Effect of platelet-rich plasma on bone healing of fresh frozen bone allograft in mandibular defects: a histomorphometric study in dogs.

Abstract:

OBJECTIVE:This study histologically analyzed the healing of fresh frozen bone allograft (FFBA) with or without platelet-rich plasma (PRP) in bony defects surgically created in the mandible of dogs. MATERIAL AND METHODS:Bilateral resection defects were surgically created on the inferior border of the mandible in 10 dogs. The defects were randomly divided into three groups: C (the defect was filled by blood clot only), FFBA (the defect was filled with particulate FFBA), and FFBA/PRP (the defect was filled with particulate FFBA combined with PRP). The animals were euthanized at 12 weeks post-surgery. Histomorphometric and histological analyses were performed. Data were statistically analyzed using Friedman test and Dunn test (P < 0.05). RESULTS:Group FFBA/PRP presented a statistically greater mineralized bone area and a smaller marrow bone area than Groups FFBA and C. CONCLUSIONS:The use of PRP improved the incorporation of FFBA, increasing the density of newly formed bone at 12 weeks post-surgery.

journal_name

Clin Oral Implants Res

authors

Messora MR,Nagata MJ,Pola NM,de Campos N,Fucini SE,Furlaneto FA

doi

10.1111/clr.12008

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

1347-53

issue

12

eissn

0905-7161

issn

1600-0501

journal_volume

24

pub_type

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