Abstract:
BACKGROUND:Depression is a common comorbidity in heart failure (HF); however, the mechanisms related to a poorer outcome of depressed patients with HF remain unclear. OBJECTIVE:To evaluate the role of severe depression in the outcome of patients with decompensated HF. METHODS:A total of 43 patients with advanced HF, EF < 40.0%, and hospitalized for cardiac compensation were consecutively studied. After history taking and physical examination, the patients underwent laboratory tests including BNP determination. After the diagnosis of depression was made, the Hamilton-D scale was applied. Severe depression was defined by a score equal to or greater than 18. The clinical and laboratory variables according to the presence or absence of severe depression were analyzed using logistic regression. The ROC curve defined the cut-off point for BNP. RESULTS:Severe or very severe depression was identified in 24 (55.8%) patients. Severely depressed patients did not differ from non-depressed patients as regards age, gender and renal function, but showed less cardiac impairment (EF 23.4 ± 7.2% vs 19.5 ± 5.2%; p = 0.046) and higher BNP levels (2,582.8 ± 1,596.6 pg/ml vs 1,206.6 ± 587.0 pg/ml; p < 0.001). However, patients with BNP levels higher than 1,100 pg/ml had a 12.0-fold higher chance (odds ratio [95% CI] = 2.61 - 55.26) of developing severe depression. CONCLUSION:Patients with severe depression showed a higher degree of neurohormonal stimulation despite their lower degree of ventricular dysfunction. The pathophysiological changes related to depression, leading to increased neurohormonal stimulation and cytokines, probably contributed to this more intense clinical manifestation even in the presence of less cardiac damage.
journal_name
Arq Bras Cardioljournal_title
Arquivos brasileiros de cardiologiaauthors
Aguiar VB,Ochiai ME,Cardoso JN,Del Carlo CH,Morgado PC,Munhoz RT,Pereira-Barretto ACdoi
10.1590/s0066-782x2010005000125subject
Has Abstractpub_date
2010-12-01 00:00:00pages
732-7issue
6eissn
0066-782Xissn
1678-4170pii
S0066-782X2010005000125journal_volume
95pub_type
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x1999000800009
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To compare blood pressure, lipid profile, food intake, and anthropometric data of adolescents with or without a familial history of hypertension. METHODS:Forty-three adolescents from both sexes were assessed, with ages ranging from 11 to 18 years old. Twenty had hypertensive parents, and 23 had normotensive ...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
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更新日期:2017-10-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
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abstract:BACKGROUND:Cardiovascular diseases (CVD) are the leading causes of death in our population. There was a progressive decrease in mortality due to CVD up to 2005. OBJECTIVE:To update the trends in mortality from cardiovascular diseases in Brazil and in the metropolitan region of São Paulo (MRSP) from 1990 to 2009. METH...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2012005000061
更新日期:2012-08-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2009000900019
更新日期:2009-09-01 00:00:00
abstract::We report on a 30-year-old female patient, with biological mitral valve prosthesis due to symptomatic mitral stenosis and a history of acute myocardial infarction and generalized tonic-clonic seizure episodes, visual hallucinations, cerebral thromboembolic events and, at present, chorea and acute carditis. The patient...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2012000200016
更新日期:2012-02-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2010005000153
更新日期:2011-02-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2010005000095
更新日期:2010-08-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2009000600017
更新日期:2009-06-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Theoretical knowledge and skill to perform good quality cardiopulmonary resuscitation (CPR) are essential for the survival of patients with sudden death. OBJECTIVE:To determine whether a theoretical course alone is sufficient to promote good quality CPR training and knowledge for health professionals in com...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2010005000104
更新日期:2010-09-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2004000300005
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2009000900006
更新日期:2009-09-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2008000100011
更新日期:2008-01-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,随机对照试验
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更新日期:2017-01-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.36660/abc.20180356
更新日期:2019-12-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2012005000116
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. OBJECTIVE:To investigate long-te...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.5935/abc.20180014
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To evaluate the electrophysiological effects of intravenous propafenone in the anterograde and retrograde effective refractory period of the accessory pathways (AP), in patients with Wolff-Parkinson-White syndrome. METHODS:Forty symptomatic patients were studied. All patients were undergone to electrophysiolog...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-07-01 00:00:00