Abstract:
OBJECTIVES:Peri-implant disease is considered to be an inflammatory disease, but many aspects of its pathogenesis remain unknown. At present, peri-implant disease is considered to be initiated and perpetuated by a small group of predominantly Gram-negative, anaerobic, or micro-aerophilic bacteria that colonize the subgingival area. Bacteria cause the observed tissue destruction directly by toxic products and indirectly by activating host defence systems, i.e. inflammation. A variety of molecular species appears in the inflamed tissues, among them are reactive species such as free radicals and reactive oxygen species (ROS). The purpose of this study was to assess levels of various antioxidants in saliva to identify differences between the saliva of patients with healthy peri-implant tissues and patients with peri-implant disease, and to examine whether the whole saliva of those with peri-implant disease conditions might have lower levels of antioxidants than that of healthy individuals. MATERIALS AND METHODS:Thirty healthy adult volunteers (14 men and 16 women) with implant-supported overdentures (Ankylos Biofunctional Implants) were selected from the group of patients from Tallinn Dental Clinic. Biochemical and clinical parameters evaluated were the following ones: the levels of urate, ascorbate, myeloperoxidase in saliva, total antioxidant status of saliva, pocket probing depth (mm), gingival index (0, 1, 2, or 3), and bleeding on probing (0 or 1). RESULTS AND CONCLUSION:Total antioxidant status (TAS) of saliva and concentration of uric acid and ascorbate, which are the main salivary antioxidants, are significantly decreased in patients with peri-implant disease. TAS in healthy subjects was 0.41+/-0.10 for resting saliva and 0.31+/-0.09 for stimulated saliva; in diseased subjects TAS was 0.19+/-0.07 and 0.12+/-0.03, respectively. In healthy subjects, the concentration of urate was 307.2+/-78.06 microM/l in resting saliva and 241.5+/-89.09 microM/l in stimulated saliva. In diseased patients, the concentration of urate was 120+/-36.13 and 91.60+/-39.35 microM/l, respectively. The concentration of ascorbate did not differ in resting and stimulated saliva. In healthy subjects, it was 2.79+/-0.81 mg/l and in diseased subjects, it was 1.54+/-0.30 mg/l. This may indicate that excessive ROS production in peri-implant disease is leading to the situation of excessive oxidative stress, which may be an important factor contributing the destruction of peri-implant tissues. The importance of these findings may be the better understanding of the processes involved in the pathogenesis of peri-implant disease and that the treatment of peri-implant disease may involve adjuvant anti-oxidants supplementation together with cumulative interceptive supportive therapy concept introduced by Mombelli & Lang.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Liskmann S,Vihalemm T,Salum O,Zilmer K,Fischer K,Zilmer Mdoi
10.1111/j.1600-0501.2006.01296.xsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
27-33issue
1eissn
0905-7161issn
1600-0501pii
CLR1296journal_volume
18pub_type
杂志文章abstract:OBJECTIVES:Diabetes mellitus is currently classified as a relative contraindication for implant treatment because of microangiopathies with the consequence of impaired bone regeneration and higher rates of implant failure. The study aim was to investigate peri-implant bone formation in a diabetic animal model in compar...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02380.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:Estimate changes in augmentation height and volume after lateral guided bone regeneration (GBR) augmentation with different ratios of deproteinized bovine bone mineral (DBBM) and particulate autogenous bone (PAB) and autogenous bone block (ABB), at different time points. MATERIAL AND METHODS:Twenty-four mini...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13687
更新日期:2020-11-20 00:00:00
abstract::The aim of this controlled, parallel design clinical study was to compare the effectiveness of an Er:YAG laser (ERL) to that of mechanical debridement using plastic curettes and antiseptic therapy for nonsurgical treatment of peri-implantitis. Twenty patients with moderate to advanced peri-implantitis lesions were ran...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2004.01051.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate, as part of an ongoing randomized pilot trial, the clinical outcomes of two-piece zirconia implants in comparison with titanium implants 80 months after delivery of all-ceramic (lithium disilicate) single-tooth restorations. MATERIAL AND METHODS:The original sample included 31 (16 ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13576
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:To assess retrospectively, over at least 5 years, the incidences of technical and biological complications and failures in young adult patients with birth defects affecting the formation of teeth. MATERIAL AND METHODS:All insurance cases with a birth defect that had crowns and fixed dental prostheses (FDPs)...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01720.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:In regenerative medicine, surface engineering of bioinert synthetic materials is often required in order to introduce bioactive species that can promote cell adhesion, proliferation, viability and enhanced ECM-secretion functions. The aim of this work is to study cell interaction with alumina-modified surfac...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01642.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:The aim of this investigation was to evaluate the potential effects of the systemically delivered combination of calcium supplementation and cholecalciferol and of the locally applied biphasic calcium alloplast on the surgically produced alveolar sockets at the early healing stage in a dog model. MATERIALS ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02284.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:The early effect of platelet-rich plasma (PRP) on bone regeneration in combination with dense biphasic hydroxyl apatite (HA)/beta-tricalcium phosphate (TCP) particles (ratio 60%/40%) was evaluated in rat cranial defects with a diameter of 6.2 mm. We hypothesize that PRP exerts its beneficial effect on bone re...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01327.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of treated periodontitis on implant outcomes in partially edentulous individuals compared with periodontally healthy patients. MATERIAL AND METHODS:Longitudinal studies reporting on implant survival, success, incidence of peri-implantitis, bone loss and periodontal status, and on p...
journal_title:Clinical oral implants research
pub_type: 杂志文章,评审
doi:10.1111/clr.12684
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:The present experiment was performed to determine the influence of Bio-Oss on hard tissue formation at sites that, following implant installation, presented a 1-1.25 mm wide marginal defect. MATERIAL AND METHODS:Four Labrador dogs were used. The premolars and first molars on both sides of the mandible were ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1046/j.1600-0501.2003.01008.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:To assess the bleeding on probing (BOP) tendency and periodontal probe penetration when applying various probing forces at implant sites in patients with a high standard of oral hygiene with well-maintained peri-implant tissues. MATERIAL AND METHODS:Seventeen healthy patients with excellent oral hygiene in ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2008.01601.x
更新日期:2009-01-01 00:00:00
abstract::The objective of the present investigation was to characterize the cellular composition of the soft tissues surrounding consecutively retrieved late failures of Brånemark implants. Criteria for implant failure were signs of loss of osseointegration (radiographic peri-fixtural radiolucency and mobility). The clinical h...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080502.x
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this laboratory study was to evaluate the fatigue resistance, fracture resistance and mode of failure of posterior hybrid-abutment-crown vs. hybrid-abutment with separate crown, both bonded to short titanium bases. MATERIALS AND METHODS:Thirty-two titanium implants were embedded perpendicularl...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13395
更新日期:2019-01-01 00:00:00
abstract::This study aimed to investigate the effect of hyperbaric oxygen (HBO) therapy on the tissue reactions to commercially pure (c.p.) titanium implants placed in free autogenous bone graft by a 1-stage procedure. Eighty c.p. titanium implants were placed in the bone grafted from iliac crest to bilateral mandible of 40 Jap...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1996.090604.x
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:This study was conducted to evaluate the effect of barrier membranes on sandwich bone augmentation (SBA) for the treatment of implant dehiscence defects. MATERIAL AND METHODS:Twenty-six implant-associated buccal dehiscence defects in 22 patients were treated according to the SBA concept - mineralized human ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2007.01408.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective pilot study was to evaluate the prosthodontic maintenance as well as the implant outcome of single implant-retained mandibular overdentures over an observation period of 6 years. METHODS:Eleven edentulous patients received one single implant in the midline of the mandible. Dentur...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12427
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate whether bone marrow aspirates (BMA) and concentrates (BMAC) influence the grafts' stability when added to deproteinized bovine bone mineral (DBBM) within the first 6 months after maxillary sinus augmentation. MATERIAL AND METHODS:26 CT data of 13 patients undergoing b...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12101
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:The aim of this manuscript is to provide a bone map that can be used as a general guide to determine the areas where miniscrews can be safely anchored. MATERIALS AND METHODS:Twenty-one computed tomographies (CTs) of maxilla and mandible were taken by the imaging centre ORTOSCAN and two measures were taken: ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01507.x
更新日期:2008-06-01 00:00:00
abstract::Parkinson's disease (PD) often affects the oro-pharyngeal musculature, leading to problems with speaking, chewing and swallowing. The inevitable reduction in food and fluid intake contributes to the further deterioration of neurological symptoms. Parkinson's disease patients have great difficulties in adjusting to the...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2000.011006566.x
更新日期:2000-12-01 00:00:00
abstract::Maxillary sinus floor augmentation with autogenous bone has become a widely accepted procedure in implant dentistry. The use of osteoconductive bone substitutes in this indication is controversial, since their use can lead to a prolonged healing time, inhomogenous ossification, foreign body reaction, migration of part...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1999.100609.x
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:This prospective clinical study investigates long-term survival and clinical parameters of non-submerged implants with large buccal dehiscences treated with a deproteinized bovine bone mineral xenograft and a non-resorbable membrane in a one-stage approach. MATERIAL AND METHODS:Sixteen consecutive non-subme...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01154.x
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Cement-retained fixed implant-supported restorations involve the risk of excess cement, which can associate peri-implantitis. In connection with routine therapy using a methacrylate cement (Premier Implant Cement, Premier(®) Dental Products Company, Plymouth Meeting, PA, USA) to retain fixed implant-supporte...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12173
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVES:The aim of this investigation was to evaluate histologically, histometrically, and histomorphometrically the influence of plaque accumulation on the peri-implant hard tissues. MATERIAL AND METHODS:Twelve fully edentulous subjects were selected for this investigation. Four to five standard titanium screw imp...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1600-0501.2003.00849.x
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to evaluate the 5-year performance and success rate of titanium screw-type implants with the titanium plasma spray (TPS) or the sand-blasted, large grit, acid-etched (SLA) surface inserted in a two-stage sinus floor elevation (SFE) procedure in the posterior maxilla. MA...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01573.x
更新日期:2008-10-01 00:00:00
abstract:AIM:To evaluate the soft tissue and the dimensional changes of the alveolar bony crest at sites where deproteinized bovine bone mineral (DBBM) particles, concomitantly with the placement of a collagen membrane, were used at implants installed into sockets immediately after tooth extraction. MATERIAL AND METHODS:The pu...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02332.x
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare between the effects of resilient liner and clip attachments of bar-implant-retained mandibular overdenture on peri-implant tissues. MATERIALS AND METHODS:In a randomized-controlled clinical trial, 30 edentulous male patients (mean age 62.5 years) were equally assigned to tw...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2009.01879.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:To determine the difference in light reflection of oral mucosa covering titanium (Ti) or zirconia (ZrO(2)) abutments as it relates to the thickness of the covering mucosa. MATERIAL AND METHODS:Fifteen anterior implants (Astra Osseo speed(®)) in 11 patients were fitted with a Ti or a ZrO(2) abutment (cross-o...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02082.x
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:In the replacement of missing teeth, a paradigm shift is currently observed with immediate implant placement and/or restoration, particularly in the aesthetic zone. In molar sites, however, anatomical, occlusal and biomechanical considerations remain deterrent factors influencing the outcome of this treatmen...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02415.x
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of scan mode of the cone beam computed tomography (CBCT) in the preoperative dental implant measurements. MATERIAL AND METHODS:Completely edentulous mandibles with entirely resorbed alveolar processes were selected for this study. Five regions were selected (i...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12080
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:(1) To assess whether there is evidence of an association between the number of peri-implant tissue complications and patient characteristics such as gender, diabetes status, smoking status, and bite force; (2) To assess whether there is evidence of an association between the number of peri-implant tissue co...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12484
更新日期:2015-12-01 00:00:00