Retinoblastoma protein expression in endometrial hyperplasia and carcinoma.

abstract：OBJECTIVE:The aims of this study were to determine the frequency of a nucleotide transition from C to T, which leads to increased transcription of interleukin-1beta (IL-1beta) in patients with different grades of cervical lesions, and to determine whether a correlation exists between the genotypes and cervical lesions....

journal_title：Gynecologic oncology

authors： Majeed GS,Glew S,Bidwell J

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:The objective was to identify the factors, if any, that may predict long-term results of CIN treatment and HPV clearance/persistence after locally excisional therapy. METHODS:A series of 252 women with CIN lesions treated by conization were subjected to sequential HPV detection by repeated PCR during the pro...

journal_title：Gynecologic oncology

authors： Costa S,De Simone P,Venturoli S,Cricca M,Zerbini ML,Musiani M,Terzano P,Santini D,Cristiani P,Syrjänen S,Syrjänen K

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVES:Terameprocol (M4N, EM-1421) is a novel transcription inhibitor that selectively interferes with HPV viral genes E6/E7 with Sp1-dependent promoters, and induces apoptosis by inactivation of the CDC2/cyclin B complex (maturation promoting factor) and production and phosphorylation of survivin. This trial was d...

journal_title：Gynecologic oncology

authors： Khanna N,Dalby R,Tan M,Arnold S,Stern J,Frazer N

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Central nervous system (CNS) metastases from ovarian adenocarcinoma are uncommon. The long-term prognosis for these patients is poor, with studies reporting a mean survival of less than 12 months. CASE:We present a case involving a 57-year-old woman diagnosed and treated for primary ovarian cancer in 1994. ...

journal_title：Gynecologic oncology

authors： Micha JP,Goldstein BH,Hunter JV,Rettenmaier MA,Brown JV

更新日期：2004-03-01 00:00:00

abstract：:Forty-eight cases subjected to radioimmunoimaging (RII) by intraperitoneal injection with 131I-C0C183B2 monoclonal antibody (MAb) prepared in our laboratory were studied. Thirteen of 14 cases of proved primary ovarian carcinoma were positive. In 11 follow-up cases of ovarian carcinoma after initial surgery and chemoth...

journal_title：Gynecologic oncology

authors： Qian H,Feng J,Cui H,Gao B,Qi G,Fu T,Wei P,Fu Z

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this phase II study was to evaluate on an intent-to-treat basis the activity and toxicity of single-agent vinorelbine (VRL) as second-line chemotherapy of patients with platinum-resistant ovarian cancer. Platinum-resistant disease was defined as disease refractory to or relapsing within 12 mont...

journal_title：Gynecologic oncology

authors： Sørensen P,Høyer M,Jakobsen A,Malmström H,Havsteen H,Bertelsen K

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To determine perioperative risk factors for prolonged hospitalization after gynecologic laparoscopic surgery. METHODS:Data on patients who underwent gynecologic laparoscopic surgery at a single academic institution from January 2000 to January 2009 were evaluated. Patient demographics, clinical history, intr...

journal_title：Gynecologic oncology

authors： Zand B,Frumovitz M,Jofre MF,Nick AM,Dos Reis R,Munsell MF,Sangi-Haghpeykar H,Levenback C,Soliman PT,Schmeler KM,Ramirez PT

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:In this study, we analyzed the PTEN expression in a large collection of clear cell adenocarcinomas of the ovary. Furthermore, we analyzed the expression of cyclin D1 and p27, and investigated the correlation among all these variables. METHODS:Totally, 40 clear cell adenocarcinomas were included in this stud...

journal_title：Gynecologic oncology

authors： Hashiguchi Y,Tsuda H,Inoue T,Berkowitz RS,Mok SC

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Since 1999, patients with low risk endometrial cancer (EC) as defined by the Mayo criteria have preferably not undergone lymphadenectomy (LND) at our institution. Here we prospectively assess survival, sites of recurrence, morbidity, and cost in this low risk cohort. METHODS:Cause-specific survival (CSS) was...

journal_title：Gynecologic oncology

authors： Dowdy SC,Borah BJ,Bakkum-Gamez JN,Weaver AL,McGree ME,Haas LR,Keeney GL,Mariani A,Podratz KC

更新日期：2012-10-01 00:00:00

abstract：:Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic neurological complication in cancer patients. Anti-Yo is one of the anti-onconeural antibodies found in PCD patients. It is believed that anti-Yo occurs almost always in women and is most likely associated with gynecologic or breast cancers, although...

journal_title：Gynecologic oncology

authors： Cao Y,Abbas J,Wu X,Dooley J,van Amburg AL

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Invasive vulvar carcinoma is reported to occur in 5 to 20% of patients with vulvar Paget's disease. We report a case in which a clinically inapparent invasive lesion was discovered on reexcision of microscopically persistent vulvar Paget's disease. CASE:A 58-year-old woman presented with a diagnosis of vulv...

journal_title：Gynecologic oncology

authors： Awtrey CS,Marshall DS,Soslow RA,Chi DS

更新日期：2003-03-01 00:00:00

abstract：:Endometrial carcinoma is the most common gynecologic malignancy and the fourth most prevalent cancer in women in the modern world. Despite a relatively high chance of surgical cure, for patients with advanced or recurrent disease there are few therapeutic options. Angiogenesis has been extensively studied ever since v...

journal_title：Gynecologic oncology

authors： Berger AA,Dao F,Levine DA

更新日期：2020-12-26 00:00:00

abstract：:Current first-line management for advanced ovarian cancer consists of cytoreductive surgery followed by chemotherapy, usually with a platinum/taxane combination. Although this approach has been shown to achieve overall response rates of 70-80% in clinical trials, the majority of patients relapse. A number of different...

journal_title：Gynecologic oncology

authors： Stuart GC

更新日期：2003-09-01 00:00:00

abstract：:One hundred and three patients treated with CAP chemotherapy were evaluated to determine the relationship between low prechemotherapy serum albumin (less than 3 g/dl) and low WBC nadir (less than 2000 cells/mm3). Additionally, the relationship of serum albumin to renal toxicity (delta serum creatinine) was examined. L...

journal_title：Gynecologic oncology

authors： Belinson JL,Jarrell MA,McClure M,Kulig PM,Badger GJ

更新日期：1990-04-01 00:00:00

abstract：:Only one case of endometrial transitional cell carcinoma (TCC) has been previously reported in the literature. We report a second case. In both the previously reported case and in this case there was a separate focus of TCC in the adnexa. Both patients were treated with adjuvant whole pelvic radiation and are alive an...

journal_title：Gynecologic oncology

authors： Spiegel GW,Austin RM,Gelven PL

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:To compare the survival experience of women with a BRCA1 mutation who enrolled in an ovarian cancer screening program with that of women who opted for preventive oophorectomy. METHODS:We followed 1964 women with a BRCA1 mutation and two ovaries intact in a prospective study. No women had ovarian cancer or ha...

journal_title：Gynecologic oncology

authors： Gronwald J,Lubinski J,Huzarski T,Cybulski C,Menkiszak J,Siołek M,Stawicka M,Sun P,Kim SJ,Kotsopoulos J,Narod SA

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:The utility of parametrial resection in women with early stage cervical cancer is controversial. In patients with favorable pathologic characteristics such as tumor size <2cm and the absence of lymphovascular space invasion, the rate of parametrial involvement is very low. More conservative surgical approach...

journal_title：Gynecologic oncology

authors： Schmeler KM,Frumovitz M,Ramirez PT

更新日期：2011-03-01 00:00:00

abstract：:CA125 and CA19-9 levels were serially evaluated in blood samples from 21 patients during and after integrated surgical and chemotherapeutic treatment for ovarian carcinoma. Serial measurement of CA125 and CA19-9 correlated with clinical course of disease in 89.7 and 72.7% of instances, respectively. The decrease of se...

journal_title：Gynecologic oncology

authors： Fioretti P,Gadducci A,Ferdeghini M,Bartolini T,Bianchi R,Facchini V

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the usefulness of pre-operative serum CA-125 in the management of women diagnosed with uterine papillary serous carcinoma (UPSC). We hypothesized that elevated pre-operative levels of serum CA-125 correlate with higher disease stage and poorer prognosis. METHODS:Patients diagnosed with UPSC and m...

journal_title：Gynecologic oncology

authors： Olawaiye AB,Rauh-Hain JA,Withiam-Leitch M,Rueda B,Goodman A,del Carmen MG

更新日期：2008-09-01 00:00:00

abstract：:Symptomatic uterine lymphangioleiomyomatosis (LAM) simulating high-stage uterine sarcoma in a patient with tuberous sclerosis complex is reported. A 49-year-old female presented with abdominal pain and anemia. Preoperative workup revealed a uterine mass and a large amount of peritoneal free fluid and possible metastat...

journal_title：Gynecologic oncology

authors： Longacre TA,Hendrickson MR,Kapp DS,Teng NN

更新日期：1996-12-01 00:00:00

abstract：:A 46-year-old women presented with an inoperable low-grade endometrial stromal sarcoma. Two doses of Depo-Lupron, 7.5 mg, and Megace, 160 mg/day, were given to control uterine bleeding and shrink the tumor mass. In 9 weeks, significant reduction in the tumor occurred allowing for surgical resection. Total abdominal hy...

journal_title：Gynecologic oncology

authors： Scribner DR Jr,Walker JL

更新日期：1998-12-01 00:00:00

abstract：:Less extensive surgical treatment has become possible for limited vulvar cancer. However, primary closure is advisable only when the defect is minimal and tissue replacement is always needed in radical excisions. Local flaps are always considered the first choice because of their characteristics of similarity to the r...

journal_title：Gynecologic oncology

authors： Tateo A,Tateo S,Bernasconi C,Zara C

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was the evaluation of endometrial histopathologic findings from 700 patients treated with tamoxifen (Tx) for breast cancer from two medical centers (United States and France). METHODS:A retrospective review of data including histologic slides from 134 hysterectomies and 566 endometrial ...

journal_title：Gynecologic oncology

authors： Deligdisch L,Kalir T,Cohen CJ,de Latour M,Le Bouedec G,Penault-Llorca F

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:BRCA-associated and sporadic ovarian cancers have different pathologic and clinical features. Our goal was to determine if BRCA mutation status is an independent predictor of residual tumor volume following primary surgical cytoreduction. METHODS:We conducted a retrospective analysis of patients with FIGO st...

journal_title：Gynecologic oncology

authors： Hyman DM,Long KC,Tanner EJ,Grisham RN,Arnold AG,Bhatia J,Phillips MF,Spriggs DR,Soslow RA,Kauff ND,Levine DA

更新日期：2012-08-01 00:00:00

abstract：:PI3K/AKT/mTOR pathway is a crucial mediator of tumor progression. As the PI3K/Akt pathway is heavily deregulated in breast cancer, the application of mTOR inhibitors in breast cancer patients seems warranted. This is the first systematic review according to PRISMA guidelines to synthesize all available data of mTOR in...

journal_title：Gynecologic oncology

authors： Zagouri F,Sergentanis TN,Chrysikos D,Filipits M,Bartsch R

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Few studies have analyzed relationships between risk factors for endometrial cancer, especially with regard to aggressive (non-endometrioid) histologic subtypes, and prognosis. We examined these relationships in the prospective NRG Oncology/Gynecologic Oncology Group 210 trial. METHODS:Prior to surgery, par...

journal_title：Gynecologic oncology

authors： Felix AS,Scott McMeekin D,Mutch D,Walker JL,Creasman WT,Cohn DE,Ali S,Moore RG,Downs LS,Ioffe OB,Park KJ,Sherman ME,Brinton LA

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to retrospectively evaluate the technique, feasibility and oncological safety of laparoscopic radical hysterectomy with vaginectomy and reconstruction of vagina in patients with stage I primary vaginal carcinomas. METHODS:Between February 2003 and July 2004, four patients, that...

journal_title：Gynecologic oncology

authors： Ling B,Gao Z,Sun M,Sun F,Zhang A,Zhao W,Hu W

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Tenascin is an extracellular matrix glycoprotein, relevant for embryonal and fetal development, which is reexpressed in the stroma of benign and malignant tumors. Little is known about the molecular interaction of tenascin during neoplastic transformation and tumor progression in cervical cancer. METHOD:We s...

journal_title：Gynecologic oncology

authors： Pilch H,Schäffer U,Schlenger K,Lautz A,Tanner B,Höckel M,Knapstein PG

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:The impact of gynecologic cancer on health-related quality of life (HRQOL) is not fully understood. To our knowledge, this is the first longitudinal study to measure HRQOL changes from before to after gynecologic cancer diagnosis in older women. METHODS:Data were obtained from the Surveillance, Epidemiology, a...

journal_title：Gynecologic oncology

authors： Klapheke AK,Keegan THM,Ruskin R,Cress RD

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Fractal geometry is a tool used to characterize irregularly shaped and complex figures. It can be used not only to generate biological structures (e.g., the human renal artery tree), but also to derive parameters such as the fractal dimension in order to quantify the shapes of structures. As such, it allows ...

journal_title：Gynecologic oncology

authors： Sedivy R,Windischberger C,Svozil K,Moser E,Breitenecker G

更新日期：1999-10-01 00:00:00