Smoking, catecholamines, and the ischemic myocardium.

Abstract:

:Catecholamine stimulation increases the heart rate and the force of cardiac contraction. Cardiac output then increases, with a decrease occurring in total peripheral resistance due to smooth muscle dilation in the vascular beds of the muscle and heart, though there is constriction of the skin and viscera; this leads to a net decrease in total peripheral resistance. Consequently, systolic pressure rises and diastolic pressure falls. The net effect is to increase myocardial oxygen demand. Smoking stimulates catecholamine secretion and may therefore be expected to have detrimental effects in patients with angina. In a double-blind study of ten patients with stable angina pectoris treated with nifedipine, propranolol, and atenolol, smoking was found to have direct and adverse effects on the heart and to interfere with the efficacy of all three antianginal drugs, but with that of nifedipine the most. Differences between the two beta blockers may be related, at least in part, to the known different metabolic pathways of these drugs.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Fox KM

subject

Has Abstract

pub_date

1988-02-29 00:00:00

pages

148-51

eissn

0032-5481

issn

1941-9260

journal_volume

Spec No

pub_type

临床试验,杂志文章,评审
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  • Serologic tests for syphilis.

    abstract::Not since the early 1950s has the number of new cases of syphilis been as high as it is now. The infectious agent, Treponema pallidum, is extremely difficult to culture in vitro and almost impossible to see by conventional light microscopy. A nonspecific antibody test is used for screening and a specific treponemal an...

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  • Serologic markers: impact on early diagnosis and disease stratification in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is difficult to diagnose, and differentiating between ulcerative colitis (UC) and Crohn's disease (CD) can be challenging. Overlapping symptoms of UC and CD often delay diagnosis, despite availability of endoscopic, radiologic, and histologic tools. This delay in diagnosis is quite com...

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  • Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS.

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    doi:10.3810/pgm.2009.03.1984

    authors: Hun L

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  • Non-insulin-dependent diabetes mellitus. Current status of oral hypoglycemic therapy.

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    pub_type: 杂志文章

    doi:10.1080/00325481.1987.11699825

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    更新日期:1987-05-01 00:00:00

  • Rheumatic diseases. 1. Differential diagnosis.

    abstract::In a case of rheumatic disease, the patient's history and a careful physical examination should yield most of the information needed to identify the specific disorder present. A convenient classification is based on four differentiating features: number of joints affected, acuteness or chronicity of disease, absence o...

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  • Clinical and economic outcomes in respiratory tract infections: The impact of bacterial resistance.

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  • Advances in refractive surgery. New options expand the scope of corrective procedures.

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    journal_title:Postgraduate medicine

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  • Accuracy and clinical utility of a point-of-care HbA1c testing device.

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  • Practical tips on prescribing home oxygen therapy.

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  • Pitfalls in diagnosis of Lyme disease. What you need to know about serologic testing.

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  • A checklist for evaluation of HIV-infected patients.

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  • Bronchiectasis in adults: a review.

    abstract::Bronchiectasis is characterized by permanent, abnormal dilation of the bronchi with chronic inflammation and infection. Bronchiectasis is either caused by or associated with several systemic disorders, and in a significant number of cases, the underlying etiology remains unidentified and is subsequently referred to as...

    journal_title:Postgraduate medicine

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    authors: Lazarus A,Myers J,Fuhrer G

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  • Using anticoagulants safely. Guidelines for therapeutic and prophylactic regimens.

    abstract::Heparin and warfarin sodium (Coumadin, Panwarfin, Sofarin) are used most often to treat acute and recurrent venous thromboembolic disease, arterial disease, valvular heart disease, and atrial fibrillation. These agents along with dextran, pneumatic compression devices, and gradient stockings are also used to prevent d...

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    doi:10.1080/00325481.1991.11700985

    authors: Dhami MS,Bona RD

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  • Evaluation of patients with syncope. Separating the 'wheat' from the 'chaff'.

    abstract::Although fairly common, syncope is a frightening symptom that can signal a serious underlying disease. The varying causes present a diagnostic challenge to the examining physician, who needs to assess whether referral for more specialized or invasive study is appropriate. The authors review common cases of syncope and...

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    doi:10.1080/00325481.1992.11701298

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    更新日期:1992-04-01 00:00:00

  • Thymoma. The most common anterior mediastinal mass.

    abstract::Thymomas may be discovered during routine evaluation, through reported symptoms, or increasingly, during evaluation for myasthenia gravis. Histologic details of these tumors have little bearing on prognosis or evaluation of malignant potential. Malignancy is determined by evidence of invasion through the tumor capsule...

    journal_title:Postgraduate medicine

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  • Helicobacter pylori and peptic ulcer disease. Bridging the gap between knowledge and treatment.

    abstract::Eradication of H pylori and cure of peptic ulcer disease are possible if effective regimens are used correctly. Treatment markedly improves clinical outcomes and significantly decreases cost of care. As primary care physicians take a larger role in management of these infections, they need to understand the importance...

    journal_title:Postgraduate medicine

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    doi:10.3810/pgm.1998.03.423

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    更新日期:1998-03-01 00:00:00

  • Use of the esophageal obturator airway; with a report of an unusual complication.

    abstract::The esophageal obturator airway is a relatively new addition to equipment for emergency resuscitation. It is simple to use after minimal training and can be inserted quickly without laryngoscopic visualization. Problems are uncommon. ...

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    更新日期:1980-02-01 00:00:00

  • Adrenal insufficiency due to recurrent renal cell carcinoma in the left adrenal gland 3 years after right radical nephrectomy for renal cell carcinoma.

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  • Pain management in primary care: strategies to mitigate opioid misuse, abuse, and diversion.

    abstract::Pain is among the most common reasons patients seek medical attention, and the care of patients with pain is a significant problem in the United States. Acute pain (mild-to-moderate intensity) represents one of the most frequent complaints encountered by primary care physicians (PCPs) and accounts for nearly half of p...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

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    更新日期:2011-03-01 00:00:00

  • Time-to-onset and -resolution of adverse events before/after atomoxetine discontinuation in adult patients with ADHD.

    abstract:BACKGROUND:Adults with attention-deficit/hyperactivity disorder treated with atomoxetine were examined for time-to-onset and -resolution of common treatment-emergent adverse events (TEAEs) and male sexual dysfunction, and for changes in blood pressure (BP) and heart rate (HR) upon atomoxetine discontinuation. METHODS:...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1080/00325481.2015.1083394

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  • Cervical spondylotic myelopathy. A diagnostic challenge in aging patients.

    abstract::Cervical spondylotic myelopathy remains a diagnostic and therapeutic challenge to physicians in a number of specialties. The diagnostic evaluation consists of a comprehensive neurologic and orthopedic examination supplemented by appropriate neurophysiologic and neuroradiologic studies. Currently, magnetic resonance im...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

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    更新日期:1990-09-01 00:00:00

  • Advantages of extended-release metformin in patients with type 2 diabetes mellitus.

    abstract::Metformin is a first-line pharmacological treatment for patients with type 2 diabetes mellitus because of its favorable overall profile, including its glucose-lowering ability, weight-neutral effects, and low risk of hypoglycemia; however, gastrointestinal (GI) intolerance may limit use in some patients. Extended-rele...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2011.01.2241

    authors: Jabbour S,Ziring B

    更新日期:2011-01-01 00:00:00

  • New treatments for rheumatoid arthritis. Available and upcoming slow-acting antirheumatic drugs.

    abstract::No single therapeutic agent has been found to be universally effective for rheumatoid arthritis, so regimens using combinations of drugs have become the rule. Recently, several new agents with unique mechanisms of action have been introduced and found to produce various degrees of clinical benefit. Among these agents ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1999.10.1.703

    authors: Fye KH

    更新日期:1999-10-01 00:00:00

  • Myasthenia gravis: pathogenesis, diagnosis, and therapy.

    abstract::Myasthenia gravis most commonly affects the ocular muscles. Abnormal fatigability of the involved muscle groups is the most remarkable feature of the physical examination. Recent studies have demonstrated that a thymus-derived antibody plays a role in the pathogenesis of myasthenia gravis, which is now thought to be a...

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    pub_type: 杂志文章

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  • Laboratory tests for rheumatic diseases.

    abstract::A carefully taken history and thorough physical examination remain the most crucial aspects of diagnosing rheumatic disorders. Non-rheumatologic conditions also need to be kept in mind. Laboratory tests should be looked on as mostly supportive or confirmatory, because many of the tests are relatively nonspecific and m...

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    pub_type: 杂志文章,评审

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