Successful reversal of pulmonary hypertension in Eisenmenger complex.

Abstract:

:We present a case of a 19-year old female with systemic pulmonary artery (PA) pressure due to a congenital ventricular septal defect (VSD) and atrial septal defect (ASD). She was pink at rest and cyanotic on exercise. Lung biopsy revealed grade IV pulmonary vascular changes. As a preliminary step PA was banded to increase right-to-left shunt and decrease aortic (Ao) saturation with consequent decrease in PA saturation. After one year, when she was no longer cyanotic, even on exercise, lung biopsy revealed total regression of pulmonary vascular changes. As a definitive procedure VSD and ASD were closed and PA was debanded. Cardiac catheterization one week postoperatively showed PA pressure to be 50% of systemic pressure. We postulate that reversal of pulmonary vascular changes were due to lowered PA saturation. We further believe that lower PA pressure could have contributed to this regression of pulmonary vascular changes. We performed the same procedure in six more patients with similar positive clinical response. This new concept brings renewed hope to many children who otherwise are candidates for heart lung transplantation.

journal_name

Arq Bras Cardiol

authors

Batista RJ,Santos JL,Takeshita N,Eocchino L,Lima PN,Goehr M,Cunha MA,Kawaguchi AT,Salerno TA

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

279-80

issue

4

eissn

0066-782X

issn

1678-4170

journal_volume

68

pub_type

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