Clinical and economic outcomes in respiratory tract infections: The impact of bacterial resistance.

Abstract:

:Drug acquisition cost is an important component in the analysis of economic and clinical outcomes in the treatment of respiratory tract infections (RTIs). However, bacterial resistance has emerged as a crucial variable that must also be considered. Drug-resistant infections result in more expensive drug therapy, longer hospital stays, and increased mortality. The high prevalence of community-acquired pneumonia (CAP), as well as the continuing growth in resistant pathogens, make RTIs an appropriate model for studying methods of cost-containment without sacrificing clinical outcome. The University of Kentucky Medical Center has developed a uniform CAP treatment pathway to minimize costs and maximize outcomes. First-line therapy in this model is doxycycline monotherapy, high-dose amoxicillin plus azithromycin, or levofloxacin monotherapy. One major future concern in selecting antibacterial agents for CAP is the spread of macrolide- and fluoroquinolone-resistant Streptococcus pneumoniae.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Rapp RP

doi

10.3810/pgm.09.2002.suppl19.100

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

12-7

issue

3 Suppl

eissn

0032-5481

issn

1941-9260

journal_volume

112

pub_type

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