Abstract:
OBJECTIVE:The aim of this study was to evaluate the effect of topical applications of melatonin and apigenin (4',5,7-trihydroxyflavone) on new bone formation in post-extraction sockets after 30, 60 and 90 days. MATERIALS AND METHODS:Six American fox hounds were used in the study, extracting mandibular premolars (P2, P3 and P4) and first molar (M1). Melatonin or apigenin impregnated in collagen sponges were applied at P3, P4 and M1 sites in both hemimandibles; P2 sites were used as control sites. Bone biopsies were taken at 30, 60 and 90 days and stained with hematoxylin-eosin. RESULTS:At 30 days, a higher percentage of immature bone was observed in the control group (58.11 ± 1.76%) than in the apigenin (34.11 ± 1.02%) and melatonin groups (24.9 ± 0.14%) with significant differences between the three groups (P < 0.05). At 60 days, results were significantly better at melatonin sites (10.34 ± 1.09%) than apigenin (19.22 ± 0.35%) and control sites (36.7 ± 1.11%) (P < 0.05). At 90 days, immature bone percentages were similar for all groups. New bone formation was higher in melatonin group (79.56 ± 1.9%) than apigenin (68.89 ± 1.5%) and control group (58.87 ± 0.12%). CONCLUSIONS:Topical applications of either melatonin or apigenin have a potential to accelerate bone tissue in early healing stages; melatonin was seen to have stimulated bone maturation to a greater extent at the 60 days of follow-up.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Calvo-Guirado JL,López-López PJ,Domínguez MF,Gosálvez MM,Prados-Frutos JC,Gehrke SAdoi
10.1111/clr.12866subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1176issue
11eissn
0905-7161issn
1600-0501journal_volume
29pub_type
杂志文章abstract:PURPOSE:The purpose of this prospective study on humans were to evaluate (a) the clinical outcome of alveolar distraction osteogenesis for the correction of vertically deficient edentulous mandibular ridges, (b) the clinical outcome of dental implants placed in the distracted areas, and (c) the quality and quantity of ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01247.x
更新日期:2006-08-01 00:00:00
abstract::A clinical and radiographical study was performed to evaluate the treatment outcome of single tooth replacements with artificial crowns retained to implants installed according to a 1-stage surgical procedure and immediate loading (Experimental Group = EG) in comparison to the original 2-stage concept (Control Group =...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1034/j.1600-0501.2000.011001026.x
更新日期:2000-02-01 00:00:00
abstract:AIM:The aim of this experimental in vitro study was to evaluate the effects of the piezoelectric device in temperature and time variations in standardized osteotomies performed with similar tip inserts in bovine bone blocks. METHODS:Two different piezosurgical devices were used the OE-F15(®) (Osada Inc., Los Angeles, ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12709
更新日期:2016-09-01 00:00:00
abstract::For certain surgical procedures (e.g. placement of implants), an accurate localisation of the mandibular canal is of utmost importance to avoid injuries to the neurovascular bundle. The aim of the present study was to evaluate, on human fresh cadavers (n = 6), the accuracy of conventional spiral tomography for the loc...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2001.012003230.x
更新日期:2001-06-01 00:00:00
abstract:INTRODUCTION:Immediate functional loading of dental implants for full-arch restoration is a patient-friendly approach, shown to be feasible with a good long-term prognosis in a completely edentulous mandible. For the complete restoration of the maxilla, acceptable long-term clinical follow-up is lacking or based on cas...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0501.2008.01586.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study is twofold: to assess the esthetic outcome of single dental implant restorations in the anterior maxillary area after up to 3 years of function, and to evaluate the relationship between the esthetic outcome and oral health-related quality of life. MATERIALS AND METHODS:Twenty patients ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12922
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to determine the relationship between patients with a history of periodontitis and development of cement-related peri-implant disease. MATERIALS AND METHODS:Seventy-seven patients with 129 implants for this retrospective analysis were selected from completed implant cases that ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02570.x
更新日期:2013-11-01 00:00:00
abstract::The study aimed to examine the relationship between the subgingival flora around implants and their periodontal parameters. Plaque samples from 561 implants (279 patients) were analyzed by means of differential phase contrast microscopy and compared with the sample site's probing depth, bleeding tendency on probing, a...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1995.060401.x
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:During the fourth Summer Camp (SC) held by the European Association of Osseointegration (EAO), 20 junior representatives from various European and non-European universities and associations were selected to partake in oral presentation and communication skill development. AIMS:The aim of the EAO Summer Camp...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13625
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:To evaluate implant survival rate, any complications, and changes in residual alveolar bone height (RABH) using saline or platelet-rich fibrin (PRF) filling after hydraulic transcrestal sinus lifting. METHODS:Dental implants were placed after hydraulic transcrestal sinus lifting and the filling of saline (2...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13655
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The aim of the present systematic review was to analyze the survival and complication rates of zirconia-based and metal-ceramic implant-supported single crowns (SCs). MATERIALS AND METHODS:An electronic MEDLINE search complemented by manual searching was conducted to identify randomized controlled clinical ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13306
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate whether bone marrow aspirates (BMA) and concentrates (BMAC) influence the grafts' stability when added to deproteinized bovine bone mineral (DBBM) within the first 6 months after maxillary sinus augmentation. MATERIAL AND METHODS:26 CT data of 13 patients undergoing b...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12101
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the clinical success of dental implants placed in severely atrophic maxilla (residual bone height ≤4 mm) using transalveolar sinus floor elevation (TSFE) without grafting. Furthermore, the implant stability during the healing period was also evaluated. MATERIALS AND METHOD...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12547
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To assess retrospectively the cumulative costs for the long-term oral rehabilitation of patients with birth defects affecting the development of teeth. METHODS:Patients with birth defects who had received fixed reconstructions on teeth and/or implants > or =5 years ago were asked to participate in a compreh...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01711.x
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:Minor sinus floor elevation is a method with relatively high predictability but is technically demanding. Improvement of the technique and increase in the predictability are desirable. MATERIAL AND METHODS:A clinical protocol for minor sinus floor elevation with SLA-ITI (large grit acid-etched implants with...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01161.x
更新日期:2005-10-01 00:00:00
abstract:AIM:The aim of the present study was to evaluate the outcome of a surgical procedure based on pocket elimination and bone re-contouring for the treatment of peri-implantitis. MATERIAL AND METHODS:The 31 subjects involved in this study presented clinical signs of peri-implantitis at one or more dental implants (i.e. ≥6...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02098.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:The early effect of platelet-rich plasma (PRP) on bone regeneration in combination with dense biphasic hydroxyl apatite (HA)/beta-tricalcium phosphate (TCP) particles (ratio 60%/40%) was evaluated in rat cranial defects with a diameter of 6.2 mm. We hypothesize that PRP exerts its beneficial effect on bone re...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01327.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:To retrospectively evaluate the conditions of the peri-implant tissues in treated patients with chronic periodontitis (CP) and in patients without chronic periodontitis (noCP). MATERIALS AND METHODS:A chart review was used to evaluate 267 implants, 134 placed in 42 CP treated patients and 133 placed in 46 n...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13712
更新日期:2021-01-16 00:00:00
abstract:OBJECTIVES:The aim of the present study was to investigate the relationships among reported methodological, statistical, clinical and paratextual variables of randomized clinical trials (RCTs) in implant therapy, and their influence on subsequent research. MATERIALS AND METHODS:The material consisted of the RCTs in im...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01350.x
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To compare the alveolar bone dimensions in patients with lower second premolar (P2) agenesis prior to and after primary molar loss on CT scans, and assess the possibility for straightforward implant placement. METHODS:Alveolar bone dimensions were evaluated on 150 mandibular CT scans in three groups: (i) ag...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13033
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Long-term success of dental implants depends on healthy peri-implant soft tissues and adequate bone levels. This prospective study aims to assess bone level changes around implants with internal conical connection and platform-switching abutments in the posterior mandible. MATERIAL AND METHODS:Adult patients...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1111/clr.12644
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to histologically compare the dynamics of bone healing response between calcium sulphate (CaS) and deproteinized bovine bone mineral (DBBM) particles in guided bone regeneration utilizing an extracellular matrix membrane (ECM) as barrier. MATERIALS AND METHODS:Eighteen rabbits were...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12425
更新日期:2015-05-01 00:00:00
abstract::In the preparation of osseointegrated dental implant sites, the use of bone drilling with conventional external irrigation has been shown to be thermally non-injurious to bovine bone, when employed as a model for dental implantology. The use of internal irrigation drilling systems is promoted on the basis of improved ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130309.x
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the synergistic effect of bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF) on the repair of bone defects around dental implants. MATERIAL AND METHODS:Five groups of scaffold were fabricated by a freeze-drying method, including pure chitosan/collagen scaffold; sca...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02164.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:To present the characteristics and level of evidence (LOE) of clinical studies published in leading oral implantology journals during 2008-2018 and to explore whether the LOE of a study is associated with its scientific and social impact. MATERIALS AND METHODS:Clinical studies with direct relevance to the e...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13641
更新日期:2020-10-01 00:00:00
abstract::Sinus augmentation has been advocated to be a surgical technique with predictable results in peri-implant surgery. Endoscopic surgery of the maxillary sinus so far has been used as diagnostic procedure. In this paper, the use of endoscopy is described as a low invasive adjunctive technique in sinus floor augmentation....
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080612.x
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:Surface modifications performed at the neck of dental implants, in the manner of micro-grooved surfaces, can reduce fibrous tissue encapsulation and prevent bacterial colonization, thereby improving fibrointegration and the formation of a biological seal. However, the applied procedures are technically compl...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02451.x
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:To assess the bleeding on probing (BOP) tendency and periodontal probe penetration when applying various probing forces at implant sites in patients with a high standard of oral hygiene with well-maintained peri-implant tissues. MATERIAL AND METHODS:Seventeen healthy patients with excellent oral hygiene in ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2008.01601.x
更新日期:2009-01-01 00:00:00
abstract::In 8 monkeys both the maxillary lateral incisors were extracted. In the 16 extraction sites an Al2O3-ceramic dental implant (Frialit) was immediately inserted. Eight implants were submerged under the oral mucosa and the other 8 were allowed to penetrate through the mucosa during the observation period. None of the imp...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1995.060206.x
更新日期:1995-06-01 00:00:00
abstract::The purpose of the following study was to evaluate the medium- to long-term prognosis of implant-supported cantilever fixed prostheses, and to establish to what degree this is influenced by factors such as length, type of cantilever (mesial or distal), and opposite dentition versus cantilever prostheses. This study wa...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2003.120905.x
更新日期:2003-06-01 00:00:00