Abstract：
BACKGROUND:Serum cystatin C (s-CC), an endogenous marker of kidney function, has also been proposed as a cardiovascular risk marker. However, it is unknown whether it is a direct marker of atherosclerosis, independently of kidney function. OBJECTIVE:The aim of this study was to correlate s-CC with two surrogate markers of subclinical atherosclerosis. METHODS:This is a cross-sectional study involving 103 middle-aged (57.49 ± 11.7 years) hypertensive outpatients, being 60 female (58.25%), most with preserved kidney function. S-CC was correlated with carotid intima media thickness (IMT) and flow-mediated dilation of brachial artery (FMD), both assessed by ultrasound, as well as with measured creatinine clearance and established cardiovascular risk factors. RESULTS:S-CC was neither significantly correlated with IMT (r = -0.024; p = 0.84) nor with FMD (r = -0.050 and p = 0.687) and no significant association was observed with conventional risk factors and inflammatory markers. In univariate analysis, s-CC was correlated with measured creatinine clearance (r = -0,498; p < 0,001), age (r = 0,408; p < 0,001), microalbuminuria (r = 0,291; p = 0,014), uric acid (r = 0,391; p < 0,001), ratio E/e' (r = 0,242; p = 0,049) and Framingham score (r = 0,359; p = 0,001). However, after multiple regression analysis, only the association with measured creatinine clearance remained significant (r = -0,491; p < 0,001). CONCLUSION:In middle-aged hypertensive outpatients, s-CC correlated with measured creatinine clearance, as expected, but no association was observed with markers of atherosclerosis neither with established cardiovascular risk factors.
journal_name
Arq Bras Cardioljournal_title
Arquivos brasileiros de cardiologiaauthors
Monteiro Junior Fd,Ferreira PA,Nunes JA,Cunha Júnior CP,Brito RL,Costa JH,Lima JR,Lages JS,Salgado Filho N,Lima VCdoi
10.1590/s0066-782x2012005000083subject
Has Abstractpub_date
2012-10-01 00:00:00pages
899-906issue
4eissn
0066-782Xissn
1678-4170pii
S0066-782X2012005000083journal_volume
99pub_type
杂志文章abstract：BACKGROUND:Changes in the behavior of the circadian rhythm can be deleterious, leading to target-organ damage, which suggests that they can have a prognostic significance and, eventually, can also demand therapeutic intervention. OBJECTIVE:To describe and compare the circadian rhythms of blood pressure (BP) in normote...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2010005000010
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abstract：PURPOSE:To compare the efficacy of carvedilol, a new antihypertensive drug that combines vasodilatory and beta-blocker properties, with nifedipine. METHODS:In a multicenter double-blind trial, 106 mild to moderate essential hypertensive patients were treated with either carvedilol (n = 51), or nifedipine (n = 55) as m...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:In patients with systemic hypertension, microalbuminuria is a marker of endothelial damage and is associated with an increased risk for cardiovascular disease. OBJECTIVE:To determine the factors that may lead to the occurrence of microalbuminuria in hypertensive patients with serum creatinine lower than 1.5...
journal_title：Arquivos brasileiros de cardiologia
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doi：10.5935/abc.20130210
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abstract：:Anticoagulation is the chief problem during pregnancy of women with mechanical prosthetic valves. Many studies have investigated a nonthrombogenic valve. Since 1978 we have used a biological porcine prosthetic valves in 16 pregnancies, 11 patients with regular clinical electrocardiographic, echocardiographic and chest...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:The authors report a case of a 65-year-old male patient who, after complaint about retrosternal discomfort and going through a thoracic radiography with mediastinal enlargement, was submitted to magnetic resonance angiography, which detected a right aortic arch with aberrant left subclavian artery and Kommerell divert...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章,评审
doi：10.1590/s0066-782x2009001200026
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abstract：OBJECTIVE:To determine the diagnostic accuracy of echocardiography for indicating surgery without catheterization in patients with congenital heart disease through a prospective analysis and comparison of the echocardiographic diagnosis with the intraoperative findings, or invasive study, or both. METHODS:From Februar...
journal_title：Arquivos brasileiros de cardiologia
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doi：10.1590/s0066-782x2005000500006
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journal_title：Arquivos brasileiros de cardiologia
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abstract：BACKGROUND:Few studies have examined the relationship of one's habitual physical activity level and autonomic nervous system (ANS) modulation on sleep quality in smokers. OBJECTIVE:The aim of this study was to identify changes in the sleep quality of smokers and its relation with their habitual physical activity level...
journal_title：Arquivos brasileiros de cardiologia
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doi：10.36660/abc.20190522
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journal_title：Arquivos brasileiros de cardiologia
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journal_title：Arquivos brasileiros de cardiologia
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doi：10.1590/s0066-782x2009001200015
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journal_title：Arquivos brasileiros de cardiologia
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-11-01 00:00:00
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journal_title：Arquivos brasileiros de cardiologia
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doi：
更新日期：1997-02-01 00:00:00
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journal_title：Arquivos brasileiros de cardiologia
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journal_title：Arquivos brasileiros de cardiologia
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-08-01 00:00:00
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journal_title：Arquivos brasileiros de cardiologia
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journal_title：Arquivos brasileiros de cardiologia
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journal_title：Arquivos brasileiros de cardiologia
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journal_title：Arquivos brasileiros de cardiologia
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journal_title：Arquivos brasileiros de cardiologia
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doi：
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journal_title：Arquivos brasileiros de cardiologia
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journal_title：Arquivos brasileiros de cardiologia
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doi：
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journal_title：Arquivos brasileiros de cardiologia
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