Abstract：
:In rat CA1 hippocampal pyramidal neurons (HPNs), somatostatin (SST) has inhibitory postsynaptic actions, including hyperpolarization of the membrane at rest and augmentation of the K+ M-current. However, the effects of SST on synaptic transmission in this brain region have not been well-characterized. Therefore we used intracellular voltage-clamp recordings in rat hippocampal slices to assess the effects of SST on pharmacologically isolated synaptic currents in HPNs. SST depressed both (R, S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate and N-methyl--aspartate (NMDA) receptor-mediated excitatory postsynaptic currents (EPSCs) in a reversible manner, with an apparent IC50 of 22 nM and a maximal effect at 100 nM. In contrast, SST at concentrations up to 5 microM had no direct effects on either gamma-aminobutyric acid-A (GABAA) or GABAB receptor-mediated inhibitory postsynaptic currents (IPSCs). The depression of EPSCs by SST was especially robust during hyperexcited states when polysynaptic EPSCs were present, suggesting that this peptide could play a compensatory role during seizurelike activity. SST effects were greatly attenuated by the alkylating agent N-ethylmaleimide, thus implicating a transduction mechanism involving the Gi/Go family of G-proteins. Use of 2 M Cs+ in the recording electrode blocked the postsynaptic modulation of K+ currents by SST, but did not alter the effects of SST on EPSCs, indicating that postsynaptic K+ currents are not involved in this action of SST. However, 2 mM external Ba2+ blocked the effect of SST on EPSCs, suggesting that presynaptic K+ channels or other presynaptic mechanisms may be involved. These findings and previous results from our laboratory show that SST has multiple inhibitory effects in hippocampus.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Tallent MK,Siggins GRdoi
10.1152/jn.1997.78.6.3008subject
Has Abstractpub_date
1997-12-01 00:00:00pages
3008-18issue
6eissn
0022-3077issn
1522-1598journal_volume
78pub_type
杂志文章abstract：:1. We have previously shown that Xenopus spinal motoneurons make both chemical and electrical synapses with neighboring motoneurons. Because motoneurons are active during swimming, these synapses would be expected to contribute excitation to their neighbors. The significance of central motoneuron to motoneuron synapse...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1995.73.3.1005
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.71.1.433
更新日期：1994-01-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1984.51.2.195
更新日期：1984-02-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
doi：10.1152/jn.1998.79.4.1942
更新日期：1998-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-23 00:00:00
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pub_type： 杂志文章
doi：10.1152/jn.00914.2009
更新日期：2010-08-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.91317.2008
更新日期：2009-07-01 00:00:00
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更新日期：2020-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1152/jn.00257.2005
更新日期：2005-10-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.71.1.429
更新日期：1994-01-01 00:00:00
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更新日期：1976-01-01 00:00:00
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更新日期：2005-08-01 00:00:00
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更新日期：2003-05-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：1991-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-05-01 00:00:00
