In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source.

abstract：:The accumulation of quinolones by Escherichia coli JF568, Pseudomonas aeruginosa PAO1, and Staphylococcus aureus ATCC 29213 was measured by a modified fluorometric assay (J. S. Chapman and N. H. Georgopapadakou, Antimicrob. Agents Chemother. 33:27-29, 1989). The quinolones examined were fleroxacin, pefloxacin, norflox...

journal_title：Antimicrobial agents and chemotherapy

authors： McCaffrey C,Bertasso A,Pace J,Georgopapadakou NH

更新日期：1992-08-01 00:00:00

abstract：:The two components of virginiamycin, virginiamycin M (VM) and virginiamycin S (VS), were used to explore the life cycle of symbiosis-dependent and -independent strains of Bdellovibrio bacteriovorus during multiplication in a two-membered system with either living or heat-inactivated Escherichia coli or in axenic cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Varon M,Cocito C,Seijffers J

更新日期：1976-01-01 00:00:00

abstract：:Invasive fungal diseases are generally difficult to treat and often fatal. The therapeutic agents available to treat fungi are limited, and there is a critical need for new agents to combat these deadly infections. Antifungal compound development has been hindered by the challenge of creating agents that are highly ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Rank LA,Walsh NM,Liu R,Lim FY,Bok JW,Huang M,Keller NP,Gellman SH,Hull CM

更新日期：2017-09-22 00:00:00

abstract：:Macrolide antibiotics are used as anti-inflammatory agents, e.g., for prevention of exacerbations in chronic obstructive pulmonary disease and cystic fibrosis. Several studies have shown improved outcomes after the addition of macrolides to β-lactam antibiotics for treatment of severe community-acquired pneumonia. How...

journal_title：Antimicrobial agents and chemotherapy

authors： Kasetty G,Bhongir RKV,Papareddy P,Herwald H,Egesten A

更新日期：2017-08-24 00:00:00

abstract：:The caspofungin clinical trial database offers an opportunity to assess susceptibility results for Candida pathogens obtained from patients with candidiasis and allows for correlations between efficacy outcomes and MICs. Candida isolates have been identified from patients enrolled in four studies of esophageal candidi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kartsonis N,Killar J,Mixson L,Hoe CM,Sable C,Bartizal K,Motyl M

更新日期：2005-09-01 00:00:00

abstract：:When developing novel microbicide products for the prevention of HIV infection, the preclinical safety program must evaluate not only the active pharmaceutical ingredient but also the product itself. To that end, we applied several relatively standard toxicology study methodologies to female sheep, incorporating an as...

journal_title：Antimicrobial agents and chemotherapy

authors： Holt JD,Cameron D,Dias N,Holding J,Muntendam A,Oostebring F,Dreier P,Rohan L,Nuttall J

更新日期：2015-07-01 00:00:00

abstract：:We report the ex vivo lysogenic transfer of erythromycin and tetracycline resistance genes among group A streptococci (GAS). Of 42 susceptible strains, 69% acquired erythromycin/tetracycline resistance when infected with purified supernatants from strain m46 culture containing the phage Φm46.1. A significant emm-type-...

journal_title：Antimicrobial agents and chemotherapy

authors： Di Luca MC,D'Ercole S,Petrelli D,Prenna M,Ripa S,Vitali LA

更新日期：2010-10-01 00:00:00

abstract：:Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kedar GC,Brown-Driver V,Reyes DR,Hilgers MT,Stidham MA,Shaw KJ,Finn J,Haselbeck RJ

更新日期：2008-06-01 00:00:00

abstract：:Clinical treatment failures have been reported to occur in early Lyme borreliosis (LB) for many suitable antimicrobial agents. Investigations of possible resistance mechanisms of the Borrelia burgdorferi complex must analyze clinical isolates obtained from LB patients, despite their receiving antibiotic treatment. Her...

journal_title：Antimicrobial agents and chemotherapy

authors： Hunfeld KP,Ruzic-Sabljic E,Norris DE,Kraiczy P,Strle F

更新日期：2005-04-01 00:00:00

abstract：:Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resi...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodero L,Mellado E,Rodriguez AC,Salve A,Guelfand L,Cahn P,Cuenca-Estrella M,Davel G,Rodriguez-Tudela JL

更新日期：2003-11-01 00:00:00

abstract：:Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact of FKS1 modulation on susceptibility to additional antifungal classes. Reduction of FKS1 expression rendered biofilms more s...

journal_title：Antimicrobial agents and chemotherapy

authors： Nett JE,Crawford K,Marchillo K,Andes DR

更新日期：2010-08-01 00:00:00

abstract：:In this study, two identical copies of a 23S-5S gene cluster, which are separately situated within the Helicobacter pylori UA802 chromosome, were cloned and sequenced. Comparison of the DNA sequence of the H. pylori 23S rRNA gene with known sequences of other bacterial 23S rRNA genes indicated that the H. pylori UA802...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor DE,Ge Z,Purych D,Lo T,Hiratsuka K

更新日期：1997-12-01 00:00:00

abstract：:Arguably, one of the most common and consequential laboratory tests performed in the world is Mycobacterium tuberculosis susceptibility testing. M. tuberculosis resistance is defined by growth of > or =1% of a bacillary inoculum on the critical concentration of an antibiotic. The critical concentration was chosen base...

journal_title：Antimicrobial agents and chemotherapy

authors： Gumbo T

更新日期：2010-04-01 00:00:00

abstract：:Currently, CTX-M β-lactamases are among the most prevalent and most heterogeneous extended-spectrum β-lactamases (ESBLs). In general, CTX-M enzymes are susceptible to inhibition by β-lactamase inhibitors. However, it is unknown if the pathway to inhibition by β-lactamase inhibitors for CTX-M ESBLs is similar to TEM an...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethel CR,Taracila M,Shyr T,Thomson JM,Distler AM,Hujer KM,Hujer AM,Endimiani A,Papp-Wallace K,Bonnet R,Bonomo RA

更新日期：2011-07-01 00:00:00

abstract：:Eravacycline (TP-434 or 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline) is a novel fluorocycline that was evaluated for antimicrobial activity against panels of recently isolated aerobic and anaerobic Gram-negative and Gram-positive bacteria. Eravacycline showed potent broad-spectrum activity against 9...

journal_title：Antimicrobial agents and chemotherapy

authors： Sutcliffe JA,O'Brien W,Fyfe C,Grossman TH

更新日期：2013-11-01 00:00:00

abstract：:The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bauernfeind A,Stemplinger I,Jungwirth R,Giamarellou H

更新日期：1996-01-01 00:00:00

abstract：:In Escherichia coli the frequency of spontaneous single-step mutation to high levels of resistance to the newer 4-quinolone agent norfloxacin was confirmed to be over 300-fold lower than that to the older agent nalidixic acid. Serial passage on incremental concentrations of drug was necessary to produce mutants highly...

journal_title：Antimicrobial agents and chemotherapy

authors： Hooper DC,Wolfson JS,Souza KS,Tung C,McHugh GL,Swartz MN

更新日期：1986-04-01 00:00:00

abstract：:Ritonavir-boosted darunavir with efavirenz may be considered a nucleoside-sparing regimen for treatment-naïve HIV-infected patients. However, the pharmacokinetics of this combination administered once daily have not been studied. We conducted a three-period interaction study with healthy volunteers. The subjects were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Soon GH,Shen P,Yong EL,Pham P,Flexner C,Lee L

更新日期：2010-07-01 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with pl...

journal_title：Antimicrobial agents and chemotherapy

authors： Klein K,Grønnemose RB,Alm M,Brinch KS,Kolmos HJ,Andersen TE

更新日期：2017-06-27 00:00:00

abstract：:We have previously identified a target site in HIV-1 RNA that was particularly accessible to a ribozyme and a short hairpin RNA (shRNA). To design small interfering RNAs (siRNAs) targeting this site, we evaluated the effects of siRNAs with different lengths on HIV-1 production. The potency and efficacy of these siRNAs...

journal_title：Antimicrobial agents and chemotherapy

authors： Scarborough RJ,Adams KL,Daher A,Gatignol A

更新日期：2015-09-01 00:00:00

abstract：:Transfer of piperaquine (PQ) into breast milk was examined in 27 Papua New Guinean women given a 3-day course of dihydroartemisinin-PQ or sulfadoxine-pyrimethamine-PQ during the second/third trimester. Breast milk was sampled on days 1, 2, 3 to 5, 7 to 11, and 14 to 17 postdelivery, a median of 70 days postdose (range...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore BR,Salman S,Benjamin J,Page-Sharp M,Yadi G,Batty KT,Siba PM,Mueller I,Davis TM

更新日期：2015-07-01 00:00:00

abstract：:In the present study we determined the resistance patterns of anaerobic bacteria from human saliva and stool specimens and investigated whether there were significant differences in resistance between outpatients and hospitalized patients, regardless of whether they had received antimicrobial agents. No bacterial stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Stark CA,Edlund C,Sjöstedt S,Kristensen G,Nord CE

更新日期：1993-08-01 00:00:00

abstract：:Limited antiretrovirals are currently available for the management of multidrug-resistant (MDR) HIV-1 infection. Ibalizumab, a recombinant humanized monoclonal antibody, represents the first novel agent for HIV-1 management in over a decade and is the first monoclonal antibody for the treatment of MDR HIV-1 infection ...

journal_title：Antimicrobial agents and chemotherapy

authors： Beccari MV,Mogle BT,Sidman EF,Mastro KA,Asiago-Reddy E,Kufel WD

更新日期：2019-05-24 00:00:00

abstract：:R4.0, a synthetic CCL5/RANTES-derived peptide, exerts potent anti-HIV-1 activity via its nonactivating interaction with CCR5, the major HIV-1 coreceptor. CCR5 chronic activation may promote undesirable inflammatory effects and enhance viral infection; thus, receptor antagonism is a necessary requisite. HIV-1 gp120, CC...

journal_title：Antimicrobial agents and chemotherapy

authors： Secchi M,Vassena L,Morin S,Schols D,Vangelista L

更新日期：2014-10-01 00:00:00

abstract：:The dose dependence of mezlocillin pharmacokinetics was examined in relation to renal function after intravenous doses of 1 and 5 g in 16 subjects with various degrees of renal impairment. Dose and time-average model-independent physiological parameters were calculated from plasma concentration and urinary excretion d...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangione A,Boudinot FD,Schultz RM,Jusko WJ

更新日期：1982-03-01 00:00:00

abstract：:The efficacy of intravenous peramivir against influenza A (H1N1) 2009 virus infection was evaluated in mice in which the immune system was suppressed by cyclophosphamide (CP) treatment. The mortality rate of the vehicle control group was 100%, and the mice lost 20% of their body weight on average by day 13 postinfecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Kodama M,Itoh Y,Kanazu T,Kobayashi M,Yoshida R,Sato A

更新日期：2013-05-01 00:00:00

abstract：:Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I...

journal_title：Antimicrobial agents and chemotherapy

authors： Osburne MS,Maiese WM,Greenstein M

更新日期：1990-07-01 00:00:00

abstract：:The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Pulse ME,Nguyen P,Peterson K,Silva J,Simecka JW,Valtierra D,Sabet M,Griffith DC

更新日期：2017-12-21 00:00:00

abstract：:The pharmacologic parameters and toxicity of netilmicin (6 mg/kg/day) given once daily (qd) or thrice daily (tid) for the treatment of urinary tract infections were studied in a randomized prospective study of 60 cancer patients. The overall efficacy was 96%. Nephrotoxicity, assessed by the measure of urinary excretio...

journal_title：Antimicrobial agents and chemotherapy

authors： Van der Auwera P,Meunier F,Ibrahim S,Kaufman L,Derde MP,Tulkens PM

更新日期：1991-04-01 00:00:00

abstract：:The in vitro inhibitory effects of quinolones on the bacterial DNA gyrase of Escherichia coli KL-16 and topoisomerase II of fetal calf thymus were compared. All the quinolones tested required higher concentrations to inhibit the topoisomerase II than to inhibit the DNA gyrase, and no correlation existed among their in...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoshino K,Sato K,Une T,Osada Y

更新日期：1989-10-01 00:00:00