New treatments for rheumatoid arthritis. Available and upcoming slow-acting antirheumatic drugs.

Abstract:

:No single therapeutic agent has been found to be universally effective for rheumatoid arthritis, so regimens using combinations of drugs have become the rule. Recently, several new agents with unique mechanisms of action have been introduced and found to produce various degrees of clinical benefit. Among these agents are folate and purine antagonists, alkylating agents, and antipyrimidines. Chimeric (mouse/ human) monoclonal antibody to tumor necrosis factor-alpha and human recombinant interleukin-1 receptor antagonist await approval for general use but have undergone considerable study.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Fye KH

doi

10.3810/pgm.1999.10.1.703

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

82-5, 88-90, 92

issue

4

eissn

0032-5481

issn

1941-9260

journal_volume

106

pub_type

杂志文章,评审
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    abstract::Many men experience sexual function disorders, the most common of which are PE and ED. However, they may hesitate to seek treatment because of the perceived embarrassment associated with discussing their symptoms with a physician. The introduction of PDE-5 inhibitors for the treatment of ED has resulted in increased a...

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    doi:10.3810/pgm.2008.04.1761

    authors: Miner M,Hellstrom WJ

    更新日期:2008-04-01 00:00:00

  • Mastalgia. Tailoring treatment to type of breast pain.

    abstract::Breast pain is a common, often distressing problem among women. After significant disease is ruled out, most patients respond to simple reassurance. Others, however, require treatment because symptoms interfere with their lifestyle. The authors offer practical suggestions for tailoring treatment for these patients acc...

    journal_title:Postgraduate medicine

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    doi:10.3810/pgm.1997.11.369

    authors: Steinbrunn BS,Zera RT,Rodriguez JL

    更新日期:1997-11-01 00:00:00

  • Incest. Its causes and repercussions.

    abstract::Throughout history, societies have circumscribed certain forms of intimacy in the family setting. Transgression has been punished by force of ecclesiastical rules and government statutes. However, no single definition of incest is widely accepted, as the degree of kinship in which marriage is allowed and the age of co...

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    doi:10.1080/00325481.1989.11700738

    authors: Lande RG

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  • Drug-induced illness. Causes for delayed diagnosis and a strategy for early recognition.

    abstract::Drug-induced illness is common in any clinical practice. The consequences of failure or delay in diagnosis--persistent or recurring illness, unnecessary diagnostic evaluation, inappropriate treatment, and future jeopardy from the drug--can be avoided by early recognition. Using descriptions of cases from his practice,...

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    doi:10.1080/00325481.1980.11715344

    authors: Savett LA

    更新日期:1980-01-01 00:00:00

  • The effects of a commercially available weight loss program among obese patients with type 2 diabetes: a randomized study.

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    journal_title:Postgraduate medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.3810/pgm.2009.09.2046

    authors: Foster GD,Borradaile KE,Vander Veur SS,Leh Shantz K,Dilks RJ,Goldbacher EM,Oliver TL,Lagrotte CA,Homko C,Satz W

    更新日期:2009-09-01 00:00:00

  • Comorbidities in patients with irritable bowel syndrome with constipation or chronic idiopathic constipation: a review of the literature from the past decade.

    abstract:BACKGROUND:Irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) are common functional bowel disorders. Patients with IBS-C or CIC often present with ≥ 1 comorbidity that coincides with either of these conditions. These comorbidities may make underappreciated contributions to the ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2013.03.2640

    authors: Nellesen D,Chawla A,Oh DL,Weissman T,Lavins BJ,Murray CW

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  • Role of primary care physicians in intrathecal pain management: a narrative review of the literature.

    abstract:OBJECTIVES:The majority of patients seeking medical care for chronic pain consult a primary care physician (PCP). Because systemic opioids are commonly prescribed to patients with chronic pain, PCPs are attempting to balance the competing priorities of providing adequate pain relief while reducing risks for opioid misu...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.2018.1448207

    authors: McDowell GC 2nd,Winchell J

    更新日期:2018-05-01 00:00:00

  • Dissection of dizziness: with emphasis on labyrinthine vertigo.

    abstract::The three most common types of vertiginous episodes area benign positional vertigo, postural vertigo, and endolymphatic hydrops. One of these conditions will be found in more than 90% of patients who present with vertigo as their main complaint. A clear understanding of the differences among these three entities will ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1981.11715757

    authors: Maragos NE,Neel HB 3rd,McDonald TJ

    更新日期:1981-05-01 00:00:00

  • The relationship of reported HIV risk and history of HIV testing among emergency department patients.

    abstract:OBJECTIVE:Among a random sample of emergency department (ED) patients, we sought to determine the extent to which reported risk for human immunodeficiency virus (HIV) is related to ever having been tested for HIV. METHODS:A random sample of patients (aged 18-64 years) from an adult, urban, northeastern United States, ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.3810/pgm.2010.01.2100

    authors: Merchant RC,Freelove SM,Langan TJ 4th,Clark MA,Mayer KH,Seage GR 3rd,DeGruttola VG

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  • The coughing child. A primary care perspective.

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    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1983.11698430

    authors: Schneider AP 2nd,Daws WR,Adams RD

    更新日期:1983-09-01 00:00:00

  • Medical clearance for vigorous exercise. Clinical evaluation and exercise testing.

    abstract::The practitioner plays an important role in providing guidance for exercise. Physical activity is one component of a life-style aimed at enhancing the health of the individual. When entered into with appropriate understanding and with reasonable expectations and goals, exercise can also be a major source of enjoyment....

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1988.11700108

    authors: Smith LK

    更新日期:1988-01-01 00:00:00

  • Fine-tuning insulin therapy.

    abstract::It is now possible to mimic normal insulin action more precisely than ever before with physiologic treatment programs using self-monitoring of blood glucose levels and newer insulins with more predictable action. Physiologic programs are more effective for both insulin-dependent (type I) and non-insulin-dependent (typ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1992.11701262

    authors: Beaser RS

    更新日期:1992-03-01 00:00:00

  • Lower extremity compartment syndrome. When to suspect acute or chronic pressure buildup.

    abstract::Acute compartment syndrome is a surgical emergency. A high index of suspicion is needed in cases of severe contusion, especially if patient complaints seem to outweigh physical findings. Acute surgical fasciotomy is an effective treatment and should be carried out expeditiously if compartment pressures are elevated ov...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1999.03.599

    authors: Swain R,Ross D

    更新日期:1999-03-01 00:00:00

  • Postsplenectomy sepsis syndrome. How to identify and manage patients at risk.

    abstract::Established postsplenectomy sepsis syndrome, although infrequent, may carry a mortality rate of over 90%. Pneumococcus (Streptococcus pneumoniae) has been the infective organism in more than 50% of published cases. Certain groups, such as infants, patients with hematologic malignancy, and those with compromised humora...

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    pub_type: 杂志文章

    doi:10.1080/00325481.1985.11699039

    authors: Brigden ML

    更新日期:1985-06-01 00:00:00

  • Differential diagnosis of jaundice. Hepatocellular versus obstructive disease.

    abstract::The patient with jaundice may be accurately diagnosed through clinical history, physical findings, and noninvasive laboratory and radiologic examinations available in most community hospitals. Ultrasonography is usually the procedure of choice in initial evaluation, but if acute cholecystitis is suspected, hepatobilia...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:

    authors: Marin GA

    更新日期:1987-01-01 00:00:00

  • Resurgence of rheumatic fever in the United States. The changing picture of a preventable illness.

    abstract::The recent resurgence of rheumatic fever reported in eight locations in the United States after years of decline has several noteworthy characteristics. Most patients were children of families in high- to middle-income brackets with ready access to medical care. In four of the outbreaks, the majority of patients were ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1992.11701445

    authors: Ayoub EM

    更新日期:1992-09-01 00:00:00

  • Layered closure of lacerations.

    abstract::The cause, depth, and location of a laceration are major determining factors in its treatment. In all cases, the wound must be completely cleansed with irrigation under pressure and then examined radiographically if necessary and debrided. Successful repair depends on understanding and using the principles of wound he...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1988.11700310

    authors: Phillips LG,Heggers JP

    更新日期:1988-06-01 00:00:00

  • Intervention in family violence. A role for the physician-and for society.

    abstract::Contrary to long-standing mores, what goes on in the person's home is not always sacred. When family relationships break down and family members deal violently with various stresses and problems, intervention is in order. Certain changes in societal attitudes would help prevent the problem. Physicians-alone or working...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11716255

    authors: Pelton CL

    更新日期:1982-11-01 00:00:00

  • Practicing effective preventive medicine. Pharmacologic interventions in coronary heart disease.

    abstract::Epidemiologic and clinical evidence clearly documents the relationship between elevated levels of low-density lipoprotein cholesterol (LDL-C) and risk of coronary heart disease (CHD). In order to reduce CHD risk, the National Cholesterol Education Program (NCEP) has identified LDL-C goals that can be achieved through ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.3810/pgm.04.2003.suppl26.137

    authors: Eisenberg DA

    更新日期:2003-04-01 00:00:00

  • Oral complications of bone marrow transplantation in adults with acute leukemia.

    abstract::In recent years bone marrow transplantation has become increasingly feasible for treating adult acute leukemia unresponsive to chemotherapy. However, the technique is not without significant intrinsic morbidity. The mouth is a singularly sensitive reflector of the cytotoxic, infectious, and hemorrhagic complications a...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1979.11715304

    authors: Dreizen S,McCredie KB,Dicke KA,Zander AR,Peters LJ

    更新日期:1979-11-01 00:00:00

  • HPV and cervical cancer: updates on an established relationship.

    abstract::Despite cervical cancer being considered a preventable disease, it still remains the second most common malignancy in women worldwide, with a higher incidence in underdeveloped countries. Human papillomavirus (HPV) is considered the causative agent of cervical cancer. The major mechanisms through which HPV contributes...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2008.11.1928

    authors: Subramanya D,Grivas PD

    更新日期:2008-11-01 00:00:00

  • Redesigning primary care in an academic medical center: lessons, challenges, and opportunities.

    abstract:PURPOSE:To evaluate patient access, provider productivity, and patient satisfaction during a 24-month redesign process of an academic medical center, which requires balance between clinical and educational missions. METHODS:A series of activities were conducted to optimize primary care across 17 attending physicians, ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

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    authors: Egede LE,Walker RJ,Nagavally S,Thakkar M,O'Sullivan M,Stulac Motzel W

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  • Hirsutism and virilization. A systematic approach to benign and potentially serious causes.

    abstract::A woman with excessive body hair may visit a physician with concerns about fertility and general health as well as appearance. Fortunately, the cause is usually benign, most often polycystic ovarian syndrome. However, life-threatening causes must be quickly ruled out. Hirsutism secondary to endocrinopathies and tumors...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Marshburn PB,Carr BR

    更新日期:1995-01-01 00:00:00

  • Alternatives to warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: a look back at the state of the field in 2012.

    abstract::Stroke is the most feared complication among patients with atrial fibrillation. Oral anticoagulation therapy with vitamin K antagonists (VKAs) has been the gold standard for stroke prevention for the past 60 years. However, VKA therapy has many downsides, including risk for bleeding, a narrow therapeutic window, and t...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2013.03.2648

    authors: Truffa AA,Lopes RD,Newby LK

    更新日期:2013-03-01 00:00:00

  • Flexible sigmoidoscopy. Illuminating the pearls for passage.

    abstract::As efforts to improve screening for colon cancer have increased, so has the importance of routine flexible sigmoidoscopy. However, the procedure is still underused, and about half of primary care physicians who recommend it refer their patients to other physicians. Increased use of this valuable screening tool is an i...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1999.06.622

    authors: Davis PW,Stanfield CB

    更新日期:1999-06-01 00:00:00

  • Clues to the mystery of multiple sclerosis.

    abstract::While the cause of multiple sclerosis (MS) remains obscure, epidemiologic investigation suggests that environmental factors encountered years before onset could be responsible. Studies elucidating age-specific onset curves, worldwide distribution, epidemics, clustering, and risk of contraction after migration are cons...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1989.11700620

    authors: Gorelick PB

    更新日期:1989-03-01 00:00:00

  • Beyond psychopharmacology. Psychosocial strategies for getting the best results when switching antipsychotic medications.

    abstract::Recent effectiveness studies have shown that over a year and a half, 3 of 4 study patients either stopped or changed their antipsychotic medication. This finding highlights the fact that psychopharmacologic treatments do not remain stable over the course of treatment. Our own interpretation is that these findings emph...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Scheifler PL,Weiden PJ

    更新日期:2006-09-01 00:00:00

  • Subclavian steal syndrome. A report of two cases.

    abstract::Two cases of subclavian steal syndrome are reported. Symptoms included light-headedness or syncope, reflecting vertebrobasilar insufficiency, and in one case, numbness and tingling in the left upper extremity, reflecting ischemia. Many persons with this syndrome are asymptomatic. Key findings include unilaterally decr...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1988.11700138

    authors: Harper CA 3rd,Haines JD Jr

    更新日期:1988-02-01 00:00:00

  • Carcinoid tumor of the thymus.

    abstract::Primary carcinoid tumor of the thymus is a rare, slow-growing neoplasm occurring most commonly in middle-aged men. The usual clinical manifestations are those of a mediastinal mass, although in asymptomatic patients, the diagnosis may be suggested by a routine chest roentgenogram. Excision is the most common treatment...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1984.11698575

    authors: Kogan J

    更新日期:1984-01-01 00:00:00

  • Office gynecology: fibroids-when not to operate.

    abstract::The mere presence of uterine fibroids is not, since qua non, an indication for their surgical removal. Knowing when not to operate is probably more important for the physician than knowing when to operate. It is easy to fall into diagnostic and therapeutic traps when uterine fibroids are known to be present, especiall...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:

    authors: Russell KP

    更新日期:1976-09-01 00:00:00