Abstract:
:Results of isolated surgical resection for stage III lung cancer are not satisfactory, since overall 5-year survival rates rarely exceed 15%. Deaths during follow-up are mainly due to metastatic progression. The multimodality approach adds chemotherapy to surgery, with the intent to improve the control of micrometastatic disease which potentially exists at the time of diagnosis. Preoperative or neoadjuvant chemotherapy is currently under evaluation. Phase 2 trials demonstrate a treatment-related mortality of 5%: complete response and partial response are rated 5-10% and 50% respectively. About 85% of patients are operated upon within an average of 3 months after onset of treatment. Exploratory thoracotomy without resection is performed in 15% of cases; a complete resection may be performed in 75% of cases. Overall post-operative mortality is close to 5%, but considerably higher rates of 10-17.5% have been reported following pneumonectomy. Median survival after treatment may reach 20 months. Indicators of improved survival are response to induction therapy and complete resection. However, ther is no objective evidence that induction therapy improves survival after resection. Interpretation of phase 2 trials is obscured by methodologic drawbacks such as heterogenous patient samples or inaccurate staging. The spare phase 3 trials suffer from identical drawbacks, and further from too short sample sizes. Mediastinoscopy prior to induction therapy is mandatory to confirm N2 or N3 disease, because radiologic staging is not reliable. Pathologic and therefore accurate staging is achieved when surgical resection is the initial step of treatment. Previous work has concluded that post-operative or adjuvant chemotherapy does not improve survival; however, these trials did not use optimal drug regimens, and compliance to treatment was not satisfactory. In fine, the 2 major objectives of surgery in the multimodality setting are to secure local control of the disease, and to confirm stage III disease owing to pathologic stating.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Massard G,Grunenwald Dsubject
Has Abstractpub_date
1998-06-01 00:00:00pages
396-406issue
3 Pt 2eissn
0761-8425issn
1776-2588journal_volume
15pub_type
杂志文章,评审abstract::The real cost of medical consumption was compared with the proportion of medication consumption of (the) GHM n(o) 681 (homogeneous group of patients, chemotherapy for cancer in day care) in the French case mix system (PMSI). For those patients in our thoracic oncology unit (Sainte-Marguerite Hospital, Marseille, Franc...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:There is no standard second-line treatment for small cell lung cancer (SCLC). The prognosis of these patients is poor and special attention should be paid to both quality of life and economic factors. METHODS:The aim of this phase II randomised trial (GFPC0501) is to compare, in patients with progressive SC...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/s0761-8425(07)91136-5
更新日期:2007-05-01 00:00:00
abstract:INTRODUCTION:To prevent and control chronic respiratory diseases, the WHO has outlined a programme to be applied in all the countries. In Sub-Saharan countries like Senegal, its application faces many barriers. METHODS:This work is a detailed analysis of the main areas of the programme based on the socio-economic, cul...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:10.1016/s0761-8425(04)71352-2
更新日期:2004-06-01 00:00:00
abstract::A case of acute interstitial pneumonia with hypoxaemia is described; this occurred after the cessation of cortico steroids in a patient suffering from myeloma treated with melphalan. The absence of any microbes and the lymphocytosis in the bronchoalveolar lavage and the rapid and favourable improvement on cortico ster...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:
更新日期:1989-01-01 00:00:00
abstract::The aim of this work was to study the kinetic of intramacrophage penetration of cotrimoxazole in guinea pigs which had received 100 mg/kg of sulfamethoxazole and 20 mg/kg of trimethoprim after a single intraperitoneal injection. 30 minutes, 1, 3, 6 and 24 hours after this injection an intra-cardiac blood sample was ta...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The authors report an "analytic epidemiological" study, showing the risk of relapse in tuberculous patients in the Bas-Rhin in 1967 to 1977. This was possible thanks to statutory notification of tuberculous cases, with an index updated by annual returns. The study relates to French subjects notified as new cases of al...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:INTRODUCTION:Evaluation of clinical practice in pulmonary oncology aims to improve both the quality of care and the control of costs. REVIEW OF THE LITERATURE:A Medline search of the literature allowed analysis of the published studies of the evaluation of clinical practice. They showed that though 82-95% of patients ...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:10.1016/s0761-8425(06)72080-0
更新日期:2006-12-01 00:00:00
abstract::Despite the progress in therapeutic strategies, overall survival of stage III non small cell lung cancers (NSCLC) is poor. Currently, the standard treatment for unresectable locally advanced NSCLC is concurrent chemoradiotherapy. However, oesophagitis is a major toxicity and this schedule should be reserved for patien...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:
更新日期:2007-10-01 00:00:00
abstract::The hyperventilation syndrome has been described for half a century but clearly remains underdiagnosed. Its acute manifestation is easily diagnosed ("the tip of the iceberg") but its recognition in numerous subtle forms requires a particular degree of alertness on the part of the clinician ("the hidden part of the ice...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:The degree of dyspnoea and muscular dysfunction during an exacerbation of COPD are so severe in some patients that they are unable to follow a traditional exercise training programme based on whole body activity (walking, cycling). Some alternative strategies like electrostimulation may be considered to in...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:10.1016/j.rmr.2009.08.004
更新日期:2010-02-01 00:00:00
abstract::Mediastinoscopy is a technique which enables palpation, inspection and biopsy of superior mediastinal glands. When this examination is done routinely in patients suffering from lung cancer which is presumed to be operable, 25-30% are found to have a positive gland and the greater part of these individuals become inope...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Patients with clinical stage IIIAN2 non-small cell lung cancer (NSCLC) are a heterogeneous subgroup in term of prognosis and therapeutic management. The optimal management of this patient group is a major focus for thoracic oncology research and the concept of multimodality treatment has recently been introduced. This...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:10.1016/j.rmr.2011.05.017
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION:Many pregnant women are asthmatics and maternal asthma is a source of questions and complications concerning both the progress of the pregnancy itself and the impact on the foetus. In this situation good asthma control is essential as the disease can deteriorate with acute exacerbations, possibly precipita...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:10.1016/s0761-8425(09)74042-2
更新日期:2009-04-01 00:00:00
abstract::Fertility and reproduction are now frequent questions for cystic fibrosis adult patients. Females are sometimes subfertile because of abnormal cervical mucus viscosity or anovulatory cycles. After genetic counseling and evaluation of respiratory prognosis, assisted reproduction can be proposed. Fertility is frequently...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract:INTRODUCTION:Low grade pulmonary sarcomas are very rare tumours. We report the case of a low grade sarcoma of the lung occurring two years prior to the finding of a uterine primary. CASE REPORT:Complete surgical excision of a low grade pulmonary sarcoma was performed. The initial search for dissemination was negative....
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Current guidelines for referring patients with idiopathic pulmonary fibrosis (IPF) for lung transplantation, based on resting parameters, are insufficient to predict 3-year mortality. The aim of this study was to determine the prognostic value of cardio-pulmonary exercise testing (CPET) in patients with IPF. A multice...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rmr.2010.08.016
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:There are few data on primary bronchial carcinoma in France. We report here the results of the study KBP 2000-CPHG in which there were 1868 patients aged 70 or more and 338 aged 80 or more. METHODS:We compared the patients under 70 (Group I) with those aged 70 or more (Group II) as well as with the detail...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract:INTRODUCTION:Rates of lung cancer in women have been increasing continually for several years. The basic surgical management of this condition is the same in both sexes but a number of differences are apparent. METHODS:We analysed data entered onto the Epithor database between June 2002 and June 2006 concerning 8535 s...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:10.1016/s0761-8425(07)91390-x
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:Sarcoidosis is a systemic granulomatous disorder. However, when epithelioid cell granulomata are found in association with malignancy, they could correspond to a sarcoid reaction. CASE REPORT:We report the case of a young woman with mediastinal lymphadenopathy containing non-caseating granulomata. She als...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:10.1016/j.rmr.2012.05.009
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:Synovial sarcoma is an uncommon tumour and thoracic involvement is rare and of varying location. Clinical characteristics are dominated by pain, with a slow progression over years. Pathological and immuno-histochemical characteristics are helpful in the diagnosis but a specific translocation between chromo...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:10.1016/j.rmr.2009.11.006
更新日期:2010-01-01 00:00:00
abstract::The diagnosis of malignant pleural mesothelioma relies mostly on the pathological examination of pleural samples, validated by a panel of experts and generally obtained during medical or surgical thoracoscopy performed for the management of an exudative pleural effusion. In the absence of pleural effusion (dry-type me...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:10.1016/j.rmr.2014.12.009
更新日期:2015-09-01 00:00:00
abstract::The development of fibreoptic bronchoscopy has enabled significant progress in the understanding of the pathogenesis of asthma. It has brought to the fore the importance of bronchial inflammation even in asymptomatic patients and/or in patients who have only mild disease. The practice of bronchial biopsy in vivo is an...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:
更新日期:1998-06-01 00:00:00
abstract::AIDS was the cause of the majority of deaths from HIV infection before 1996 but since the introduction of antiretroviral therapies the causes of mortality have changed considerably. In 2010, 75 % of deaths were due to diseases other than AIDS, the majority being cancers. Lung cancer is the most common in terms of both...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:10.1016/j.rmr.2013.07.009
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The management of COPD aims to improve integrated indices such as health-related quality of life (HRQoL). Experts recommend repeated and methodical assessment of HRQoL, particularly by the use of questionnaires. Though these tools give pertinent information for groups of patients, they have limitations in des...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:10.1016/j.rmr.2010.03.020
更新日期:2010-05-01 00:00:00
abstract::We report a case of interstitial pneumonia found by a woman who suffered from a gastroesophageal reflux unamenable to usual treatments. The HR-tomographic discovery of a tone esophagus lead to a manometric study. The association of high autoantibodies levels and radiographic and manometric data were characteristic of ...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::The medical treatment of left ventricular failure classically relies upon the use of diuretics with or without digitalis. The recent arrival of vasodilators allows for both an improvement in the quality of life as well as a prolongation of survival for people in heart failure. The "new" positive inotropic agents which...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:
更新日期:1987-01-01 00:00:00
abstract::When administered in a single dose, nedocromil can inhibit the effect of various stimuli: adenosine, SO2, cold air, smog, tachykinins, metabisulfite, exercise and antigen. When administered in a chronic way, this preparation diminishes bronchial hyperresponsiveness. In a clinical study done in England, nedocromil has ...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Hypersensitivity pneumonitis (HP) are typically subacute in their presentation and the diagnosis may be difficult. METHOD:We report a case of a hypersensitivity pneumonitis in a 27-years-old woman, caused by exposure to mould in an insalubrious mobile home. The initial presentation was with acute respirat...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:10.1016/j.rmr.2017.12.006
更新日期:2019-06-01 00:00:00
abstract::The authors review the literature about respiratory burns and their initial and late functional repercussions. Upper airway oedema induces initial upper airway obstructive impairment. Pulmonary parenchymal failure is characterised by the functional consequences observed with adult respiratory distress syndrome. Surviv...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Optimal duration of first line chemotherapy for non surgical non small cell lung cancer (NSCLC) is still debated. It concerns the length of initial chemotherapy and the use of maintenance treatments. METHODS:Literature review was performed on maintenance and duration of chemotherapy. RESULTS:The use of mai...
journal_title:Revue des maladies respiratoires
pub_type: 杂志文章,评审
doi:
更新日期:2006-11-01 00:00:00