[Use of carvedilol compared to nifedipine in the treatment of mild and moderate essential arterial hypertension].

Abstract:

PURPOSE:To compare the efficacy of carvedilol, a new antihypertensive drug that combines vasodilatory and beta-blocker properties, with nifedipine. METHODS:In a multicenter double-blind trial, 106 mild to moderate essential hypertensive patients were treated with either carvedilol (n = 51), or nifedipine (n = 55) as monotherapy. Following 4 weeks of wash-out/run-in period, patients from the carvedilol group received this drug once a day at a dosage of 25 mg/day for 8 consecutive weeks. In order to maintain the double-blind character of the study, a placebo was administered in the carvedilol group at identical dosage intervals as used in the nifedipine s.r. group. Nifedipine was also administered for 8 weeks at a dosage of 40 mg/day given b.i.d. RESULTS:Both treatments were equally efficient in reducing blood pressure in the seated and upright positions. Blood pressure response to treatment was obtained in 79% and 78% of patients treated with carvedilol and nifedipine, respectively. The carvedilol group did not develop reflex tachycardia which is usually seen when prescribing vasodilators. Blood biochemistry remained unchanged with both treatments. Besides similar blood pressure efficacy, side effects by patients taking carvedilol were less frequent than nifedipine group. CONCLUSION:Carvedilol is a safe, efficient, once/day choice as monotherapy for mild to moderate essential hypertensive patients.

journal_name

Arq Bras Cardiol

authors

Plavnik FL,Freitas AF,Portela JE,Dantas M,Spritzer T,Kohlmann NE,Spritzer N,Furtado MR,Kohlmann O Jr

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

405-8

issue

5

eissn

0066-782X

issn

1678-4170

journal_volume

63

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    doi:

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,随机对照试验

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    更新日期:2006-09-01 00:00:00

  • [Different therapies in the treatment of obesity in hypertensive patients].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Monego ET,Peixoto Mdo R,Jardim PC,Sousa AL,Braga VL,Moura MF

    更新日期:1996-06-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:

    authors: Mota VG,Markman Filho B

    更新日期:2013-04-01 00:00:00

  • High blood pressure detection in adolescents by clustering overall and abdominal adiposity markers.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2011005000050

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    更新日期:2011-06-01 00:00:00

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2005000400013

    authors: Sousa JM,Knobel M,Buchelle G,Sousa JA,Fisher CH,Born D,Akamine N,Knobel E

    更新日期:2005-04-01 00:00:00

  • [Radiofrequency catheter ablation of type I atrial flutter].

    abstract:PURPOSE:To verify the efficacy and safety of the creation of a barrier with radiofrequency (RF) in the tricuspid annulus and the vena cava ostium (TA-IVC). METHODS:Nine consecutive patients, 7 males, with age ranging from 36 to 76 years, with paroxysmal (7 patients) or permanent (2) type I atrial flutter (negative P w...

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    pub_type: 临床试验,杂志文章

    doi:

    authors: Sosa EA,Scanavacca MI,Lewandowski A,Kuniyoshi R,Magalhães L,Sarabanda A,Piccioni JL,Bellotti G,Pileggi F

    更新日期:1994-09-01 00:00:00

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    doi:

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    更新日期:1995-09-01 00:00:00

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    doi:

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  • [Doppler echocardiographic evaluation of heart transplantation].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Del Castillo JM,Marotta RH,Ortiz J,Matsumoto AY,Souza EL,Silva CE,Macruz R,Carvalho VB

    更新日期:1989-09-01 00:00:00

  • Subclinical ventricular dysfunction detected by speckle tracking two years after use of anthracycline.

    abstract:BACKGROUND:Heart failure is a severe complication associated with doxorubicin (DOX) use. Strain, assessed by two-dimensional speckle tracking (2D-STE), has been shown to be useful in identifying subclinical ventricular dysfunction. OBJECTIVES:a) To investigate the role of strain in the identification of subclinical ve...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20140209

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  • Determinants of Aortic Prosthesis Mismatch in a Brazilian Public Health System Hospital: Big Patients or Small Prosthesis?

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  • Cardiac magnetic resonance and its anatomical planes: how do I do it?

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0066-782x2010001600014

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    更新日期:2010-12-01 00:00:00

  • Leisure-Time Physical Activity, but not Commuting Physical Activity, is Associated with Cardiovascular Risk among ELSA-Brasil Participants.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20170178

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  • Cardiovascular risks in adolescents with different degrees of obesity.

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    pub_type: 杂志文章

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  • Chronic stress improves NO- and Ca2+ flux-dependent vascular function: a pharmacological study.

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    pub_type: 杂志文章

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章,随机对照试验

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2011005000104

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    更新日期:2011-10-01 00:00:00

  • Ruthenium Complex Improves the Endothelial Function in Aortic Rings From Hypertensive Rats.

    abstract:Background::The endothelium is a monolayer of cells that extends on the vascular inner surface, responsible for the modulation of vascular tone. By means of the release of nitric oxide (NO), the endothelium has an important protective function against cardiovascular diseases. Objective::Verify if cis- [Ru(bpy)2(NO2)(N...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20170090

    authors: Vatanabe IP,Rodrigues CNDS,Buzinari TC,Moraes TF,Silva RSD,Rodrigues GJ

    更新日期:2017-06-29 00:00:00

  • Prevalence of coronary risk factors and myocardial perfusion scintigraphy abnormalities in asymptomatic diabetic outpatients.

    abstract:OBJECTIVE:To determine the prevalence of coronary artery disease (CAD) risk factors (RF) and myocardial ischemia in a sample of asymptomatic diabetic patients treated on an outpatient basis. METHODS:From 80 type 2 diabetic patients initially recruited at an university outpatient endocrinology clinic, with no symptoms ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2007001700005

    authors: Monteiro Fd Jr,Cunha Fda S,Salgado Filho N,Barbosa JB,Furtado JR,Ferreira PA,Nina V,Lages J,Santana N

    更新日期:2007-11-01 00:00:00

  • [Acute effects of propafenone in patients with ventricular pre-excitation].

    abstract:PURPOSE:To evaluate the electrophysiological effects of intravenous propafenone in the anterograde and retrograde effective refractory period of the accessory pathways (AP), in patients with Wolff-Parkinson-White syndrome. METHODS:Forty symptomatic patients were studied. All patients were undergone to electrophysiolog...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章

    doi:

    authors: Maia IG,Cruz Filho F,Fagundes ML,Loyola LH,Pimenta J,Lorga AM

    更新日期:1993-07-01 00:00:00