Abstract:
:1. The propagation of antidromically activated action potentials in CA1 pyramidal neurons was examined with intrasomatic and intradendritic electrical recording and optical measurements using the fluorescent calcium indicator Calcium Green-1. 2. In somatic recordings, trains of 40 action potentials, activated at rates up to 100 Hz, showed modest amplitude reduction. Recordings in the apical dendrites, 150 microns from the soma, showed smaller initial amplitudes and much greater decrement during trains. Higher frequencies caused a greater rate of reduction with a lower final amplitude. 3. Calcium concentration changes ([Ca2+]i), measured with the fluorescent indicator Calcium Green-1 and a fast, cooled charge coupled device (CCD) camera, were detected over the entire length of the apical dendrites in response to single antidromic action potentials, although the changes in distal dendrites were smaller. These changes were rapid, decaying to half-amplitude in < 150 ms in distal dendritic locations. 4. Trains of action potentials at all frequencies up to 100 Hz caused transient [Ca2+]i, increases for each spike at 150 microns from the soma. In the last 100 microns of the distal branches, only the first few spikes caused a [Ca2+]i increase for frequencies above approximately 40 Hz. These patterns could be matched with a simple model of calcium influx and removal, where later spikes in a train brought in less calcium than earlier spikes. 5. These results show that the action-potential amplitude and the spatial extent of their propagation in the dendrites is frequency dependent.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Callaway JC,Ross WNdoi
10.1152/jn.1995.74.4.1395subject
Has Abstractpub_date
1995-10-01 00:00:00pages
1395-403issue
4eissn
0022-3077issn
1522-1598journal_volume
74pub_type
杂志文章abstract::Results from previous studies suggest that two-dimensional spatial patterns are processed similarly in vision and touch when the patterns are equated for effective size or when visual stimuli are blurred to mimic the spatial filtering of the skin. In the present study, we measured subjects' ability to perceive the sha...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00654.2015
更新日期:2016-01-01 00:00:00
abstract::In the Aplysia mechanoafferent B21, afferent transmission is in part regulated via the control of active spike propagation. When B21 is peripherally activated at its resting membrane potential, spikes fail to propagate to an output process, and afferent transmission does not occur. In this report, we show that the pro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01341.2006
更新日期:2007-04-01 00:00:00
abstract::Most studies investigating neural representations of species-specific vocalizations in non-human primates and other species have involved studying neural responses to vocalization tokens. One limitation of such approaches is the difficulty in determining which acoustical features of vocalizations evoke neural response...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00818.2005
更新日期:2006-02-01 00:00:00
abstract::The last few years have seen an increase in the variety of in vivo experiments used for studying cerebellar physiological mechanisms. A combination of ketamine and xylazine has become a particularly popular form of anesthesia. However, because nonanesthetized control conditions are lacking in these experiments, so far...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00057.2007
更新日期:2007-09-01 00:00:00
abstract::The present paper investigates the sensory-driven modulations of central pattern generator dynamics that can be expected to reproduce human behavior during rhythmic hybrid tasks. We propose a theoretical model of human sensorimotor behavior able to account for the observed data from the ball-bouncing task. The novel c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00054.2017
更新日期:2017-10-01 00:00:00
abstract::A total of 51 dorsal horn units responsive to heat were isolated and their receptive fields characterized (i.e., response properties and adequate stimuli determined) in pentobarbital-anesthetized, paralyzed rats. In 39 of the 51 units, the descending inhibition of heat-evoked activity produced by focal electrical stim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.56.5.1397
更新日期:1986-11-01 00:00:00
abstract::Motor cortex plays a substantial role in driving movement, yet the details underlying this control remain unresolved. We analyzed the extent to which movement-related information could be extracted from single-trial motor cortical activity recorded while monkeys performed center-out reaching. Using information theoret...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00391.2013
更新日期:2014-07-15 00:00:00
abstract::The rhythmic delivery of visual stimuli evokes large-scale neuronal entrainment in the form of steady-state oscillatory field potentials. The spatiotemporal properties of stimulus drive appear to constrain the relative degrees of neuronal entrainment. Specific frequency ranges, for example, are uniquely suited for enh...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00129.2017
更新日期:2017-07-01 00:00:00
abstract::The capabilities of any sensory system are ultimately constrained by the properties of the sensory neurons: the ability to detect and represent stimuli is limited by noise due to spontaneous activity, and optimal decoding in downstream circuitry must be matched to the nature of the encoding performed at the input. Her...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00108.2011
更新日期:2011-07-01 00:00:00
abstract::Processing of temporal information is key in auditory processing. In this study, we recorded single-unit activity from rat auditory cortex while they performed an interval-discrimination task. The animals had to decide whether two auditory stimuli were separated by either 150 or 300 ms and nose-poke to the left or to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00381.2013
更新日期:2013-11-01 00:00:00
abstract::Adaptation to novel dynamics requires learning a motor memory, or a new pattern of predictive feedforward motor commands. Recently, we demonstrated the upregulation of rapid visuomotor feedback gains early in curl force field learning, which decrease once a predictive motor memory is learned. However, even after learn...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00748.2016
更新日期:2017-11-01 00:00:00
abstract::According to Alexander's law (AL), the slow phase velocity of nystagmus of vestibular origin is dependent on horizontal position, with lower velocity when gaze is directed in the slow compared with the fast phase direction. Adaptive changes in the velocity-to-position neural integrator are thought to cause AL. Althoug...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90381.2008
更新日期:2008-12-01 00:00:00
abstract::Reach-to-grasp movements require information about the distance and size of target objects. Calibration of this information could be achieved via feedback information (visual and/or haptic) regarding terminal accuracy when target objects are grasped. A number of reports suggest that the nervous system alters reach-to-...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00112.2013
更新日期:2013-12-01 00:00:00
abstract::We evaluated the role of the sodium/glutamate transporter at the synaptic terminals of cone photoreceptors in controlling postsynaptic response kinetics. The strategy was to measure the changes in horizontal cell response rate induced by blocking transporter uptake in cones with dihydrokainate (DHK). DHK was chosen as...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.1.190
更新日期:1998-01-01 00:00:00
abstract::1. The functional organization of interneurons in spinal laminae III-V was studied in an isolated preparation of hamster dorsal horn with sensory innervation from an excised skin patch. Morphological details of 40 neurons were visualized by intracellular injection of horseradish peroxidase. Active and passive membrane...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.5.1746
更新日期:1992-11-01 00:00:00
abstract::We have used a computer-based mathematical model of alpha-motoneurons and of group Ia synaptic input to them, based on anatomical and electrophysiological data from the cat spinal cord, in order to examine the effects of variations in neuron size and input resistance and of conductance magnitude and duration on the ge...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.50.2.399
更新日期:1983-08-01 00:00:00
abstract::A spherical approximation technique is presented that affords a mathematical characterization of a virtual space receptive field (VSRF) based on first-spike latency in the auditory cortex of cat. Parameterizing directional sensitivity in this fashion is much akin to the use of difference-of-Gaussian (DOG) functions fo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.5.2645
更新日期:1998-11-01 00:00:00
abstract::It is well known that pro- and antisaccades may deploy different cognitive processes. However, the specific reason why antisaccades have longer latencies than prosaccades is still under debate. In three experiments, we studied the factors contributing to the antisaccade cost by taking attentional orienting and target ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00815.2009
更新日期:2010-03-01 00:00:00
abstract::The hearing ability of five Japanese macaques (Macaca fuscata) was assessed following two-stage bilateral auditory cortex lesions. The animals were tested using a shock-avoidance procedure with a conditioned-suppression procedure used for comparison in two cases. The animals initially were unable to respond to sound, ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.55.2.256
更新日期:1986-02-01 00:00:00
abstract::Iontophoresis of glutamate at sites on the apical dendrite 278-555 microm from the somata of rat neocortical pyramidal neurons evoked low-threshold, small, slow spikes and/or large, fast spikes in 71% of recorded cells. The amplitude of the small, slow spikes recorded at the soma averaged 9.1 mV, and their apparent th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.5.2466
更新日期:1997-05-01 00:00:00
abstract::The CNS controls reproduction through pulsatile secretion of gonadotropin-releasing hormone (GnRH). Episodic increases in the firing rate of unidentified hypothalamic neurons have been associated with downstream markers of GnRH secretion. Whether this episodic electrical activity is intrinsic to GnRH neurons, intrinsi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.1.86
更新日期:2001-07-01 00:00:00
abstract::1. Presynaptic inhibition of synaptic transmission in the hippocampus was investigated by comparing the effects of several agonists on miniature excitatory and inhibitory postsynaptic currents (mEPSCs and mIPSCs). 2. The Ca2+ ionophore ionomycin increased the frequency of mEPSCs and mIPSCs but did not affect their amp...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.5.2017
更新日期:1996-05-01 00:00:00
abstract::We examined the contribution of the motor cortex to the control of intralimb coordination during reaching in the standing cat. We recorded the activity of 151 pyramidal tract neurons (PTNs) in the forelimb representation of three cats during a task in which the cat reached forward from a standing position to press a l...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00469.2010
更新日期:2011-01-01 00:00:00
abstract::1. Activation of neurokinin receptors contributes to the excitation of many dorsal horn neurons by cutaneous sensory stimuli, particularly noxious stimuli. In the present study we investigate the role of neurokinin receptors in the activation of primate spinothalamic tract (STT) neurons by cutaneous mechanical stimuli...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.4.1464
更新日期:1994-10-01 00:00:00
abstract::The median nerve N20 and P22 SEP components constitute the initial response of the primary somatosensory cortex to somatosensory stimulation of the upper extremity. Knowledge of the underlying generators is important both for basic understanding of the initial sequence of cortical activation and to identify landmarks ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00116.2010
更新日期:2010-12-01 00:00:00
abstract::Chronic pain after nerve injury is often accompanied by hypersensitivity to mechanical stimuli, yet whether this reflects altered input, altered processing, or both remains unclear. Spinal nerve ligation or transection results in hypersensitivity to mechanical stimuli in skin innervated by adjacent dorsal root ganglia...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00506.2014
更新日期:2015-01-01 00:00:00
abstract::Sciatic nerve section (axotomy) increases the excitability of rat dorsal root ganglion (DRG) neurons. The changes in Ca2+ currents, K+ currents, Ca2+ sensitive K+ current, and hyperpolarization-activated cation current (I(H)) that may be associated with this effect were examined by whole cell recording. Axotomy affect...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.2.644
更新日期:2001-02-01 00:00:00
abstract::Cold-sensitive and nociceptive neural pathways interact to shape the quality and intensity of thermal and pain perception. Yet the central processing of cold thermosensation in the human brain has not been extensively studied. Here, we used magnetoencephalography and EEG in healthy volunteers to investigate the time c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00843.2016
更新日期:2017-05-01 00:00:00
abstract::The sensorimotor calibration of visually guided reaching changes on a trial-to-trial basis in response to random shifts in the visual feedback of the hand. We show that a simple linear dynamical system is sufficient to model the dynamics of this adaptive process. In this model, an internal variable represents the curr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00897.2006
更新日期:2007-04-01 00:00:00
abstract::Secondary hyperalgesia is believed to be a key feature of "central sensitization" and is characterized by enhanced pain to mechanical nociceptive stimuli. The aim of the present study was to characterize, using EEG, the effects of pinprick stimulation intensity on the magnitude of pinprick-elicited brain potentials [e...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00444.2015
更新日期:2015-11-01 00:00:00