Alternatives to warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: a look back at the state of the field in 2012.

Abstract:

:Stroke is the most feared complication among patients with atrial fibrillation. Oral anticoagulation therapy with vitamin K antagonists (VKAs) has been the gold standard for stroke prevention for the past 60 years. However, VKA therapy has many downsides, including risk for bleeding, a narrow therapeutic window, and the need for frequent monitoring, as well as numerous diet and lifestyle considerations that make its use cumbersome. Thus, development of new drugs that can preserve the benefits of VKAs while eliminating the negative aspects of VKA therapy has been enthusiastically sought. This article reviews the anticoagulant agents that are clinically available or under development as alternatives to VKAs for stroke prevention in patients with nonvalvular atrial fibrillation.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Truffa AA,Lopes RD,Newby LK

doi

10.3810/pgm.2013.03.2648

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

146-57

issue

2

eissn

0032-5481

issn

1941-9260

journal_volume

125

pub_type

杂志文章,评审
  • Metabolic aspects of psoriasis: the basis for specific therapy.

    abstract::Psoriasis, like diabetes, is a multifactorial genetic disease with complex interactions of deranged metabolism. Factors that affect epidermal differentiation and proliferation include cyclic nucleotide interactions, polyamine metabolism, cell surface--cytoskeleton interactions, and arachidonic acid--prostaglandin casc...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1980.11715476

    authors: Anderson TF,Voorhees JJ

    更新日期:1980-06-01 00:00:00

  • Exercise-induced asthma.

    abstract::Exercise-induced asthma can appear as one of many forms of airway hyperreactivity or as a unique clinical entity. Simple spirometry confirms the suspected clinical diagnosis in most instances, although more sensitive measurements of airway obstruction may be required. In general, the asthmatic need not restrict physic...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1980.11715395

    authors: Gerhard H,Schachter EN

    更新日期:1980-03-01 00:00:00

  • Hoarseness. From viral laryngitis to glottic cancer.

    abstract::Hoarseness indicates an abnormality at the level of the glottis. This symptom may result from either structural or physiologic disorders. The differential diagnosis is lengthy and includes both benign and malignant diseases. History taking and physical examination, particularly laryngeal visualization, provide key clu...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:

    authors: Dettelbach M,Eibling DE,Johnson JT

    更新日期:1994-04-01 00:00:00

  • Lymphedema of the limb. An overview of treatment options.

    abstract::In developed countries, prevalence is increasing of malignancy-related secondary lymphedema, usually resulting from lymph node resection or irradiation. Untreated lymphedema usually increases over time, and the physical and psychological sequelae in even mild cases demand appropriate diagnosis and treatment. Patients ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1998.10.450

    authors: Tunkel RS,Lachmann E

    更新日期:1998-10-01 00:00:00

  • Listerial meningitis and renal allografts: a life-threatening affinity.

    abstract::Two cases of Listeria monocytogenes infection in patients receiving immunosuppressive treatment after kidney transplantation are described. In the first, the infection, which occurred soon after transplantation and was accompanied by signs of mild chronic rejection, was the immediate cause of death. The other case occ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1980.11715622

    authors: Holden FA,Kaczmer JE,Kinahan CC

    更新日期:1980-12-01 00:00:00

  • Sinusitis. Its association with asthma.

    abstract::Sinusitis may present as an indolent infection, without the classic symptoms and signs commonly expected, and will probably be missed in children who have only cough and persistent rhinorrhea unless this diagnosis is kept in mind. Plain radiography is the most commonly used diagnostic procedure for sinusitis, but comp...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1990.11704634

    authors: Herrera AM,deShazo RD

    更新日期:1990-04-01 00:00:00

  • Health benefits of aerobic exercise.

    abstract::Regular aerobic exercise has significant cardiovascular benefits, including a reduction in incidence of and mortality from coronary artery disease--probably because of positive effects on blood lipid levels and blood pressure. Aerobic exercise can also be an important adjunct to a weight-loss program. Many persons who...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1991.11700983

    authors: Mersy DJ

    更新日期:1991-07-01 00:00:00

  • Mortality rates in major and subthreshold depression: 10-year follow-up of a Singaporean population cohort of older adults.

    abstract:OBJECTIVES:To investigate the associations of major and subthreshold depression with all-cause, cardiovascular disease and stroke mortality, and the extent to which health behaviour, medical comorbidity and functional disability explained the associations. METHODS:A cohort of 1070 persons aged ≥60 with Geriatric Menta...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2016.1221319

    authors: Ho CSh,Jin A,Nyunt MS,Feng L,Ng TP

    更新日期:2016-09-01 00:00:00

  • Medical clearance for vigorous exercise. Clinical evaluation and exercise testing.

    abstract::The practitioner plays an important role in providing guidance for exercise. Physical activity is one component of a life-style aimed at enhancing the health of the individual. When entered into with appropriate understanding and with reasonable expectations and goals, exercise can also be a major source of enjoyment....

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1988.11700108

    authors: Smith LK

    更新日期:1988-01-01 00:00:00

  • A systematic review of telestroke.

    abstract:BACKGROUND:The use of 2-way audiovisual (AV) technology for delivery of acute stroke evaluation and management, termed "telestroke," is supported by a rapidly growing literature base. A systematic review that provides a comprehensive, easily digestible overview of telestroke science and practice is lacking. PURPOSE:To...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2013.01.2623

    authors: Rubin MN,Wellik KE,Channer DD,Demaerschalk BM

    更新日期:2013-01-01 00:00:00

  • Lactose intolerance. Pinpointing the source of nonspecific gastrointestinal symptoms.

    abstract::Lactose intolerance is a common condition that can cause nonspecific gastrointestinal symptoms. A reliable diagnosis cannot be made on the basis of the patient's history. The breath hydrogen test is simple, noninvasive, accurate, and inexpensive and is the diagnostic method of choice. In addition to traditional dietar...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1991.11700961

    authors: Montes RG,Perman JA

    更新日期:1991-06-01 00:00:00

  • Refractory left ventricular failure: use of two-dimensional echocardiography in identification of thrombi.

    abstract::A 65-year-old woman was hospitalized several times after having an acute anteroseptal transmural infarction. Her course was complicated by recurrent ventricular tachycardia and severe left ventricular failure. Chest x-ray films showed pulmonary congestion and mild right pleural effusion. Two-dimensional echocardiograp...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11716219

    authors: Cheng TC

    更新日期:1982-10-01 00:00:00

  • Thymoma. The most common anterior mediastinal mass.

    abstract::Thymomas may be discovered during routine evaluation, through reported symptoms, or increasingly, during evaluation for myasthenia gravis. Histologic details of these tumors have little bearing on prognosis or evaluation of malignant potential. Malignancy is determined by evidence of invasion through the tumor capsule...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699321

    authors: Cohen DJ

    更新日期:1986-03-01 00:00:00

  • The epidemic challenge of chronic kidney disease in older patients.

    abstract::Since the introduction of estimated glomerular filtration rate (GFR), the number of patients with chronic kidney disease (CKD) has considerably increased. This is particularly true for elderly patients as the majority have a low GFR. Chronic kidney disease has a significant impact on a patient's outcome. We have revie...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2008.11.1943

    authors: Abdelhafiz AH,Tan E,El Nahas M

    更新日期:2008-11-01 00:00:00

  • Proximal gastric vagotomy without drainage.

    abstract::Proximal gastric vagotomy without drainage is widely accepted in Great Britain and Europe but in the United States has been done mainly in university centers. The operation denervates the acid-secreting parietal cell mass of the stomach, preserving vagal innervation to the gastric antrum and extragastric abdominal vis...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1978.11714810

    authors: Sawyers JL

    更新日期:1978-04-01 00:00:00

  • Turkish doctors' cohort: healthy despite low screening.

    abstract:OBJECTIVES:We aimed to determine the prevalence of chronic diseases and unhealthy lifestyle behaviors of Turkish doctors as compared with the general population and the frequency of compliance with preventive clinical practices among doctors. METHODS:This was an observational, prospective cohort study that enrolled gr...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2017.1272399

    authors: Unal S,Tanriover MD,Ascioglu S,Demirkazik A,Ertenli I,Eskioglu E,Guler K,Kiraz S,Ozbakkaloglu M,Ozer B,Tukek T,Akyar S,Erdem Y

    更新日期:2017-04-01 00:00:00

  • Laboratory tests for rheumatic diseases.

    abstract::A carefully taken history and thorough physical examination remain the most crucial aspects of diagnosing rheumatic disorders. Non-rheumatologic conditions also need to be kept in mind. Laboratory tests should be looked on as mostly supportive or confirmatory, because many of the tests are relatively nonspecific and m...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1991.11700818

    authors: Yancey WB Jr,Williams RC Jr

    更新日期:1991-02-01 00:00:00

  • A practical approach to disorders of hemostasis.

    abstract::Simple screening tests are available to detect abnormalities in the plasma coagulation system and platelet function. Prothrombin time reflects the integrity of the extrinsic system, while activated partial thromboplastin time indicates whether the intrinsic system is intact. Thrombin clotting time is a measure of the ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1981.11715704

    authors: Horwitz CA

    更新日期:1981-03-01 00:00:00

  • Evaluation of heart sounds and murmurs in children.

    abstract::Auscultation is the core of pediatric cardiovascular evaluation and should be performed according to a routine. The four heart sounds should be sought in order at their usual locations, with particular attention to the second sound because of its important diagnostic role in congenital cyanotic heart disease. The next...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11716128

    authors: Kulangara RJ,Strong WB,Miller MD

    更新日期:1982-07-01 00:00:00

  • Sports injuries. Practical diagnostic and management concerns for primary care physicians.

    abstract::Both recreational and elite athletes often sustain musculoskeletal injuries. Common problems--muscle cramps, burners (or stingers), and ankle and shoulder injuries--can be managed effectively with certain basic techniques. Initial measures are particularly important in facilitating the injured athlete's rapid return t...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:

    authors: Sellers RG

    更新日期:1992-08-03 00:00:00

  • Thromboembolism after hip surgery. Comparison of screening methods.

    abstract::Venous thromboembolism is a serious and, often, asymptomatic complication of hip surgery. A reliable screening test is needed to detect thrombi early to prevent death from pulmonary emboli. Noninvasive screening tests were ineffective in our study of 453 patients. We recommend early use of ventilation/perfusion lung s...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699529

    authors: Mitsunaga MM,Ferris EB 3rd,Kong AY,Kistner RL,Mayfield GW,Lindberg RF,Jones DA

    更新日期:1986-09-15 00:00:00

  • Eyelid dermatitis. A common, often confounding rash.

    abstract::Five common conditions and several less common ones cause eyelid dermatitis. Diagnosis and treatment depend on recognizing their characteristics, obtaining a good history, performing a careful skin examination, administering and interpreting patch tests, prescribing the proper medications at the right time, and teachi...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1996.08.61

    authors: Parkinson RW

    更新日期:1996-08-01 00:00:00

  • Problems+Solutions.

    abstract::Readers are invited to submit questions relating to problem cases. Inquiries will be answered by qualified consultants and replies forwarded by mail promptly. Selected problems and solutions are published every month in this section. ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1985.11698867

    authors: Spitzer AR,Berberian DA,Moe JH

    更新日期:1985-02-01 00:00:00

  • Angina pectoris. Clinical strategies in diagnosis.

    abstract::Angina pectoris is a clinical diagnosis with various forms and manifestations. In many cases, the diagnosis can be made without expensive supplementary cardiovascular tests. In a given patient, the likelihood of significant coronary artery disease can be assessed clinically from such variables as age, sex, type of sym...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1984.11698713

    authors: Shub C

    更新日期:1984-09-01 00:00:00

  • Viral infections in the elderly. The challenges of managing herpes zoster, influenza, and RSV.

    abstract::Viral diseases are an important cause of morbidity and mortality in elderly patients, whether they live in the community or in long-term care facilities. Management of viral infections in older adults is complicated by factors that include the infrequency or absence of common signs and symptoms of infection and advers...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2005.11.1687

    authors: Bader MS,McKinsey DS

    更新日期:2005-11-01 00:00:00

  • Problems/Solutions.

    abstract::Readers are invited to submit questions relating to problem cases. Inquiries will be answered by qualified consultants and replies forwarded by mail promptly. Selected problems and solutions are published every month in this section. ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1973.11713331

    authors:

    更新日期:1973-01-01 00:00:00

  • Dose selection and dosing interval determination for LTRA use in asthma.

    abstract::The dose and dosing interval for leukotriene receptor antagonists montelukast and zafirlukast in adult asthmatic patients were determined by bronchoprovocation with exercise or leukotriene D4 inhalation. Subsequent dose-ranging studies confirmed that once-daily ingestion of a 10-mg dose of montelukast was effective an...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.3810/pgm.09.15.2000.suppl7.40

    authors: Hendeles L

    更新日期:2000-09-15 00:00:00

  • Pseudomonas folliculitis from a health club whirlpool.

    abstract::In public whirlpools, low disinfectant levels and inadequate monitoring are clearly a public health concern. Implementing guidelines published by the Centers for Disease Control seems to be the most reasonable approach to preventing dermatitis in persons who use these facilities. Physicians should be on the alert for ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1991.11701042

    authors: Breitenbach RA

    更新日期:1991-09-01 00:00:00

  • Gastroesophageal reflux.

    abstract::Preview Although heartburn is the most common symptom of gastroesophageal reflux, many patients with reflux have other, more obscure manifestations. Recognition of all potential signs and symptoms of reflux is important for expeditious management. This article focuses on these atypical presentations and discusses how ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1996.11946110

    authors: Barr LL

    更新日期:1996-04-01 00:00:00

  • Practical tips on prescribing home oxygen therapy.

    abstract::Oxygen therapy is tremendously valuable for patients with chronic respiratory insufficiency. A physician's prescription is needed to obtain Medicare, Medicaid, or insurance-company reimbursement, and certain guidelines must be followed: Patients are selected if significant hypoxemia is present, appropriate pharmacolog...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1988.11700464

    authors: Petty TL

    更新日期:1988-11-01 00:00:00