Abstract：
:Alternatively spliced protein segments tend to be intrinsically disordered and contain linear interaction motifs and/or post-translational modification sites. An emerging concept is that differential inclusion of such disordered segments can mediate new protein interactions, and hence change the context in which the biochemical or molecular functions are carried out by the protein. Since genes with disordered regions are enriched in regulatory and signaling functions, the resulting protein isoforms could alter their function in different tissues and organisms by rewiring interaction networks through the recruitment of distinct interaction partners via the alternatively spliced disordered segments. In this manner, the alternative splicing of mRNA coding for disordered segments may contribute to the emergence of new traits during evolution, development and disease.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Buljan M,Chalancon G,Dunker AK,Bateman A,Balaji S,Fuxreiter M,Babu MMdoi
10.1016/j.sbi.2013.03.006subject
Has Abstractpub_date
2013-06-01 00:00:00pages
443-50issue
3eissn
0959-440Xissn
1879-033Xpii
S0959-440X(13)00048-1journal_volume
23pub_type
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journal_title：Current opinion in structural biology
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journal_title：Current opinion in structural biology
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