Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats.

Abstract:

OBJECTIVES:Osteoporosis is known to impair the process of implant osseointegration. The recent discovery that statins (HMG-CoA reductase inhibitors) act as bone anabolic agents suggests that statins can be used as potential agents in the treatment of osteoporosis. Therefore, we hypothesized that statins will promote osteogenesis around titanium implants in subjects with osteoporosis. MATERIAL AND METHODS:Fifty-four female Sprague Dawley rats, aged 3 months old, were randomly divided into three groups: Sham-operated group (SHAM; n=18), ovariectomized group (OVX; n=18), and ovariectomized with Simvastatin treatment group (OVX+SIM; n=18). Fifty-six days after being ovariectomized (OVX), screw-shaped titanium implants were inserted into the tibiae. Simvastatin was administered orally at 5 mg/kg each day after the placement of the implant in the OVX+SIM group. The animals were sacrificed at either 28 or 84 days after implantation and the undecalcified tissue sections were obtained. Bone-to-implant contact (BIC) and bone area (BA) within the limits of implant threads were measured around the cortical (zone A) and cancellous (zone B) bone regions. Furthermore, bone density (BD) of zone B in a 500 microm wide zone lateral to the implants was also measured. RESULTS:There were no significant differences in BIC and BA measurements in zone A in any of the three groups at either 28 or 84 days after implantation (P>0.05). By contrast, in zone B, significant differences in the measurement of BIC, BA, and BD were observed at 28 and 84 days between all three groups. Bone healing decreased with lower BIC, BA, and BD around implant in OVX group compared with other two groups, and Simvastatin reversed the negative effect of OVX on bone healing around implants with the improvement of BIC, BA, and BD in zone B. CONCLUSION:Osteoporosis can significantly influence bone healing in the cancellous bone around titanium implants and Simvastatin was shown to significantly improve the osseointegration of pure titanium implants in osteoporotic rats.

journal_name

Clin Oral Implants Res

authors

Du Z,Chen J,Yan F,Xiao Y

doi

10.1111/j.1600-0501.2008.01630.x

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

145-50

issue

2

eissn

0905-7161

issn

1600-0501

pii

CLR1630

journal_volume

20

pub_type

杂志文章
  • Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs.

    abstract::The purpose of this study was to examine the healing potential and re-osseointegration in peri-implant infection defects adjacent to various implant surfaces. In 7 female Beagle dogs, a total of 41 titanium oral implants (ITI, Straumann, Waldenburg; Switzerland) with a sink depth of 6 mm (diameter 2.8 mm) were placed ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1034/j.1600-0501.1999.100205.x

    authors: Wetzel AC,Vlassis J,Caffesse RG,Hämmerle CH,Lang NP

    更新日期:1999-04-01 00:00:00

  • Influence of titanium base, lithium disilicate restoration and vertical soft tissue thickness on bone stability around triangular-shaped implants: A prospective clinical trial.

    abstract:OBJECTIVE:To evaluate how vertical mucosal tissue thickness affects crestal bone stability around triangular-shaped bone-level implants, restored with low profile titanium bases and monolithic lithium disilicate restorations. MATERIAL AND METHODS:Fifty-five bone-level implants of 4.3 mm diameter were evaluated in 55 p...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/clr.13263

    authors: Linkevicius T,Linkevicius R,Alkimavicius J,Linkeviciene L,Andrijauskas P,Puisys A

    更新日期:2018-07-01 00:00:00

  • Clinical study on survival rate of short implants placed in the posterior mandibular region: resonance frequency analysis.

    abstract:OBJECTIVE:Short implants are increasingly used, but there is doubt about their performance being similar to that of regular implants. The aim of this study was to compare the mechanical stability of short implants vs. regular implants placed in the edentulous posterior mandible. MATERIAL AND METHODS:Twenty-three patie...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.12394

    authors: Queiroz TP,Aguiar SC,Margonar R,de Souza Faloni AP,Gruber R,Luvizuto ER

    更新日期:2015-09-01 00:00:00

  • Radiographic changes in height and volume after lateral GBR procedures with different ratios of deproteinized bovine bone mineral and autogenous bone at different time points. An experimental study.

    abstract:OBJECTIVE:Estimate changes in augmentation height and volume after lateral guided bone regeneration (GBR) augmentation with different ratios of deproteinized bovine bone mineral (DBBM) and particulate autogenous bone (PAB) and autogenous bone block (ABB), at different time points. MATERIAL AND METHODS:Twenty-four mini...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.13687

    authors: Aludden H,Mordenfeld A,Cederlund A,Dahlin C,Spin-Neto R,Veiss-Pedersen P,Sritharan B,Starch-Jensen T

    更新日期:2020-11-20 00:00:00

  • Immediate functional loading of TiOblast dental implants in full-arch edentulous maxillae: a 3-year prospective study.

    abstract:INTRODUCTION:Immediate functional loading of dental implants for full-arch restoration is a patient-friendly approach, shown to be feasible with a good long-term prognosis in a completely edentulous mandible. For the complete restoration of the maxilla, acceptable long-term clinical follow-up is lacking or based on cas...

    journal_title:Clinical oral implants research

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0501.2008.01586.x

    authors: Collaert B,De Bruyn H

    更新日期:2008-12-01 00:00:00

  • Therapeutic concepts and methods for improving dental implant outcomes. Summary and consensus statements. The 4th EAO Consensus Conference 2015.

    abstract:BACKGROUND:Different therapeutic concepts and methods have been proposed for improving dental implant outcomes in three specific clinical situations: (i) the fresh extraction socket with alveolar ridge preservation protocols; (ii) the posterior maxilla with limited bone height with either the placement of regular-sized...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.12674

    authors: Sanz M,Donos N,Alcoforado G,Balmer M,Gurzawska K,Mardas N,Milinkovic I,Nisand D,Rocchietta I,Stavropoulos A,Thoma DS,Torsello F

    更新日期:2015-09-01 00:00:00

  • Perioperative use of non-steroidal anti-inflammatory drugs might impair dental implant osseointegration.

    abstract:OBJECTIVE:To appraise whether adverse biological events following oral implant placement may be associated with perioperative use of non-steroidal anti-inflammatory drugs (NSAIDs). METHODS:All patients treated in a university faculty postgraduate dental clinic between 1979 and 2012 that had experienced a failing and s...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.12493

    authors: Winnett B,Tenenbaum HC,Ganss B,Jokstad A

    更新日期:2016-02-01 00:00:00

  • 'Bone map' for a safe placement of miniscrews generated by computed tomography.

    abstract:OBJECTIVES:The aim of this manuscript is to provide a bone map that can be used as a general guide to determine the areas where miniscrews can be safely anchored. MATERIALS AND METHODS:Twenty-one computed tomographies (CTs) of maxilla and mandible were taken by the imaging centre ORTOSCAN and two measures were taken: ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2007.01507.x

    authors: Hernández LC,Montoto G,Puente Rodríguez M,Galbán L,Martínez V

    更新日期:2008-06-01 00:00:00

  • Osseointegration of SLActive implants in diabetic pigs.

    abstract:OBJECTIVES:Diabetes mellitus is currently classified as a relative contraindication for implant treatment because of microangiopathies with the consequence of impaired bone regeneration and higher rates of implant failure. The study aim was to investigate peri-implant bone formation in a diabetic animal model in compar...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2011.02380.x

    authors: Schlegel KA,Prechtl C,Möst T,Seidl C,Lutz R,von Wilmowsky C

    更新日期:2013-02-01 00:00:00

  • Primary stability, insertion torque and bone density of cylindric implant ad modum Branemark: is there a relationship? An in vitro study.

    abstract:OBJECTIVES:Protocols of immediate loading have been reported in several studies. It has also been demonstrated that the cause of failure of immediate loaded implants is due to the micromotion on the bone-implant interface induced by immediate loading. There should be a minimum gap between the implant and the peri-impla...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2010.02036.x

    authors: Trisi P,De Benedittis S,Perfetti G,Berardi D

    更新日期:2011-05-01 00:00:00

  • The potential effects of cholecalciferol on bone regeneration in dogs.

    abstract:OBJECTIVES:The aim of this investigation was to evaluate the potential effects of the systemically delivered combination of calcium supplementation and cholecalciferol and of the locally applied biphasic calcium alloplast on the surgically produced alveolar sockets at the early healing stage in a dog model. MATERIALS ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2011.02284.x

    authors: Hong HH,Chou TA,Yang JC,Chang CJ

    更新日期:2012-10-01 00:00:00

  • Characterization of the antioxidant profile of human saliva in peri-implant health and disease.

    abstract:OBJECTIVES:Peri-implant disease is considered to be an inflammatory disease, but many aspects of its pathogenesis remain unknown. At present, peri-implant disease is considered to be initiated and perpetuated by a small group of predominantly Gram-negative, anaerobic, or micro-aerophilic bacteria that colonize the subg...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2006.01296.x

    authors: Liskmann S,Vihalemm T,Salum O,Zilmer K,Fischer K,Zilmer M

    更新日期:2007-02-01 00:00:00

  • Immediately restored one-piece single-tooth implants with reduced diameter: one-year results of a multi-center study.

    abstract:OBJECTIVES:The aim of the present multi-center study was to evaluate the treatment outcome of immediately restored one-piece single-tooth implants with a diameter of 3 mm after 1 year. MATERIAL AND METHODS:A total of 57 one-piece implants (NobelDirect 3.0) were inserted in 47 patients (26 females, 21 males) with a mea...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1600-0501.2011.02174.x

    authors: Zembić A,Johannesen LH,Schou S,Malo P,Reichert T,Farella M,Hämmerle CH

    更新日期:2012-01-01 00:00:00

  • Osteotome sinus floor elevation technique without grafting material: 3-year results of a prospective pilot study.

    abstract:OBJECTIVE:In a prospective pilot study, short< or =10 mm ITI-SLA implants were placed in the resorbed posterior maxilla by means of an osteotome sinus floor elevation (OSFE) procedure without grafting material. This paper presents 3-year data assessing bone-level changes around implants. MATERIAL AND METHODS:Twenty-fi...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2008.01696.x

    authors: Nedir R,Bischof M,Vazquez L,Nurdin N,Szmukler-Moncler S,Bernard JP

    更新日期:2009-07-01 00:00:00

  • Sinus augmentation via transcrestal approach: a comparison between the balloon and osteotome technique in a cadaver study.

    abstract:BACKGROUND:The transcrestal approach with osteotomes is a commonly applied and predictable technique for maxillary sinus floor elevation. However, Schneiderian membrane perforation is a common and often inevitable intraoperative complication. Recently, the use of balloons has been proposed to reduce the risk of sinus m...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0501.2012.02506.x

    authors: Chan HL,Oh TJ,Fu JH,Benavides E,Avila-Ortiz G,Wang HL

    更新日期:2013-09-01 00:00:00

  • Dimensional soft tissue changes following soft tissue grafting in conjunction with implant placement or around present dental implants: a systematic review.

    abstract:OBJECTIVES:To systematically review changes in mucosal soft tissue thickness and keratinised mucosa width after soft tissue grafting around dental implants. MATERIALS AND METHODS:An electronic literature search was conducted of the MEDLINE database published between 2009 and 2014. Sequential screenings at the title, a...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,评审

    doi:10.1111/clr.12606

    authors: Poskevicius L,Sidlauskas A,Galindo-Moreno P,Juodzbalys G

    更新日期:2017-01-01 00:00:00

  • Clinical outcome of autogenous bone blocks or guided bone regeneration with e-PTFE membranes for the reconstruction of narrow edentulous ridges.

    abstract::The aim of this study was to analyse the clinical outcome of two different surgical methods for the reconstruction of narrow edentulous ridges before implant installation: guided bone regeneration with e-PTFE membranes and autologous bone chips or grafting of autologous bone blocks without e-PTFE membranes. Thirty par...

    journal_title:Clinical oral implants research

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1600-0501.1999.100404.x

    authors: Chiapasco M,Abati S,Romeo E,Vogel G

    更新日期:1999-08-01 00:00:00

  • Comparing bar and double-crown attachments in implant-retained prosthetic reconstruction: a follow-up investigation.

    abstract:OBJECTIVES:A removable implant-retained dental prosthesis in an edentulous mandible can use telescopic crowns or a bar superstructure as anchorage elements for an overdenture. The aim of this study was to compare the clinical results for bar-anchored and telescopic crown-retained overdentures in implant prosthetic trea...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0501.2007.01500.x

    authors: Eitner S,Schlegel A,Emeka N,Holst S,Will J,Hamel J

    更新日期:2008-05-01 00:00:00

  • The Why, What, How and What if-The method to present your research and clinical cases.

    abstract:BACKGROUND:During the fourth Summer Camp (SC) held by the European Association of Osseointegration (EAO), 20 junior representatives from various European and non-European universities and associations were selected to partake in oral presentation and communication skill development. AIMS:The aim of the EAO Summer Camp...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.13625

    authors: Fickl S,Francisco H,Gurzawska-Comis K,Milinkovic I,Mühlemann S,Sanz Sánchez I,Torsello F,Van de Valde T

    更新日期:2020-08-01 00:00:00

  • Different sealing materials preventing the microbial leakage into the screw-retained implant restorations: an in vitro analysis by DNA checkerboard hybridization.

    abstract:OBJECTIVES:The aim of this controlled in vitro study was to identify and quantify up to 38 microbial species penetrating through the screw-retained implant prostheses with different sealing materials. MATERIAL AND METHODS:Sixty morse cone implants were restored with single-unit screw-retained prostheses. All the compo...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.12790

    authors: do Nascimento C,Pita MS,Calefi PL,de Oliveira Silva TS,Dos Santos JB,Pedrazzi V

    更新日期:2017-02-01 00:00:00

  • Osteoblast-like cells are sensitive to submicron-scale surface structure.

    abstract:OBJECTIVES:Studies showing that osteoblasts exhibit a more differentiated phenotype on rough titanium (Ti) surfaces and osteoclast-resorbed bone surfaces used materials characterized by average peak to valley distance (Ra). Other surface features impacting the cells include distance between peaks, curvature of the vall...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2005.01195.x

    authors: Zhao G,Zinger O,Schwartz Z,Wieland M,Landolt D,Boyan BD

    更新日期:2006-06-01 00:00:00

  • Prospective study to estimate mandibular cancellous bone density using large-volume cone-beam computed tomography.

    abstract:OBJECTIVE:Because pixel or voxel values obtained from cone-beam computed tomography (CBCT) images are not absolute values, the bone density cannot be evaluated. Hence, the regression line between voxel values of CBCT and the bone mineral density (BMDs) of multislice CT (MSCT) was prospectively evaluated to investigate ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2010.01950.x

    authors: Naitoh M,Hirukawa A,Katsumata A,Ariji E

    更新日期:2010-12-01 00:00:00

  • Sequential healing of onlay bone grafts using combining biomaterials with cross-linked collagen in dogs.

    abstract:OBJECTIVES:The aim of this study was to observe the sequential healing of onlay grafts in terms of the volumetric and histologic changes using different bone substances and absorbable membranes according to the presence of collagen cross-linking. MATERIAL AND METHODS:Four groups involving onlay grafting with different...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.12763

    authors: Cha JK,Joo MJ,Yoon S,Lee JS,Choi SH,Jung UW

    更新日期:2017-01-01 00:00:00

  • The influence of stiffness of implant-abutment connection on load-deflection ratios of a screw-retained stiff cantilever beam. 3-D measurements in vitro.

    abstract:AIM:The purpose of this in vitro study was to investigate the influence of degree of stiffness of implant-abutment connection of a Brånemark implant system on load- deflection ratios in three dimensions of the beam-end of a screw-retained stiff cantilever beam when subjected to vertically directed loads. MATERIAL AND ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2012.02563.x

    authors: Cassel B,Lundgren D,Karlsson D

    更新日期:2013-11-01 00:00:00

  • Immediate function on the day of surgery compared with a delayed implant loading process in the mandible: a randomized clinical trial over 5 years.

    abstract:OBJECTIVES:To appraise the feasibility of loading four implants with a pre-existing denture converted to a fixed dental prosthesis (FDP) on the day of implant surgery compared with waiting for 3- to 4-month healing. METHODS:Patients with an edentulous, fully healed mandible were recruited in a faculty clinic to partak...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/clr.12279

    authors: Jokstad A,Alkumru H

    更新日期:2014-12-01 00:00:00

  • Fibroblast adhesion and activation onto micro-machined titanium surfaces.

    abstract:OBJECTIVES:Surface modifications performed at the neck of dental implants, in the manner of micro-grooved surfaces, can reduce fibrous tissue encapsulation and prevent bacterial colonization, thereby improving fibrointegration and the formation of a biological seal. However, the applied procedures are technically compl...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0501.2012.02451.x

    authors: Guillem-Marti J,Delgado L,Godoy-Gallardo M,Pegueroles M,Herrero M,Gil FJ

    更新日期:2013-07-01 00:00:00

  • Immediate loading of post-extractive single-tooth implants: a 1-year prospective study.

    abstract:PURPOSE:The aim of this prospective clinical trial was to assess clinical, radiological, and esthetic outcomes of immediate-loaded post-extractive implants after 1 year of follow-up. MATERIALS AND METHODS:Twenty-four consecutive patients (15 females and nine males) with a mean age of 47.27 years (range 35-65) requirin...

    journal_title:Clinical oral implants research

    pub_type: 临床试验,杂志文章

    doi:10.1111/clr.12403

    authors: Cristalli MP,Marini R,La Monaca G,Sepe C,Tonoli F,Annibali S

    更新日期:2015-09-01 00:00:00

  • Rotating titanium brush for plaque removal from rough titanium surfaces--an in vitro study.

    abstract:OBJECTIVES:The purpose of this study was the evaluation of the effectiveness of plaque removing of a new rotating brush made of titanium in comparison with the cleaning procedure with steel curettes. MATERIALS AND METHODS:Plaque was collected by six volunteers for 48 h. A total of 60 samples were randomly designated t...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.12147

    authors: John G,Becker J,Schwarz F

    更新日期:2014-07-01 00:00:00

  • Retracted: Histologic evaluation of new bone in post-extraction sockets induced by melatonin and apigenin: an experimental study in American fox hound dogs.

    abstract:OBJECTIVE:The aim of this study was to evaluate the effect of topical applications of melatonin and apigenin (4',5,7-trihydroxyflavone) on new bone formation in post-extraction sockets after 30, 60 and 90 days. MATERIALS AND METHODS:Six American fox hounds were used in the study, extracting mandibular premolars (P2, P...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1111/clr.12866

    authors: Calvo-Guirado JL,López-López PJ,Domínguez MF,Gosálvez MM,Prados-Frutos JC,Gehrke SA

    更新日期:2018-11-01 00:00:00

  • Endoscopically controlled sinus floor augmentation. A preliminary report.

    abstract::Sinus augmentation has been advocated to be a surgical technique with predictable results in peri-implant surgery. Endoscopic surgery of the maxillary sinus so far has been used as diagnostic procedure. In this paper, the use of endoscopy is described as a low invasive adjunctive technique in sinus floor augmentation....

    journal_title:Clinical oral implants research

    pub_type: 杂志文章

    doi:10.1034/j.1600-0501.1997.080612.x

    authors: Engelke W,Deckwer I

    更新日期:1997-12-01 00:00:00