...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:Code status specifies the action that healthcare providers should take in the event of cardiac arrest. Studies have shown, however, that patients with do-not-resuscitate/do-not-intubate (DNR/DNI) orders have worse outcomes and do not consistently receive the standard of care. Several studies have demonstrate...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000001112
更新日期:2020-07-01 00:00:00