Alcoholic liver disease. Treatment strategies for the potentially reversible stages.

Abstract:

:Even modest alcohol ingestion can increase the risk of steatosis, and long-term, excessive consumption can lead to alcoholic hepatitis and eventually cirrhosis. Most patients with clinically significant alcoholic liver disease have histologic findings typical of all three conditions. The only clearly beneficial treatment is abstinence from alcohol. Abstinence in combination with proper nutrition and general supportive care is state of the art. Steatosis is reversible upon withdrawal of alcohol, but alcoholic hepatitis can persist even with abstinence and may progress to cirrhosis. Corticosteroid therapy may reduce short-term mortality rates in patients with moderate or severe alcoholic hepatitis who have hepatic encephalopathy but no evidence of infection or gastrointestinal bleeding. Treatment with colchicine may decrease the risk of cirrhosis; however, once cirrhosis has developed, the liver damage is irreversible. The prognosis is improved with abstinence, but complications (e.g., ascites, gastrointestinal bleeding) often occur. Liver transplantation may be considered in patients with severe complications.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Hill DB,Kugelmas M

doi

10.3810/pgm.1998.04.462

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

261-4, 267-8, 273-5

issue

4

eissn

0032-5481

issn

1941-9260

journal_volume

103

pub_type

杂志文章,评审
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