Abstract:
BACKGROUND:In hypertrophic cardiomyopathy (HCM), interstitial myocardial fibrosis is an important histological modification that has been associated with sudden death and evolution toward myocardial dilation. OBJECTIVE:To prospectively evaluate the prognostic value of the collagen volume fraction in HCM. METHODS:An endomyocardial biopsy of the right ventricle was successfully performed in 21 symptomatic patients with HCM. The myocardial collagen volume fraction (CVF) was determined by histology. The CVF was also determined in fragments of nine normal hearts from subjects deceased from non-cardiac causes. The patients were divided into above-median CVF and below-median CVF groups, and their clinical and echocardiographic characteristics and survival curves were compared. RESULTS:Among the patients, the CVF ranged from 1.86% to 29.9%, median 6.19%; in normal hearts, from 0.13% to 1.46%, median 0.61% (p <0.0001 between HCM and control). There were no significant correlations between CVF and baseline echocardiographic measures. Patients with CVF < or =6.19% and CVF> 6.19% were compared and no baseline differences were observed. However, after an average follow-up period of 110 months, four deaths occurred (two sudden, two due to heart failure) in the group with increased CVF, whereas the patients of the group with lower CVF were all alive at the end of the period (p = 0.02). CONCLUSION:For the first time, myocardial fibrosis was prospectively associated with a worse prognosis in patients with HCM. Efforts should be directed to the quantification of myocardial fibrosis in HCM, on the premise that its association with the prognosis can aid in the stratification of risk for defibrillator implantation, and in the prescription of drugs that potentially promote myocardial repair.
journal_name
Arq Bras Cardioljournal_title
Arquivos brasileiros de cardiologiaauthors
Arteaga E,de Araújo AQ,Bernstein M,Ramires FJ,Ianni BM,Fernandes F,Mady Cdoi
10.1590/s0066-782x2009000300010subject
Has Abstractpub_date
2009-03-01 00:00:00pages
210-4, 216-20issue
3eissn
0066-782Xissn
1678-4170pii
S0066-782X2009000300010journal_volume
92pub_type
杂志文章abstract:BACKGROUND:Cardiovascular diseases show high incidence and prevalence in Brazil; however, participation in Cardiac Rehabilitation (CR) is limited and has been poorly investigated in the country. The Cardiac Rehabilitation Barriers Scale (CRBS) was developed to assess the barriers to participation and adherence to CR. ...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2012005000025
更新日期:2012-04-01 00:00:00
abstract::A 19-years-old female with a primary right atrial angiosarcoma partially obstructing the tricuspid valve, developed severe hypoxemia due to right-to-left shunting through a patient foramen ovale. This is the first report of such clinical situation with this type of tumor. A complete resection of the tumor was attempte...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
abstract::This is the case of a 42 year-old male with systemic amyloidosis, probably primary, and heart involvement. Physiopathological and clinical aspects are described as well as the rarity of the diagnosis in vivo. The limited aspects of therapy are also described. ...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x1998000200010
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:The decrease in mortality due to cardiovascular diseases (CVD) has been achieved in the United States and the same decrease has been happening in developing countries, thanks to favorable changes in lifestyle and risk factors. Despite such consideration, the volume of information available on the distribution...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2005001400005
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:This analysis was undertaken to determine the composite incidence of cumulative adverse events (death, reinfarction, disabling stroke, and target vessel revascularization) at the end of the first year after acute myocardial infarction, in diabetic patients who underwent coronary stenting or primary coronary b...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1590/s0066-782x2001001200006
更新日期:2001-12-01 00:00:00
abstract::Two male black patients, 18 and 12-year-old, with mental retardation and typical elfin face, presented with severe supravalvular aortic stenosis, thus characterizing Williams's or aortic supravalvular stenosis syndrome. Both were submitted to surgical treatment of the stenosis, and are asymptomatic after a one and fou...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Cardiac magnetic resonance imaging is considered the gold-standard method for the calculation of cardiac volumes. Transthoracic impedance cardiography assesses the cardiac output. No studies validating this measurement, in comparison to that obtained by magnetic resonance imaging, are available. OBJECTIVE:T...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2012005000104
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To assess advanced heart failure (HF) treatment in relation to reduction of ventricular filling pressures, with the use of greater doses of vasodilators, through invasive hemodynamic monitoring. METHODS:Nineteen advanced HF patients were studied, in whom Swan-Ganz catheter was inserted to direct administrati...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2005001700004
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation is the most common persistent arrhythmia, and is the main factor that leads to thromboembolism. OBJECTIVE:To investigate the value of left atrial diameter combined with CHA2DS2-VASc score in predicting left atrial/left atrial appendage thrombosis in non-valvular atrial fibrillation. MET...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.36660/abc.20190492
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:Evidences suggest that paraoxonase 1 (PON1) confers important antioxidant and anti-inflammatory properties when associated with high-density lipoprotein (HDL). OBJECTIVE:To investigate the relationships between p.Q192R SNP of PON1, biochemical parameters and carotid atherosclerosis in an asymptomatic, normo...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.5935/abc.20150053
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:To verify whether accentuated reductions of left ventricular volume lead to mitral valve prolapse. METHODS:Seven mongrel dogs were bled through the internal jugular vein, the systolic systemic pressure being kept between 100 and 140 mmHg by means of continuous infusion of dopamine; the inferior vena cava vein,...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Percutaneous transluminal coronary angioplasty is unusual in acute myocardial infarction after left main coronary artery occlusion. We applied this therapy in two cases. The first, a 54-year-old man, submitted to mechanical reperfusion and left main coronary artery angioplasty 145 minutes after the beginning of the sy...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Case report on a 6-year-old patient with vascular ring, due to double aortic arch. The patient was asymptomatic. The barium-filled esophagus showed bilateral indentations and a large posterior indentation. Echocardiographic study in notch suprasternal view revealed features of this pathology. The diagnosis was made by...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::We report a case of chronic nonspecific constrictive pericarditis with myocardial involvement in a 19-month-old infant. The patient underwent total pericardiectomy and had irreversible hemodynamic instability. Constrictive pericarditis is rare in childhood. It may follow several processes, most frequently an infectiou...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To report the experience of one of the most severe fetal rhythm disturbances, the complete atrioventricular block. METHODS:Descriptive study of 14 fetuses diagnosed and monitored at the Fetal Cardiology Unit, from January, 1991 to August, 1995. RESULTS:Fourteen cases of complete AV block were identified durin...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,评审
doi:
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:There is few data evaluating the prevalence and influence of adverse psychological characteristics on the prognosis of individuals submitted to percutaneous coronary interventions. No study has addressed this issue in Brazil. OBJECTIVE:To investigate the prevalence of depression, anxiety, psychological stre...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2011005000104
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To determine hypertension prevalence and its associated risk factors. METHODS:A cross-sectional, population-based study of people ages 20 to 69 living in the urban area of Pelotas, Rio Grande do Sul, Brazil, was conducted. The dependent variable systemic hypertension was defined as blood pressure > or = 160 ...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2007000100010
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To evaluate the cardiogenic depressor Bezold-Jarisch reflex in rats with chronic myocardial infarction. METHODS:Adult Wistar rats were submitted to ligation of the anterior descending coronary artery of the left ventricle (group INF, n = 15) and compared with rats submitted to sham-operation (group Sham, n = 1...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:The exercise treadmill test can be used in ventricular dysfunction patients for functional capacity or predicting prognosis. The cardiac image with 123I MIBG shows cardiac sympathetic activation. OBJECTIVE:To evaluate the relationship between exercise treadmill test variables and cardiac image changes in 12...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2011005000044
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To assess the incidence of problems requiring reprogramming of atrioventricular pacemakers in a long-term follow-up, and also the causes for this procedure. METHODS:During the period from May '98 to December '99, 657 patients were retrospectively studied, An actuarial curve for the event reprogramming of the...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) is an important public health problem, of which main clinical symptoms are dyspnea and fatigue. Noninvasive ventilatory support has been used as adjuvant therapy in cardiac rehabilitation in order to improve the functional capacity of patients. OBJECTIVE:To evaluate the functional capacit...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,随机对照试验
doi:10.1590/s0066-782x2011005000002
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To evaluate septal perfusion and contractility in patients with left bundle branch block (LBBB). METHODS:Twenty patients were submitted to myocardial scintigraphy with Tecnecium-99m isontrile after exercise and dipyridamole infusion. The septal contractility was observed during the radionuclide ventriculograph...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:PURPOSE:To evaluate the nitroglycerin patches efficacy and tolerability in patients with stable angina pectoris. METHODS:One thousand and five hundred and thirty nine patients with stable angina pectoris, mean age 61.0 +/- 10.3, 891 men and 648 women were prospectively evaluated by five hundred and thirty five special...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,多中心研究
doi:
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Myeloperoxidase (MPO) is a highly expressed enzyme due to leukocyte activation, with multiple atherogenic actions, including LDL cholesterol oxidation, and is related to the instability of atherosclerotic plaque. It is a predictor of adverse events in healthy individuals, patients with heart disease or those...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2007001800005
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:To compare cardiac muscle cells width and cardiomyocyte lipofuscin pigment presence between malnourished and non-malnourished necropsied adults. METHODS:Out of 315 necropsy protocols of adults randomly chosen, those with edema, ascitis, systemic arterial hypertension, chronic liver disease, and heart disease w...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVES:To analyze retrograde conduction during junctional ectopic tachycardia (JET) episodes and investigate the existence of a relationship between the presence of a retrograde block and the risk of atrioventricular block (AVB) development during radiofrequency ablation procedures in patients with nodal atrioventr...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2007000200003
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To assess the in-hospital results and clinical follow-up of young patients (< 50 years) with multivessel coronary artery disease undergoing stent implantation in native coronary arteries and to compare their results with those of patients with single-vessel coronary artery disease. METHODS:We retrospectively...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2003001300006
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:The analysis of immediate and long-term results of mitral valvoplasty by balloon catheter (MVRBC) are still lacking in literature, mainly in the national context. OBJECTIVE:To assess the immediate and late results of patients submitted to mitral valve repair by balloon catheter. METHOD:A total of 330 conse...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2010000300020
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To evaluate the results of percutaneous balloon valvuloplasty (PBV) for membranous subaortic stenosis (MSAS). METHODS:Seven patients with MSAS were submitted to PBV using the retrograde approach. Hemodynamic and angiographic studies were performed before and after the procedure. The balloon/annulus ratio varie...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of thyroid dysfunction in patients receiving amiodarone, and the possible associated factors. The study also aimed at assessing the effect of amiodarone on thyroid function through the application of a questionnaire to cardiologists. METHOD:Fifty-six patients chronically (> 3 mont...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2004000600005
更新日期:2004-06-01 00:00:00