Treatments for Alzheimer disease.

Abstract:

:As our population ages, the incidence and prevalence of Alzheimer disease (AD) will increase dramatically. A number of therapies have been investigated for the treatment and prevention of AD. Clinicians should be prepared to provide evidence-based answers to inquiries regarding AD treatment. There is insufficient evidence to recommend ginkgo biloba, estrogen, statins, or nonsteroidal anti-inflammatory drugs for the prevention or treatment of AD. The use of vitamin E is supported by a single randomized controlled trial, while data on other antioxidants is mixed. There is good evidence that cholinesterase inhibitors and memantine are modestly effective in the treatment of AD. Cholinesterase inhibitors appear to be effective throughout the spectrum of AD, while memantine, alone or in combination with cholinesterase inhibitors, is effective in late stage disease. There is insufficient evidence to suggest superiority of one cholinesterase over another.

journal_name

South Med J

journal_title

Southern medical journal

authors

Potyk D

doi

10.1097/01.SMJ.0000166671.86815.C1

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

628-35

issue

6

eissn

0038-4348

issn

1541-8243

journal_volume

98

pub_type

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