[Use of carvedilol compared to nifedipine in the treatment of mild and moderate essential arterial hypertension].


PURPOSE:To compare the efficacy of carvedilol, a new antihypertensive drug that combines vasodilatory and beta-blocker properties, with nifedipine. METHODS:In a multicenter double-blind trial, 106 mild to moderate essential hypertensive patients were treated with either carvedilol (n = 51), or nifedipine (n = 55) as monotherapy. Following 4 weeks of wash-out/run-in period, patients from the carvedilol group received this drug once a day at a dosage of 25 mg/day for 8 consecutive weeks. In order to maintain the double-blind character of the study, a placebo was administered in the carvedilol group at identical dosage intervals as used in the nifedipine s.r. group. Nifedipine was also administered for 8 weeks at a dosage of 40 mg/day given b.i.d. RESULTS:Both treatments were equally efficient in reducing blood pressure in the seated and upright positions. Blood pressure response to treatment was obtained in 79% and 78% of patients treated with carvedilol and nifedipine, respectively. The carvedilol group did not develop reflex tachycardia which is usually seen when prescribing vasodilators. Blood biochemistry remained unchanged with both treatments. Besides similar blood pressure efficacy, side effects by patients taking carvedilol were less frequent than nifedipine group. CONCLUSION:Carvedilol is a safe, efficient, once/day choice as monotherapy for mild to moderate essential hypertensive patients.


Arq Bras Cardiol


Plavnik FL,Freitas AF,Portela JE,Dantas M,Spritzer T,Kohlmann NE,Spritzer N,Furtado MR,Kohlmann O Jr


Has Abstract


1994-11-01 00:00:00












  • Real-world use of drug-eluting stents: the importance of registries.

    abstract::Over the last decades the efficacy and safety of bare metal (BMS) and drug eluting stents (DES) have been demonstrated in many different clinical scenarios, leading to their use in more than 75% of the procedures worldwide. Compared to BMS, DES have shown lower rates of angiographic restenosis and target-vessel revasc...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,meta分析,评审


    authors: Ribeiro EE,Ribeiro HB

    更新日期:2010-07-01 00:00:00

  • Transhepatic access for atrioseptostomy in a neonate.

    abstract::We report a case in which a neonate with complete transposition of the great arteries was submitted to an atrial septostomy through transhepatic access due to congenital interruption of the inferior vena cava. The technical aspects of the procedure are discussed. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Neves JR,Ferreiro CR,Fontes VF,Pedra CA

    更新日期:2007-03-01 00:00:00

  • Mild stunting is associated with higher blood pressure in overweight adolescents.

    abstract:BACKGROUND:Studies have shown that pre/postnatal undernutrition leads to higher risk of non communicable diseases such as diabetes, hypertension and obesity in adulthood. OBJECTIVE:To determine whether overweight adolescents with mild stunting [height-for-age Z scores (HAZ) in the range <-1 to ≥ -2] have higher blood ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Clemente AP,Santos CD,Silva AA,Martins VJ,Marchesano AC,Fernandes MB,Albuquerque MP,Sawaya AL

    更新日期:2012-01-01 00:00:00

  • [Cor triatriatum].

    abstract::A 16-year-old patient was evaluated for congestive heart failure and pulmonary hypertension, suggesting mitral valve stenosis. A left atrial membrane with a 4 mm orifice was seen in echocardiography and angiography, and a diagnosis of cor triatriatum was made. The membrane was successfully removed by surgery. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Wüsthof AR,Sacomani CA,Rossetti FT,Benacchio M,Rivetti LA,Franken RA

    更新日期:1991-09-01 00:00:00

  • Radiofrequency ablation of childhood arrhythmia: observational registry in 125 children.

    abstract:BACKGROUND:Radiofrequency ablation (RFA) in children is an increasingly common practice. OBJECTIVE:To evaluate, in our institution, the results of RFA in children younger than 15 years. METHODS:A total of 125 children submitted to RFA between May 1991 and May 2010 were analyzed. RESULTS:Sixty-seven (53.6%) children ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Melo SL,Scanavacca MI,Pisani C,Darrieux F,Hachul D,Hardy C,Camargo PR,Atik E,Sosa EA

    更新日期:2012-06-01 00:00:00

  • Clinical, Anthropometric and Biochemical Characteristics of Patients with or without Genetically Confirmed Familial Hypercholesterolemia.

    abstract:BACKGROUND:Familial hypercholesterolemia (FH) is a common autosomal dominant disorder, characterized by a high level of low-density lipoprotein cholesterol (LDL-C) and a high risk of premature cardiovascular disease. OBJECTIVE:To evaluate clinical and anthropometric characteristics of patients with the familiar hyperc...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Lorenzo A,Silva JDLD,James CE,Pereira AC,Moreira ASB

    更新日期:2018-02-01 00:00:00

  • High dose of amiodarone in a short-term period reduces the incidence of postoperative atrial fibrillation and atrial flutter.

    abstract:OBJECTIVE:To investigate whether oral amiodarone administered before surgery for a short period in high dose would reduce the incidence of postoperative atrial fibrillation or atrial flutter and reduces the length of hospital stay. METHODS:In the double-blind, randomized study, 93 patients were given either oral amiod...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,随机对照试验


    authors: Alcalde RV,Guaragna JC,Bodanese LC,Castro I,Sussenbach E,Noer R,Goldani MA,Feier F,Petracco JB

    更新日期:2006-09-01 00:00:00

  • [Different therapies in the treatment of obesity in hypertensive patients].

    abstract:PURPOSE:To evaluate the efficacy and tolerability of different therapies associated with diet in the treatment of hypertensive obese patients. METHODS:In a clinical study we randomly evaluated 39 hypertensive obese patients (body mass index (BMI) > or = 30 kg/m2). After 45 days of diet the patients were again randomly...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Monego ET,Peixoto Mdo R,Jardim PC,Sousa AL,Braga VL,Moura MF

    更新日期:1996-06-01 00:00:00

  • Echocardiography in chronic liver disease: systematic review.

    abstract:BACKGROUND:Doppler echocardiography (Echo) is a non-invasive method of excellent accuracy to screen portopulmonary hypertension (PPH) and to assess intrapulmonary shunts (IPS) in chronic liver disease (CLD). In the past decade, Echo proved to play a fundamental role in the diagnosis of cirrhotic cardiomyopathy (CCM). ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审


    authors: Mota VG,Markman Filho B

    更新日期:2013-04-01 00:00:00

  • High blood pressure detection in adolescents by clustering overall and abdominal adiposity markers.

    abstract:BACKGROUND:Obesity is linked to high blood pressure (HBP) in childhood. However, the role of fat as a predictor of HBP in adolescents remains unknown. OBJECTIVE:To investigate the association between general and abdominal obesity with HBP and to identify the sensitivity and specificity of these indicators to detect HB...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Christofaro DG,Ritti-Dias RM,Fernandes RA,Polito MD,Andrade SM,Cardoso JR,Oliveira AR

    更新日期:2011-06-01 00:00:00

  • [Transient ventricular dysfunction (Takotsubo cardiomyopathy)].

    abstract::The patient was a male with myasthenia gravis, hospitalized with acute respiratory failure due to decompensation of the underlying disease. He evolved with findings suggestive of acute myocardial infarction, with electrocardiographic and enzymatic alterations compatible with that diagnosis. The patient underwent emerg...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Sousa JM,Knobel M,Buchelle G,Sousa JA,Fisher CH,Born D,Akamine N,Knobel E

    更新日期:2005-04-01 00:00:00

  • [Radiofrequency catheter ablation of type I atrial flutter].

    abstract:PURPOSE:To verify the efficacy and safety of the creation of a barrier with radiofrequency (RF) in the tricuspid annulus and the vena cava ostium (TA-IVC). METHODS:Nine consecutive patients, 7 males, with age ranging from 36 to 76 years, with paroxysmal (7 patients) or permanent (2) type I atrial flutter (negative P w...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章


    authors: Sosa EA,Scanavacca MI,Lewandowski A,Kuniyoshi R,Magalhães L,Sarabanda A,Piccioni JL,Bellotti G,Pileggi F

    更新日期:1994-09-01 00:00:00

  • [Effect of dopamine in dopaminergic doses on pulmonary circulation of dogs in normoxia and hypoxia].

    abstract:PURPOSE:To study if dopamine in dopaminergic doses (1.5 and 4.0 micrograms/kg/min) had some effect on the pulmonary vasoconstriction mechanism, and if in those doses the drug had some action on systemic and pulmonary hemodynamic variables, as well as in the pulmonary gas exchange. METHODS:Seventeen normal mongrel dogs...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: de Araújo FG,Romaldini H,Bogossian M,Afonso JE,Uehara C

    更新日期:1995-09-01 00:00:00

  • Evaluation of the medical care of patients with hypertension in an emergency department and in ambulatory hypertension unit.

    abstract:OBJECTIVE:To evaluate the characteristics of the patients receiving medical care in the Ambulatory of Hypertension of the Emergency Department, Division of Cardiology, and in the Emergency Unit of the Clinical Hospital of the Ribeirão Preto Medical School. METHODS:Using a protocol, we compared the care of the same hyp...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,多中心研究


    authors: Nobre F,Chauchar F,Viana JM,Pereira GJ,Lima NK

    更新日期:2002-02-01 00:00:00

  • Safety and efficacy of angioplasty with intracoronary stenting in patients with unstable coronary syndromes. Comparison with stable coronary syndromes.

    abstract:OBJECTIVE:To assess safety and efficacy of coronary angioplasty with stent implantation in unstable coronary syndromes. METHODS:Retrospective analysis of in-hospital and late evolution of 74 patients with unstable coronary syndromes (unstable angina or infarction without elevation of the ST segment) undergoing coronar...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Correia LC,Brito JC,Barbosa AC,Azevedo Júnior AM,Rocha MS,Carvalho HG,Esteves JP

    更新日期:2000-06-01 00:00:00

  • [Anatomo-clinical correlation. Case 4/2003 - A 61 year-old patient Chagasic woman, with ventricular dysfunction, recurrent ventricular tachycardia and cardiac pacemaker, presented asystole after surgical resection of apical aneurysm].

    abstract::A 61 year-old Chagasic woman, with previous left ventricular systolic disfunction, ventricular tachychardia and cardiac pacemaker, presented cardiac arrest in asystolia after surgical ressection of apical aneurysm. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Franco FG,Moffa PJ,Higuchi Mde L

    更新日期:2003-08-01 00:00:00

  • [Pulmonary arteriovenous fistula. A case report and review of the literature].

    abstract::The aim of this paper is to review clinical and laboratory features of this unusual pathology and its complications, indicating transcatheter embolization as a first choice for its management. Our case report is of a seven year-old child, with complex pulmonary arteriovenous fistula of the anterior segment of right su...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审


    authors: de Melo JC,de Araújo AP,Monteiro Eda S,Rongel EB,Felipe H,Ferreira MC,Tavares W,Medeiros R

    更新日期:1989-07-01 00:00:00

  • [Diabetes mellitus and ischemie heart disease. Comparison by gender].

    abstract:PURPOSE:To test the association between diabetes mellitus and ischaemic heart disease (IHD) in males and females, after adjusting for known confounders and/or modifiers of effect. METHODS:The study was designed as a case-control and the period of data collection was one year (March/93 until February/94). The associati...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: de Moraes SA,de Souza JM

    更新日期:1996-02-01 00:00:00

  • [Doppler echocardiographic evaluation of heart transplantation].

    abstract::In order to evaluate major Doppler-Echocardiographic parameters for the diagnosis of acute cardiac allograft rejection episodes a serial of 54 Doppler Echocardiograms were performed simultaneously with endomyocardial biopsy in five patients (mean age = 40.2 y/o). Measurements included: right and left chambers diameter...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Del Castillo JM,Marotta RH,Ortiz J,Matsumoto AY,Souza EL,Silva CE,Macruz R,Carvalho VB

    更新日期:1989-09-01 00:00:00

  • Subclinical ventricular dysfunction detected by speckle tracking two years after use of anthracycline.

    abstract:BACKGROUND:Heart failure is a severe complication associated with doxorubicin (DOX) use. Strain, assessed by two-dimensional speckle tracking (2D-STE), has been shown to be useful in identifying subclinical ventricular dysfunction. OBJECTIVES:a) To investigate the role of strain in the identification of subclinical ve...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: de Almeida AL,Silva VA,de Souza Filho AT,Rios VG,Lopes JR,de Afonseca SO,Cunha Dde C,Mendes MO,Miranda DL,dos Santos Júnior EG

    更新日期:2015-04-01 00:00:00

  • Determinants of Aortic Prosthesis Mismatch in a Brazilian Public Health System Hospital: Big Patients or Small Prosthesis?

    abstract:BACKGROUND:Prosthesis-patient mismatch (PPM) is associated with worse outcomes. OBJECTIVE:Determine the frequency and evaluate preoperatory variables independently associated with severe PPM in a tertiary hospital focused on Public Health Care. METHODS:A total of 316 patients submitted to aortic valve replacement, wh...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Otto ME,Atik FA,Moreira MDN,Ribeiro LCM,Mello BCR,Lima JGE,Ribeiro MS,Domingues ACPM,Calzada RP,Jreige A Jr,Schloicka LL,Pibarot P

    更新日期:2020-01-01 00:00:00

  • Cardiac magnetic resonance and its anatomical planes: how do I do it?

    abstract::Due to the increasing use of the cardiac magnetic resonance (CMR) method and the frequent implementation of such method in new services, we describe herein, in a step-by-step format, the acquisition techniques that are necessary for a complete cardiac approach, of the main anatomical planes of the heart used by CMR. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审


    authors: Nacif MS,Oliveira Junior AC,Carvalho AC,Rochitte CE

    更新日期:2010-12-01 00:00:00

  • Leisure-Time Physical Activity, but not Commuting Physical Activity, is Associated with Cardiovascular Risk among ELSA-Brasil Participants.

    abstract:BACKGROUND:Despite reports in the literature that both leisure-time physical activity (LTPA) and commuting physical activity (CPA) can promote health benefits, the literature lacks studies comparing the associations of these domains of physical activity with cardiovascular risk scores. OBJECTIVE:To investigate the ass...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Pitanga FJG,Matos SMA,Almeida MDC,Barreto SM,Aquino EML

    更新日期:2018-01-01 00:00:00

  • Cardiovascular risks in adolescents with different degrees of obesity.

    abstract:BACKGROUND:There have been few studies on cardiovascular risk factors in adolescents with different degrees of obesity. OBJECTIVE:To evaluate metabolic effects associated with different degrees of obesity in adolescents and their impact on cardiovascular risks. METHODS:Cross-sectional study of 80 obese adolescents, d...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Lavrador MS,Abbes PT,Escrivão MA,Taddei JA

    更新日期:2011-03-01 00:00:00

  • Chronic stress improves NO- and Ca2+ flux-dependent vascular function: a pharmacological study.

    abstract:BACKGROUND:Stress is associated with cardiovascular diseases. OBJECTIVE:This study aimed at assessing whether chronic stress induces vascular alterations, and whether these modulations are nitric oxide (NO) and Ca(2+) dependent. METHODS:Wistar rats, 30 days of age, were separated into 2 groups: control (C) and Stress...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Bruder-Nascimento T,Campos DH,Cicogna AC,Cordellini S

    更新日期:2015-03-01 00:00:00

  • One-year follow-up after primary coronary intervention for acute myocardial infarction in diabetic patients. A substudy of the STENT PAMI trial.

    abstract:OBJECTIVE:This analysis was undertaken to determine the composite incidence of cumulative adverse events (death, reinfarction, disabling stroke, and target vessel revascularization) at the end of the first year after acute myocardial infarction, in diabetic patients who underwent coronary stenting or primary coronary b...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mattos LA,Grines CL,Sousa JE,Sousa AG,Stone GW,Cox D,Garcia E,Morice MC,O'Neill W,Grines L,Boura J

    更新日期:2001-12-01 00:00:00

  • Psychological characteristics of patients undergoing percutaneous coronary interventions.

    abstract:BACKGROUND:There is few data evaluating the prevalence and influence of adverse psychological characteristics on the prognosis of individuals submitted to percutaneous coronary interventions. No study has addressed this issue in Brazil. OBJECTIVE:To investigate the prevalence of depression, anxiety, psychological stre...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Schmidt MM,Quadros AS,Abelin AP,Minozzo EL,Wottrich SH,Kunert HZ,Vigueras ES,Ruschel PP,Sarmento-Leite R,Gottschall CA

    更新日期:2011-10-01 00:00:00

  • Ruthenium Complex Improves the Endothelial Function in Aortic Rings From Hypertensive Rats.

    abstract:Background::The endothelium is a monolayer of cells that extends on the vascular inner surface, responsible for the modulation of vascular tone. By means of the release of nitric oxide (NO), the endothelium has an important protective function against cardiovascular diseases. Objective::Verify if cis- [Ru(bpy)2(NO2)(N...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Vatanabe IP,Rodrigues CNDS,Buzinari TC,Moraes TF,Silva RSD,Rodrigues GJ

    更新日期:2017-06-29 00:00:00

  • Prevalence of coronary risk factors and myocardial perfusion scintigraphy abnormalities in asymptomatic diabetic outpatients.

    abstract:OBJECTIVE:To determine the prevalence of coronary artery disease (CAD) risk factors (RF) and myocardial ischemia in a sample of asymptomatic diabetic patients treated on an outpatient basis. METHODS:From 80 type 2 diabetic patients initially recruited at an university outpatient endocrinology clinic, with no symptoms ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Monteiro Fd Jr,Cunha Fda S,Salgado Filho N,Barbosa JB,Furtado JR,Ferreira PA,Nina V,Lages J,Santana N

    更新日期:2007-11-01 00:00:00

  • [Acute effects of propafenone in patients with ventricular pre-excitation].

    abstract:PURPOSE:To evaluate the electrophysiological effects of intravenous propafenone in the anterograde and retrograde effective refractory period of the accessory pathways (AP), in patients with Wolff-Parkinson-White syndrome. METHODS:Forty symptomatic patients were studied. All patients were undergone to electrophysiolog...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章


    authors: Maia IG,Cruz Filho F,Fagundes ML,Loyola LH,Pimenta J,Lorga AM

    更新日期:1993-07-01 00:00:00