Abstract:
OBJECTIVES:As biomaterial-induced modulation of mediators of the immune response may be a potential therapeutic approach to enhance wound healing events, the aim of this study was to delineate the effects of titanium surface modification on macrophage phenotype and function. MATERIAL AND METHODS:Rodent bone marrow-derived macrophages were polarized into M1 and M2 phenotypes and cultured on micro-rough (SLA) and hydrophilic modified SLA (modSLA) titanium discs. Macrophage phenotype and cytokine secretion were subsequently assessed by immunostaining and ELISA, respectively. Osteoblast gene expression in response to culture in the M1 and M2 macrophage conditioned media was also evaluated over 7 days by RT-PCR. RESULTS:M1 macrophage culture on the modSLA surface promoted an M2-like phenotype as demonstrated by marked CD163 protein expression, Arg1 gene expression and the secretion of cytokines that significantly upregulated in osteoblasts the expression of genes associated with the TGF-ß/BMP signalling pathway and osteogenesis. In comparison, M2 macrophage culture on SLA surface promoted an inflammatory phenotype and cytokine profile that was not conducive for osteogenic gene expression. CONCLUSIONS:Macrophages are able to alter or switch their phenotype according to the signals received from the biomaterial surface. A hydrophilic micro-rough titanium surface topography elicits a macrophage phenotype associated with reduced inflammation and enhanced pro-osteogenic signalling.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Hamlet SM,Lee RSB,Moon HJ,Alfarsi MA,Ivanovski Sdoi
10.1111/clr.13522subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1085-1096issue
11eissn
0905-7161issn
1600-0501journal_volume
30pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to investigate the osteoconductive properties and biological performance of porous titanium granules used in osseous defects adjacent to titanium implants. MATERIAL AND METHODS:In this animal experimental study, calibrated defects were prepared in the tibias of 24 New Zealand rabbi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01813.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To evaluate how vertical mucosal tissue thickness affects crestal bone stability around triangular-shaped bone-level implants, restored with low profile titanium bases and monolithic lithium disilicate restorations. MATERIAL AND METHODS:Fifty-five bone-level implants of 4.3 mm diameter were evaluated in 55 p...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13263
更新日期:2018-07-01 00:00:00
abstract:AIM:The aim of this prospective, randomized, controlled multicenter study was to determine the 3-year efficacy and stability of the soft and hard tissues at implants with a different geometry that were placed in fresh extraction sockets. MATERIAL AND METHODS:Implants with two different configurations, cylindrical (Gro...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/clr.12140
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:The present experiment was performed to determine the influence of Bio-Oss on hard tissue formation at sites that, following implant installation, presented a 1-1.25 mm wide marginal defect. MATERIAL AND METHODS:Four Labrador dogs were used. The premolars and first molars on both sides of the mandible were ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1046/j.1600-0501.2003.01008.x
更新日期:2004-06-01 00:00:00
abstract:UNLABELLED:Osseointegration failure is a complex, multifactorial trait shown to concentrate in some treated populations. There has been shown evidence for genetic contribution to dental implant loss. Genetic polymorphisms have been classically considered as genetic risk factors for several diseases and, more recently, ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01532.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:Osteoporosis is known to impair the process of implant osseointegration. The recent discovery that statins (HMG-CoA reductase inhibitors) act as bone anabolic agents suggests that statins can be used as potential agents in the treatment of osteoporosis. Therefore, we hypothesized that statins will promote os...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01630.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To compare the effect of two surgical techniques, lateral condensation and bone drilling, on changes in temperature of the adjacent low-density bone during implant placement into posterior maxilla and to investigate the influence of the host factors - age, gender, region of implantation, bone density, and th...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12191
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:Maxillary sinus augmentation procedures with bone replacement grafts aimed to increase bone height in the posterior maxilla. During healing, bone particles are partially resorbed and replaced by the patient's own bone. Vitamin D plays an essential role in calcium homeostasis and is critical for bone formatio...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12641
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:This study investigated the surface characteristics and in vitro biocompatibility of titanium (Ti) surfaces incorporated with strontium ions (Sr) and/or phosphate ions (P) produced by hydrothermal treatment for future applications as endosseous implant surfaces. MATERIAL AND METHODS:Sr and/or P-incorporated ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01863.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To assess the cleaning potential of commonly used implant debridement methods, simulating non-surgical peri-implantitis therapy in vitro. MATERIALS AND METHODS:One-hundred-and-eighty dental implants were ink-stained and mounted in combined soft and hard tissue models, representing peri-implantitis defects w...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12773
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:The objectives of this systematic review were to assess the 5-year survival of resin-bonded bridges (RBBs) and to describe the incidence of technical and biological complications. METHODS:An electronic Medline search complemented by manual searching was conducted to identify prospective and retrospective co...
journal_title:Clinical oral implants research
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0501.2007.01527.x
更新日期:2008-02-01 00:00:00
abstract::Non-submerged ITI Bonefit implants (ITI Dental Implant System) were inserted in edentulous lower jaws of 46 patients. The patients were provided with either a fixed prosthesis or an overdenture, and has been followed during a 2-year-period. At the 1-year examination, the suprastructures were removed permitting test of...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1996.070406.x
更新日期:1996-12-01 00:00:00
abstract:AIM:To evaluate surface roughness alterations at the smooth neck of dental implants after the use of eight different prophylactic procedures. MATERIALS AND METHODS:50 tissue level implants (Institut Straumann AG, Basel, Switzerland) were used for the present investigation. The smooth collar of each implant was divided...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12849
更新日期:2017-07-01 00:00:00
abstract:AIM OF THE STUDY:To present the results of a prospective study on the management of infectious complications following maxillary sinus floor elevation procedures with a combined endoscopic (FESS) and intra-oral approach. MATERIALS AND METHODS:From 2005 to 2009, twenty consecutive patients were diagnosed for sinusal ch...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1600-0501.2012.02440.x
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare between the effects of resilient liner and clip attachments of bar-implant-retained mandibular overdenture on peri-implant tissues. MATERIALS AND METHODS:In a randomized-controlled clinical trial, 30 edentulous male patients (mean age 62.5 years) were equally assigned to tw...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2009.01879.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate whether bone marrow aspirates (BMA) and concentrates (BMAC) influence the grafts' stability when added to deproteinized bovine bone mineral (DBBM) within the first 6 months after maxillary sinus augmentation. MATERIAL AND METHODS:26 CT data of 13 patients undergoing b...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12101
更新日期:2014-02-01 00:00:00
abstract::The aim of this controlled, parallel design clinical study was to compare the effectiveness of an Er:YAG laser (ERL) to that of mechanical debridement using plastic curettes and antiseptic therapy for nonsurgical treatment of peri-implantitis. Twenty patients with moderate to advanced peri-implantitis lesions were ran...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2004.01051.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:To assess retrospectively the cumulative costs for the long-term oral rehabilitation of patients with birth defects affecting the development of teeth. METHODS:Patients with birth defects who had received fixed reconstructions on teeth and/or implants > or =5 years ago were asked to participate in a compreh...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01711.x
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:The aims of this study were (i) to evaluate the efficacy of ridge preservation and repair procedures involving the application of SocketKAP(™) and SocketKAGE(™) devices following tooth removal and (ii) to evaluate alveolar bone volumetric changes at 6 months post-extraction in intact sockets or those with fa...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12687
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:This in vitro study describes and characterizes a developed novel method to produce coatings on Ti. Hydrophobic coatings on substrates are needed in prosthetic dentistry to promote durable adhesion between luting resin cements and coated Ti surfaces. In implant dentistry the hydrophobic coatings on a Ti impl...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02504.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare changes at the marginal bone level adjacent to implants placed with flapless surgery and flap surgery during a stress-free healing period. MATERIAL AND METHODS:Seven hundred and eighty-five implants were placed in 417 patients with a flapless approach and 459 implants...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.01961.x
更新日期:2010-12-01 00:00:00
abstract::Bovine mineral spongiosa block (B-SB) was used as a bone substitute in sinus augmentation procedures in 10 consecutive patients. Implants were placed during the same session. The purpose of this study was to histopathologically examine the healing of the grafted site around the implants at 12 months. Radiographic foll...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130411.x
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of the configuration of the marginal aspect of implants placed immediately into extraction sockets on peri-implant hard tissue adaptation. MATERIAL AND METHODS:In 6 Labrador dogs, endodontic treatments of the mesial roots of 1 M1 were performed and the distal roots were removed. 2 P...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12262
更新日期:2014-10-01 00:00:00
abstract:AIM:The objective of the study was to compare (i) esthetic, (ii) clinical and (iii) patient-centered outcomes following immediate (Type 1) and early implant placement (Type 2). MATERIAL AND METHODS:Thirty-eight subjects needing a single extraction (premolar to premolar) were randomly allocated to Type 1 or Type 2 impl...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12577
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:The goal of this study was to enhance the blood responses to titanium (Ti) surfaces used for dental implant application through the formation of a TiO2 nano-mesh surface layer produced by a fast electrochemical anodization treatment. MATERIAL AND METHODS:Electrochemical anodization treatments with different...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2010.02152.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:The aim was to evaluate the peri-implant tissue levels over a 1-year period for implants connected to either convex or concave final abutments at the time of implant placement. MATERIALS AND METHODS:In this randomized, double masked, controlled clinical study, twenty-eight patients with one missing maxillar...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13493
更新日期:2019-09-01 00:00:00
abstract::Mandibular bone density, vertebral density and resorption of the edentulous ridge were correlated in a group of 17 partially edentulous subjects. Bone density was quantified by Quantitative Computerized Tomography; resorption was evaluated on panoramic radiographs. Mean bone density in dentate areas was significantly ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1999.100503.x
更新日期:1999-10-01 00:00:00
abstract:AIM:This study compared the effects of Escherichia-coli-produced recombinant human bone morphogenetic protein 2 (ErhBMP-2) with a biphasic calcium phosphate (BCP) carrier to those of deproteinized bovine bone in human maxillary sinus floor augmentation. MATERIAL AND METHODS:Screening for this clinical trial selected 5...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/clr.12471
更新日期:2015-12-01 00:00:00
abstract::A dog model for study of supracrestal bone growth around partially inserted implants is described. The mandibular premolar teeth (P1, P2, P3 and P4) were extracted on both sides of the mandible in four dogs. At a surgical exposure 12 weeks later, two 10 mm titanium implants were partially inserted on each side, 15 mm ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130502.x
更新日期:2002-10-01 00:00:00
abstract::This study details the structural and ultrastructural features of the interfaces between titanium implants and their surrounding tissues. The material stemmed from an experiment in dogs in which guided tissue regeneration with Gore-Tex membranes was used to treat peri-implant, ligature-induced tissue breakdown around ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1994.050201.x
更新日期:1994-06-01 00:00:00