[Natural history of myocardial hypertrophy and its association with hyperinsulinism in infants of diabetic mothers].

Abstract:

PURPOSE:To test the hypothesis that myocardial hypertrophy is associated with increased serum insulin levels in children of diabetic mothers and to determine the frequency and timing of this spontaneous regression. METHODS:Seventy-two patients were studied (54 children of diabetic mothers and 18 controls). Diagnosis of myocardial hypertrophy was made by fetal echocardiography. Amniotic fluid insulin levels were obtained from a previous prenatal study on hypertrophic cardiomyopathy, since the participation of the mothers was common to both projects. RESULTS:There were 10 cases of myocardial hypertrophy among children of diabetic mothers (18.52%). Septal thickness was significantly different between the 2 groups (children of diabetic mothers and controls) in the evaluation performed at the age of 1 month (p = 0.04). Insulin levels were still increased in children of diabetic mothers until the age of 3 months. During this period insulin levels were significantly higher than those of controls (p = 0.003 and p = 0.001, at 1 and 3 months, respectively). The association between regression of ventricular septum thickness and the decrease of insulin levels occurred up to the age of 1 month. CONCLUSION:There was spontaneous regression of ventricular septum thickness in children of diabetic mothers during the first 6 months of life. The association between hyperinsulinism and hypertrophic cardiomyopathy was present up to the first month of life.

journal_name

Arq Bras Cardiol

authors

Zielinsky P,da Costa MH,Oliveira LT,Bonow FP,da Silva NI,Hagemann LL

doi

10.1590/s0066-782x1997001200005

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

389-94

issue

6

eissn

0066-782X

issn

1678-4170

journal_volume

69

pub_type

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