Abstract：
:Active-specific immunotherapy with concanavalin A or with neuraminidase-modified syngeneic tumor cells has been studied in an experimental model of colon cancer. Systemic immunotherapy with concanavalin A-modified tumor cells or with neuraminidase-modified tumor cells has resulted in up to 70 percent cure of rats receiving a lethal inoculum of tumor in a model tumor system which otherwise proved 80 percent lethal to untreated hosts. The possible mechanisms whereby neuraminidase or concanavalin A are effective cell-surface modifiers for active-specific immunotherapy are discussed. In vitro studies suggest markedly heightened antigenic recognition following immunization with concanvalin A-modified syngeneic tumor cells. These studies represent the first apparent evidence for the definitive value of systemic active-specific immunotherapy for the adjuvant treatment of large bowel cancer.
journal_name
Surgeryjournal_title
Surgeryauthors
Enker WE,Jacobitz JLsubject
Has Abstractpub_date
1976-08-01 00:00:00pages
164-70issue
2eissn
0039-6060issn
1532-7361journal_volume
80pub_type
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