Serotype IV and invasive group B Streptococcus disease in neonates, Minnesota, USA, 2000-2010.

Abstract:

:Group B Streptococcus (GBS) is a major cause of invasive disease in neonates in the United States. Surveillance of invasive GBS disease in Minnesota, USA, during 2000-2010 yielded 449 isolates from 449 infants; 257 had early-onset (EO) disease (by age 6 days) and 192 late-onset (LO) disease (180 at age 7-89 days, 12 at age 90-180 days). Isolates were characterized by capsular polysaccharide serotype and surface-protein profile; types III and Ia predominated. However, because previously uncommon serotype IV constitutes 5/31 EO isolates in 2010, twelve type IV isolates collected during 2000-2010 were studied further. By pulsed-field gel electrophoresis, they were classified into 3 profiles; by multilocus sequence typing, representative isolates included new sequence type 468. Resistance to clindamycin or erythromycin was detected in 4/5 serotype IV isolates. Emergence of serotype IV GBS in Minnesota highlights the need for serotype prevalence monitoring to detect trends that could affect prevention strategies.

journal_name

Emerg Infect Dis

authors

Ferrieri P,Lynfield R,Creti R,Flores AE

doi

10.3201/eid1904.121572

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

551-8

issue

4

eissn

1080-6040

issn

1080-6059

journal_volume

19

pub_type

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