Cardiovascular risks of androgen deprivation therapy.

Abstract:

:Prostate adenocarcinoma is the most common cancer type in the male sex after skin cancer. Among the several types of treatment for prostate cancer, the androgen deprivation therapy has been highly recommended in patients with metastatic or locally advanced disease, which probably results in increased survival. However, the androgen deprivation is the cause of several adverse effects. Complications such as osteoporosis, sexual dysfunction, gynecomastia, anemia and body composition alterations are well-known effects of the therapy. Recently, a number of metabolic complications have been described, such as increase in the abdominal circumference, insulin resistance, hyperglycemia, diabetes, dyslipidemia and metabolic syndrome, with a consequent increase in the risk of coronary events and cardiovascular mortality in this specific population. This update article presents a literature review carried out at MEDLINE database of all literature published in English from 1966 to June 2009, using the following key words: androgen deprivation therapy, androgen suppression therapy, hormone treatment, prostate cancer, metabolic syndrome and cardiovascular disease, with the objective of analyzing which would be the actual cardiovascular risks of androgen deprivation therapy, also called androgen suppression, in patients with prostate cancer.

journal_name

Arq Bras Cardiol

authors

Ribeiro AF,Camara C,Segre CA,Srougi M,Serrano CV Jr

doi

10.1590/s0066-782x2010001300019

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

412-5

issue

3

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2010001300019

journal_volume

95

pub_type

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