Natural thermal resistance of human tumor cells and the role of prostaglandin.

Abstract:

:We found that human malignant melanoma cells had varying thermal sensitivity and that some exhibited natural thermal resistance, a heretofore unrecognized phenomenon. Samples of 73 melanoma cell suspensions were heated at 42 degrees C for 1 hour before plating in the soft agar clonogenic assay or the thymidine assay for proliferating cells. We observed greater than 75% cell kill after hyperthermia in 39 (53%) tumors. Native thermal resistance was apparent in 17 (23%) tumors and growth enhancement in 17 (23%) at this temperature and exposure time. We postulated that prostaglandin, known to protect stomach mucosa against thermal injury, has a role in stabilizing the tumor cell membrane exposed to heat. Three melanoma cell lines known to be thermosensitive were heated to 42 degrees C without and with exogenous prostaglandin E2 (PGE2). The survival of colony-forming cells was increased in all three lines in the presence of 30 microM PGE2. A naturally thermoresistant cell line was exposed to 1 microgram/ml indomethacin for 24 hours before hyperthermic treatment. The survival of colony-forming cells was significantly decreased compared to cells not treated with indomethacin. The addition of 30 microM of exogenous PGE2 to indomethacin-treated cells reestablished thermal resistance. These preliminary data suggest that some tumor cells synthesize prostaglandins to render the cell thermoresistant. Treatment with indomethacin blocks prostaglandin synthesis and induces thermosensitivity. These discoveries may have important clinical applications for hyperthermia treatment of human cancers.

journal_name

Surgery

journal_title

Surgery

authors

Storm FK,Roe DJ,Hildebrand-Zanki S,Worth GD,Morton DL,Kern DH

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

376-83

issue

2

eissn

0039-6060

issn

1532-7361

pii

0039-6060(83)90116-2

journal_volume

94

pub_type

杂志文章

相关文献

SURGERY文献大全
  • Role of reoperation in recurrence of adrenal cortical carcinoma: results from 188 cases collected in the Italian National Registry for Adrenal Cortical Carcinoma.

    abstract:BACKGROUND:Recurrence of adrenal cortical carcinoma (ACC) after radical surgery is a common finding. Although successful reoperations have been reported with encouraging results, most published experiences are anecdotal and based on few cases. We report the results of surgical treatment for recurrent ACC in a multiinst...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/s0039-6060(97)90229-4

    authors: Bellantone R,Ferrante A,Boscherini M,Lombardi CP,Crucitti P,Crucitti F,Favia G,Borrelli D,Boffi L,Capussotti L,Carbone G,Casaccia M,Cavallaro A,Del Gaudio A,Dettori G,Di Giovanni V,Mazziotti A,Marrano D,Masenti E,Mi

    更新日期:1997-12-01 00:00:00

  • Desmoid tumor: musculoaponeurotic fibrosis of the abdominal wall.

    abstract::A 26-year-old woman developed a desmoid tumor of the lower abdominal wall shortly after the birth of her fourth child. It measured 15 by 17 cm. and involved most of the lower abdominal wall of this small-framed woman. Operative removal would have been mutilating and almost surely doomed to failure. No treatment was gi...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Caldwell EH

    更新日期:1976-01-01 00:00:00

  • The natural resistance-associated macrophage protein gene is associated with Crohn's disease.

    abstract:BACKGROUND:Identification of the genes causing inflammatory bowel disease (IBD) would enhance the understanding of and the treatment options for this disease. A hyperreactive immune response toward the intestinal flora has been implicated in the pathology of IBD. The natural resistance-associated macrophage protein (NR...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/s0039-6060(97)90006-4

    authors: Hofmeister A,Neibergs HL,Pokorny RM,Galandiuk S

    更新日期:1997-08-01 00:00:00

  • Feasibility and safety of enzymatic debridement for the prevention of operative escharotomy in circumferential deep burns of the distal upper extremity.

    abstract:BACKGROUND:Burn-induced compartment syndrome is a severe sequela after circumferential burns of the extremities and is avoidable by immediate release of the underlying pressure under the eschar. Although the current gold standard is operative escharotomy, this procedure carries considerable morbidity. Our study evaluat...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2018.11.019

    authors: Fischer S,Haug V,Diehm Y,Rhodius P,Cordts T,Schmidt VJ,Kotsougiani D,Horter J,Kneser U,Hirche C

    更新日期:2019-06-01 00:00:00

  • Intraoperative parathyroid hormone monitoring fails to detect double parathyroid adenomas: a 2-institution experience.

    abstract:BACKGROUND:We hypothesized that intraoperative parathyroid hormone monitoring (IOPTH) reliably would detect double parathyroid adenomas. METHODS:This was a retrospective study of 20 patients undergoing conventional parathyroidectomy with resection of exactly 2 abnormal glands. Full exploration was performed regardless...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2001.118385

    authors: Gauger PG,Agarwal G,England BG,Delbridge LW,Matz KA,Wilkinson M,Robinson BG,Thompson NW

    更新日期:2001-12-01 00:00:00

  • Acute arterial and deep venous thromboembolism in COVID-19 patients: Risk factors and personalized therapy.

    abstract:BACKGROUND:The Lombardy region suffered severely during the acute phase of the coronavirus disease 2019 outbreak in Italy (Mar-Apr 2020) with 16,000 diagnosed coronavirus disease 2019-related deaths (49% of the total coronavirus disease 2019-related deaths in Italy). In the area surrounding Pavia during the critical st...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2020.09.009

    authors: Bozzani A,Arici V,Tavazzi G,Franciscone MM,Danesino V,Rota M,Rossini R,Sterpetti AV,Ticozzelli G,Rumi E,Mojoli F,Bruno R,Ragni F

    更新日期:2020-12-01 00:00:00

  • Use of a somatostatin analog (SMS 201-995) in the glucagonoma syndrome.

    abstract::A long-acting somatostatin analog, SMS 201-995, is now available to treat the hormonal manifestations of islet cell tumors. We report its use in a patient with a metastatic glucagonoma refractory to conventional therapy. This patient, who was severely disabled by the rash of necrolytic migratory erythema and brittle d...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Altimari AF,Bhoopalam N,O'Dorsio T,Lange CL,Sandberg L,Prinz RA

    更新日期:1986-12-01 00:00:00

  • Effect of sepsis on calcium uptake and content in skeletal muscle and regulation in vitro by calcium of total and myofibrillar protein breakdown in control and septic muscle: results from a preliminary study.

    abstract::Because high calcium concentration in vitro stimulates muscle proteolysis, calcium has been implicated in the pathogenesis of increased muscle breakdown in different catabolic conditions. Protein breakdown in skeletal muscle is increased during sepsis, but the effect of sepsis on muscle calcium uptake and content is n...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Benson DW,Hasselgren PO,Hiyama DT,James JH,Li S,Rigel DF,Fischer JE

    更新日期:1989-07-01 00:00:00

  • Replacement of the inferior vena cava and iliac veins with heterologous grafts in animal tests.

    abstract::The use of a modified bovine collagen graft as a low-pressure conduit was investigated by implantation into the iliocaval system of dogs. In the 210 day observation period, a patency rate of 87.5% was achieved. Nearly all graft failures occured within the first 14 days following implantation; failure after that time d...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Horsch S,Pichlmaier H,Walter P,Landes T

    更新日期:1978-11-01 00:00:00

  • Myeloid zinc finger-1 regulates expression of cancer-associated fibroblast and cancer stemness profiles in breast cancer.

    abstract:BACKGROUND:Osteopontin acts thru myeloid zinc finger-1 and transforming growth factor-β to drive the adoption of a cancer-associated fibroblast phenotype by local mesenchymal stem cells. Cancer-associated fibroblasts increase cancer cell stemness. METHODS:Mesenchymal stem cells were exposed to osteopontin or were cocu...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2019.05.042

    authors: Kuo MC,Kuo PC,Mi Z

    更新日期:2019-10-01 00:00:00

  • Umbilical vein bypass in patients with severe lower limb ischemia: a report of 121 consecutive cases.

    abstract::In 112 patients with severe ischemia of the lower limb and without a suitable saphenous vein, 99 femoropopliteal and 22 femorodistal bypass procedures were performed with the modified human umbilical vein (Biograft, Meadox Medicals Inc., Oakland, N.J.). Seventy-eight percent of the operations were performed for limb s...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Andersen LI,Nielsen OM,Buchardt Hansen HJ

    更新日期:1985-03-01 00:00:00

  • Continued experience with intraoperative angioscopy for monitoring infrainguinal bypass grafting.

    abstract::Intraoperative angioscopy provides direct, in vivo, three-dimensional visualization of the interior of the blood vessels and grafts. We have shown previously that with the application of the basic principles of irrigation and with a dedicated irrigation pump that routine intraoperative angioscopy can be performed with...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Miller A,Stonebridge PA,Jepsen SJ,Tsoukas A,Gibbons GW,Pomposelli FB Jr,Freeman DV,Campbell DR,LoGerfo FW

    更新日期:1991-03-01 00:00:00

  • Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats.

    abstract:BACKGROUND:The carcinogenic effect of duodenoesophageal reflux, gastroesophageal reflux, and nitrosamines was studied in the rat esophagus. METHODS:Twenty male Sprague-Dawley rats underwent esophagogastroplasty to produce gastroesophageal reflux and 60 underwent duodenoesophageal anastomosis to produce duodenoesophage...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Attwood SE,Smyrk TC,DeMeester TR,Mirvish SS,Stein HJ,Hinder RA

    更新日期:1992-05-01 00:00:00

  • Reduction of transfusion requirements during major hepatic resection for metastatic disease.

    abstract:BACKGROUND:Our purpose was to determine whether the combination of total liver vascular inflow occlusion (Pringle maneuver) and rapid hepatic transection with a clamp-crush technique results in significant reduction of blood loss and transfusion requirements during major hepatic resections. METHODS:A series of 49 adul...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Arnoletti JP,Brodsky J

    更新日期:1999-02-01 00:00:00

  • Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage.

    abstract:BACKGROUND:Tumor necrosis factor (TNF) is rapidly gaining recognition as one of the early, critical mediators of several inflammatory conditions, most notably endotoxic shock. The purposes of this study were to determine whether TNF levels are raised in severe acute pancreatitis, thus pointing to its role as a potentia...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Grewal HP,Kotb M,el Din AM,Ohman M,Salem A,Gaber L,Gaber AO

    更新日期:1994-02-01 00:00:00

  • NBCA medical adhesive (n-butyl-2-cyanoacrylate) versus suture for patch fixation in Lichtenstein inguinal herniorrhaphy: a randomized controlled trial.

    abstract:BACKGROUND:We compared the effectiveness of n-butyl-2-cyanoacrylate (NBCA) and traditional suture for patch fixation in Lichtenstein tension-free herniorrhaphy for inguinal hernias. METHODS:A total of 110 patients with primary unilateral inguinal hernia were assigned randomly to either experimental or control groups. ...

    journal_title:Surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.surg.2011.09.031

    authors: Shen YM,Sun WB,Chen J,Liu SJ,Wang MG

    更新日期:2012-04-01 00:00:00

  • The reoperation of choice for aortofemoral graft occlusion.

    abstract::Restoration of circulation following occlusion of an aortofemoral graft was attempted in 50 limbs in 38 patients. Progressive arteriosclerosis in the femoral vessels was the cause of graft limb thrombosis in most instances. Profundaplasty was employed in 47 limbs and femoral-popliteal bypass in two to provide effectiv...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Bernhard VM,Ray LI,Towne JB

    更新日期:1977-12-01 00:00:00

  • A randomized, prospective, blinded comparison of postoperative pain, metabolic response, and perceived health after laparoscopic and small incision cholecystectomy.

    abstract:BACKGROUND:We have previously shown that in a randomized comparison of laparoscopic (LC) versus small incision (SC) cholecystectomy, postoperative hospital stay is comparable. This randomized prospective study compares the postoperative pain, analgesic and antiemetic consumption, perceived health, and metabolic and res...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/msy.1998.87552

    authors: Squirrell DM,Majeed AW,Troy G,Peacock JE,Nicholl JP,Johnson AG

    更新日期:1998-05-01 00:00:00

  • Screening for primary hyperparathyroidism before thyroid surgery: A prospective study.

    abstract:BACKGROUND:Misdiagnosed primary hyperparathyroidism (PHPT) during thyroid surgery may lead to a difficult reoperation. Because PHPT is often asymptomatic, calcium measurements have been recommended before thyroid surgery, but no study has focused on the results of a prospective PHPT screening. METHODS:The prospective ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2002.121379

    authors: Denizot A,Dadoun F,Meyer-Dutour A,Alliot P,Argème M

    更新日期:2002-03-01 00:00:00

  • Regression of intimal hyperplasia with restoration of endothelium-dependent relaxing factor-mediated relaxation in experimental vein grafts.

    abstract:BACKGROUND:The reversibility of the morphologic and functional alterations that occur in veins transplanted into the arterial circulation was examined in this study. METHODS:Common carotid vein bypass grafts (VG) were performed in 20 male New Zealand White rabbits. Ten VG and jugular veins (CV) were harvested after 14...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Davies MG,Klyachkin ML,Dalen H,Svendsen E,Hagen PO

    更新日期:1993-08-01 00:00:00

  • Administration of a dipeptidyl peptidase IV inhibitor enhances the intestinal adaptation in a mouse model of short bowel syndrome.

    abstract:BACKGROUND:Glucagon-like peptide-2 induces small intestine mucosal epithelial cell proliferation and may have benefit for patients who suffer from short bowel syndrome. However, glucagon-like peptide-2 is inactivated rapidly in vivo by dipeptidyl peptidase IV. Therefore, we hypothesized that selectively inhibiting dipe...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2011.05.013

    authors: Okawada M,Holst JJ,Teitelbaum DH

    更新日期:2011-08-01 00:00:00

  • Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor.

    abstract:BACKGROUND:No reports have yet precisely determined corticotropin (ACTH) responsiveness in virilizing adrenocortical adenoma. METHODS:Five women with an androgen-secreting adrenal adenoma were reviewed. Three of them were examined by in vitro steroidogenesis. Two of these 3 patients were studied by immunohistochemistr...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Imai T,Tobinaga J,Morita-Matsuyama T,Kikumori T,Sasano H,Seo H,Funahashi H

    更新日期:1999-04-01 00:00:00

  • Intrahepatic portosystemic vascular stents: a bridge to hepatic transplantation.

    abstract::Refractory esophageal variceal hemorrhage (EVH) remains a formidable problem in patients awaiting liver transplantations. Transjugular intrahepatic portosystemic shunts (TIPS) have provided an alternative approach for managing EVH that may obviate the need for portosystemic shunt surgery. Experience with TIPS placemen...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Woodle ES,Darcy M,White HM,Perdrizet GA,Vesely TM,Picus D,Hicks M,So SK,Jendrisak MD,McCullough CS

    更新日期:1993-03-01 00:00:00

  • Evaluation and management of thoracopancreatic fistula.

    abstract:BACKGROUND:Thoracopancreatic fistula is a rare clinical entity but a serious complication of inflammatory pancreatic diseases, caused by a disruption of the pancreatic ductal system. Its diagnosis is frequently misleading, however, and thus is often delayed. METHODS:Seven patients with thoracopancreatic fistula who pr...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2006.02.020

    authors: Tajima Y,Tsutsumi R,Kuroki T,Mishima T,Adachi T,Kitasato A,Kanematsu T

    更新日期:2006-11-01 00:00:00

  • Complications after radial artery harvesting for coronary artery bypass grafting: our experience.

    abstract:BACKGROUND:The aim of this study was to evaluate the incidence of complications in the upper limbs as a new event after radial artery (RA) harvesting for coronary artery bypass grafting (CABG). METHODS:From June 1997 to August 2001, the RA graft was used in 271 patients who underwent cardiac surgery at our department....

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2003.43

    authors: Budillon AM,Nicolini F,Agostinelli A,Beghi C,Pavesi G,Fragnito C,Busi M,Gherli T

    更新日期:2003-03-01 00:00:00

  • Right trisegment portal vein embolization for biliary tract carcinoma: technique and clinical utility.

    abstract:BACKGROUND:Right portal vein embolization has become popular in preparation for right hepatic lobectomy. However, right trisegment portal vein embolization (R3PE) is not well established. METHODS:We performed R3PE in 15 patients with biliary tract carcinoma and 1 patient with primary sclerosing cholangitis. We used 2 ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2000.101273

    authors: Nagino M,Kamiya J,Kanai M,Uesaka K,Sano T,Yamamoto H,Hayakawa N,Nimura Y

    更新日期:2000-02-01 00:00:00

  • Histamine type-2 receptor antagonist immune modulation. II. Cimetidine and ranitidine increase interleukin-2 production.

    abstract::The effect of cimetidine and ranitidine (histamine type-2 receptor antagonists) on the production of interleukin-2 (IL-2) by mitogen-activated, normal murine spleen cells was studied in vitro. Cimetidine (10(-4) mol/L to 10(-6) mol/L) increased IL-2 production to a maximal 8.8 +/- 1.6 U (IL-2 activity), as compared wi...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Gifford RR,Tilberg AF

    更新日期:1987-08-01 00:00:00

  • Intraoperative parathyroid hormone assay and parathyroid reoperations.

    abstract:BACKGROUND:The purpose of this study was to determine whether intraoperative parathyroid hormone (IOPTH) assay improved results of reoperations. METHODS:One hundred two patients with persistent/recurrent sporadic primary hyperparathyroidism underwent 108 reoperations (1996-2002). IOPTH was not used (n=58) from 1996-19...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2003.08.007

    authors: Sebag F,Shen W,Brunaud L,Kebebew E,Duh QY,Clark OH

    更新日期:2003-12-01 00:00:00

  • Radiation injuries to the bowel associated with the treatment of carcinoma of the cervix.

    abstract::Advances in radiation techniques and increased dosage have improved the cure rate of patients with cancer of the cervix to 65 percent. Associated with this increased dosage (betatron, 5,250 r and intracavitary 137-cesium, 4,000 r at point A) has been a serious complication incidence of 10 percent. Major intestinal com...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Palmer JA,Bush RS

    更新日期:1976-10-01 00:00:00

  • A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets.

    abstract:BACKGROUND:Effective cytoprotection to xenoislets would circumvent the major tissue limitation for pancreatic islet transplantation (PIT). Cell-surface engineering with poly[ethylene glycol] (PEG) derivatives can successfully prevent antibody binding to the surface antigens. Gene transfer of the antiapoptotic Bcl-2 gen...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2004.05.031

    authors: Contreras JL,Xie D,Mays J,Smyth CA,Eckstein C,Rahemtulla FG,Young CJ,Anthony Thompson J,Bilbao G,Curiel DT,Eckhoff DE

    更新日期:2004-09-01 00:00:00