Abstract：
PURPOSE:To evaluate the influence of age on response to pravastatin treatment in patients treated by community physicians. METHODS:According to age, 873 patients were divided in three groups: group A with ages ranging from 45 to 59 years (n = 55), group B with ages from 60 to 64 years (n = 182) and group C with ages from 65 to 70 years (n = 143). After four weeks only with diet orientation, patients received 10 mg/day of pravastatin for 12 weeks. RESULTS:There was a greater prevalence of risk factors in elderly patients: hypertension (45.7%, 54.4% and 57.1% in groups A, B and C respectively p = 0.0165), diabetes mellitus (9.3%, 17.6% and 25.8% respectively in groups A, B and C p < 0.0001), and previous heart disease (23.1%, 34.3% and 34.7% in groups A, B and C respectively p < 0.001). During the period of diet orientation there was a similar total cholesterol reduction in the three groups (about 10.5%), the reduction reached 30.0% with the introduction of pravastatin for 12 weeks. Low density cholesterol level decreased during the diet period in the three groups (about 10.5%), pravastatin prescription induced further reduction (about 31.7%). The high density cholesterol level (HDL) increased significantly with pravastatin treatment (12.7%). After pravastatin treatment the increase in HDL levels was more significantly among those patients with initial low levels of HDL (< 35 mg/dL) in the three groups. CONCLUSION:In patients selected by community physicians to receive lipid lowering therapy, increased age was associated with greater prevalence of risk factors and heart disease. Regardless of age, there was a good response to pravastatin treatment, however less than half of patients had received treatment prior to the protocol.
journal_name
Arq Bras Cardioljournal_title
Arquivos brasileiros de cardiologiaauthors
Barretto AC,Wajngarten M,Gebara OC,do Serro Azul JB,Pierri H,Nussbacher A,Pivotto L,Bellotti G,Pileggi Fsubject
Has Abstractpub_date
1996-08-01 00:00:00pages
93-8issue
2eissn
0066-782Xissn
1678-4170journal_volume
67pub_type
临床试验,杂志文章abstract：BACKGROUND:Regular physical activity (PA) induces desirable changes in plasma levels of high- and low-density lipoproteins (HDL and LDL, respectively) and triglycerides (TG), important risk factors for cardiometabolic diseases. However, doubts whether intensity and duration have equivalent benefits remain. OBJECTIVE:T...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.5935/abc.20160091
更新日期：2016-07-01 00:00:00
abstract：:Several studies have reported the benefits of beta-blockers (BB) for patients presenting with systolic heart failure. however, many patients hospitalized as a result of acute heart failure are already using BB and require dobutamine for arterial hypotension and low cardiac output. Therefore, a decision must be made re...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章,评审
doi：10.5935/abc.20130034
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Recent MADIT II and SCD-HeFT trials have led to an expansion of indications for use of prophylactic Implantable Cardioverter Defibrillator (ICD) in patients with severe left-ventricular impairment. This therapy has not been fully adopted in our health care system, mainly due to its high cost. OBJECTIVE:To a...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2008000500006
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Data from over 4 decades have reported a higher incidence of silent infarction among patients with diabetes mellitus (DM), but recent publications have shown conflicting results regarding the correlation between DM and presence of pain in patients with acute coronary syndromes (ACS). OBJECTIVE:Our primary o...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.5935/abc.20140106
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Myeloperoxidase (MPO) is a highly expressed enzyme due to leukocyte activation, with multiple atherogenic actions, including LDL cholesterol oxidation, and is related to the instability of atherosclerotic plaque. It is a predictor of adverse events in healthy individuals, patients with heart disease or those...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2007001800005
更新日期：2007-12-01 00:00:00
abstract：:Total generalized lipodystrophy (Berardinelli - Seip Syndrome) is a rare hereditary disease characterized by insulin-resistant diabetes mellitus and a small quantity of adipose tissue and is of unknown origin. Common cardiovascular alterations related to this syndrome are cardiac hypertrophy and arterial hypertension....
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章,评审
doi：10.1590/s0066-782x2000000900006
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:The effect of vaccination against the influenza virus on the mortality due to cardiovascular diseases (CVD) remains controversial. OBJECTIVE:To analyze the mortality by CVD before and after the start of the vaccination against the Influenza virus in the city of Sao Paulo, Brazil. METHODS:We analyzed the mo...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2009001000013
更新日期：2009-10-01 00:00:00
abstract：:Drug intoxication with disulfiram is a rare condition that may lead to severe and potentially fatal cardiovascular manifestations such as cardiogenic shock. We report the case of a female patient with refractory shock after deliberate self-poisoning with disulfiram. Clinical, biochemical and echocardiographic assessme...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2009000300016
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that short periods of ischemia may increase the myocardial protection obtained with intermittent crossclamping of the aorta. METHODS:In the control group (18 patients), surgery was performed with systemic hypothermia at 32 degrees C and intermittent crossclamping of the aorta. Extracor...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1590/s0066-782x2001001000001
更新日期：2001-10-01 00:00:00
abstract：:We report a case of chronic nonspecific constrictive pericarditis with myocardial involvement in a 19-month-old infant. The patient underwent total pericardiectomy and had irreversible hemodynamic instability. Constrictive pericarditis is rare in childhood. It may follow several processes, most frequently an infectiou...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Clinical and epidemiological studies have demonstrated a strong association between eating habits and chronic diseases, particularly cardiovascular events, although not all the mechanisms of action are understood. OBJECTIVE:To describe and analyze the cardiovascular risk (CVR) in vegetarians and omnivores r...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2007001600005
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To describe a surgical procedure utilizing a malleable bovine pericardium ring in mitral valve repair and clinical and Doppler echocardiographic results. METHODS:Thirty-two (25 female and 7 male) patients, aged between 9 and 66 (M=36.4+/-17.2) years, were studied over a 16-month period, with 100% follow-up. ...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2000001100003
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:The occurrence of minute-ventilation oscillations during exercise, named periodic breathing, exhibits important prognostic information in heart failure. Considering that exercise training could influence the fluctuation of ventilatory components during exercise, we hypothesized that ventilatory variability d...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.5935/abc.20170104
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Heart failure (HF) is an important public health problem, of which main clinical symptoms are dyspnea and fatigue. Noninvasive ventilatory support has been used as adjuvant therapy in cardiac rehabilitation in order to improve the functional capacity of patients. OBJECTIVE:To evaluate the functional capacit...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章,随机对照试验
doi：10.1590/s0066-782x2011005000002
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:There is evidence indicating that blood pressure control is more effective in reducing macrovascular complications of diabetes mellitus (DM) than glycemic control. However, the reduction in BP to levels recommended by international guidelines is difficult in clinical practice. OBJECTIVE:To assess the percen...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2010005000034
更新日期：2010-05-01 00:00:00
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journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2011001500016
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Cardiac magnetic resonance imaging is considered the gold-standard method for the calculation of cardiac volumes. Transthoracic impedance cardiography assesses the cardiac output. No studies validating this measurement, in comparison to that obtained by magnetic resonance imaging, are available. OBJECTIVE:T...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2012005000104
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Although the radial approach offers an unquestionable result in terms of reduction of vascular complications and occurrence of severe bleeding in comparison to the femoral approach, so far it has only been used in few centers which elected it as the preferential access. OBJECTIVE:To evaluate the current sta...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2011005000026
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abstract：:Prosthetic thrombosis is a rare complication, but it has high mortality and morbidity. Young women of childbearing age that have prosthetic heart valves are at increased risk of thrombosis during pregnancy due to changes in coagulation factors. Anticoagulation with adequate control and frequent follow-up if pregnancy ...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.5935/abc.20150130
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:To evaluate the antihypertensive efficacy and tolerability of captopril 50 mg + hydrochlorothiazide 25 mg daily in mild to moderate primary hypertension. METHODS:Out-patients (n = 471) with mild to moderate hypertension, diastolic blood pressure (DBP) 95-115 mmHg, with 15 days of washout, were included to the ...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1995-06-01 00:00:00
abstract：:A case of pulmonary atresia with intact ventricular septum and a hypoplastic right ventricle, with three wall formed portions, that became naturally well developed until 2 years of age, is related. A Blalock-Taussig shunt had been performed early in life. Z value of tricuspid valve of 0.3 and left ventricular in ECG h...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the prevalence of cardiovascular events (CVE) secondary to atherosclerosis in lupus patients and correlate them to the traditional risk factors, disease duration and drug therapy used. METHODS:A retrospective study was carried out based on data obtained from patients charts. Patients included wer...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2006001600012
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Chronic exercise and food restriction (FR) have directionally opposite changes in transcription of molecular structures of calcium handling and thyroid hormone (TH) status. OBJECTIVE:Evaluate the association of chronic exercise and FR on serum thyroid hormones and gene transcription of molecular structures ...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2011005000066
更新日期：2011-07-01 00:00:00
abstract：:Two 38 and 53-year old male patients with unstable angina, whose hemodynamic study showed an isolated stenosis of the left coronary artery ostium, were submitted to a surgical angioplasty of the left main coronary artery (LMCA) with saphenous vein patch. At the end of the operation, the patients presented intermitent ...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x1997000900007
更新日期：1997-09-01 00:00:00
abstract：PURPOSE:To test the association between diabetes mellitus and ischaemic heart disease (IHD) in males and females, after adjusting for known confounders and/or modifiers of effect. METHODS:The study was designed as a case-control and the period of data collection was one year (March/93 until February/94). The associati...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:To study electrophysiological characteristics that enable the identification and ablation of sites of chagasic tachycardia. METHODS:Thirty-one patients with chronic Chagas' heart disease and sustained ventricular tachycardia (SVT) underwent electrophysiological study to map and ablate that arrhythmia. Fiftee...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x1999000400006
更新日期：1999-04-01 00:00:00
abstract：:Fifty eight year old man, with dyspnea, fatigue and progressive angina underwent cinecoronarography, which showed an arterio-venous coronary-pulmonary fistula originating from the circumflex artery to the pulmonary circulation. We decided to occlude it percutaneously, using a detachable balloon technic. The occlusion ...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：PURPOSE:To evaluate left ventricular mass (LVM) index in hypertensive and normotensive obese individuals. METHODS:Using M mode echocardiography, 544 essential hypertensive and 106 normotensive patients were evaluated, and LVM was indexed for body surface area (LVM/BSA) and for height2 (LVM/h2). The 2 indexes were then...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2002000400001
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:The determination of the prevalence of electrocardiographic alterations in the older age strata of the Brazilian population represents important information with clinical and epidemiological purpose. OBJECTIVE:To verify the prevalence rates of atrial fibrillation, enlarged Q/QS waves (Minnesota code 1.1-1.2...
journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：10.1590/s0066-782x2009001200015
更新日期：2009-12-01 00:00:00
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journal_title：Arquivos brasileiros de cardiologia
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
