Abstract:
INTRODUCTION:Stretch injuries in peripheral nerves can cause pain, paralysis, and loss of sensation. Although optimal treatment depends on the degree of injury, it is difficult to determine the severity of induced nerve damage. METHODS:The load-deformation curves of rat median nerves were generated from monotonic load-to-failure experiments to determine low, medium, and high strain levels. Additional excised median nerves were then elongated to induce damage at low (4%), medium (10% and 12%), and high (14% and 20%) tensile strains and the resulting structural damage was evaluated using second harmonic generation (SHG) imaging and light microscopy. RESULTS:No substantial structural changes occurred at 4% strain, but higher strain values resulted in disruption of the normal collagen architecture. CONCLUSIONS:The results demonstrate a spectrum of structural damage that can be monitored using SHG, a non-destructive imaging modality, and that the pattern of damage may correspond to functional deficit.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Sinclair EB,Andarawis-Puri N,Ros SJ,Laudier DM,Jepsen KJ,Hausman MRdoi
10.1002/mus.23443subject
Has Abstractpub_date
2012-12-01 00:00:00pages
899-907issue
6eissn
0148-639Xissn
1097-4598journal_volume
46pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::We propose a comprehensive model of spastic hypertonia based on clinical neurophysiology and validated using experimental data obtained from the pendulum test of the leg in 8 healthy volunteers and 15 spastic patients. This nonlinear computational model includes mechanical parameters and a stretch reflex representatio...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.1196
更新日期:2001-12-01 00:00:00
abstract::To define numerically the clinical severity of facioscapulohumeral muscular dystrophy (FSHD), we developed a protocol that quantifies muscle weakness by combining the functional evaluation of six muscle groups affected in this disease. To validate reproducibility of the protocol, 69 patients were recruited. Each patie...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21671
更新日期:2010-08-01 00:00:00
abstract:INTRODUCTION:Diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) remains uncertain when nerve conduction studies (NCS) fail to show demyelination. METHODS:We conducted a retrospective study of patients who presented with clinical criteria of CIDP in whom electrodiagnostic (EDx) criteria of definite o...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24693
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Thymectomy is required for the treatment of thymoma-associated myasthenia gravis (MG). However, MG may develop only after thymectomy, a condition known as post-thymectomy MG. This study aimed to investigate the risk factors for post-thymectomy MG in patients with thymoma. METHODS:We retrospectively identi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.27169
更新日期:2021-01-12 00:00:00
abstract::The electrical and mechanical properties of paralyzed human thenar muscles were measured in response to supramaximal stimulation of the median nerve in individuals with chronic cervical spinal cord injury. These data were compared to those recorded from control muscles. Spontaneous motor unit activity was common in pa...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199707)20:7<788::aid-mus2>
更新日期:1997-07-01 00:00:00
abstract::A careful monitoring of the accuracy of diagnosis in six cases of Guillain-Barre syndrome has shown that a substantial proportion of these patients initially diagnosed as having Guillain-Barre syndrome on the basis of characteristic clinical findings and an elevated level of protein in the spinal fluid had a neuropath...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880050206
更新日期:1982-02-01 00:00:00
abstract::Variable-frequency stimulation trains (VFTs) that take advantage of the catchlike property of skeletal muscle have been shown to augment the force production of fatigued muscles compared with constant-frequency trains (CFTs). The present study is the first to report the force augmentation produced by VFTs after fatigu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199809)21:9<1145::aid-mus5
更新日期:1998-09-01 00:00:00
abstract::Central fatigue is a subjective phenomenon which can be examined using transcranial magnetic stimulation (TMS). To assess central fatigue, we compared TMS and peripheral electrical stimulations in patients with central nervous system (CNS) lesions and controls before and after an exhaustive task. The recovery times of...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199611)19:11<1429::AID-MUS
更新日期:1996-11-01 00:00:00
abstract:INTRODUCTION:Posttraumatic elbow contracture is clinically challenging because injury often disrupts multiple periarticular soft tissues. Tissue specific contribution to contracture, particularly muscle, remains poorly understood. METHODS:In this study we used a previously developed animal model of elbow contracture. ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26344
更新日期:2018-12-01 00:00:00
abstract::Macroelectromyography is used to study the electrical activity of the entire motor unit. The amplitude of the motor unit action potential (MUP), recorded from a bared cannula, is dependent on the number and size of muscle fibers in the motor unit. In most situations of reinnervation the local fiber density (FD) as rec...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:INTRODUCTION:We describe the nerve ultrasound findings in patients with type II diabetes mellitus who have neuropathic symptoms and signs. METHODS:Fifty-five healthy controls and 44 diabetic patients underwent clinical, sonographic, and electrophysiological evaluation. Patients were studied at a mean of 14.3 years aft...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24981
更新日期:2016-06-01 00:00:00
abstract::Peripheral neuropathies are reported to arise as a result of the systemic inflammatory response produced by a full-thickness cutaneous burn injury. This study was designed to characterize the magnitude and time course of functional and morphological changes in peripheral axons that arise after a full-thickness dermal ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20306
更新日期:2005-05-01 00:00:00
abstract::Changes in contractile rate of force development (RFD), measured within a short time interval from contraction initiation, were measured after a period of strength training that led to increases in muscle fascicle length but no measurable change in neuromuscular activity. The relationship between training-induced shif...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21259
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:Venous access for therapeutic plasma exchange (TPE) in myasthenia gravis (MG) can be achieved by central venous catheters (CVC) or peripheral veins (PV), and the preferred method varies among providers. We evaluated our institutional experience with TPE venous access method and complications. METHODS:We r...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23508
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:Breast cancer is exceptionally associated with anti-collapsin response mediator protein 5 (anti-CRMP5) antibody or demyelinating neuropathy. This paraneoplastic antibody is itself not associated with demyelinating neuropathy. METHODS:Herein we describe a patient with a predominantly sensory ataxic demyeli...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22036
更新日期:2011-05-01 00:00:00
abstract::Impaired torque production is a major physical impairment following stroke, and has been studied extensively in isometric conditions. However, functional use of a limb requires torque production during movement, and the effects of velocity on maximal torque production may be abnormally enhanced in the paretic limb. Th...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20157
更新日期:2004-12-01 00:00:00
abstract::Immersion of rat hemidiaphragms in Ca2+-free Krebs solution (KS) containing Ca2+ chelator in vitro leads to separation of basal lamina from the plasma membrane, as well as transient contracture and rapid loss of twitch response [calcium paradox (CP) phase 1]. Subsequent immersion in regular KS results in necrosis of m...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090306
更新日期:1986-03-01 00:00:00
abstract::Intraoperative electrophysiological monitoring of the spinal cord has traditionally been done by recording somatosensory evoked potentials (SEP). There is a risk that SEPs can be unaltered when significant injury to the anterior spinal cord has occurred. The purpose of this report is to describe a simple technique for...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880180309
更新日期:1995-03-01 00:00:00
abstract::There is a paucity of validated tests to quantify hand function impairment due to carpal tunnel syndrome (CTS). The aim of this study was to test the validity and reliability of the Purdue Pegboard Test (PPT) in CTS patients. We compared 190 CTS patients with 122 healthy, age-matched controls. CTS severity was determi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21856
更新日期:2011-02-01 00:00:00
abstract::The loss of contractile protein in Duchenne muscular dystrophy could result from low rates of synthesis, abnormally high rates of protein degradation, or a combination of both. We measured overall protein degradation rates in cultured human muscle cells obtained at biopsy from patients with Duchenne dystrophy or vario...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880080312
更新日期:1985-03-01 00:00:00
abstract::The present study was conducted to determine the effects of acute overload exercise on mitochondrial DNA and the structure of skeletal muscles. Rats were forced to run for 20 min until reaching complete exhaustion. We detected the large-scale deletion (7052 bp) of mitochondrial DNA by the nested polymerase chain react...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199902)22:2<258::aid-mus15
更新日期:1999-02-01 00:00:00
abstract:INTRODUCTION:Autosomal dominant haploinsufficiency of GATA2 causes monocytopenia and natural killer cell lymphopenia, resulting in predisposition to mycobacterial, fungal, and viral infections. METHODS:Herein we report on the clinical, serologic, electrophysiologic, and pathologic evaluations of a 29-year-old woman wi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25581
更新日期:2018-01-01 00:00:00
abstract::A patient in perfect health prior to electrical shock developed an ALS-like syndrome after the shock. Onset of the disease occurred in the limb through which the shock entered, and subsequently followed a course well-described in previous case reports. Possible mechanisms of disease are discussed. ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880141008
更新日期:1991-10-01 00:00:00
abstract::The clinical and neurophysiological features of multifocal motor neuropathy (MMN) indicate selective involvement of motor axons, but pathological abnormalities in sensory axons suggest a more widespread disease process. The present study was undertaken to determine whether the focal abnormalities are associated with w...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10262
更新日期:2002-12-01 00:00:00
abstract:INTRODUCTION:Congenital myotonic dystrophy (CDM) occurs when symptoms of myotonic dystrophy present at birth. In this study we evaluated the relationship between physical function, muscle mass, and age to provide an assessment of the disease and help prepare for therapeutic trials. METHODS:CDM participants performed t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25482
更新日期:2017-08-01 00:00:00
abstract::To investigate whether various myelin markers could detect pathological changes in myelination, the activity of 2'-3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and the level of PO protein were compared in the peripheral nervous system (PNS) of the dystrophic mouse and chicken and their phenotypically normal sibling...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880080207
更新日期:1985-02-01 00:00:00
abstract::Polylysines, polyornithine, and protamine increased the release of creatine kinase (CK) and lactate dehydrogenase (LDH) from frog muscles. With 5 micrograms/ml (50 nM) of a polylysine of molecular weight 100,000, enzyme release reached peak values (ten-fold above control) within 30 minutes; subsequent removal of the p...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880080212
更新日期:1985-02-01 00:00:00
abstract::The recommendations for clinical research standards published in 2000 by a task force of the Medical Scientific Advisory Board (MSAB) of the Myasthenia Gravis Foundation of America (MGFA) were largely successful in introducing greater uniformity in the recording and reporting of MG clinical trials. Recognizing that ch...
journal_title:Muscle & nerve
pub_type: 共识发展会议,杂志文章
doi:10.1002/mus.23330
更新日期:2012-06-01 00:00:00
abstract::Peripheral nerve lesions are sometimes associated with focal dystonia. We diagnosed ulnar neuropathy in 28 of 73 (40%) cases of occupational cramp in musicians. Focal slowing of ulnar conduction across the elbow was identified in 15 of 19 (79%) patients using the near nerve technique and in 5 of 17 (29%) patients usin...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880190403
更新日期:1996-04-01 00:00:00
abstract::An electrophysiologic study of peripheral nerve excitability was performed in patients with hyperkalemic periodic paralysis (HPP) and in normal controls. It was found that a marked degree of neural hyperexcitability existed in all patients with HPP who showed cold sensitivity. The results suggest involvement of the ne...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880020402
更新日期:1979-07-01 00:00:00