Abstract:
BACKGROUND:The high mortality rate in congenital diaphragmatic hernia (CDH) is attributed to pulmonary hypoplasia (PH). Insulin-like growth factor 2 (IGF2) is an important regulator of fetal growth. The highest levels of IGF2 expression are found in the placenta, which are negatively regulated by decidual retinoid acid receptor alpha (RARα). It has been demonstrated that prenatal administration of retinoic acid (RA) suppresses decidual RARα expression. Previous studies have further shown that prenatal administration of RA can reverse PH in nitrofen-induced CDH model. In IGF2 knockout animals, low levels of IGF2 are associated with decreased placental growth and PH. We therefore hypothesized that nitrofen decreases trophoblastic IGF2 expression and prenatal administration of RA increases it through decidual RARα in the nitrofen-induced CDH model. METHODS:Pregnant rats were exposed to either olive oil or nitrofen on day 9 of gestation (D9). RA was given intraperitoneally on D18, D19 and D20. Fetuses were harvested on D21 and divided into three groups: control, CDH and nitrofen+RA. Immunohistochemistry was performed to evaluate decidual RARα and trophoblastic IGF2 expression. Protein levels of IGF2 in serum, intra-amniotic fluid and left lungs were measured by enzyme-linked immunosorbent assay. RESULTS:Significant growth retardation of placenta and left lungs was observed in the CDH group compared to control and nitrofen+RA group. Markedly increased decidual RARα and decreased IGF2 immunoreactivity were found in the CDH group compared to control and nitrofen+RA group. Significantly decreased IGF2 protein levels were detected in serum, intra-amniotic fluid and left lungs in the CDH group compared to control and nitrofen+RA group. CONCLUSION:Our findings suggest that nitrofen may disturb trophoblastic IGF2 expression through decidual RARα resulting in retarded placental growth and PH in the nitrofen-induced CDH. Prenatal administration of RA may promote lung and placental growth by increasing trophoblastic IGF2 expression.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Kutasy B,Friedmacher F,Duess JW,Puri Pdoi
10.1007/s00383-013-3449-7subject
Has Abstractpub_date
2014-02-01 00:00:00pages
137-42issue
2eissn
0179-0358issn
1437-9813journal_volume
30pub_type
杂志文章abstract::Pediatric germ cell tumors comprise 1-3% of all malignant pediatric tumors and are found in variable locations. We present the case of a term 3.7 kg neonate who was found to have a giant liver mass at birth, later determined to be an immature teratoma arising from the hepatoduodenal ligament. This case report and imag...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-017-4123-2
更新日期:2017-09-01 00:00:00
abstract::Postoperative abdominal evisceration may lead to high morbidity and mortality. The purpose of the present study was to determine possible risk factors, morbidity and mortality associated with abdominal evisceration in children. A total of 3,591 children underwent abdominal exploration in our clinic between 1983 and 20...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-006-1722-8
更新日期:2006-08-01 00:00:00
abstract::The aspiration of a bronchial foreign body (FB) remains a common pediatric problem with serious and sometimes fatal sequelae. The diagnosis is often delayed or overlooked. With the aim of determining a reliable clinical and/or radiologic finding to indicate the requirement for bronchoscopy, 100 patients admitted to ou...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050080
更新日期:1997-03-21 00:00:00
abstract::Extrarenal malignant rhabdoid tumour is a rare neoplasm of childhood. A congenital example has only been reported once previously, presenting as a facial mass. We report a second congenital case with the tumour over the right shoulder in which postoperative investigations revealed multiple hepatic metastases proving f...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00497837
更新日期:1996-06-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Snodgrass tubularized incised plate urethroplasty and 2 modifications were evaluated in 75 hypospadiacs (distal and midpenile). PATIENTS AND METHODS:The initial 25 patients (group A), underwent Snodgrass tubularized incised plate urethroplasty. In the next 25 patients (group B), the urethra...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1148-0
更新日期:2004-03-01 00:00:00
abstract::Reflux nephropathy (RN) is recognized as a major cause of end-stage renal failure in children and young adults. Inhibition of nitric oxide (NO) exacerbates and enhanced production ameliorates tubulointerstitial fibrosis (TIF) in experimental obstructive uropathy. NO is synthesised by NO synthase (NOS), three distinct ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0858-4
更新日期:2002-10-01 00:00:00
abstract::We present the case of a 14-year-old male with a history of small bowel transplantation for long segment Hirschsprung's disease who underwent Duhamel ileorectal pull-through procedure. In post-transplant, the patient had no restrictions and was not TPN-dependent. To improve his quality of life, he and his family were ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-017-4216-y
更新日期:2018-01-01 00:00:00
abstract::To assess the relation between continence and the manometric and endosonographic state of the anorectal segment after surgery for anorectal anomalies (ARA), 33 adolescents operated upon for ARA and 14 controls were examined. Seventeen patients had low and 16 intermediate or high ARA. Fecal continence was recorded, and...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF01258715
更新日期:1997-09-01 00:00:00
abstract::Parathyroid carcinoma is unusual and its intrathyroidal variant is extremely rare. Therefore, few cases have been reported to describe a case of parathyroid carcinoma located inside the thyroid gland. The case corresponds to a 14-year-old girl who came to the office with a severe osteoarticular disease, depression, ca...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-011-2904-6
更新日期:2011-12-01 00:00:00
abstract::We describe the case of a 4-year-old boy with a unilateral right-sided Wilms tumor with stromal predominance and teratoid features, which was localized to the kidney and hence, was completely resected. The pediatric surgeon and pathologist, both should be aware of this rare appearance of nephroblastoma so as to avoid ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-009-2333-y
更新日期:2009-03-01 00:00:00
abstract::The transverse colon is an exceptional location of intestinal duplication. Perforated duplications are rarely described in neonates. Meconium peritonitis (MP) can originate from prenatal perforated intestinal duplication. The authors report a case of a baby girl with prenatal diagnosis of MP. Rapid worsening of clinic...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1349-6
更新日期:2005-02-01 00:00:00
abstract::We present three cases of abdominal and abdomino-thoracic extra-lobar pulmonary sequestrations detected by antenatal ultrasound (US) over a 12-month period. In addition, we briefly refer to a case previously described. A cystic mass was demonstrated in the left upper abdomen of the fetus in all four cases, with two ex...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00183739
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:We previously showed that meticulous probing and resection of the intrahepatic bile duct stenosis (IHBDS)-causing membrane or septum was effective in preventing hepatolithiasis after choledochal cyst excisions in open surgeries. Then, we introduced this maneuver into laparoscopic choledochal cyst excisions in 2...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4320-7
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To compare open repair (OR) with thoracoscopic repair (TR) for congenital diaphragmatic hernia (CDH) in neonates. METHODS:Twenty-four neonatal CDH cases diagnosed prenatally or within 6 h of birth at our institute from 2002 to 2012 with mild pulmonary hypertension managed without inhaled nitric oxide, were stu...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-013-3382-9
更新日期:2013-11-01 00:00:00
abstract::An experimental study was conducted to determine the end-results of two different defects on the anterior abdominal wall: an abdominal wall defect (AWD) versus an umbilical cord defect (UCD) using chick embryos. The AWD was created by leaving an intact skin bridge between the defect and the umbilical cord in group 1; ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF01371904
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Rapid assessment of volume status in children is often difficult. The purpose of this study was to evaluate the feasibility of surgeon-performed ultrasound to assess volume status in patients with hypertrophic pyloric stenosis. METHODS:Ultrasounds were performed on admission and before operation. The diameters...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3798-5
更新日期:2015-12-01 00:00:00
abstract::Mucosa-associated lymphoid tissue (MALT) lymphomas comprise a group of indolent B-cell non-Hodgkin lymphomas (NHL), which are rare in pediatric age. The clinical presentation of MALT lymphomas varies according to the location of the lymphoma. We report on a case of MALT lymphoma involving the appendix in a 6-year-old ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-1957-z
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:The need for clinically applicable skin substitutes continues to be a matter of fact. Hypothetically, a laboratory grown autologous skin analog with near normal architecture might be a suitable approach to yield both satisfactory functional and cosmetic long-term results. In this study, we explored the use of h...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3808-7
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Objectively evaluating the lack of bowel control (fecal incontinence) continues to be a challenge. Many have attempted to measure the severity of fecal incontinence and to evaluate its impact on the quality of life by developing standardized scoring systems. Some of these systems have been validated but no...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-016-3909-y
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:Since DX/HA was approved by the Food and Drug Administration in 2001 as an acceptable tissue-augmenting substance for subureteral injection, endoscopic treatment has become increasingly popular for treating vesicoureteral reflux (VUR). However, most paediatric urologists still continue to recommend ureteral rei...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2650-1
更新日期:2010-10-01 00:00:00
abstract::The issues of sexual function and fertility are becoming relevant in patients with posterior urethral valves (PUV), as more of them reach adulthood. To evaluate the semen of post-pubertal patients with PUV as a determinant of future fertility, all such patients (age >16 years) attending the follow-up urology clinic of...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830100679
更新日期:2002-03-01 00:00:00
abstract::Cryptorchidism is a common paediatric complaint and is traditionally managed surgically by orchidopexy. We aimed to prospectively review the success of the Bianchi high scrotal incision technique for performing orchidopexy in boys with palpable non-descended testis. A total of 206 orchidopexies were performed in 85 pa...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-008-2149-1
更新日期:2008-06-01 00:00:00
abstract::Endoscopic management is the accepted form of treatment for posterior urethral valves (PUV). The Nd:YAG laser has been in clinical use for many decades, but has been used only sporadically for ablating PUV. In this study, PUV were diagnosed by micturating cystourethrogram (MCU). In the 9-month period beginning March 1...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050018
更新日期:2000-01-01 00:00:00
abstract::To determine which laser can be used for a vascular lesion, the different working mechanisms of the individual lasers must first be understood. The localization and diameter of the vessels to be treated define whether a certain laser is appropriate for that lesion. For teleangiectasias and port-wine stains the pulsed-...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00497797
更新日期:1996-06-01 00:00:00
abstract::Retrocaval ureter is abnormal looping of the proximal ureter behind the inferior vena cava. The aberrant anatomy results in the compression of the ureter causing hydronephrosis. This is a very infrequent cause of hydronephrosis in children. Association of retrocaval ureter with a stone in the looping segment of the ur...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2607-4
更新日期:2010-08-01 00:00:00
abstract::The first description diaphragmatic hernia appeared in 1575. In 1848, Bochdalek described congenital diaphragmatic hernia (CDH) occurring through a posterolateral defect. Successful surgical treatment of CDH in an infant was first performed in 1902, whereas the first neonate operated within 24 hours of life was report...
journal_title:Pediatric surgery international
pub_type: 历史文章,杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract:AIMS AND OBJECTIVES:Hirschsprung's disease-associated enterocolitis (HAEC) is the most serious complication of Hirschsprung's disease (HSCR). HAEC occurs in 17-50% of patients with HSCR and may occur before or after a properly performed pull-through operation. The pathogenesis of HAEC is poorly understood. It is well r...
journal_title:Pediatric surgery international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00383-017-4178-0
更新日期:2018-02-01 00:00:00
abstract::The association of Enterobius vermicularis infestation with acute appendicitis varies from 0.2-41.8% worldwide. Our purpose was to determine the significance of Enterobius-associated appendicitis by retrospective review of appendectomies performed during a 5-year period at a major children's hospital. The Surgical Pat...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-004-1151-5
更新日期:2004-05-01 00:00:00
abstract::The management of a critical airway in infants and toddlers with congenital tracheal stenosis (CTS) continues to be an enormous challenge to the surgeon. Until recently, this condition often proved fatal. Improvements in surgical techniques, anesthetic management, and postoperative critical care have resulted in succe...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830050028
更新日期:2000-01-01 00:00:00
abstract::New development in the vascular network is a significant process for the proliferation, as well as metastatic expand, of cancer cells that depends on a sufficient provider of oxygen and nutrients and the removal of waste products. New blood and lymphatic vessels form via step called angiogenesis and lymphangiogenesis....
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-013-3398-1
更新日期:2013-12-01 00:00:00