Abstract:
PURPOSE:To evaluate the role of bone marrow-derived mononuclear cells (BMC) in rat bile duct ligation (BDL) model. METHODS:Wistar rats were categorized into four Groups A-D. Normal liver biopsy was taken from Group A. BDL model was created in Groups B and C (15 each). Normal saline and BMC were injected through portal vein (PV) in Groups B and C, respectively. In Group D (healthy rat), only BMC were infused through PV. Groups B and C were compared for body weight, liver functions, survival, and histopathological changes. RESULTS:Serum bilirubin was lower in Group C at day 6 (p = 0.0010). Median survival time was 5 (4, 6) and 13 (9, 17) days in Groups B and C (p = 0.0147), respectively. Portal edema (p = 0.013) and portal inflammation (p = 0.025) were less in Group C vs Group B. On post hoc subgroup analysis of rats surviving 8-26 days, portal inflammation (p = 0.004), bile duct proliferation (p = 0.016) and portal fibrosis (p = 0.038) were less in Group C vs Group B. Hepatocyte regeneration was found in four rats in Group C. CD34-positive cells were prominent in sinusoids and portal tracts in the BDL rat model. CONCLUSIONS:BMC have shown to delay fibrosis, facilitate hepatocyte regeneration and improve survival in an experimental BDL model, with potential clinical implication in obstructive cholangiopathy.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Sharma S,Mohanty S,Das P,DattaGupta S,Kumar L,Gupta Ddoi
10.1007/s00383-013-3314-8subject
Has Abstractpub_date
2013-06-01 00:00:00pages
623-32issue
6eissn
0179-0358issn
1437-9813journal_volume
29pub_type
杂志文章abstract::This review gives an overview of the disease spectrum of congenital diaphragmatic hernia (CDH). Etiological factors, prenatal predictors of survival, new treatment strategies and long-term morbidity are described. Early recognition of problems and improvement of treatment strategies in CDH patients may increase surviv...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-009-2425-8
更新日期:2009-09-01 00:00:00
abstract::Accessory hepatic tissue, unlike accessory splenic and pancreatic tissue, is rare and has a limited and almost exclusively sub diaphragmatic distribution. Fewer than ten cases of intrathoracic ectopic liver have been reported so far in the literature. This paper reports a case that caused a diagnostic dilemma. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830000520
更新日期:2001-07-01 00:00:00
abstract::Congenital hepatic cysts are rare lesions of infancy. While operative management and outcomes have been extensively studied in adult patients with hepatic cysts, data in pediatric patients are limited. We discuss our experience in an infant and review relevant literature regarding operative technique and surgical outc...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-013-3312-x
更新日期:2013-08-01 00:00:00
abstract::Multiple endocrine neoplasia (MEN) 2B is a hereditary syndrome including medullary thyroid carcinoma (MTC), pheochromocytoma, gastrointestinal (GI) disorders, marfanoid facies, and multiple ganglioneuromas. MTC is the major cause of mortality, and often appears during the 1st decade of life. RET proto-oncogene mutatio...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0824-1
更新日期:2002-09-01 00:00:00
abstract::Colonic interposition is a treatment option in childhood when esophageal replacement (ER) is necessary. We reviewed 18 children who underwent ER by colon between 1984 and 1999. There were 5 with esophageal atresia and 13 with corrosive esophagitis; 15 had long-term follow-up (mean 38 months). Three procedures were per...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000422
更新日期:2000-01-01 00:00:00
abstract::Congenital anterior penile urethral fistula is a rare anomaly; only seven cases have been reported to date. This report outlines the clinical presentation and the embryologic mechanism of a case associated with urethral duplication. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-003-1063-9
更新日期:2003-12-01 00:00:00
abstract:INTRODUCTION:Though the lifetime risk of colorectal carcinoma (CRC) in general population is 5-6 %, it is uncommon in pediatric age group. Here, we are reporting our experience of CRC in the first decade of life. METHODS:From January 2010 to December 2013, seven patients with histopathologically confirmed colorectal c...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3537-3
更新日期:2014-08-01 00:00:00
abstract::Meckel's diverticulum has previously been reported to be present in patients with Crohn's disease. However, the finding is typically an incidental one, and involvement of the diverticulum in the disease process is uncommon. We report a case of an adolescent with known Crohn's disease who presented with symptoms though...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-1971-1
更新日期:2008-03-01 00:00:00
abstract::The first description diaphragmatic hernia appeared in 1575. In 1848, Bochdalek described congenital diaphragmatic hernia (CDH) occurring through a posterolateral defect. Successful surgical treatment of CDH in an infant was first performed in 1902, whereas the first neonate operated within 24 hours of life was report...
journal_title:Pediatric surgery international
pub_type: 历史文章,杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::The confluence of the right and left hepatic ducts at the hepatic hilum frequently shows normal anatomic variations. Choledochal cysts (CC) are also accompanied by similar variations, and devices for free drainage of bile are occasionally required in biliary reconstruction. We present a CC that had an aberrant posteri...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF01371914
更新日期:1997-01-01 00:00:00
abstract::Retrocaval ureter is abnormal looping of the proximal ureter behind the inferior vena cava. The aberrant anatomy results in the compression of the ureter causing hydronephrosis. This is a very infrequent cause of hydronephrosis in children. Association of retrocaval ureter with a stone in the looping segment of the ur...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2607-4
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:We aim to evaluate the diagnostic performance and relationship between clinical characteristics, imaging findings, and final diagnosis for the neonatal contrast enema (CE). METHODS:Retrospective 10-year review of all neonatal CEs including imaging findings, clinical information, indication, and final diagnosis...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-020-04701-4
更新日期:2020-09-01 00:00:00
abstract::Anorectal malformations (ARM) remain a significant birth defect with geographic variation in incidence, individual phenotypes and regional geographic subtypes. Although early studies indicated a low incidence in Black patients, there is a great paucity of knowledge as to the types, frequency and incidence of ARMs enco...
journal_title:Pediatric surgery international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00383-008-2131-y
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:We performed a systematic review and meta-analysis to compare the efficacy and safety between single-incision, transscrotal orchidopexy, and the traditional inguinal orchidopexy in children. METHODS:A systematic search of the electronic databases was conducted to identify studies compared the transscrotal orch...
journal_title:Pediatric surgery international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00383-016-3956-4
更新日期:2016-10-01 00:00:00
abstract::A case of retrocecal appendicitis is described in a 6-year-old male child who presented with thigh abscess. The presence of a positive psoas stretch test, feculent discharge, an enteric growth on bacteriological examination, and intraabdominal fluid collection on abdominal ultrasound provided clues to the presence of ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1356-7
更新日期:2005-04-01 00:00:00
abstract::Pyloric atresia (PA) is an uncommon anomaly that may be associated with many other congenital anomalies, the commonest of which is junctional epidermolysis bullosa (JEB). Most of the cases of PA associated with JEB (Herlitz syndrome) reported have been fatal. A case of PA associated with JEB, malrotation, and a high a...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050572
更新日期:1999-01-01 00:00:00
abstract::An infant born in the 34th week of gestation weighing 5,355 g with a massive sacrococcygeal (SC) tumor was delivered by elective cesarean section. An ultrasonographic examination showed solid and cystic components in the tumor. Resection was successfully undertaken with insertion of a Nélaton catheter into the rectum ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000451
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:There are many advantages of a SMOF emulsion (SMOF-lipid), such as liver-protective properties and anti-inflammatory effects. The objective of this study was to compare the clinical outcomes of SMOF-lipid with medium-chain triglycerides (MCT) /long-chain triglycerides (LCT) in infants after intestinal surger...
journal_title:Pediatric surgery international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00383-018-4422-2
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to review the clinical characteristics and prognosis of children with adrenocortical tumors (ACT). METHODS:We retrospectively reviewed the medical records of 28 patients with ACT at our hospital between March 2010 and March 2017. RESULTS:The main clinical presentations were sexua...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4409-z
更新日期:2019-03-01 00:00:00
abstract::At bilateral orchiopexy bilateral biopsies may be indicated to determine fertility potential. It is currently unknown if the serum inhibin B levels at time of orchiopexy reflect the testicular status of the bilaterally cryptorchid child. The aim of this study was to relate the results of inhibin B and FSH measurements...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-006-1839-9
更新日期:2007-02-01 00:00:00
abstract::In spite of advances in the treatment of childhood bladder and prostate rhabdomyosarcoma (RMS), the ability to detect minimal residual disease correlates imperfectly with the ultimate outcome. We report the long-term follow-up of a child with microscopic residual RMS after chemotherapy. The correct interpretation of t...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830200017
更新日期:2002-01-01 00:00:00
abstract::We report a rare case of massive haematochezia due to hookworm infestation that required two laparotomies before the cause of bleeding could be diagnosed. The need to consider this parasite as a possible cause of gut bleeding in endemic countries is stressed, as early recognition may avoid unnecessary investigations a...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00497827
更新日期:1996-06-01 00:00:00
abstract:AIM OF STUDY:Few studies have evaluated the incidence of familial vesicoureteral reflux (VUR) among multiple gestation births. The purpose of this study was to determine the incidence and characteristics of VUR in twins in a large cohort of families with VUR. METHODS:Between 1998 and 2010, data were collected on 251 f...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2821-0
更新日期:2011-05-01 00:00:00
abstract::The authors report two patients with extrahepatic portal hypertension and repeated massive bleeding from esophageal varices who underwent urgent distal splenorenal shunting (DSRS) after having proved refractory to medical treatment, endoscopic sclerotherapy, and ligation of esophageal varices. Their ages and weights w...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830100014
更新日期:2001-11-01 00:00:00
abstract::Cryptorchidism is a common paediatric complaint and is traditionally managed surgically by orchidopexy. We aimed to prospectively review the success of the Bianchi high scrotal incision technique for performing orchidopexy in boys with palpable non-descended testis. A total of 206 orchidopexies were performed in 85 pa...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-008-2149-1
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:Retroperitoneal teratomas (RTs) are rare among germ cell tumors and predominantly occur in infants. RTs are often difficult to manage by perioperative management. In this study, we retrospectively reviewed our series of RTs. METHODS:Seventy patients with germ cell tumors were treated from 1989 to 2015 in our i...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3938-6
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine the incidence of gastroschisis-related complications (GRCs) after closure of the abdominal wall defect, with a focus on frequency, type and timing of required surgical interventions, and to identify the impact of these on further outcome. METHODS:All gastroschisis patient...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3500-3
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The high mortality rate in congenital diaphragmatic hernia (CDH) is attributed to pulmonary hypoplasia (PH). Insulin-like growth factor 2 (IGF2) is an important regulator of fetal growth. The highest levels of IGF2 expression are found in the placenta, which are negatively regulated by decidual retinoid acid...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-013-3449-7
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:Adnexal torsion is a gynecologic emergency, requiring intervention for tissue preservation. At our institution, torsion is managed by pediatric surgeons or gynecologists. We evaluated differences between specialties to streamline evaluation for children with gynecological emergencies, develop a clinical pathway...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-020-04782-1
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:Surgery of the inguinal canal is very common in infancy. Occasionally, injury of the bladder may occur with severe consequences. The aim of this paper was to warn young surgeons of this serious complication. METHODS:During the last 2 years, we observed four cases of bladder injury following surgery on inguinal...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2707-1
更新日期:2010-12-01 00:00:00