Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity.

Abstract:

OBJECTIVE:Free radical-induced postasphyxial reperfusion injury has been recognized as an important cause of brain tissue damage. We investigated the effect of high-dose allopurinol (ALLO; 40 mg/kg), a xanthine-oxidase inhibitor and free radical scavenger, on free radical status in severely asphyxiated newborns and on postasphyxial cerebral perfusion and electrical brain activity. METHODS:Free radical status was assessed by serial plasma determination of nonprotein-bound iron (microM), antioxidative capacity, and malondialdehyde (MDA; microM). Cerebral perfusion was investigated by monitoring changes in cerebral blood volume (delta CBV; mL/100 g brain tissue) with near infrared spectroscopy; electrocortical brain activity (ECBA) was assessed in microvolts by cerebral function monitor. Eleven infants received 40 mg/kg ALLO intravenously, and 11 infants served as controls (CONT). Plasma nonprotein-bound iron, antioxidative capacity, and MDA were measured before 4 hours, between 16 and 20 hours, and at the second and third days of age. Changes in CBV and ECBA were monitored between 4 and 8, 16 and 20, 58 and 62, and 104 and 110 hours of age. RESULTS:Six CONT and two ALLO infants died after neurologic deterioration. No toxic side effects of ALLO were detected. Nonprotein-bound iron (mean +/- SEM) in the CONT group showed an initial rise (18.7 +/- 4.6 microM to 21.3 +/- 3.4 microM) but dropped to 7.4 +/- 3.5 microM at day 3; in the ALLO group it dropped from 15.5 +/- 4.6 microM to 0 microM at day 3. Uric acid was significantly lower in ALLO-treated infants from 16 hours of life on. MDA remained stable in the ALLO group, but increased in the CONT group at 8 to 16 hours versus < 4 hours (mean +/- SEM; 0.83 +/- 0.31 microM vs 0.50 +/- 0.14 microM). During 4 to 8 hours, delta CBV-CONT showed a larger drop than delta CBV-ALLO from baseline. During the subsequent registrations CBV remained stable in both groups. ECBA-CONT decreased, but ECBA-ALLO remained stable during 4 to 8 hours of age. Neonates who died had the largest drops in CBV and ECBA. CONCLUSION:This study suggests a beneficial effect of ALLO treatment on free radical formation, CBV, and electrical brain activity, without toxic side effects.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Van Bel F,Shadid M,Moison RM,Dorrepaal CA,Fontijn J,Monteiro L,Van De Bor M,Berger HM

doi

10.1542/peds.101.2.185

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

185-93

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

101

pub_type

临床试验,杂志文章
  • Outpatient Rehabilitation for Medicaid-Insured Children Hospitalized With Traumatic Brain Injury.

    abstract:OBJECTIVES:To describe the prevalence of postdischarge outpatient rehabilitation among Medicaid-insured children hospitalized with a traumatic brain injury (TBI) and to identify factors associated with receipt of services. METHODS:Retrospective cohort of children <21 years, hospitalized for a TBI between 2007 and 2012...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-3500

    authors: Jimenez N,Symons RG,Wang J,Ebel BH,Vavilala MS,Buchwald D,Temkin N,Jaffe KM,Rivara FP

    更新日期:2016-06-01 00:00:00

  • Impact of income and income inequality on infant health outcomes in the United States.

    abstract:OBJECTIVES:The goal was to investigate the relationships of income and income inequality with neonatal and infant health outcomes in the United States. METHODS:The 2000-2004 state data were extracted from the Kids Count Data Center. Health indicators included proportion of preterm births (PTBs), proportion of infants ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2009-3378

    authors: Olson ME,Diekema D,Elliott BA,Renier CM

    更新日期:2010-12-01 00:00:00

  • Pacifying effects of nonnutritive sucking on term and preterm neonates during heelstick procedures.

    abstract::Behavioral state, heart rate, and respiration were monitored during heelstick procedures in samples of healthy, term neonates (N = 48) and preterm neonates treated in minimal care (N = 48) and intensive care (N = 48) nurseries. The treated infants who were given pacifiers spent significantly less time fussing and cryi...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Field T,Goldson E

    更新日期:1984-12-01 00:00:00

  • Reducing violent injuries: priorities for pediatrician advocacy.

    abstract::A basic framework for developing an advocacy plan must systematically break down the large task of policy development implementation into manageable components. The basic framework described in detail in this paper includes three steps: Setting policy objectives by narrowing the scope of policy, by reviewing policy op...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Dolins JC,Christoffel KK

    更新日期:1994-10-01 00:00:00

  • Parental smoking and vascular damage in their 5-year-old children.

    abstract:BACKGROUND:The relation between smoke exposure in early life, the prenatal period in particular, and the vascular development of young children is largely unknown. METHODS:Data from the birth cohort participating in the WHISTLER-Cardio study were used to relate the smoking of parents during pregnancy to subsequent vas...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0249

    authors: Geerts CC,Bots ML,van der Ent CK,Grobbee DE,Uiterwaal CS

    更新日期:2012-01-01 00:00:00

  • Laparoscopy in children.

    abstract::Laparoscopy has been performed in 120 infants and children for a variety of indications including chronic abdominal pain, debatable appendicitis, liver biopsy, biliary atresia, and abdominal trauma. A specific diagnosis was made in 71% of patients and 59% were spared laparotomy. There were one complication and four er...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Leape LL,Ramenofsky ML

    更新日期:1980-08-01 00:00:00

  • A controlled trial of high-intensity double-surface phototherapy on a fluid bed versus conventional phototherapy in neonatal jaundice.

    abstract:OBJECTIVE:To evaluate a simple, relatively inexpensive method using the fluid bed to provide high-intensity double-surface (HIDS) phototherapy and to confirm that the method described is more effective than conventional phototherapy (CPT) in the treatment of neonatal hyperbilirubinemia. DESIGN:Prospective controlled s...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Garg AK,Prasad RS,Hifzi IA

    更新日期:1995-06-01 00:00:00

  • Simulation in Pediatric Emergency Medicine Fellowships.

    abstract:BACKGROUND AND OBJECTIVES:Graduate medical education faces challenges as programs transition to the next accreditation system. Evidence supports the effectiveness of simulation for training and assessment. This study aims to describe the current use of simulation and barriers to its implementation in pediatric emergenc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-4158

    authors: Doughty CB,Kessler DO,Zuckerbraun NS,Stone KP,Reid JR,Kennedy CS,Nypaver MM,Auerbach MA

    更新日期:2015-07-01 00:00:00

  • Hypertrophic obstructive cardiomyopathy in an infant with an adrenocortical tumor.

    abstract::Nonfamilial cardiomyopathies in childhood have been only sporadically ascribed to endocrine disorders. We report on a 4-month-old male infant presenting with Cushing's syndrome associated with excessive body weight (8.9 kg; >97th percentile) and features of virilization (Tanner stage 2 for pubic hair development). Abd...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2692

    authors: Hauser J,Riedl S,Michel-Behnke I,Minkov M,Perneczky E,Horcher E

    更新日期:2013-08-01 00:00:00

  • Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth.

    abstract:OBJECTIVE:Insulin-like growth factor I (IGF-I) is necessary for normal development of retinal blood vessels in mice and humans. Because retinopathy of prematurity (ROP) is initiated by abnormal postnatal retinal development, we hypothesized that prolonged low IGF-I in premature infants might be a risk factor for ROP. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.5.1016

    authors: Hellström A,Engström E,Hård AL,Albertsson-Wikland K,Carlsson B,Niklasson A,Löfqvist C,Svensson E,Holm S,Ewald U,Holmström G,Smith LE

    更新日期:2003-11-01 00:00:00

  • Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography.

    abstract:OBJECTIVE:To define normal and abnormal patterns, test interobserver variability, and the prognostic accuracy of amplitude-integrated electroencephalography (aEEG) soon after the onset of neonatal encephalopathy. METHODS:Consecutive cases of neonatal encephalopathy (n = 56; gestation median, 40; range, 35-42 weeks) an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.6.1263

    authors: al Naqeeb N,Edwards AD,Cowan FM,Azzopardi D

    更新日期:1999-06-01 00:00:00

  • Human metapneumovirus infection in the United States: clinical manifestations associated with a newly emerging respiratory infection in children.

    abstract:OBJECTIVE:Respiratory tract infections are a leading cause of morbidity and mortality worldwide. Recently, a newly identified human respiratory virus, human metapneumovirus (hMPV), was reported by investigators in the Netherlands. We sought to determine whether hMPV was circulating in our community and to determine the...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.6.1407

    authors: Esper F,Boucher D,Weibel C,Martinello RA,Kahn JS

    更新日期:2003-06-01 00:00:00

  • Detection of Mycobacterium tuberculosis in clinical specimens from children using a polymerase chain reaction.

    abstract:OBJECTIVE:We evaluated the usefulness of the polymerase chain reaction (PCR) using the insertion sequence IS6110 as the target for DNA to detect Mycobacterium tuberculosis in clinical specimens from children. STUDY DESIGN:This was a prospective, controlled, blinded study comparing PCR on clinical specimens, mycobacter...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Smith KC,Starke JR,Eisenach K,Ong LT,Denby M

    更新日期:1996-02-01 00:00:00

  • Blood-brain phenylalanine relationships in persons with phenylketonuria.

    abstract:OBJECTIVES:Clinicians caring for persons with phenylketonuria (PKU) have been perplexed by the occasional normal individual with the classical biochemical profile consistent with the diagnosis of PKU. Usually untreated subjects with the biochemical profile of blood phenylalanine (Phe) levels >1200 micromol/L are severe...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.5.1093

    authors: Koch R,Moats R,Guttler F,Guldberg P,Nelson M Jr

    更新日期:2000-11-01 00:00:00

  • The medical cost of abusive head trauma in the United States.

    abstract:OBJECTIVES:Health consequences of shaken baby syndrome, or pediatric abusive head trauma (AHT), can be severe and long-lasting. We aimed to estimate the multiyear medical cost attributable to AHT. METHODS:Using Truven Health MarketScan data, 2003-2011, we identified children 0 to 4 years old with commercial or Medicai...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0117

    authors: Peterson C,Xu L,Florence C,Parks SE,Miller TR,Barr RG,Barr M,Steinbeigle R

    更新日期:2014-07-01 00:00:00

  • Tocopherol efficacy and safety for preventing retinopathy of prematurity: a randomized, controlled, double-masked trial.

    abstract::To test the efficacy and safety of vitamin E in preventing retinopathy of prematurity, 287 infants with birth weights of less than 1.5 kg or gestational ages of less than 33 weeks were enrolled within 24 hours of birth in a randomized, double-masked trial of IV, followed by oral, placebo v tocopherol (adjusted to plas...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Phelps DL,Rosenbaum AL,Isenberg SJ,Leake RD,Dorey FJ

    更新日期:1987-04-01 00:00:00

  • Frequency and significance of physical evidence in legally proven cases of child sexual abuse.

    abstract::Clinicians have long recognized and attorneys have disputed that physical evidence of injury, sexually transmitted diseases, and seminal fluid are often absent in cases of child sexual abuse. To determine the frequency and significance of physical evidence in legally "proven" felony cases with penetration, a retrospec...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: De Jong AR,Rose M

    更新日期:1989-12-01 00:00:00

  • Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease.

    abstract::We report a case of bone pain associated with primary hyperparathyroidism in a patient with sickle cell disease. A 17-year-old girl with sickle cell disease (SS phenotype) was seen for bilateral knee and back pain. She had had recurrent severe vaso-occlusive crises and acute chest syndrome in the course of her disease...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0337

    authors: Krishnamoorthy P,Alyaarubi S,Abish S,Gale M,Albuquerque P,Jabado N

    更新日期:2006-08-01 00:00:00

  • Pacifier use and morbidity in the first six months of life.

    abstract:OBJECTIVE:To assess the prevalence of pacifier use and whether this habit adversely affects the health of 6-month-old infants. DESIGN:Data collected via self-completion questionnaires from mothers forming part of the prospective, population-based Avon Longitudinal Study of Pregnancy and Childhood. METHODS:The mothers...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.3.e34

    authors: North K,Fleming P,Golding J

    更新日期:1999-03-01 00:00:00

  • Bilirubin photoisomerization in premature neonates under low- and high-dose phototherapy.

    abstract::Photoisomerization of native bilirubin to more polar configurational isomers (Z,E-bilirubin) and structural isomers (lumirubin) was studied in 20 premature infants with physiologic jaundice to determine the effect of low-dose (6 microW/cm2/nm) v high-dose (12 microW/cm2/nm) phototherapy. Patients were assigned prospec...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Costarino AT,Ennever JF,Baumgart S,Speck WT,Paul M,Polin RA

    更新日期:1985-03-01 00:00:00

  • Selective intrapartum prophylaxis for group B streptococcus colonization: management and outcome of newborns.

    abstract:OBJECTIVE:Intrapartum antibiotic prophylaxis (IAP) in mothers with group B streptococcus (GBS) colonization presents difficult neonatal management decisions. IAP was instituted in response to an increased incidence of early-onset GBS sepsis (EOGBSS), and a study was conducted to evaluate the outcome of these newborns. ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Pylipow M,Gaddis M,Kinney JS

    更新日期:1994-04-01 00:00:00

  • Child abuse and neglect and cognitive function at 14 years of age: findings from a birth cohort.

    abstract:OBJECTIVE:To examine the association between child maltreatment (abuse and neglect) and long-term cognitive outcomes within a prospective birth cohort. METHODS:A birth cohort of 7223 children was recruited. Independent reports of suspected child maltreatment were confidentially linked to the longitudinal study databas...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3479

    authors: Mills R,Alati R,O'Callaghan M,Najman JM,Williams GM,Bor W,Strathearn L

    更新日期:2011-01-01 00:00:00

  • Pharyngitis in low-resources settings: a pragmatic clinical approach to reduce unnecessary antibiotic use.

    abstract:OBJECTIVE:Existing scoring systems for the diagnosis of group A streptococcus pharyngitis are insensitive or inapplicable in low-resources settings. Bacterial cultures and rapid tests can allow for antibiotic prescription abstention in high-income regions. These techniques are not feasible in many low-resources setting...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2006-1025

    authors: Smeesters PR,Campos D Jr,Van Melderen L,de Aguiar E,Vanderpas J,Vergison A

    更新日期:2006-12-01 00:00:00

  • Long-term reduction in adverse drug events: an evidence-based improvement model.

    abstract:OBJECTIVES:To develop and test an evidence-based model for reducing medication errors and harm in hospitalized children. METHODS:Prospective interrupted time series study evaluating the effectiveness of a multifaceted, staged intervention over 4 years in a major urban pediatric referral hospital. Guidelines for safe p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1902

    authors: Gazarian M,Graudins LV

    更新日期:2012-05-01 00:00:00

  • Children plus all nonautomobile motorized vehicles (not just all-terrain vehicles) equals injuries.

    abstract:OBJECTIVES:The goals were to describe the epidemiological features of pediatric nonautomobile motorized vehicle-related injuries sustained between 1990 and 2003 and to compare all-terrain vehicle-related injuries with other types of nonautomobile motorized vehicle-related injuries. METHODS:An analysis of nationally re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3612

    authors: Collins CL,Smith GA,Comstock RD

    更新日期:2007-07-01 00:00:00

  • Sleep environment and the risk of sudden infant death syndrome in an urban population: the Chicago Infant Mortality Study.

    abstract:OBJECTIVE:To examine risk factors for sudden infant death syndrome (SIDS) with the goal of reducing SIDS mortality among blacks, which continues to affect this group at twice the rate of whites. METHODS:We analyzed data from a population-based case-control study of 260 SIDS deaths that occurred in Chicago between 1993...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hauck FR,Herman SM,Donovan M,Iyasu S,Merrick Moore C,Donoghue E,Kirschner RH,Willinger M

    更新日期:2003-05-01 00:00:00

  • A Previously Healthy Adolescent With Acute Psychosis and Severe Hyperhidrosis.

    abstract::A previously healthy 15-year-old boy presented with 3 months of progressive psychosis, insomnia, back and groin pain, and hyperhidrosis. On examination, the patient was disheveled, agitated, and soaked with sweat, with systolic blood pressure in the 160s and heart rate in the 130s. Aside from occasional auditory and v...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-3786

    authors: Rosenblatt T,Ort K,Shaw R,Levy RJ,Chen C,Niemi A,Hoang K

    更新日期:2020-06-01 00:00:00

  • A systematic review of vocational interventions for young adults with autism spectrum disorders.

    abstract:BACKGROUND AND OBJECTIVE:Many individuals with autism spectrum disorders (ASDs) are approaching adolescence and young adulthood; interventions to assist these individuals with vocational skills are not well understood. This study systematically reviewed evidence regarding vocational interventions for individuals with A...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2012-0682

    authors: Taylor JL,McPheeters ML,Sathe NA,Dove D,Veenstra-Vanderweele J,Warren Z

    更新日期:2012-09-01 00:00:00

  • Time in continuity clinic as a predictor of continuity of care for pediatric residents.

    abstract:OBJECTIVE:In 1996, the Residency Review Committee-Pediatrics recommended doubling time in continuity clinic to 2 half days per week. It has yet to be demonstrated that increased time in clinic yields greater continuity of care. The objective of this study was to determine whether increasing the number of half days spen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2003-0280-L

    authors: McBurney PG,Moran CM,Ector WL,Quattlebaum TG,Darden PM

    更新日期:2004-10-01 00:00:00

  • Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up Study.

    abstract:OBJECTIVE:The goal was to assess the association of metabolic syndrome in childhood with adult cardiovascular disease 25 years later. METHODS:Data from the National Heart, Lung, and Blood Institute Lipid Research Clinics Princeton Prevalence Study (1973-1976) and the Princeton Follow-up Study (2000-2004) were used. BM...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1699

    authors: Morrison JA,Friedman LA,Gray-McGuire C

    更新日期:2007-08-01 00:00:00