Abstract:
OBJECTIVE:The aim of this study was to evaluate the effect of the topical application of melatonin compared with collagenized porcine bone grafts to accelerate bone formation 2 months after their insertion in tibiae rabbits. MATERIAL AND METHODS:Twenty New Zealand rabbits weighing 3,900-4,500 g were used. Twenty collagenized porcine bone (MP3) grafts, twenty melatonin-impregnated bone grafts, and twenty control areas were placed in the proximal metaphyseal area of both rear tibias. Four groups were formed according to the moment in which animal killing was carried out: Group I (15 days), Group II (30 days), Group III (45 days) and Group IV (60 days). Cortical width and cortical length of bone formation was measured. Following implantation, an anteroposterior and lateral radiological study was carried out. Samples were sectioned at 5 μm and stained using hematoxylin-Eeosin, Masson's trichromic, and Gordon-Switt reticulin stains. RESULTS:After 60 days of treatment period, melatonin increased the length of cortical bone formation 99.03 ± 0.61% like control 98.90 ± 3.82% compared with porcine bone 92.73 ± 1.08%. Related to perimeter of cortical bone of the tibiae melatonin new bone was 98.35 ± 1.14% like control 98.0 ± 1.43% more than porcine bone 92.05 ± 1.03%. Histomorphometric values related to porcine bone were connective tissue 49.16 ± 2.4%, graft material (MP3) 23.52 ± 2.3%, and new bone formation 27.32 ± 1.4% compared with test group with melatonin 24.5 ± 1.2%, connective tissue 45.1 ± 1.2%, and new bone formation of 30.4 ± 1.0%. CONCLUSION:Melatonin has proven to regenerate the width and length of cortical bone in tibiae rabbits more quickly than collagenized porcine bone. Melatonin acts as a bone stimulator compared with porcine bone and control sites.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Calvo-Guirado JL,Gómez-Moreno G,Maté-Sánchez JE,López-Marí L,Delgado-Ruiz R,Romanos GEdoi
10.1111/clr.12364subject
Has Abstractpub_date
2015-04-01 00:00:00pages
399-406issue
4eissn
0905-7161issn
1600-0501journal_volume
26pub_type
杂志文章,收录出版abstract:OBJECTIVE:Bacterial species have been found harboring the internal surface of dental implants as consequence of their failed connections. The aim of the present study was to compare the detection frequency of bacterial leakage from human saliva through the implant-abutment interface, under non-loading conditions, using...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02280.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:Published information regarding the use of rat jawbones for dental implant osseointegration research is limited and often inconsistent. This study assessed the suitability and feasibility of placing dental implants into the rat maxilla and to establish parameters to be used for dental implant research using ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12571
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:The aim of this controlled in vitro study was to identify and quantify up to 38 microbial species penetrating through the screw-retained implant prostheses with different sealing materials. MATERIAL AND METHODS:Sixty morse cone implants were restored with single-unit screw-retained prostheses. All the compo...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12790
更新日期:2017-02-01 00:00:00
abstract::Parkinson's disease (PD) often affects the oro-pharyngeal musculature, leading to problems with speaking, chewing and swallowing. The inevitable reduction in food and fluid intake contributes to the further deterioration of neurological symptoms. Parkinson's disease patients have great difficulties in adjusting to the...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2000.011006566.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVES:To appraise the feasibility of loading four implants with a pre-existing denture converted to a fixed dental prosthesis (FDP) on the day of implant surgery compared with waiting for 3- to 4-month healing. METHODS:Patients with an edentulous, fully healed mandible were recruited in a faculty clinic to partak...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12279
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:The goal of this study was to enhance the blood responses to titanium (Ti) surfaces used for dental implant application through the formation of a TiO2 nano-mesh surface layer produced by a fast electrochemical anodization treatment. MATERIAL AND METHODS:Electrochemical anodization treatments with different...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02152.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of treated periodontitis on implant outcomes in partially edentulous individuals compared with periodontally healthy patients. MATERIAL AND METHODS:Longitudinal studies reporting on implant survival, success, incidence of peri-implantitis, bone loss and periodontal status, and on p...
journal_title:Clinical oral implants research
pub_type: 杂志文章,评审
doi:10.1111/clr.12684
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To appraise whether adverse biological events following oral implant placement may be associated with perioperative use of non-steroidal anti-inflammatory drugs (NSAIDs). METHODS:All patients treated in a university faculty postgraduate dental clinic between 1979 and 2012 that had experienced a failing and s...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12493
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:This study evaluated implant stability and clinical outcomes obtained with magnesium-incorporated oxidised implants (Mg titanate) and compared them to those blasted magnesium-incorporated oxidised implants (blasted Mg titanate). PATIENTS AND METHODS:Mg titanate was manufactured using the microarc oxidation ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12091
更新日期:2014-05-01 00:00:00
abstract:AIM:The aim of this controlled randomized clinical trial was to evaluate the efficacy of a xenogeneic collagen matrix (CM) to augment the keratinized tissue around implants supporting prosthetic restorations at 6 months when compared with the standard treatment, the connective tissue autograft, CTG). MATERIALS AND MET...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2011.02260.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:To determine the difference in light reflection of oral mucosa covering titanium (Ti) or zirconia (ZrO(2)) abutments as it relates to the thickness of the covering mucosa. MATERIAL AND METHODS:Fifteen anterior implants (Astra Osseo speed(®)) in 11 patients were fitted with a Ti or a ZrO(2) abutment (cross-o...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02082.x
更新日期:2011-10-01 00:00:00
abstract:AIM:To evaluate the soft tissue and the dimensional changes of the alveolar bony crest at sites where deproteinized bovine bone mineral (DBBM) particles, concomitantly with the placement of a collagen membrane, were used at implants installed into sockets immediately after tooth extraction. MATERIAL AND METHODS:The pu...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02332.x
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVES:Osteoporosis is known to impair the process of implant osseointegration. The recent discovery that statins (HMG-CoA reductase inhibitors) act as bone anabolic agents suggests that statins can be used as potential agents in the treatment of osteoporosis. Therefore, we hypothesized that statins will promote os...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01630.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:In regenerative medicine, surface engineering of bioinert synthetic materials is often required in order to introduce bioactive species that can promote cell adhesion, proliferation, viability and enhanced ECM-secretion functions. The aim of this work is to study cell interaction with alumina-modified surfac...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01642.x
更新日期:2009-03-01 00:00:00
abstract::The aim of the study was to evaluate two bioresorbable polylactic acid (PLA) filler materials in a guided bone regeneration (GBR) model system. The first was Polyfibre, a fibrous PLA filler material. Polyfoam, the second material tested, consisted of a spongy PLA filler material. In each group there were eight rabbits...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1046/j.0905-7161.2003.00930.x
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:The early effect of platelet-rich plasma (PRP) on bone regeneration in combination with dense biphasic hydroxyl apatite (HA)/beta-tricalcium phosphate (TCP) particles (ratio 60%/40%) was evaluated in rat cranial defects with a diameter of 6.2 mm. We hypothesize that PRP exerts its beneficial effect on bone re...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01327.x
更新日期:2007-04-01 00:00:00
abstract::The purpose of this study was to examine the healing potential and re-osseointegration in peri-implant infection defects adjacent to various implant surfaces. In 7 female Beagle dogs, a total of 41 titanium oral implants (ITI, Straumann, Waldenburg; Switzerland) with a sink depth of 6 mm (diameter 2.8 mm) were placed ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1999.100205.x
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:Maxillary sinus augmentation procedures with bone replacement grafts aimed to increase bone height in the posterior maxilla. During healing, bone particles are partially resorbed and replaced by the patient's own bone. Vitamin D plays an essential role in calcium homeostasis and is critical for bone formatio...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12641
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:Retrospectively, we assessed the likelihood that peri-implantitis was associated with a history of systemic disease, periodontitis, and smoking habits. METHODS:Data on probing pocket depth (PPD), bleeding on probing (BOP), and radiographic bone levels were obtained from individuals with dental implants. Per...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12208
更新日期:2014-04-01 00:00:00
abstract::The aim of this study was to evaluate guided bone regeneration (GBR) around dental implants placed in atrophic alveolar ridges using an experimental, nonporous bioresorbable barrier. In 8 Rhesus monkeys, the maxillary canines and lateral incisors were extracted bilaterally and the remaining alveoli were reduced to cre...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080411.x
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:To measure in vivo impact of dense bone overheating on implant osseointegration and peri-implant bone resorption comparing different bur irrigation methods vs. no irrigation. MATERIALS AND METHODS:Twenty TI-bone implants were inserted in the inferior edge of mandibles of sheep. Different cooling procedures ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12127
更新日期:2014-06-01 00:00:00
abstract::Bovine mineral spongiosa block (B-SB) was used as a bone substitute in sinus augmentation procedures in 10 consecutive patients. Implants were placed during the same session. The purpose of this study was to histopathologically examine the healing of the grafted site around the implants at 12 months. Radiographic foll...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130411.x
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:The transcrestal approach with osteotomes is a commonly applied and predictable technique for maxillary sinus floor elevation. However, Schneiderian membrane perforation is a common and often inevitable intraoperative complication. Recently, the use of balloons has been proposed to reduce the risk of sinus m...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2012.02506.x
更新日期:2013-09-01 00:00:00
abstract::In a prospective study, 20 patients who underwent harvesting of chin grafts as outpatients, were followed up for 12 months (3 further patients with incomplete follow-up data were excluded from the study). Preoperatively and 7 days, 1, 3, 6 and 12 months postoperatively, follow-up data were assessed. Evaluation of the ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2001.120510.x
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVES:To present the characteristics and level of evidence (LOE) of clinical studies published in leading oral implantology journals during 2008-2018 and to explore whether the LOE of a study is associated with its scientific and social impact. MATERIALS AND METHODS:Clinical studies with direct relevance to the e...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13641
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To identify clinical studies evaluating efficiency and/or effectiveness of digital technologies as compared to conventional manufacturing procedures for the fabrication of implant-supported reconstructions. MATERIALS AND METHODS:A systematic search from 1990 through July 2017 was performed using the online d...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13300
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:Guided bone regeneration (GBR) is a commonly utilized surgical technique in the craniofacial region. The transcriptional mechanisms associated with this type of bone regeneration are not well understood. The aim of this study was to characterize the transcriptome associated with GBR of a critical-size calvar...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02104.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the necessity of three-dimensional imaging (computed tomography [CT]/cone-beam computed tomography [CBCT]) for paramedian insertion of palatal implants. MATERIAL AND METHODS:Lateral radiographs and CBCT scans were performed from 18 human skulls. For lateral cephalometry, the nasal floor (right/l...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02021.x
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the osteoconductive properties and biological performance of porous titanium granules used in osseous defects adjacent to titanium implants. MATERIAL AND METHODS:In this animal experimental study, calibrated defects were prepared in the tibias of 24 New Zealand rabbi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01813.x
更新日期:2010-02-01 00:00:00
abstract::The purpose of this study was to clinically evaluate an absorbable collagen membrane (Bio-Gide) and a nonabsorbable polytetrafluoroethylene membrane (PTFE), associated or not with bone grafts, for the treatment of ligature-induced peri-implantitis defects in dogs. The bilateral mandibular premolars were removed from 5...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2001.012002115.x
更新日期:2001-04-01 00:00:00