[Use of carvedilol compared to nifedipine in the treatment of mild and moderate essential arterial hypertension].

Abstract:

PURPOSE:To compare the efficacy of carvedilol, a new antihypertensive drug that combines vasodilatory and beta-blocker properties, with nifedipine. METHODS:In a multicenter double-blind trial, 106 mild to moderate essential hypertensive patients were treated with either carvedilol (n = 51), or nifedipine (n = 55) as monotherapy. Following 4 weeks of wash-out/run-in period, patients from the carvedilol group received this drug once a day at a dosage of 25 mg/day for 8 consecutive weeks. In order to maintain the double-blind character of the study, a placebo was administered in the carvedilol group at identical dosage intervals as used in the nifedipine s.r. group. Nifedipine was also administered for 8 weeks at a dosage of 40 mg/day given b.i.d. RESULTS:Both treatments were equally efficient in reducing blood pressure in the seated and upright positions. Blood pressure response to treatment was obtained in 79% and 78% of patients treated with carvedilol and nifedipine, respectively. The carvedilol group did not develop reflex tachycardia which is usually seen when prescribing vasodilators. Blood biochemistry remained unchanged with both treatments. Besides similar blood pressure efficacy, side effects by patients taking carvedilol were less frequent than nifedipine group. CONCLUSION:Carvedilol is a safe, efficient, once/day choice as monotherapy for mild to moderate essential hypertensive patients.

journal_name

Arq Bras Cardiol

authors

Plavnik FL,Freitas AF,Portela JE,Dantas M,Spritzer T,Kohlmann NE,Spritzer N,Furtado MR,Kohlmann O Jr

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

405-8

issue

5

eissn

0066-782X

issn

1678-4170

journal_volume

63

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    pub_type: 临床试验,杂志文章

    doi:10.36660/abc.20180426

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    pub_type: 杂志文章

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  • [Study of the prevalence and multiplicity of cardiovascular risk factors in hypertensive individuals from the city of Brusque, SC, Brazil].

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    pub_type: 杂志文章,多中心研究

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  • Cardiovascular risks of androgen deprivation therapy.

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    pub_type: 杂志文章,评审

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    doi:

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