Abstract：
OBJECTIVES:Collagen membranes are not limited to be occlusive barriers as they actively support bone regeneration. However, the impact of bone-derived growth factors on their osteoconductive competence has not been examined. METHODS:Twenty adult Sprague Dawley rats were included in the study. Calvaria defects with a diameter of five millimeter were created. The defect was covered with one layer of a collagen membrane previously soaked in conditioned medium of porcine bone chips or in culture medium alone. After 4 weeks, microcomputed tomography was performed. Undecalcified thin-ground sections were subjected to light and scanning electron microscopy. Primary outcome parameter was the bone volume in the defect. Unit of analysis was the bone-conditioned medium (BCM). RESULTS:In the central defect area of the control and the BCM group, median new bone connected to the host bone was 0.54 and 0.32 mm³, respectively (p = .10). In the ectocranial defect area, the control group showed significantly more bone than the BCM group (0.90 and 0.26 mm³; p = .02). Based on an exploratory interpretation, the control group had smaller bony islands than the BCM group. Scanning electron microscopy and histology indicate the formation of bone but also the collagen membrane to be mineralized in the defect site. CONCLUSIONS:These results demonstrate that the commercial collagen membrane holds an osteoconductive competence in a rat calvaria defect model. Soaking collagen membranes with BCM shifts bone formation toward the formation of bony islands rather than new bone connected to the host bone.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Kuchler U,Rybaczek T,Dobask T,Heimel P,Tangl S,Klehm J,Menzel M,Gruber Rdoi
10.1111/clr.13133subject
Has Abstractpub_date
2018-04-01 00:00:00pages
381-388issue
4eissn
0905-7161issn
1600-0501journal_volume
29pub_type
杂志文章abstract：:The aim of the present study was to compare three different systems for preparing platelet concentrates: two commercially available bed-side techniques (Curasan system and PCCS) and a procedure used routinely in transfusion medicine. Platelet concentrates were prepared from venous blood of 12 healthy male volunteers u...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.2002.130512.x
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:In a prospective pilot study, short< or =10 mm ITI-SLA implants were placed in the resorbed posterior maxilla by means of an osteotome sinus floor elevation (OSFE) procedure without grafting material. This paper presents 3-year data assessing bone-level changes around implants. MATERIAL AND METHODS:Twenty-fi...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2008.01696.x
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:This study investigated the surface characteristics and in vitro biocompatibility of titanium (Ti) surfaces incorporated with strontium ions (Sr) and/or phosphate ions (P) produced by hydrothermal treatment for future applications as endosseous implant surfaces. MATERIAL AND METHODS:Sr and/or P-incorporated ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2009.01863.x
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVE:The purpose of this prospective study was to evaluate one-stage dental implants clinically and radiographically after 10 years in function. MATERIAL AND METHODS:Twenty-five patients with a total of 68 implants [46 hollow screws (HS) and 22 hollow cylinders (HC)] who previously participated in 5-year prospect...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2007.01479.x
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:The aim of this prospective study was to evaluate the soft tissue changes around implants in the aesthetic zone, placed under a trimodal approach (immediate post-extraction placement, flapless, and immediate provisional restoration) and its relationship to gingival/periodontal biotype of the patient. MATERIALS...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2012.02516.x
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:Recent studies have suggested that magnesium (Mg) ions exert a beneficial effect on implant osseointegration. This study assessed the osseointegration of nanoporous titanium (Ti) surface incorporating the Mg produced by hydrothermal treatment in rabbit cancellous bone to determine whether this surface would f...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2010.02144.x
更新日期：2012-03-01 00:00:00
abstract：:The aim of this study was to determine the cell characteristics that regulate implant osseointegration. The heterogeneity of bone marrow stromal cells obtained from 11 donors was assessed by measuring the expression of a large panel of adhesion molecules. Large differences in expression of adhesion molecules were dete...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.2003.00949.x
更新日期：2003-10-01 00:00:00
abstract：:A qualitative and quantitative histological study of the initial healing response adjacent to 24 submerged and non-submerged implants placed in the lower jaws of 6 monkeys is presented. The histomorphometric analysis showed no significant differences in mineralized bone-implant contact length between submerged and non...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.1991.020104.x
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:A systematic review and meta-analysis are carried out to assess the scientific evidence that bisphosphonate therapy can decrease the success rate of dental implants. MATERIAL AND METHODS:The PubMed (Medline) database was used to search for articles published up until February 22, 2014. The meta-analysis was ...
journal_title：Clinical oral implants research
pub_type： 杂志文章,meta分析,评审
doi：10.1111/clr.12526
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVES:Peri-implant disease is considered to be an inflammatory disease, but many aspects of its pathogenesis remain unknown. At present, peri-implant disease is considered to be initiated and perpetuated by a small group of predominantly Gram-negative, anaerobic, or micro-aerophilic bacteria that colonize the subg...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2006.01296.x
更新日期：2007-02-01 00:00:00
abstract：:We tested in a randomized controlled clinical trial the effect of pain and instability of dentures on bite force with different degrees of mucosal support. The trial involved 3 groups who had received: 1) a new conventional denture (CD-group), 2) an implant-mucosa-borne overdenture on 2 IMZ implants (IMZ-group) or 3) ...
journal_title：Clinical oral implants research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-0501.2001.012001046.x
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Non-surgical mechanical therapy of peri-implantitis (PI) with/without adjunctive measures yields limited clinical improvements. AIM:To evaluate the clinical outcomes following non-surgical mechanical therapy of PI with adjunctive application of a diode laser after an observation period ≥2 years. MATERIAL A...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12689
更新日期：2016-07-01 00:00:00
abstract：:This study details the structural and ultrastructural features of the interfaces between titanium implants and their surrounding tissues. The material stemmed from an experiment in dogs in which guided tissue regeneration with Gore-Tex membranes was used to treat peri-implant, ligature-induced tissue breakdown around ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.1994.050201.x
更新日期：1994-06-01 00:00:00
abstract：:This study was undertaken to evaluate the use of tissue-engineered bone as grafting material for alveolar augmentation with simultaneous implant placement. Twelve adult hybrid dogs were used in this study. One month after the extraction of teeth in the mandible region, bone defects on both sides of the mandible were i...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2006.01246.x
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVES:To assess the bleeding on probing (BOP) tendency and periodontal probe penetration when applying various probing forces at implant sites in patients with a high standard of oral hygiene with well-maintained peri-implant tissues. MATERIAL AND METHODS:Seventeen healthy patients with excellent oral hygiene in ...
journal_title：Clinical oral implants research
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-0501.2008.01601.x
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the implant failure, marginal bone loss (MBL), and other biological or technical complications of restorations supported by tilted and straight implants after at least 3 years in function. METHODS:Electronic and manual searches were performed in MEDLINE, Embase, Web of Science, and OpenGrey to i...
journal_title：Clinical oral implants research
pub_type： 杂志文章,meta分析
doi：10.1111/clr.13279
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVES:To compare clinical and radiographic outcomes between transcrestal sinus floor elevation (TSFE) and lateral sinus floor elevation (LSFE) approaches of simultaneous implant placement in atrophic maxilla. MATERIALS AND METHODS:Patients with a residual bone height (RBH) ≤6 mm were enrolled and randomly assigne...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.13688
更新日期：2020-11-21 00:00:00
abstract：BACKGROUND:Connecting teeth and osseointegrated implants in fixed reconstructions is not generally recommended because of differences in their response to loading. AIM:The aim of the present study was to assess the clinical and radiographic performance of the teeth and implants used to support three unit fixed bridges...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2005.01110.x
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:A precise and scientifically established method for the evaluation of the bone quality/primary stability is the measure of the insertion torque (IT). The aim of this study was a comparison between the IT values and the bone-implant contact percentage (BIC) of human implants retrieved after a 4/8-week healing ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2008.01599.x
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effect of topical applications of melatonin and apigenin (4',5,7-trihydroxyflavone) on new bone formation in post-extraction sockets after 30, 60 and 90 days. MATERIALS AND METHODS:Six American fox hounds were used in the study, extracting mandibular premolars (P2, P...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12866
更新日期：2018-11-01 00:00:00
abstract：:Maxillary sinus floor augmentation with autogenous bone has become a widely accepted procedure in implant dentistry. The use of osteoconductive bone substitutes in this indication is controversial, since their use can lead to a prolonged healing time, inhomogenous ossification, foreign body reaction, migration of part...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.1999.100609.x
更新日期：1999-12-01 00:00:00
abstract：:The objective of the present investigation was to characterize the cellular composition of the soft tissues surrounding consecutively retrieved late failures of Brånemark implants. Criteria for implant failure were signs of loss of osseointegration (radiographic peri-fixtural radiolucency and mobility). The clinical h...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.1997.080502.x
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Cement-retained fixed implant-supported restorations involve the risk of excess cement, which can associate peri-implantitis. In connection with routine therapy using a methacrylate cement (Premier Implant Cement, Premier(®) Dental Products Company, Plymouth Meeting, PA, USA) to retain fixed implant-supporte...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12173
更新日期：2014-07-01 00:00:00
abstract：:It has been documented that the long-term clinical outcome of the Brånemark system is very favourable. However, failures do occur before and after loading. This study examined the differences in marginal bone loss between standard and self-tapping fixtures and attempted to explain excessive marginal bone loss or loss ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.1992.030302.x
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:To review systematically whether supportive implant treatment during a follow-up of at least 10 years after functional loading is effective in prevention of biological complications and fixture loss. METHODS:A MEDLINE search was conducted for the period of 1965 to April 2006 of longitudinal clinical studies ...
journal_title：Clinical oral implants research
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0501.2007.01447.x
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVES:Minor sinus floor elevation is a method with relatively high predictability but is technically demanding. Improvement of the technique and increase in the predictability are desirable. MATERIAL AND METHODS:A clinical protocol for minor sinus floor elevation with SLA-ITI (large grit acid-etched implants with...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2005.01161.x
更新日期：2005-10-01 00:00:00
abstract：:Non-submerged ITI Bonefit implants (ITI Dental Implant System) were inserted in edentulous lower jaws of 46 patients. The patients were provided with either a fixed prosthesis or an overdenture, and has been followed during a 2-year-period. At the 1-year examination, the suprastructures were removed permitting test of...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.1996.070406.x
更新日期：1996-12-01 00:00:00
abstract：OBJECTIVES:To evaluate the effect of vertical and periosteal-releasing incisions (PRI) on the extension of the buccal flap in a trapezoidal flap design. MATERIAL AND METHODS:Thirty patients scheduled for implant surgery accompanied by bone augmentation were recruited. The amount of flap extension pulled with a minimal...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2011.02244.x
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the osteoconductive properties and biological performance of porous titanium granules used in osseous defects adjacent to titanium implants. MATERIAL AND METHODS:In this animal experimental study, calibrated defects were prepared in the tibias of 24 New Zealand rabbi...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2009.01813.x
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVES:Interforaminal implant surgery requires anatomical knowledge of the area and adequate information on the location of the various landmarks of significance such as the mental foramen, the anterior loop of the inferior alveolar nerve and the mandibular incisive canal. Cone beam computed tomography (CBCT) is a ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2011.02261.x
更新日期：2012-09-01 00:00:00
