当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Metabolomic analysis for first-trimester trisomy 18 detection.

Metabolomic analysis for first-trimester trisomy 18 detection.

Abstract：

OBJECTIVE:The purpose of this study was to determine whether nuclear magnetic resonance-based metabolomic markers in first-trimester maternal serum can detect fetuses with trisomy 18. STUDY DESIGN:This was a study of pregnancies between 11 weeks and 13 weeks 6 days' gestation. We analyzed 30 cases of trisomy 18 and a total of 114 euploid cases. Nuclear magnetic resonance-based metabolomic analysis was performed. A further analysis was performed that compared 30 cases with trisomy 18 and 30 trisomy 21 (T21) cases. RESULTS:Metabolomic markers were sensitive for trisomy 18 detection. A combination of 2-hydroxybutyrate, glycerol and maternal age had a 73.3% sensitivity and 96.6% specificity for trisomy 18 detection, with an area under the receiver operating curve: 0.92 (P < .001). Other metabolite markers, which include trimethylamine, were sensitive for distinguishing trisomy 18 from T21 cases. CONCLUSION:This is the first report of prenatal trisomy 18 detection that has been based on metabolomic analysis. Preliminary results suggest that such markers are sensitive not only for the detection of fetal trisomy 18 but also for distinguishing this aneuploidy from T21.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Bahado-Singh RO,Akolekar R,Chelliah A,Mandal R,Dong E,Kruger M,Wishart DS,Nicolaides K

doi

10.1016/j.ajog.2013.03.028

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

65.e1-9

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(13)00341-4

journal_volume

209

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Robotic-assisted laparoscopic exenteration in recurrent cervical cancer Robotics improved the surgical experience for 2 women with recurrent cervical cancer.

    abstract：:Pelvic exenteration can be used to cure women with a central pelvic recurrence or persistence of gynecologic malignancy after initial definitive therapy. Refinements in patient selection, operative techniques, and surgical instrumentation have significantly improved outcomes over the past 60 years, but the procedure i...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2010.04.004

    authors： Davis MA,Adams S,Eun D,Lee D,Randall TC

    更新日期：2010-06-01 00:00:00

  • Pregnancy-induced hypertension and acute fatty liver of pregnancy: atypical presentations.

    abstract：:Severe pregnancy-induced hypertension and markedly elevated levels of serum alkaline phosphatase developed in a 29-year-old-woman in whom one pregnancy resulted in intrauterine death. Acute fatty liver of pregnancy developed with good fetal outcome in the next pregnancy. This case suggests that pregnancy-induced hyper...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(90)90677-y

    authors： Brown MA,Passaris G,Carlton MA

    更新日期：1990-10-01 00:00:00

  • A prospective randomized study of the aggressive management of early labor.

    abstract：:The aggressive management of early labor has been suggested as a means to lower the cesarean section rate for dystocia. The aim of our study was to prospectively evaluate a protocol of early intervention in primigravid women with infrequent uterine contractions during early labor in relation to the course of labor, th...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-9378(87)80288-0

    authors： Cohen GR,O'Brien WF,Lewis L,Knuppel RA

    更新日期：1987-11-01 00:00:00

  • Increased placental progesterone may cause decreased placental prostacyclin production in preeclampsia.

    abstract：UNLABELLED:Placentas obtained from women with preeclampsia produce more thromboxane and less prostacyclin than normal. They also produce more progesterone than normal. This study tested whether a progesterone concentration equivalent to that in the medium after in vitro incubation of placentas from women with preeclamp...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(89)90931-9

    authors： Walsh SW,Coulter S

    更新日期：1989-12-01 00:00:00

  • Hormonal evaluation and autoimmune background in pruritic urticarial papules and plaques of pregnancy.

    abstract：:There is little insight into the pathogenesis of most of the dermatoses specifically associated with pregnancy. We evaluated the hormonal profile and the autoimmune background in 11 pregnant women with pruritic urticarial papules and plaques of pregnancy. No statistically significant difference was found between the s...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(88)90168-8

    authors： Alcalay J,Ingber A,Kafri B,Segal J,Kaufmann H,Hazaz B,Sandbank M

    更新日期：1988-02-01 00:00:00

  • Clinical findings among young women with genital human papillomavirus infection.

    abstract：OBJECTIVE:The purpose of this study was to identify clinical signs and symptoms associated with detection of human papillomavirus (HPV) DNA in the female genital tract. STUDY DESIGN:A total of 516 university students (18 to 24 years old) enrolled in a cohort study that included the collection of genital specimens for ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2003.164

    authors： Mao C,Hughes JP,Kiviat N,Kuypers J,Lee SK,Adam DE,Koutsky LA

    更新日期：2003-03-01 00:00:00

  • Placenta accreta.

    abstract：OBJECTIVE:We sought to review the risks of placenta accreta, increta, and percreta, and provide guidance regarding interventions to improve maternal outcomes when abnormal placental implantation occurs. METHODS:Relevant documents were identified through a search of the English-language literature for publications incl...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2010.09.013

    authors： Publications Committee, Society for Maternal-Fetal Medicine.,Belfort MA

    更新日期：2010-11-01 00:00:00

  • Oral contraception and the recognition of endometritis.

    abstract：OBJECTIVE:Oral contraceptive use has been associated with a lower risk of symptomatic pelvic inflammatory disease but a higher risk of chlamydial cervicitis. To explain these seemingly contradictory findings, we asked whether oral contraceptive use was more common among women with unrecognized endometritis than among w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0002-9378(97)70551-9

    authors： Ness RB,Keder LM,Soper DE,Amortegui AJ,Gluck J,Wiesenfeld H,Sweet RL,Rice PA,Peipert JF,Donegan SP,Kanbour-Shakir A

    更新日期：1997-03-01 00:00:00

  • Third-generation oral contraceptive and deep venous thrombosis: from epidemiologic controversy to new insight in coagulation.

    abstract：:Four epidemiologic studies showed a twofold increase in risk of deep venous thrombosis with the use of oral contraceptives containing third-generation progestins, relative to second-generation products. These findings have been strongly debated ever since, and new studies have been added. In the current article we exa...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/s0002-9378(97)70289-8

    authors： Vandenbroucke JP,Helmerhorst FM,Bloemenkamp KW,Rosendaal FR

    更新日期：1997-10-01 00:00:00

  • Antenatal glucocorticoid therapy increases glucose delivery to cerebral circulations during acute hypoxemia in fetal sheep during late gestation.

    abstract：OBJECTIVE:To determine the effects of 2 maternal injections with dexamethasone on the calculated oxygen and glucose deliveries to fetal cerebral and peripheral circulations during acute hypoxemia in sheep. STUDY DESIGN:Beginning at 124 days, ewes received 2 intramuscular injections of either dexamethasone (2 x 12 mg, ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2009.01.012

    authors： Jellyman JK,Gardner DS,McGarrigle HH,Fowden AL,Giussani DA

    更新日期：2009-07-01 00:00:00

  • Responsiveness of human carcinoma cells of gynecologic origin to 1,25-dihydroxycholecalciferol.

    abstract：:In responsive tissues the induction of 25-hydroxycholecalciferol 24-hydroxylase activity is a marker of 1,25-dihydroxycholecalciferol action. In this study we investigated the responsiveness of various malignant cells, which were derived from carcinomas of gynecologic origin, to 1,25-dihydroxycholecalciferol; we did s...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(86)90162-6

    authors： Christopherson WA,Porter JC,MacDonald PC,Casey ML

    更新日期：1986-12-01 00:00:00

  • Advanced-stage ovarian carcinoma presenting during infertility evaluation.

    abstract：:Fecundity has been extended to the menopause by advances in assisted reproductive techniques. The incidence of ovarian cancer increases with age, and an increased risk of ovarian cancer has been associated with incessant ovulation and infertility. The increased risk of ovarian cancer in older infertility patients must...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(94)90164-3

    authors： Karlan BY,Marrs R,Lagasse LD

    更新日期：1994-11-01 00:00:00

  • Comparison of drinking and smoking patterns during pregnancy over a six-year interval.

    abstract：:Changes in the drinking and smoking habits of pregnant women in Seattle, Washington, were examined in the 6-year period that followed the first American announcement of the fetal alcohol syndrome. Between 1974/1975 and 1980/1981, the number of women who reported any alcohol use around the time of the first prenatal vi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(83)90579-3

    authors： Streissguth AP,Darby BL,Barr HM,Smith JR,Martin DC

    更新日期：1983-03-15 00:00:00

  • The effect of magnesium sulfate on bleeding time in pregnancy.

    abstract：OBJECTIVE:The bleeding time is one of the most commonly used diagnostic tests to evaluate platelet-related hemorrhagic disorders. Magnesium has been shown in vitro to be a platelet antiaggregant. This study was conducted to evaluate the hypothesis that magnesium sulfate has no effect on the template bleeding time. STU...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(95)91363-7

    authors： Fuentes A,Rojas A,Porter KB,Saviello G,O'Brien WF

    更新日期：1995-10-01 00:00:00

  • Placental growth factor predicts time to delivery in women with signs or symptoms of early preterm preeclampsia: a prospective multicenter study.

    abstract：BACKGROUND:There is a robust association between altered angiogenic factor concentrations, which includes placental growth factor and clinically recognized preeclampsia. Alterations in concentrations of angiogenic factors precede the clinical onset of preeclampsia by several weeks. The temporal relationship between the...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajog.2019.09.003

    authors： Barton JR,Woelkers DA,Newman RB,Combs CA,How HY,Boggess KA,Martin JN Jr,Kupfer K,Sibai BM,PETRA (Preeclampsia Triage by Rapid Assay) Trial.

    更新日期：2020-03-01 00:00:00

  • Effect of a cholesterol-lowering diet during pregnancy on maternal and fetal Doppler velocimetry: the CARRDIP study.

    abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of a low-cholesterol low-saturated fat diet on Doppler indices in the fetus and mother. STUDY DESIGN:Two hundred ninety nonsmoking white women, aged 21-38 years, without previous pregnancy complications and carrying a single fetus were assigned randomly to...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajog.2007.01.017

    authors： Khoury J,Haugen G,Tonstad S,Frøslie KF,Henriksen T

    更新日期：2007-06-01 00:00:00

  • Work and pregnancy: the role of fatigue and the "second shift" on antenatal morbidity.

    abstract：OBJECTIVE:This study was undertaken to evaluate factors at home and work associated with antenatal morbidity (emergency department visits and hospitalizations) among employed pregnant women. STUDY DESIGN:This prospective study of 213 women included 3 antenatal interviews at about 16, 24, and 30 weeks' gestation with q...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(99)70103-1

    authors： Luke B,Avni M,Min L,Misiunas R

    更新日期：1999-11-01 00:00:00

  • Severe maternal morbidity and comorbid risk in hospitals performing

    abstract：BACKGROUND:While research has demonstrated increasing risk for severe maternal morbidity in the United States, risk at lower volume hospitals remains poorly characterized. More than half of all obstetric units in the United States perform <1000 deliveries per year and improving care at these hospitals may be critical t...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2016.10.029

    authors： Hehir MP,Ananth CV,Wright JD,Siddiq Z,D'Alton ME,Friedman AM

    更新日期：2017-02-01 00:00:00

  • Acute pulmonary complications of molar pregnancy.

    abstract：:Of 128 patients receiving primary treatment for molar pregnancy at Women's Hospital, Los Angeles County/University of Southern California Medical Center, after uterine evacuation 12 (10.7%) developed self-limited, acute pulmonary complications characterized by tachycardia, tachypnea, and hypoxemia. Multiple contributi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(79)90341-7

    authors： Twiggs LB,Morrow CP,Schlaerth JB

    更新日期：1979-09-15 00:00:00

  • The prognostic value of molecular biomarkers in tissue removed by curettage from FIGO stage 1 and 2 endometrioid type endometrial cancer.

    abstract：OBJECTIVE:To analyze the prognostic value of molecular biomarkers in curettages of endometrioid endometrial cancer pathologic FIGO stages 1 and 2. STUDY DESIGN:Population-based survival analysis in 258 patients of classical prognostic features and molecular biomarkers of cell cycle regulation, (anti)apoptosis, prolife...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2008.07.020

    authors： Steinbakk A,Skaland I,Gudlaugsson E,Janssen EA,Kjellevold KH,Klos J,Løvslett K,Fiane B,Baak JP

    更新日期：2009-01-01 00:00:00

  • Early and simple determination of chorionic and amniotic type in multifetal gestations in the first fourteen weeks by high-frequency transvaginal ultrasonography.

    abstract：OBJECTIVE:Our aim was to determine the chorionic and amniotic types in multifetal pregnancies with transvaginal ultrasonography at > or = 14 weeks' gestation. STUDY DESIGN:Two hundred twelve multifetal pregnancies were scanned transvaginally at or before 14 weeks' gestation. The number of fetuses and the chorionic and...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(94)70291-8

    authors： Monteagudo A,Timor-Tritsch IE,Sharma S

    更新日期：1994-03-01 00:00:00

  • Hypoxia, the subsequent systemic metabolic acidosis, and their relationship with cerebral metabolite concentrations: An in vivo study in fetal lambs with proton magnetic resonance spectroscopy.

    abstract：OBJECTIVE:The relationship among decreased fetal arterial oxygen saturation, the subsequent systemic metabolic acidosis, and changes in cerebral metabolite concentrations in the fetal lamb brain was investigated by means of quantitative proton magnetic resonance spectroscopy. STUDY DESIGN:Fetal hypoxia was induced in ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(99)70401-1

    authors： van Cappellen AM,Heerschap A,Nijhuis JG,Oeseburg B,Jongsma HW

    更新日期：1999-12-01 00:00:00

  • The effect of exercise on uterine activity in the last eight weeks of pregnancy.

    abstract：:In order to determine if moderate maternal exercise increased uterine activity, a prospective study was done during the last 8 weeks of pregnancy in 17 women. Two forms of exercise were chosen, weight-bearing (running) and non-weight-bearing (stationary bicycle), to study this hypothesis. The results show that with th...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(85)90505-8

    authors： Veille JC,Hohimer AR,Burry K,Speroff L

    更新日期：1985-03-15 00:00:00

  • Persistent elevation of cell-free fetal DNA levels in maternal plasma after selective laser coagulation of chorionic plate anastomoses in severe midgestational twin-twin transfusion syndrome.

    abstract：OBJECTIVE:This study was undertaken to determine whether laser thermocoagulation for twin-twin transfusion syndrome (TTTS) causes increased cell-free fetal DNA levels in maternal plasma, potentially as a result of placental injury. STUDY DESIGN:We enrolled 34 patients with twin pregnancies complicated by severe TTTS w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2004.07.019

    authors： Wataganara T,Gratacos E,Jani J,Becker J,Lewi L,Sullivan LM,Bianchi DW,Deprest JA

    更新日期：2005-02-01 00:00:00

  • Use of Norplant contraceptive implants in the immediate postpartum period: safety and tolerance.

    abstract：OBJECTIVE:Our purpose was to determine the safety and tolerance of levonorgestrel contraceptive implants (Norplant, Wyeth-Ayerst, Philadelphia) when inserted immediately post partum, to document the effects on weight and blood pressure, and to determine the side effects. STUDY DESIGN:After vaginal delivery, 250 women ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-9378(95)90109-4

    authors： Phemister DA,Laurent S,Harrison FN Jr

    更新日期：1995-01-01 00:00:00

  • A survey of recommendations by gynecologists in Canada regarding oral contraceptive use in the perioperative period.

    abstract：OBJECTIVE:This survey was conducted to determine the practice patterns of gynecologists in Canada regarding the discontinuation of oral contraceptives before gynecologic surgical procedures. STUDY DESIGN:In May and June of 1997, surveys were sent to all obstetricians and gynecologists on the mailing list of the Societ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.127372

    authors： Oakes J,Hahn PM,Lillicrap D,Reid RL

    更新日期：2002-12-01 00:00:00

  • Postirradiation squamous cell carcinoma in situ of the vagina: treatment by topical 20 percent 5-fluorouracil cream.

    abstract：:Eight patients with squamous cell carcinoma in situ of the vagina were treated with monthly 5 day courses of 20% 5-fluorouracil cream applied to the vagina. Seven (87.5%) of the women had an initial complete response; however, three subsequently developed recurrence after the treatment was stopped. They were retreated...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(79)90709-9

    authors： Piver MS,Barlow JJ,Tsukada Y,Gamarra M,Sandecki A

    更新日期：1979-10-01 00:00:00

  • Work hours for practicing obstetrician-gynecologists: the reality of life after residency.

    abstract：OBJECTIVE:Recently the Accreditation Council for Graduate Medical Education placed restrictions on all residency programs that limited work hours to 80 hours per week. The objective of this study was to determine the work hours for practicing obstetrician-gynecologists in an urban center. STUDY DESIGN:A questionnaire ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/s0002-9378(03)00888-3

    authors： Promecene PA,Schneider KM,Monga M

    更新日期：2003-09-01 00:00:00

  • The relaxation responses to corticotropin-releasing factor in rat aorta are endothelium dependent and gestationally regulated.

    abstract：OBJECTIVE:Our purpose was to examine the hypothesis that the relaxant response to corticotropin-releasing factor is endothelium dependent and changes during pregnancy. STUDY DESIGN:Relaxant responses to cumulative concentrations of corticotropin-releasing hormone were measured in rings of thoracic aorta, precontracted...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)80042-7

    authors： Jain V,Vedernikov YP,Saade GR,Chwalisz K,Garfield RE

    更新日期：1997-01-01 00:00:00

  • Attempted operative vaginal delivery vs repeat cesarean in the second stage among women undergoing a trial of labor after cesarean delivery.

    abstract：BACKGROUND:It is not well-characterized whether attempting operative vaginal delivery is a safe and effective alternative among women who undergo a trial of labor after cesarean delivery who are unable to complete second-stage labor with a spontaneous vaginal delivery. OBJECTIVE:The purpose of this study was to compar...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2017.01.013

    authors： Son M,Roy A,Grobman WA

    更新日期：2017-04-01 00:00:00