Colorectal carcinoma in first decade of life: our experience.

Abstract:

INTRODUCTION:Though the lifetime risk of colorectal carcinoma (CRC) in general population is 5-6 %, it is uncommon in pediatric age group. Here, we are reporting our experience of CRC in the first decade of life. METHODS:From January 2010 to December 2013, seven patients with histopathologically confirmed colorectal carcinoma were treated in the Department of Pediatric Surgery, Chittagong Medical College and hospital. Age, sex, presenting symptoms, location of the primary tumor, serum CEA level, treatment modalities and outcomes were evaluated. RESULTS:There were four male and three female patients and age ranged from 6.5 to 10.5 years. Rectum (3 patients) and rectosigmoid (2 patients) were the most common primary sites. Serum carcinoembryonic antigen level was obtained in six patients and in only one patient the level was raised markedly (137 ng/ml). Two patients of familial adenomatous polyposis had localized disease and others presented in an advanced stage. Histopathologically, poorly differentiated adenocarcinoma was noted in five patients with one signet ring cell type and well differentiated in rest of the two patients. Only one patient was surviving at the last follow up. CONCLUSION:Advanced stage at diagnosis, aggressive histologic subtype and poor survival are the hallmarks of pediatric CRC.

journal_name

Pediatr Surg Int

authors

Rahman MA,Chowdhury TK,Bhuiyan MA,Al Farooq MA,Sajid MM,Banu T

doi

10.1007/s00383-014-3537-3

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

847-51

issue

8

eissn

0179-0358

issn

1437-9813

journal_volume

30

pub_type

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