Abstract:
OBJECTIVE:The early effect of platelet-rich plasma (PRP) on bone regeneration in combination with dense biphasic hydroxyl apatite (HA)/beta-tricalcium phosphate (TCP) particles (ratio 60%/40%) was evaluated in rat cranial defects with a diameter of 6.2 mm. We hypothesize that PRP exerts its beneficial effect on bone regeneration within the first and second week after application in a bone defect combined with an osteoconductive material. MATERIALS AND METHODS:Forty-five rats were used in the study, in which always one cranial defect was created. The defects were filled with HA/beta-TCP particles and HA/beta-TCP particles combined with PRP gel. Some defects were also left unfilled as control. One and two weeks after surgery specimens were retrieved for light microscopy [hematoxylin-eosin, trichrome staining (Masson modification Goldner) and basic fuchsin-methylene blue] and micro-CT analysis to evaluate bone formation and neovascularization. One-way analysis of variance was performed on the raw data obtained from micro-CT analyses. RESULTS:The histological evaluation showed no effect of PRP on bone formation and neovascularization for both implantation times. In the first week, the defect closure was evaluated subjectively to be between 10% and 50% in all samples, whereas no difference among the groups appeared to occur. After 2 weeks, complete bridging of the original bone defect was observed for most of the empty defects, as well as for the defects that contained HA/beta-TCP particles. The trichrome staining revealed no difference in the number of blood vessels between the PRP and non-PRP groups for both implantation times. The osteoconductive nature of dense HA/beta-TCP particles was confirmed, as the bone formation was guided by their outer surfaces and resulted in a larger amount of newly formed bone in comparison with the empty defects. The quantitative micro-CT analysis demonstrated a statistically significant difference in new bone formation between the empty defects and defects filled with particles after 1 week of implantation, but there was no difference between the non-PRP and PRP groups. In at the second week, no difference in bone formation among all groups was observed, whereas even the non-filled control defects were almost completely closed. CONCLUSIONS:A 6.2 mm cranial defect is not a critical-sized defect in rats. Rat PRP had no effect on the early stages of bone healing in addition to an osteoconductive material. Dense HA/beta-TCP particles showed a beneficial effect on bone formation already after 1 and 2 weeks of implantation in non-critical-sized cranial defects in rats.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Plachokova AS,van den Dolder J,Stoelinga PJ,Jansen JAdoi
10.1111/j.1600-0501.2006.01327.xsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
244-51issue
2eissn
0905-7161issn
1600-0501pii
CLR1327journal_volume
18pub_type
杂志文章abstract:OBJECTIVES:To analyze the clinical performance and bone-to-implant contact (BIC) rate of two loading concepts on successfully healed and explanted palatal implants in humans. METHODS:From 2000 to 2006, two independent groups of patients, requiring maximum anchorage, were treated. Group 1 (n=36) was subjected to immedi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01732.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:A precise and scientifically established method for the evaluation of the bone quality/primary stability is the measure of the insertion torque (IT). The aim of this study was a comparison between the IT values and the bone-implant contact percentage (BIC) of human implants retrieved after a 4/8-week healing ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01599.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:To assess the bleeding on probing (BOP) tendency and periodontal probe penetration when applying various probing forces at implant sites in patients with a high standard of oral hygiene with well-maintained peri-implant tissues. MATERIAL AND METHODS:Seventeen healthy patients with excellent oral hygiene in ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2008.01601.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To appraise the feasibility of loading four implants with a pre-existing denture converted to a fixed dental prosthesis (FDP) on the day of implant surgery compared with waiting for 3- to 4-month healing. METHODS:Patients with an edentulous, fully healed mandible were recruited in a faculty clinic to partak...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12279
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:To assess the impact of collagen membrane application on bone formation surrounding implants placed simultaneously with the bone ring technique. MATERIAL AND METHODS:Dental implants were inserted simultaneously with the bone ring technique in standardized, vertical alveolar bony defects in the mandible of d...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13543
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Graft consolidation follows a gradient that reflects the properties of bone substitutes at sites of sinus augmentation. Here we present an analytical method to investigate the process of graft consolidation taking the distance from the maxillary host bone into account. MATERIAL AND METHODS:We therefore evalu...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01733.x
更新日期:2009-10-01 00:00:00
abstract::The prosthodontic section of the 1997 ITI Consensus Conference in Vitznau, Switzerland, examined a broad spectrum of issues related to the prosthodontic phase of dental implant therapy. Topics included diagnosis and treatment planning, considerations for the use of ITI prosthodontic components, management of the parti...
journal_title:Clinical oral implants research
pub_type: 共识发展会议,杂志文章,评审
doi:10.1034/j.1600-0501.2000.011s1101.x
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to evaluate the 5-year performance and success rate of titanium screw-type implants with the titanium plasma spray (TPS) or the sand-blasted, large grit, acid-etched (SLA) surface inserted in a two-stage sinus floor elevation (SFE) procedure in the posterior maxilla. MA...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01573.x
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:Dental implants have traditionally been made from titanium or its alloys, but recently full-ceramic implants have been developed with comparable osseointegration properties and functional strength properties to titanium. These ceramic implants may have advantages in certain patients and situations, for exa...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12598
更新日期:2016-12-01 00:00:00
abstract::The aim of this study was to compare implant-bone interface stresses and peri-implant principal strains in anisotropic versus isotropic three-dimensional finite element models of an osseointegrated implant in the posterior mandible. We obtained anisotropic (transversely isotropic) elastic constants for mandibular bone...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2001.120614.x
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of the topical application of melatonin compared with collagenized porcine bone grafts to accelerate bone formation 2 months after their insertion in tibiae rabbits. MATERIAL AND METHODS:Twenty New Zealand rabbits weighing 3,900-4,500 g were used. Twenty colla...
journal_title:Clinical oral implants research
pub_type: 杂志文章,收录出版
doi:10.1111/clr.12364
更新日期:2015-04-01 00:00:00
abstract::This study was undertaken to evaluate the use of tissue-engineered bone as grafting material for alveolar augmentation with simultaneous implant placement. Twelve adult hybrid dogs were used in this study. One month after the extraction of teeth in the mandible region, bone defects on both sides of the mandible were i...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01246.x
更新日期:2006-10-01 00:00:00
abstract::In a prospective study, 20 patients who underwent harvesting of chin grafts as outpatients, were followed up for 12 months (3 further patients with incomplete follow-up data were excluded from the study). Preoperatively and 7 days, 1, 3, 6 and 12 months postoperatively, follow-up data were assessed. Evaluation of the ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2001.120510.x
更新日期:2001-10-01 00:00:00
abstract::The present paper is part of a comprehensive study of dental conditions and attitudes in a Swedish county population aged 45-69 years. A questionnaire was mailed to 3000 randomly-sampled individuals. The response rate was 79.4%. Part of the questionnaire contained questions about subjective need for implant treatment....
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1991.020301.x
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVES:To analyze clinical, esthetic, radiographic, and prosthetic outcomes of implants and implant-supported reconstructions using two types of dental implants with non-matching implant abutment junctions. MATERIALS AND METHODS:A total of 64 patients in need of dental implant therapy with fixed reconstructions we...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12721
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate histologic and histomorphometric bone characteristics with a focus on vitality after lateral alveolar ridge augmentation using an autogenous bone graft as a block covered by either a platelet-rich fibrin (PRF) membrane (test group) or a standard procedure involving coverage of th...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13605
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:The objective of this biomechanical study was to explore the effect of bone micro-morphology on initial intraosseous stability of implants with different designs. MATERIAL AND METHODS:Straumann and Astra Tech dental implants were placed into anterior and posterior regions of completely edentulous maxilla and m...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01265.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine the microbial composition of early (after 3 days, D3) and mature biofilms (after 31 days, D31) on materials typically used in implant/abutment buildups. Implant/abutment materials with different surface roughness values (Ra ) were compared to detect differences in the qua...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13656
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the reproducibility and the accuracy of volumetric measurements of specimens imitating localized alveolar ridge defects using an optical three-dimensional (3D) system. MATERIAL AND METHODS:Eight pairs of specimens (five with a cuboid and three with a geometrically compl...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01382.x
更新日期:2007-10-01 00:00:00
abstract::Bovine mineral spongiosa block (B-SB) was used as a bone substitute in sinus augmentation procedures in 10 consecutive patients. Implants were placed during the same session. The purpose of this study was to histopathologically examine the healing of the grafted site around the implants at 12 months. Radiographic foll...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130411.x
更新日期:2002-08-01 00:00:00
abstract:PURPOSE:The aim of this prospective clinical trial was to assess clinical, radiological, and esthetic outcomes of immediate-loaded post-extractive implants after 1 year of follow-up. MATERIALS AND METHODS:Twenty-four consecutive patients (15 females and nine males) with a mean age of 47.27 years (range 35-65) requirin...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1111/clr.12403
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to evaluate the Nobel Direct and Nobel Perfect one-piece implants (OPIs) when used for immediate function. MATERIAL AND METHODS:Forty-eight patients were provided with 115 OPIs for loading with a provisional crown or a bridge within 24 h and followed for at least 12 mon...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01346.x
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To compare the effect of two surgical techniques, lateral condensation and bone drilling, on changes in temperature of the adjacent low-density bone during implant placement into posterior maxilla and to investigate the influence of the host factors - age, gender, region of implantation, bone density, and th...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12191
更新日期:2014-08-01 00:00:00
abstract::Well integrated and clinically functional titanium dental implants retrieved in humans after 14 and 40 months of settlement were used for the characterization of the interfacial area between the plasma-sprayed coating and the surrounding mineralized bone. Electron microscopic studies were performed from undecalcified ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2000.011004279.x
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to determine how the crown-implant ratio (C/I ratio) influences crestal bone loss and implant success rates after a 3-year follow-up, using implants with a sintered porous surface (SPS). MATERIALS AND METHODS:On the basis of preestablished inclusion and exclusion criter...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12105
更新日期:2014-02-01 00:00:00
abstract::The aim of the study was to investigate temperature changes at the implant-bone interface during simulated implant surface decontamination with a 809-nm gallium-aluminium-arsenid (GaAlAs) semiconductor laser. Stepped cylinder implants with a diameter of 3.8 mm and a length of 11 mm with two different surfaces (sand-bl...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2003.140112.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the effects of a nanostructured calcium coating on the surfaces of blasted Ti implants on peri-implant bone formation in the rabbit tibiae. MATERIAL AND METHODS:Threaded implants (3.75 mm in diameter, 6 mm in length) were roughened by hydroxyapatite (HA) blasting ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01323.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:As biomaterial-induced modulation of mediators of the immune response may be a potential therapeutic approach to enhance wound healing events, the aim of this study was to delineate the effects of titanium surface modification on macrophage phenotype and function. MATERIAL AND METHODS:Rodent bone marrow-der...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13522
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To assess the influence of a collagen membrane placed subjacent to a pristine sinus mucosa on the healing outcome of a sinus floor elevation procedure. MATERIALS AND METHODS:Eight Pelibuey sheep (Cubano rojo) underwent sinus floor elevation on both sides of the maxilla. At a randomly selected side (test), a ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12762
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Crestal bone loss around dental implants is a criterion for success as this could prevent loss of implant and superstructure. The macrogeometry of the implant could influence bone remodelling when the implant-abutment connection is placed at crestal bone level or above. The aim of this study was to evaluate c...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12581
更新日期:2016-12-01 00:00:00