Thyroid dysfunction and cardiological management in patients receiving amiodarone.


OBJECTIVE:To determine the prevalence of thyroid dysfunction in patients receiving amiodarone, and the possible associated factors. The study also aimed at assessing the effect of amiodarone on thyroid function through the application of a questionnaire to cardiologists. METHOD:Fifty-six patients chronically (> 3 months) receiving amiodarone were assessed by measurement of their serum levels of TSH, free T4, total T3, and anti-TPO antibodies. Patients with changes in TSH levels were defined as having thyroid dysfunction (TD). RESULTS:The prevalence of thyroid dysfunction was 33.9%. No difference was observed between this group and that of patients with no dysfunction, except for the greater prevalence of anti-TPO positivity in patients with TD (P=0.02). Subclinical hypothyroidism was diagnosed in 10 (17.9%) patients and clinical hypothyroidism in 6 (10.7%). The prevalence of subclinical hyperthyroidism was 3.6% and that of clinical hyperthyroidism was 1.8%. Anti-TPO antibodies were positive in 5 (8%) patients (of whom, 4 had thyroid dysfunction). When compared with patients negative for anti-TPO antibodies, that group had a greater prevalence of dysfunction (80% vs 29.4%; P=0.04). Only 49.2% of the cardiologists routinely treated their patients' thyroid function, and the prevalence of the referred dysfunction for most of them ranged from 1 to 10%. CONCLUSION:The prevalence of thyroid dysfunction in our population was high, showing the need for implementing a laboratory routine. The cardiologists disagreed greatly in regard to the type of follow-up required for patients using amiodarone.


Arq Bras Cardiol


Fuks AG,Vaisman M,Buescu A




Has Abstract


2004-06-01 00:00:00














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    authors: Romagna Cavalheiro PT,da Rosa EM,Vargas Avila AO

    更新日期:1995-12-01 00:00:00

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  • [Detection of myocardial ischemia during dobutamine stress echocardiography. Correlation with coronary cineangiography].

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    pub_type: 杂志文章


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    pub_type: 信件


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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Hueb JC,Vicentini JT,Roscani MG,Fusco D,Mattos R,Zanatti SG,Okoshi K,Matsubara BB

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  • Isolated unilateral pulmonary artery agenesis: evaluation of natural and long term evolution after corrective surgery.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Atik E,Tanamati C,Kajita L,Barbero-Marcial M

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    pub_type: 杂志文章


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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,随机对照试验


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    更新日期:2010-03-01 00:00:00

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    abstract::There are limited data regarding the use of hypolipidemic agents concomitantly with immunosuppressive drugs. Best evidence is provided for the use of statins and cyclosporine. In terms of pharmacodynamics, these two drugs have different substrates. In respect to pharmacokinetics, statins usually do not modify serum co...

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    pub_type: 杂志文章


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    abstract::A 56-year-old female with unstable angina, presented an acute embolic ischaemic stroke of right medium cerebral artery during elective coronary angiography. Complete patency was achieved after an intraarterial infusion of rt-PA (60mg/60min) with important functional improvement. ...

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  • [Bacterial infections in 100 patients submitted to heart transplantation].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Falcao CA,Alves IC,Chahade WH,Duarte AL,Lucena-Silva N

    更新日期:2002-09-01 00:00:00

  • Mortality due to cardiovascular diseases in Brazil and in the metropolitan region of São Paulo: a 2011 update.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Mansur Ade P,Favarato D

    更新日期:2012-08-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2013-04-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Anello AL,Moscoso I,Tófano RJ,Salman AA,Cristóvão SA,Mauro MF,Batista de O Neto J,Mangione JA

    更新日期:2003-11-01 00:00:00

  • [Value of pericardial biopsy in the etiologic diagnosis of pericardial diseases].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Fernandes F,Ianni BM,Arteaga E,Benvenutti L,Mady C

    更新日期:1998-06-01 00:00:00

  • [The porcine valve prosthesis and pregnancy].

    abstract::Anticoagulation is the chief problem during pregnancy of women with mechanical prosthetic valves. Many studies have investigated a nonthrombogenic valve. Since 1978 we have used a biological porcine prosthetic valves in 16 pregnancies, 11 patients with regular clinical electrocardiographic, echocardiographic and chest...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Kadri T,Franken RA,Rivetti LA,Tedesco JJ,Suelotto RR,Santos RG

    更新日期:1989-06-01 00:00:00

  • [Diagnosis using nuclear medicine of anterior descending artery stenosis in patients with left bundle branch block].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章


    authors: Smanio PE,Martins LR,Tazima S,Meneghelo R,Thom A,Sousa JE

    更新日期:1995-11-01 00:00:00

  • Dobutamine stress echocardiography-induced broken heart syndrome (Takotsubo Syndrome).

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章


    authors: Vasconcelos Filho FJ,Gomes CA,Queiroz OA,Barreto JE

    更新日期:2009-07-01 00:00:00