Antiretroviral therapy for HIV infection. Heartening successes mixed with continuing challenges.

Abstract:

:Probably nothing in the field of medicine has changed as rapidly over the last decade as antiretroviral (ARV) therapy for HIV infection. New insights into pathogenesis, new tests for measuring virus levels in plasma, and availability of powerful new drugs have combined to transform the care of persons with HIV infection into a field infused with real hope. However, ARV therapy remains complex, expensive, and not universally effective or available. This article focuses on a general approach to the use of ARV agents.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Henry K,Stiffman M,Feldman J

doi

10.3810/pgm.1997.10.331

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

100-7, 111-3, 119-20

issue

4

eissn

0032-5481

issn

1941-9260

journal_volume

102

pub_type

杂志文章,评审
  • Demystifying autoimmune thyroid disease. Which disorders require treatment?

    abstract::The term "autoimmune thyroid disease" encompasses all of the autoimmune thyroid conditions, including Hashimoto's thyroiditis, Graves' disease, most cases of silent thyroiditis, and postpartum thyroiditis. Extrathyroidal manifestations (e.g., ophthalmopathy, dermopathy) can occur in Graves' disease and, less commonly,...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.3810/pgm.2000.01.810

    authors: Fatourechi V

    更新日期:2000-01-01 00:00:00

  • Flexible sigmoidoscopy. Illuminating the pearls for passage.

    abstract::As efforts to improve screening for colon cancer have increased, so has the importance of routine flexible sigmoidoscopy. However, the procedure is still underused, and about half of primary care physicians who recommend it refer their patients to other physicians. Increased use of this valuable screening tool is an i...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1999.06.622

    authors: Davis PW,Stanfield CB

    更新日期:1999-06-01 00:00:00

  • Carcinoma of the lung. Who will benefit from surgery?

    abstract::The present staging methods for non-small-cell lung cancer provide little more than epidemiologic assessment of prognosis for grossly defined groups of patients. Except in extreme instances, physicians can tell patients very little about their prognosis or the need for supplemental therapy. More effective and less tox...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1990.11704526

    authors: Landreneau RJ

    更新日期:1990-01-01 00:00:00

  • Acute poisoning: management protocol.

    abstract::Management of the acutely poisoned patient should start with decontamination of the skin and irrigation of the eyes, if necessary, and assessment of cardiorespiratory status, neurologic status, and pupils and eye movement. If a definable toxic syndrome is present, the specific "antidote" should be given. If no such sy...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11716063

    authors: Saxena K,Kingston R

    更新日期:1982-05-01 00:00:00

  • Managing obesity like any other chronic condition. Long-term therapy may reduce comorbidity as well.

    abstract::Patients often seek help from their primary care physician for weight loss, so familiarity with pharmacologic options and their risks is important. Anorexiants have been available for decades and are relatively safe. Orlistat and sibutramine are two of the newer medications that patients may have heard about in televi...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2000.07.1158

    authors: Agrawal M,Worzniak M,Diamond L

    更新日期:2000-07-01 00:00:00

  • A practical approach to dizziness. Questions to bring vertigo and other causes into focus.

    abstract::Evaluation of a patient presenting with dizziness begins with and largely depends on the patient's history. The diagnosis often can be accurately determined in a primary care setting when a stepwise algorithmic approach is used. The first step is getting a detailed account of precisely what the patient means by "dizzi...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Ruckenstein MJ

    更新日期:1995-03-01 00:00:00

  • Prescribing opioids for chronic noncancer pain in primary care: risk assessment.

    abstract::The use of opioids for patients with chronic noncancer pain has increased dramatically, and with increasing use there is increasing concern about the potential for abuse and addiction during long-term treatment. Clinicians should avoid viewing formal or subjective risk assessment as a means of classifying patients int...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2014.09.2810

    authors: Gordon A,Cone EJ,DePriest AZ,Axford-Gatley RA,Passik SD

    更新日期:2014-09-01 00:00:00

  • SGLT2 inhibitors in patients with type 2 diabetes and renal disease: overview of current evidence.

    abstract::Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and is associated with poor clinical outcomes, including an increased risk of all-cause and cardiovascular mortality, as well as adverse economic and social effects. Slowing the development and progression of CKD remains an unme...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.2019.1601404

    authors: Davidson JA

    更新日期:2019-05-01 00:00:00

  • Iron deficiency and anemia of chronic disease. Clues to differentiating these conditions.

    abstract::Iron deficiency occurs when the body's iron stores are exhausted. The source of blood loss leading to iron deficiency must be identified in all cases. Anemia of chronic disease generally results from an infectious, inflammatory, or malignant process. However, in some reported cases, no such process could be identified...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1992.11701469

    authors: Mohler ER Jr

    更新日期:1992-09-15 00:00:00

  • Weight considerations in psychotropic drug prescribing and switching.

    abstract::Our review describes potential weight-altering effects of psychotropic medications (antipsychotics, antidepressants, anti-anxiety medications, mood stabilizers, sedative-hypnotics, medications for attention-deficit/hyperactivity disorder, and other psychotropic medications) and offers guidance on switching a medicatio...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2013.09.2706

    authors: Hasnain M,Vieweg WV

    更新日期:2013-09-01 00:00:00

  • A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes.

    abstract:OBJECTIVE:The objective was to assess the relative risk (RR) for cardiovascular (CV) events across all 8 randomized phase 2/3 trials evaluating saxagliptin in patients with type 2 diabetes mellitus. METHODS:Cardiovascular events (death, myocardial infarction [MI], stroke, revascularization procedures, and cardiac isch...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.3810/pgm.2010.05.2138

    authors: Frederich R,Alexander JH,Fiedorek FT,Donovan M,Berglind N,Harris S,Chen R,Wolf R,Mahaffey KW

    更新日期:2010-05-01 00:00:00

  • Rocky Mountain spotted fever. When and why to consider the diagnosis.

    abstract::Rocky Mountain spotted fever, caused by a rickettsial organism transmitted by the bite of a tick, can be confused with many more common diseases. Diagnosis is made more challenging by the fact that treatment is most efficacious if begun before the second week of illness. Tetracycline and doxycycline are the most succe...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1990.11704599

    authors: Fischer JJ

    更新日期:1990-03-01 00:00:00

  • Disorders of defecation in children: evaluation and management.

    abstract::In a series of 123 children with disorders of defecation, constipation was the main problem in 89 and fecal incontinence in 34. All but three of the latter also had constipation. The principal physical findings were abdominal protuberance with palpable stool in the bowel and the presence of a fecal mass in the rectal ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1979.11715223

    authors: Liebman WM

    更新日期:1979-08-01 00:00:00

  • Evaluation of involuntary weight loss. Where do you start?

    abstract::When a patient presents with involuntary weight loss, the etiologic considerations can be overwhelming. To plan a cost-effective workup, physicians need to be aware of the most common causes of weight loss and the tests that yield the most pertinent data. Drs Wise and Craig review the clinical studies on unintentional...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Wise GR,Craig D

    更新日期:1994-03-01 00:00:00

  • Chemosensory dysfunction. Clinical evaluation results from a taste and smell clinic.

    abstract::Findings from 441 patient evaluations performed at the Taste and Smell Clinic of the Connecticut Chemosensory Clinical Research Center are presented. Taste and smell dysfunction was the chief complaint in all patients. The diagnostic approach included tests of taste and smell function; history taking; physical, neurol...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1987.11699680

    authors: Goodspeed RB,Gent JF,Catalanotto FA

    更新日期:1987-01-01 00:00:00

  • Colorectal carcinoma: overview of management techniques.

    abstract::The fact that the national death rate from carcinoma of the colon and rectum has remained static over the past two decades is strong incentive for future investigation of measures to allow detection in its early and more favorable stage. Although no significant improvements in surgical techniques have afforded improve...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1979.11715249

    authors: Bland KI,Garrison RN,Knutson CO

    更新日期:1979-09-01 00:00:00

  • Reversal agents in development for the new oral anticoagulants.

    abstract::The new oral anticoagulants have many advantages over vitamin K antagonists, but they are still associated with a troublesome incidence of major bleeding. Additionally, the absence of a reversal agent for the new oral anticoagulants is a barrier to their more widespread use. Currently, there are 3 potential reversal a...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2014.11.2829

    authors: Costin J,Ansell J,Laulicht B,Bakhru S,Steiner S

    更新日期:2014-11-01 00:00:00

  • Arthritis associated with common viral infections: mumps, coxsackievirus, and adenovirus.

    abstract::Arthritis complicating the common viral infections--mumps, coxsackievirus, and adenovirus--can be enigmatic. Mumps arthritis is often difficult to identify, especially when parotitis is mild, because the arthritic syndrome generally follows complete clearing of salivary adenitis by one to two weeks. Migratory polyarth...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1980.11715487

    authors: Bayer AS

    更新日期:1980-07-01 00:00:00

  • Practicing effective preventive medicine. Pharmacologic interventions in coronary heart disease.

    abstract::Epidemiologic and clinical evidence clearly documents the relationship between elevated levels of low-density lipoprotein cholesterol (LDL-C) and risk of coronary heart disease (CHD). In order to reduce CHD risk, the National Cholesterol Education Program (NCEP) has identified LDL-C goals that can be achieved through ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.3810/pgm.04.2003.suppl26.137

    authors: Eisenberg DA

    更新日期:2003-04-01 00:00:00

  • Coronary revascularization in multivessel disease. Which is better, stents or surgery?

    abstract::Coronary artery disease (CAD) remains the major cardiovascular health issue in contemporary clinical practice. Treatment options for multivessel CAD include medical therapy, percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). Here, the authors review the most recent data that compare ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2005.12.1670

    authors: Almeda FQ,Snell RJ

    更新日期:2005-12-01 00:00:00

  • Evaluation of the bleeding patient.

    abstract::The evaluation of the bleeding patient starts with the integration of data from the history and physical examination. From this results either one probable explanation that can easily be substatniated by laboratory studies or, as more commonly occurs in practice, several possibilities that are reasonable and must be i...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1977.11712257

    authors: Marengo-Rowe AJ,Leveson JE

    更新日期:1977-07-01 00:00:00

  • Common ear diseases: recognition and management.

    abstract::External otitis is directly related to patient habit patterns. It is easily treated, but the habits must be changed to effect permanent cure. Serous otitis media is the most common cause of conductive hearing loss, and its presence my predispose to development of purulent otitis media. Removal of middle ear fluid may ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1977.11712183

    authors: Keim RJ

    更新日期:1977-05-01 00:00:00

  • Pediatric poisoning the first 30 minutes.

    abstract::Two distinct subpopulations in the pediatric age-group are particularly at risk for poisoning, and the substances likely to be ingested by each group differ. The method of critical care given here incorporates consideration of specific types of poisoning into an overall plan of general diagnostic and therapeutic measu...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11716152

    authors: Driggers DA

    更新日期:1982-08-01 00:00:00

  • Prospectus.

    abstract::To help you save time in identifying those meetings and courses of greatest interest to you, POSTGRADUATE MEDICINE offers this objectively rated listing as a regular reader service. Each event has been rated on the factors that matter most to you: relevance of the subject to primary care, number of credit hours, cost ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1977.11714671

    authors:

    更新日期:1977-11-01 00:00:00

  • Coronary artery disease in Hispanic Americans. How does ethnic background affect risk factors and mortality rates?

    abstract::A concerted national effort has reduced cardiovascular mortality rates in the general US population. Unfortunately, not all ethnic groups have benefited equally from these improvements in our national health. The author presents insights into social and clinical factors that affect cardiovascular disease among Hispani...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1992.11701252

    authors: Caralis PV

    更新日期:1992-03-01 00:00:00

  • Aggressive systolic blood pressure control in older subjects: benefits and risks.

    abstract::Systolic hypertension, especially isolated systolic hypertension (ISH) is very common in older subjects aged ≥ 65 years and is a major risk factor for cardiovascular disease (CVD), strokes, heart failure (HF) and chronic kidney disease (CKD). It is also, directly and linearly related with these complications irrespect...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.2018.1433434

    authors: Chrysant SG

    更新日期:2018-03-01 00:00:00

  • Beneficial effects resulting from thiazolidinediones for treatment of type 2 diabetes mellitus.

    abstract::Because new drugs continue to be developed, physicians treating patients with type 2 diabetes have a wide range of agents from which to choose. The newest class, the thiazolidinediones (TZDs), should be a mainstay of treatment for most patients with type 2 diabetes, because these agents reduce insulin resistance as we...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Bell DS

    更新日期:2003-05-01 00:00:00

  • Diagnosis and management of chronic hepatitis B in the primary care setting.

    abstract::Chronic hepatitis B is a complex disease for which there are an increasing number of approved treatment options. Clinicians who strive to keep up to date on the diagnosis and treatment of hepatitis B will be in the best position to meet the challenge of managing patients with this serious infection. ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2006.07.1745

    authors: Tsai N

    更新日期:2006-07-01 00:00:00

  • Rheumatoid arthritis. Targeted interventions can minimize joint destruction.

    abstract::Rheumatoid arthritis can cause joint erosion and deformity, pain, stiffness, and decreased function and range of motion. Early diagnosis is crucial to prevent permanent joint damage. In this article, Drs Williams and Fye discuss articular and extra-articular manifestations of rheumatoid arthritis as well as the evolvi...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2003.11.1525

    authors: Williams EA,Fye KH

    更新日期:2003-11-01 00:00:00

  • Evaluating facial paralysis. Expensive diagnostic tests are often unnecessary.

    abstract::In most cases, the cause of facial paralysis can be determined on the basis of the clinical evaluation, and expensive diagnostic tests can be avoided. Because Bell's palsy is not always the cause, physicians need to be able to identify critical findings on history and physical examination that indicate an alternative ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1998.06.522

    authors: Ruckenstein MJ

    更新日期:1998-06-01 00:00:00