The impact of drug metabolizing enzyme polymorphisms on outcomes after antenatal corticosteroid use.

Abstract:

OBJECTIVE:To determine the impact of maternal and fetal single nucleotide polymorphisms in key betamethasone pathways on neonatal outcomes. STUDY DESIGN:DNA was obtained from women given betamethasone and their infants. Samples were genotyped for 73 exploratory drug metabolism and glucocorticoid pathway single nucleotide polymorphisms. Clinical variables and neonatal outcomes were obtained. Logistic regression analysis using relevant clinical variables and genotypes to model for associations with neonatal respiratory distress syndrome was performed. RESULTS:One hundred nine women delivering 117 infants were analyzed. Sixty-four infants (49%) developed respiratory distress syndrome. Multivariable analysis revealed that respiratory distress syndrome was associated with maternal single nucleotide polymorphisms in CYP3A5 (odds ratio [OR], 1.63; 95% confidence interval [CI], 1.16-2.30) and the glucocorticoid resistance (OR, 0.28; 95% CI, 0.08-0.95) and fetal single nucleotide polymorphisms in ADCY9 (OR, 0.17; 95% CI, 0.03-0.80) and CYP3A7*1E (rs28451617; OR, 23.68; 95% CI, 1.33-420.6). CONCLUSION:Maternal and fetal genotypes are independently associated with neonatal respiratory distress syndrome after treatment with betamethasone for preterm labor.

journal_name

Am J Obstet Gynecol

authors

Haas DM,Lehmann AS,Skaar T,Philips S,McCormick CL,Beagle K,Hebbring SJ,Dantzer J,Li L,Jung J

doi

10.1016/j.ajog.2012.02.016

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

447.e17-24

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(12)00179-2

journal_volume

206

pub_type

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