Metastatic prostatic carcinoma presenting as fulminant hepatic failure.

Abstract:

:A 68-year-old male presented with progressive abdominal pain, dyspnea, weight loss, and dysuria. Lab work revealed elevated creatine phosphokinase levels, prostate-specific antigen level (approximately 60 ng/mL), and elevated liver enzymes. He was admitted to the intensive care unit for worsening respiratory distress and confusion. He continued to deteriorate, and his bilirubin peaked at 8.5 mg/dL. The patient subsequently died, and an autopsy revealed extensive hepatic necrosis with diffuse intravascular and intraparenchymal permeation of metastatic prostatic carcinoma. Fulminant hepatic failure remains a rare presentation of metastatic prostatic carcinoma, with a rapidly progressive course toward hepatic coma and death. A high index of suspicion is needed to investigate the possibility of palliative chemotherapy.

journal_name

South Med J

journal_title

Southern medical journal

authors

Shakir FA,Madhoun M,Whorton J,Harty R

doi

10.1097/SMJ.0b013e31817c74c3

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1049-50

issue

10

eissn

0038-4348

issn

1541-8243

journal_volume

101

pub_type

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