Abstract:
PURPOSE:To evaluate the cardiogenic depressor Bezold-Jarisch reflex in rats with chronic myocardial infarction. METHODS:Adult Wistar rats were submitted to ligation of the anterior descending coronary artery of the left ventricle (group INF, n = 15) and compared with rats submitted to sham-operation (group Sham, n = 15). Thirty days after the surgery, without influence of anesthetics, the basal mean arterial pressure (MAP) and heart rate (HR) were measured. Immediately after, the Bezold-Jarisch reflex was evaluated measuring the falls in diastolic arterial pressure (DAP) and the simultaneous bradycardia induced by injections of 5-hydroxytryptamine (5-HT, 4 to 32 micrograms/kg, i.v.). RESULTS:The INF group showed significantly lower basal MAP and HR values (103 +/- 3 mmHg and 328 +/- 6 bpm) when compared to the Sham group (110 +/- 2 mmHg and 348 +/- 7 bpm). The Bezold-Jarisch reflex was significantly attenuated in the INF group (falls of DAP from 2 +/- 2 to 31 +/- 3 mmHg and HR from 8 +/- 5 to 204 +/- 15 bpm), when compared to the Sham group (falls of DAP from 10 +/- 3 to 41 +/- 3 mmHg and HR from 58 +/- 12 to 276 +/- 16 bpm). The morphological analysis showed a myocardial infarction mainly located at the anterolateral portion of the left ventricle with a maximal extension of 35% of the left ventricle circumference. The INF group showed right ventricular and left atrial hypertrophy when compared to the Sham group. CONCLUSION:The experimental chronic myocardial infarction in rats is followed by significant attenuation of the Bezold-Jarisch reflex, probably as result of a heart failure and, consequently, of functional alterations in the chemosensitive receptors of cardiac unmyelinated vagal afferents.
journal_name
Arq Bras Cardioljournal_title
Arquivos brasileiros de cardiologiaauthors
Meyrelles SS,Mill JG,Vasquez ECsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
521-4issue
6eissn
0066-782Xissn
1678-4170journal_volume
64pub_type
杂志文章abstract:PURPOSE:To study the spatial arrangement of the bundles of myocardial fibers presents in the left atrial-venous junctions and in the wall of the pulmonary veins. METHODS:The study was made on 24 human adult hearts, together with pulmonary vessels, fixed in 10% formaldehyde solution. Each specimen was cleared of remnan...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x1998000200010
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
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