Echocardiography in thalassemic patients on blood transfusions and chelation without heart failure.

Abstract:

BACKGROUND:Patients with thalassemia major present chronic hemolysis and require regular blood transfusions which may cause iron overload cardiomyopathy and chronic heart failure. Hemochromatosis is characterized by excessive iron accumulation in tissues, and heart involvement is the main cause of death in patients with thalassemia. OBJECTIVE:The aim of this study was to evaluate cardiac structure and function by conventional Doppler echocardiography and tissue Doppler imaging in patients with TM and no clinical evidence of heart failure. METHODS:This is a prospective observational study including 18 patients with thalassemia major (TM) receiving regular blood transfusion. To separately evaluate anemia and blood transfusion effects, two gender, age, weight, and height-matched control groups were included: one with healthy individuals (Healthy, n=18) and one with iron deficient anemia patients (Anemia, n=18). Statistical analysis was performed using ANOVA followed by Tukey's test or Kruskal-Wallis's and Dunn's test. RESULTS:The following echocardiographic variables presented significantly higher values in TM than the Anemia and Healthy groups: left atrium volume index (Healthy: 16.4±6.08; Anemia: 17.9±7.02; TM: 24.1±8.30 cm³/m²); mitral septal E/Em ratio (Healthy: 6.55±1.60; Anemia: 6.74±0.74; TM: 8.10±1.31); and duration of reverse pulmonary vein flow [Healthy: 74.0 (59.0-74.0); Anemia: 70.5 (67.0-74.0); TM: 111 (87.0-120) ms]. The mitral E/A ratio was higher in TM than Anemia (Healthy: 1.80±0.40; Anemia: 1.80±0.24; TM: 2.03±0.34). No differences were found in left ventricular structures and systolic function indexes. CONCLUSION:Conventional Doppler echocardiography and tissue Doppler allow changes in left ventricular diastolic function to be identified in asymptomatic patients with thalassemia major.

journal_name

Arq Bras Cardiol

authors

Rodrigues A,Guimarães-Filho FV,Braga JC,Rodrigues CS,Waib P,Fabron-Junior A,Tan DM,França AC,Okoshi MP,Okoshi K

doi

10.1590/s0066-782x2013005000001

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

75-81

issue

1

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2013005000001

journal_volume

100

pub_type

杂志文章
  • Prevalence and surgical approach of supravalvular pulmonary stenosis after Jatene operation for transposition of great arteries.

    abstract:BACKGROUND:The Transposition of the Great Arteries is the most frequent congenital cyanogenic cardiopathy in the neonatal period, corresponding to 7% of all congenital cardiopathies. Among the operations for surgical treatment, the Jatene operation, with arterial correction, is the treatment of choice. During the late ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,多中心研究

    doi:10.1590/s0066-782x2008001300003

    authors: Jatene MB,Jatene IB,Oliveira PM,Moysés RA,Souza LC,Fontes V,Miura N,Lopes AA,Marcial MB,Jatene AD

    更新日期:2008-07-01 00:00:00

  • Multivessel percutaneous treatment of Takayasu arteritis.

    abstract::We report the case of a female patient with obstructive lesions in the right and left carotid, right renal, left subclavian and left common iliac arteries which were percutaneously treated. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2006001800024

    authors: Tumelero RT,Teixeira JC,Duda NT,Tognon AP,Rossato M

    更新日期:2006-11-01 00:00:00

  • Impact of hypertension on ventricular remodeling in patients with aortic stenosis.

    abstract:BACKGROUND:Left ventricular hypertrophy (LVH) is a marker of increased cardiovascular risk and is frequently associated with both arterial hypertension (AH) and aortic stenosis (AoS). Also, these two maladies may co-exit in a same patient. However, in these cases, it is not clear the impact of each one in LVH. OBJECTI...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2011005000081

    authors: Hueb JC,Vicentini JT,Roscani MG,Fusco D,Mattos R,Zanatti SG,Okoshi K,Matsubara BB

    更新日期:2011-09-01 00:00:00

  • Baroreflex sensitivity and its association with arrhythmic events in Chagas disease.

    abstract:BACKGROUND:Sudden death is the leading cause of death in Chagas disease (CD), even in patients with preserved ejection fraction (EF), suggesting that destabilizing factors of the arrhythmogenic substrate (autonomic modulation) contribute to its occurrence. OBJECTIVE:To determine baroreflex sensitivity (BRS) in patient...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20140066

    authors: Santos AM,Scanavacca MI,Darrieux F,Ianni B,Melo SL,Pisani C,Santos Neto F,Sosa E,Hachul DT

    更新日期:2014-06-01 00:00:00

  • [Multicenter study of elderly patients assisted at outpatient cardiology and geriatrics clinics in Brazilian institutions].

    abstract:PURPOSE:To evaluate epidemiological, clinical and therapeutic aspects of elderly patients with cardiovascular disease in Brazil. METHODS:Elderly patients with cardiovascular disease treated in 36 centers of cardiology and geriatrics were investigated through a questionnaire applied to those who had an appointment duri...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,多中心研究

    doi:10.1590/s0066-782x1997001100007

    authors: Taddei CF,Ramos LR,de Moraes JC,Wajngarten M,Libberman A,Santos SC,Savioli F,Dioguardi G,Franken R

    更新日期:1997-11-01 00:00:00

  • [Use of carvedilol compared to nifedipine in the treatment of mild and moderate essential arterial hypertension].

    abstract:PURPOSE:To compare the efficacy of carvedilol, a new antihypertensive drug that combines vasodilatory and beta-blocker properties, with nifedipine. METHODS:In a multicenter double-blind trial, 106 mild to moderate essential hypertensive patients were treated with either carvedilol (n = 51), or nifedipine (n = 55) as m...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Plavnik FL,Freitas AF,Portela JE,Dantas M,Spritzer T,Kohlmann NE,Spritzer N,Furtado MR,Kohlmann O Jr

    更新日期:1994-11-01 00:00:00

  • [Anatomo-clinical correlation. Case 4/2003 - A 61 year-old patient Chagasic woman, with ventricular dysfunction, recurrent ventricular tachycardia and cardiac pacemaker, presented asystole after surgical resection of apical aneurysm].

    abstract::A 61 year-old Chagasic woman, with previous left ventricular systolic disfunction, ventricular tachychardia and cardiac pacemaker, presented cardiac arrest in asystolia after surgical ressection of apical aneurysm. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2003001000010

    authors: Franco FG,Moffa PJ,Higuchi Mde L

    更新日期:2003-08-01 00:00:00

  • The results of the campaign for evaluating sphygmomanometers accuracy and their physical conditions.

    abstract:OBJECTIVE:To evaluate the sphygmomanometers calibration accuracy and the physical conditions of the cuff-bladder, bulb, pump, and valve. METHODS:Sixty hundred and forty five aneroid sphygmomanometers were evaluated, 521 used in private practice and 124 used in hospitals. Aneroid manometers were tested against a proper...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Mion Júnior D,Pierin AM,Alavarce DC,Vasconcellos JH

    更新日期:2000-01-01 00:00:00

  • [Reduction of central sleep apnea in heart failure patients with beta-blockers therapy].

    abstract:BACKGROUND:Sleep apneas are frequent in patients with heart failure (HF). Estimate of the pre-beta blocker age (BB) point out to 45% of central apneas in these patients. OBJECTIVE:Assess the influence of BB in central apneas and their interference in the quality of sleep and life of patients with heart failure. METHO...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Silva CP,Lorenzi-Filho G,Marcondes B,Osmundo G Jr,Mangini S,Freitas AF Jr,Pires PV,Bocchi EA,Bacal F

    更新日期:2010-02-01 00:00:00

  • Influence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area.

    abstract:OBJECTIVE:We determined the effects of losartan and PD 123319 (antagonists of the AT1 and AT2 angiotensin receptors, respectively), and [Sar1, Ala8] ANG II (a relatively peptide antagonist of angiotensin receptors) injected into the paraventricular nucleus (PVN) on water and 3% NaCl intake, and the diuretic, natriureti...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2003000400004

    authors: Saad WA,Camargo LA

    更新日期:2003-04-01 00:00:00

  • [Coronary arteriography with a very low profile catheter: efficacy and safety of the procedure and of the 60 minute hospital discharge].

    abstract:PURPOSE:To evaluate the feasibility, efficacy and safety of the use of 4F Judkins catheters for coronary angiography. METHODS:From August/95 to January/96, 70 patients with suspected coronary artery disease underwent coronary cineangiography by the Judkins technique, with 4F catheters. Following puncture of the right ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x1998000100002

    authors: Berti S,Feres F,Castro D,Gusmão M,Staico R,Padilha R,Chaves A,Centemero M,Mattos LA,Sousa A,Sousa JE

    更新日期:1998-01-01 00:00:00

  • Strain Analysis of Left Ventricular Function in the Association of Hypertrophic Cardiomyopathy and Systemic Arterial Hypertension.

    abstract:BACKGROUND:Hypertrophic cardiomyopathy (HCM) is the most common heart disease of genetic origin in the world population, with a prevalence of at least 1/500. The association with systemic arterial hypertension (SAH) is not uncommon, as it affects approximately 25% of the world population. Most studies aim at the differ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20190176

    authors: Gil TCP,Castier MB,Gondar AFP,Sales AF,Santos MO,Lima FCDS,Mourilhe-Rocha R

    更新日期:2019-09-02 00:00:00

  • Is there evidence favoring the use of beta-blockers and dobutamine in acute heart failure?

    abstract::Several studies have reported the benefits of beta-blockers (BB) for patients presenting with systolic heart failure. however, many patients hospitalized as a result of acute heart failure are already using BB and require dobutamine for arterial hypotension and low cardiac output. Therefore, a decision must be made re...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审

    doi:10.5935/abc.20130034

    authors: Passos LC,Barbosa AC,Oliveira MG,Santos EG Jr

    更新日期:2013-02-01 00:00:00

  • Congenital Heart Disease as a Warning Sign for the Diagnosis of the 22q11.2 Deletion.

    abstract::Background: To alert for the diagnosis of the 22q11.2 deletion syndrome (22q11.2DS) in patients with congenital heart disease (CHD). Objective: To describe the main CHDs, as well as phenotypic, metabolic and immunological findings in a series of 60 patients diagnosed with 22q11.2DS. Methods: The study included 60 pati...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20140145

    authors: Grassi MS,Jacob CM,Kulikowski LD,Pastorino AC,Dutra RL,Miura N,Jatene MB,Pegler SP,Kim CA,Carneiro-Sampaio M

    更新日期:2014-11-01 00:00:00

  • Prevalence of systemic hypertension in students aged 7 to 14 years in the municipality of Barbacena, in the State of Minas Gerais, in 1999.

    abstract:OBJECTIVE:To detect the prevalence of systemic hypertension in children and to establish the relation between blood pressure levels and sex, age, ethnicity, weight, and height. METHODS:The prevalence of systemic hypertension and its relation to sex, age, ethnicity, weight, and height were studied in 611 students aged ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2003001200005

    authors: de Rezende DF,Scarpelli RA,de Souza GF,da Costa JO,Scarpelli AM,Scarpelli PA,de Carvalho GB,D'Agostini HM,Pedrosa JC

    更新日期:2003-10-01 00:00:00

  • Association between immunological diseases and their similar clinical manifestations.

    abstract::We report on a 30-year-old female patient, with biological mitral valve prosthesis due to symptomatic mitral stenosis and a history of acute myocardial infarction and generalized tonic-clonic seizure episodes, visual hallucinations, cerebral thromboembolic events and, at present, chorea and acute carditis. The patient...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2012000200016

    authors: Soeiro Ade M,Almeida MC,Accorsi TA,Spina GS,Serrano CV Jr,Tarasoutchi F

    更新日期:2012-02-01 00:00:00

  • The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction.

    abstract:OBJECTIVE:To assess the association of the A1166C polymorphism of the angiotensin II type-1 receptor (AT1R) gene with acute myocardial infarction and also with the severity of coronary artery disease. METHODS:A prospective, cross-sectional study was carried out with 110 patients with acute myocardial infarction, who, ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:/S0066-782X2004001700007

    authors: Araújo MA,Menezes BS,Lourenço C,Cordeiro ER,Gatti RR,Goulart LR

    更新日期:2004-11-01 00:00:00

  • Influence of Aerobic Training on The Mechanics of Ventricular Contraction After Acute Myocardial Infarction: A Pilot Study.

    abstract::The study of myocardial contractility, based on the new anatomical concepts that govern cardiac mechanics, represents a promising strategy of analysis of myocardial adaptations related to physical training in the context of post-infarction. We investigated the influence of aerobic training on physical capacity and on ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20180049

    authors: Santi GL,Moreira HT,Carvalho EEV,Crescêncio JC,Schmidt A,Marin-Neto JA,Gallo-Júnior L

    更新日期:2018-04-01 00:00:00

  • Intrauterine detection of Ebstein's anomaly and Down's syndrome. Prenatal diagnosis of a rare combination.

    abstract::Ebstein's anomaly, although the most common malformation of the tricuspid valve, is a rare disease. Its association with other syndromes and extracardiac anomalies is very rare and has been reported in only a few cases. A case of prenatal diagnosis of Ebstein's anomaly in a patient with Down's syndrome is reported. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2004000400011

    authors: Leite Mde F,Gianisella RB,Zielinsky P

    更新日期:2004-04-01 00:00:00

  • [Cardiac amyloidosis. A disease with many faces and different prognosis].

    abstract:PURPOSE:To identify the principal forms of cardiac amiloydosis presentation in a terciary hospital. METHODS:Eight cases with cardiac amyloidosis were identified. Five were women, their ages ranged from 23 to 83 years (mean 62). After a medical history and clinical examination the patients were submitted to complementa...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x1997000800003

    authors: Barretto AC,Precoma D,Serro-Azul JB,Wajngarten M,Pierri H,Pivotto L,Nussbacher A,Gebara OC,Bellotti G

    更新日期:1997-08-01 00:00:00

  • Ruthenium Complex Improves the Endothelial Function in Aortic Rings From Hypertensive Rats.

    abstract:Background::The endothelium is a monolayer of cells that extends on the vascular inner surface, responsible for the modulation of vascular tone. By means of the release of nitric oxide (NO), the endothelium has an important protective function against cardiovascular diseases. Objective::Verify if cis- [Ru(bpy)2(NO2)(N...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20170090

    authors: Vatanabe IP,Rodrigues CNDS,Buzinari TC,Moraes TF,Silva RSD,Rodrigues GJ

    更新日期:2017-06-29 00:00:00

  • Body mass index and waist circumference: association with cardiovascular risk factors.

    abstract:OBJECTIVE:To evaluate the association between cardiovascular risk factors and the anthropometric values--body mass index (BMI) and waist circumference (WC). METHODS:It was studied 231 employees of Federal University of Viçosa, Brazil, 54.1% of them were men (21-76 years old). Glycemia, total cholesterol, LDL, HDL, tri...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2006001900008

    authors: Rezende FA,Rosado LE,Ribeiro Rde C,Vidigal Fde C,Vasques AC,Bonard IS,de Carvalho CR

    更新日期:2006-12-01 00:00:00

  • Plexiform Lesions in an Experimental Model of Monocrotalin-Induced Pulmonary Arterial Hypertension.

    abstract:BACKGROUND:The monocrotaline (MCT)-induced pulmonary arterial hypertension model is one of the most reproduced today, presenting as a limitation the absence of plexiform lesions, typical manifestations of the severe disease in humans. OBJECTIVE:To evaluate the severity of MCT-induced pulmonary arteriopathy by patholog...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.36660/abc.20190306

    authors: Gewehr DM,Salgueiro GR,Noronha L,Kubrusly FB,Kubrusly LF,Coltro GA,Preto PC,Bertoldi AS,Vieira HI

    更新日期:2020-09-01 00:00:00

  • Effect of ventilatory support on functional capacity in patients with heart failure: a pilot study.

    abstract:BACKGROUND:Heart failure (HF) is an important public health problem, of which main clinical symptoms are dyspnea and fatigue. Noninvasive ventilatory support has been used as adjuvant therapy in cardiac rehabilitation in order to improve the functional capacity of patients. OBJECTIVE:To evaluate the functional capacit...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,随机对照试验

    doi:10.1590/s0066-782x2011005000002

    authors: Lima Eda S,Cruz CG,Santos FC,Gomes-Neto M,Bittencourt HS,Reis FJ,Aras R,Guimarães AC,Rodrigues-Junior Ede S

    更新日期:2011-03-01 00:00:00

  • Atrioventricular pacemaker. Incidence and causes of reprogramming in long-term follow-up.

    abstract:OBJECTIVE:To assess the incidence of problems requiring reprogramming of atrioventricular pacemakers in a long-term follow-up, and also the causes for this procedure. METHODS:During the period from May '98 to December '99, 657 patients were retrospectively studied, An actuarial curve for the event reprogramming of the...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Martinelli M,de Arruda Melo S,Nishióka SA,Pedrosa AA,de Siqueira SF,Costa R,Sosa E

    更新日期:2001-01-01 00:00:00

  • Degree of Agreement between Cardiovascular Risk Stratification Tools.

    abstract:Background::Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Brazil, and primary prevention care may be guided by risk stratification tools. The Framingham (FRS) and QRISK-2 (QRS) risk scores estimate 10-year overall cardiovascular risk in asymptomatic individuals, but the instrument of c...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20170057

    authors: Garcia GT,Stamm AMNF,Rosa AC,Marasciulo AC,Marasciulo RC,Battistella C,Remor AAC

    更新日期:2017-05-01 00:00:00

  • Isolated unilateral pulmonary artery agenesis: evaluation of natural and long term evolution after corrective surgery.

    abstract:OBJECTIVE:Unilateral pulmonary artery agenesis is an uncommon isolated anomaly and since 1978 only 119 cases have been reported. In general the condition presents as pulmonary hypertension (PH) in children and hemoptysis in adults. Interventions such as pulmonary artery reconstruction and lobectomies were performed in ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2006001700005

    authors: Atik E,Tanamati C,Kajita L,Barbero-Marcial M

    更新日期:2006-10-01 00:00:00

  • Atorvastatin Reduces Accumulation of Vascular Smooth Muscle Cells to Inhibit Intimal Hyperplasia via p38 MAPK Pathway Inhibition in a Rat Model of Vein Graft.

    abstract:BACKGROUND:The rate of saphenous vein graft failure one year after coronary artery bypass grafting ranges from 10% to 25%. The aim of this study was to explore whether atorvastatin can reduce accumulation of vascular smooth muscle cells to inhibit intimal hyperplasia via p38 MAPK pathway inhibition. METHODS:Forty-five...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.36660/abc.20190231

    authors: Chu T,Huang M,Zhao Z,Ling F,Cao J,Ge J

    更新日期:2020-10-01 00:00:00

  • [Inadequate blood pressure control in patients with type 2 diabetes mellitus].

    abstract:BACKGROUND:There is evidence indicating that blood pressure control is more effective in reducing macrovascular complications of diabetes mellitus (DM) than glycemic control. However, the reduction in BP to levels recommended by international guidelines is difficult in clinical practice. OBJECTIVE:To assess the percen...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2010005000034

    authors: Pinto LC,Ricardo ED,Leitão CB,Kramer CK,Zanatta CM,Gross JL,Canani LH

    更新日期:2010-05-01 00:00:00

  • [Pulmonary arteriovenous fistula. A case report and review of the literature].

    abstract::The aim of this paper is to review clinical and laboratory features of this unusual pathology and its complications, indicating transcatheter embolization as a first choice for its management. Our case report is of a seven year-old child, with complex pulmonary arteriovenous fistula of the anterior segment of right su...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审

    doi:

    authors: de Melo JC,de Araújo AP,Monteiro Eda S,Rongel EB,Felipe H,Ferreira MC,Tavares W,Medeiros R

    更新日期:1989-07-01 00:00:00