Abstract：
OBJECTIVE:The bleeding time is one of the most commonly used diagnostic tests to evaluate platelet-related hemorrhagic disorders. Magnesium has been shown in vitro to be a platelet antiaggregant. This study was conducted to evaluate the hypothesis that magnesium sulfate has no effect on the template bleeding time. STUDY DESIGN:The study group consisted of 24 women who required magnesium sulfate in pregnancy. A blood cell count, platelet count, magnesium level, bleeding time, and mean arterial pressure were obtained before and 2 hours after magnesium sulfate infusion. Magnesium sulfate was infused beginning with a 6 gm intravenous bolus followed by 2 gm/hr. A template bleeding time was performed with a Simplate-II (Organon Teknika, Durham, N.C.) device. Two of the authors performed all the bleeding times. Data were analyzed with a paired t test and Wilcoxon rank test. RESULTS:Fifteen (63%) patients received magnesium sulfate for tocolysis or before external cephalic version and nine (37%) for preeclampsia prophylaxis. No differences were found between the normotensive and hypertensive groups regarding maternal age, gestational age, initial bleeding time, or platelet count. Analysis of the entire study group revealed a prolongation of the bleeding time after magnesium sulfate (5.7 +/- 1.8 vs 6.6 +/- 1.9 minutes, p < 0.05); a lowering of the mean arterial pressure (p < 0.05), and a rise in the magnesium level (p < 0.05). Four patients (16.7%) had a postmagnesium bleeding time > 9 minutes. CONCLUSION:Magnesium sulfate appears to prolong the bleeding time in pregnancy. The clinical significance remains to be determined.
journal_name
Am J Obstet Gynecoljournal_title
American journal of obstetrics and gynecologyauthors
Fuentes A,Rojas A,Porter KB,Saviello G,O'Brien WFdoi
10.1016/0002-9378(95)91363-7subject
Has Abstractpub_date
1995-10-01 00:00:00pages
1246-9issue
4eissn
0002-9378issn
1097-6868pii
0002-9378(95)91363-7journal_volume
173pub_type
杂志文章abstract：BACKGROUND:There is a marked increase in the use of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors in the last decade. Many newborns are likely to be exposed during pregnancy and labor. OBJECTIVE:We aimed to evaluate the association between exposure to selective serotonin reup...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,meta分析
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更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:Our purpose was to evaluate the role of fetal ultrasonography in prenatal detection of trisomy 21. STUDY DESIGN:A retrospective study was performed on all cases of trisomy 21 diagnosed prenatally or postnatally between January 1990 and December 1993 in the Jerusalem metropolitan area. Our program of prenatal...
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更新日期：2001-10-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
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journal_title：American journal of obstetrics and gynecology
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doi：10.1016/0002-9378(90)91054-g
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journal_title：American journal of obstetrics and gynecology
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更新日期：1984-01-01 00:00:00
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更新日期：2008-05-01 00:00:00
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更新日期：2000-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-02-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,评审
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更新日期：2010-11-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
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更新日期：1977-05-15 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
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更新日期：2004-10-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2006.01.058
更新日期：2006-05-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(99)70181-x
更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2013-01-01 00:00:00
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更新日期：1981-06-15 00:00:00
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journal_title：American journal of obstetrics and gynecology
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更新日期：1990-08-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
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更新日期：2014-01-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(84)90533-7
更新日期：1984-04-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
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更新日期：1975-07-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
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更新日期：1979-06-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajog.2009.02.038
更新日期：2009-05-01 00:00:00
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journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2012.02.016
更新日期：2012-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.ajog.2010.10.913
更新日期：2011-03-01 00:00:00
abstract：:Fifty-five patients with Stage IB adenocarcinoma of the cervix were treated by radical hysterectomy and pelvic lymphadenectomy from 1965 through 1985. Bleeding was the presenting symptom in 56% of the patients. Twenty patients underwent cone biopsy for diagnostic purposes and 70% had residual carcinoma at the time of ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(89)90877-6
更新日期：1989-06-01 00:00:00
