Abstract:
:The aim of this study was to determine the cell characteristics that regulate implant osseointegration. The heterogeneity of bone marrow stromal cells obtained from 11 donors was assessed by measuring the expression of a large panel of adhesion molecules. Large differences in expression of adhesion molecules were detected depending on the culture conditions used. Cells cultured in fetal bovine serum induced the expression of different adhesion molecules from cells cultured in human serum. Donor-to-donor variation was determined by measuring the expression of adhesion molecules for stromal cells obtained from different donors that were processed identically. Fat adherent cells but also loose bone marrow cells showed large differences in expression of some but not all adhesion molecules. The flow cytometric data demonstrated large heterogeneity in expression of adhesion molecules, and this heterogeneity was influenced by culture conditions and varied from donor to donor. This demonstrates that the implant encounters different cell types, which could lead to different levels of integration. Surprisingly, in vitro only a subfraction of bone marrow stromal cells attached to titanium coated with ceramic hydroxyapatite. Adaptation of all cell types present in heterogeneous bone marrow to a coated surface is apparently not possible. Differential binding was not caused by aberrant staining of the stromal cells as the results were confirmed with bone marrow cells obtained from transgenic GFP mice. These results demonstrate that hydroxyapatite ceramics are selective in cell recruitment from the bone marrow, explaining the differences found in vivo for these coatings compared with titanium.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Torensma R,ter Brugge PJ,Jansen JA,Figdor CGdoi
10.1034/j.1600-0501.2003.00949.xsubject
Has Abstractpub_date
2003-10-01 00:00:00pages
569-77issue
5eissn
0905-7161issn
1600-0501pii
949journal_volume
14pub_type
杂志文章abstract::Sandblasted and acid-etched (SLA) implants were recently introduced to reduce the healing period between surgery and prosthesis. In this split-mouth study, SLA implants were compared to titanium plasma-sprayed (TPS) implants under loaded conditions one year after placement in 32 healthy patients, with comparable bilat...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1600-0501.2001.120604.x
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:This retrospective study was set to assess the influence of systemic and local bone and intra-oral factors on the occurrence of implant loss from abutment connection up to 2 years. MATERIALS AND METHODS:The files of 700 patients, have been collected randomly from the total patient group treated by means of ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01534.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:As biomaterial-induced modulation of mediators of the immune response may be a potential therapeutic approach to enhance wound healing events, the aim of this study was to delineate the effects of titanium surface modification on macrophage phenotype and function. MATERIAL AND METHODS:Rodent bone marrow-der...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13522
更新日期:2019-11-01 00:00:00
abstract::Sinus augmentation has been advocated to be a surgical technique with predictable results in peri-implant surgery. Endoscopic surgery of the maxillary sinus so far has been used as diagnostic procedure. In this paper, the use of endoscopy is described as a low invasive adjunctive technique in sinus floor augmentation....
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080612.x
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:Bacterial species have been found harboring the internal surface of dental implants as consequence of their failed connections. The aim of the present study was to compare the detection frequency of bacterial leakage from human saliva through the implant-abutment interface, under non-loading conditions, using...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02280.x
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:The aim of this prospective clinical trial was to assess clinical, radiological, and esthetic outcomes of immediate-loaded post-extractive implants after 1 year of follow-up. MATERIALS AND METHODS:Twenty-four consecutive patients (15 females and nine males) with a mean age of 47.27 years (range 35-65) requirin...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1111/clr.12403
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of the topical application of melatonin compared with collagenized porcine bone grafts to accelerate bone formation 2 months after their insertion in tibiae rabbits. MATERIAL AND METHODS:Twenty New Zealand rabbits weighing 3,900-4,500 g were used. Twenty colla...
journal_title:Clinical oral implants research
pub_type: 杂志文章,收录出版
doi:10.1111/clr.12364
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:The objectives of this working group were to update the existing knowledge base in computer-guided implant treatment (accuracy and clinical advantages), to search for scientific evidence on the need for keratinized tissue around implants, and to review recent literature in the search for new insights into ...
journal_title:Clinical oral implants research
pub_type: 共识发展会议,杂志文章,评审
doi:10.1111/j.1600-0501.2012.02553.x
更新日期:2012-10-01 00:00:00
abstract::The aim of this controlled, parallel design clinical study was to compare the effectiveness of an Er:YAG laser (ERL) to that of mechanical debridement using plastic curettes and antiseptic therapy for nonsurgical treatment of peri-implantitis. Twenty patients with moderate to advanced peri-implantitis lesions were ran...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2004.01051.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:In a prospective pilot study, short< or =10 mm ITI-SLA implants were placed in the resorbed posterior maxilla by means of an osteotome sinus floor elevation (OSFE) procedure without grafting material. This paper presents 3-year data assessing bone-level changes around implants. MATERIAL AND METHODS:Twenty-fi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01696.x
更新日期:2009-07-01 00:00:00
abstract::Treatment with denture for edentulous people is highly important for maintaining quality of life. However, its effect on the brain is unknown. In this experimental study, we hypothesized that dental prosthesis can recover not only the physical condition of mastication system but also the regional brain activity. We ev...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01171.x
更新日期:2005-12-01 00:00:00
abstract::In the literature intraoral periapical radiographs are commonly used for densitometric measurements of the mandible with implants. These films give detailed information of the implant and the surrounding bone. However, in extreme mandibular atrophy it can be difficult to obtain intraoral radiographs of adequate diagno...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1034/j.1600-0501.2000.011005476.x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate peri-implant soft tissue attachment and alveolar bone height on nanoporous TiO(2) thin film on commercial titanium dental implants compared with unmodified standard implants. MATERIAL AND METHODS:In six adult beagle dogs, the mandibular premolars P2-P4 were extrac...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01478.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Using computed tomography, to compare vertical and volumetric bone augmentation after interposition grafting with bovine bone mineral matrix (GEISTLICH BIO-OSS® ) or hydroxyapatite/tricalcium phosphate (STRAUMANN® BONECERAMIC) for atrophic posterior mandible reconstruction through segmental osteotomy. MATERI...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12985
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:The objective of this biomechanical study was to explore the effect of bone micro-morphology on initial intraosseous stability of implants with different designs. MATERIAL AND METHODS:Straumann and Astra Tech dental implants were placed into anterior and posterior regions of completely edentulous maxilla and m...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01265.x
更新日期:2006-08-01 00:00:00
abstract::In the present study, the influence of initial instability on the healing of titanium implants was studied in 9 lop-eared rabbits. Titanium implants (Brånemark System) were inserted in the tibiae, a location with cortical bone only, in such a way that they were either stable (control), rotation-mobile, or totally mobi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVES:Maintaining oral health around titanium implants is essential. The formation of a biofilm on the titanium surface will influence the continuing success of the implant. These concerns have led to modified ultrasonic scaler instruments that look to reduce implant damage while maximising the cleaning effect. Th...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02186.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:A removable implant-retained dental prosthesis in an edentulous mandible can use telescopic crowns or a bar superstructure as anchorage elements for an overdenture. The aim of this study was to compare the clinical results for bar-anchored and telescopic crown-retained overdentures in implant prosthetic trea...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2007.01500.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of enamel matrix derivative in liquid form (EMD-liquid) as adjunct to grafting with natural bovine bone (NBB), on new bone formation and osseointegration in buccal dehiscence defects at dental implants. MATERIAL AND METHODS:In six beagles, 3 months after extraction of the mandibular p...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13512
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to evaluate the biofilm formation of Porphyromonas gingivalis on disks of titanium (Ti) grade 4 (G4) and Ti-6Al-4V alloy grade 5 (G5) with different surface topographies. MATERIALS AND METHODS:Porphyromonas gingivalis ATCC 33277 was used to develop an in vitro mature biofilm on a tot...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12659
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:One main problem occurring after bone grafting is resorption, leading to insufficient bone volume and quality, and may subsequently cause dental implant failure. Comparison of graft volume and bone density of iliac crest and calvarial transplants determined by animal studies demonstrates significantly lower ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01182.x
更新日期:2006-04-01 00:00:00
abstract:AIM:The aim of this clinical trial was to evaluate the safety and efficiency of a one-piece zirconia oral implant after 1 year of function. MATERIALS AND METHODS:Two centers included 60 subjects in need of implant-supported single-tooth restorations or three-unit bridges. A total of 71 zirconia one-piece implants were...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/clr.12670
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:To assess retrospectively, over at least 5 years, the incidences of technical and biological complications and failures in young adult patients with birth defects affecting the formation of teeth. MATERIAL AND METHODS:All insurance cases with a birth defect that had crowns and fixed dental prostheses (FDPs)...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01720.x
更新日期:2009-08-01 00:00:00
abstract::A clinical and radiographical study was performed to evaluate the treatment outcome of single tooth replacements with artificial crowns retained to implants installed according to a 1-stage surgical procedure and immediate loading (Experimental Group = EG) in comparison to the original 2-stage concept (Control Group =...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1034/j.1600-0501.2000.011001026.x
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVES:The aim of the present publication was to report on the EAO Workshop group-4 discussions and consensus statements on the five reviews previously prepared. These reviews provided the scientific evidence on the effect of crown-to-implant ratio, on reconstructions with cantilevers in fully and partially edentul...
journal_title:Clinical oral implants research
pub_type: 共识发展会议,杂志文章
doi:10.1111/clr.13284
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the effects of a nanostructured calcium coating on the surfaces of blasted Ti implants on peri-implant bone formation in the rabbit tibiae. MATERIAL AND METHODS:Threaded implants (3.75 mm in diameter, 6 mm in length) were roughened by hydroxyapatite (HA) blasting ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01323.x
更新日期:2007-06-01 00:00:00
abstract::Parkinson's disease (PD) often affects the oro-pharyngeal musculature, leading to problems with speaking, chewing and swallowing. The inevitable reduction in food and fluid intake contributes to the further deterioration of neurological symptoms. Parkinson's disease patients have great difficulties in adjusting to the...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2000.011006566.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVES:This study evaluated implant stability and clinical outcomes obtained with magnesium-incorporated oxidised implants (Mg titanate) and compared them to those blasted magnesium-incorporated oxidised implants (blasted Mg titanate). PATIENTS AND METHODS:Mg titanate was manufactured using the microarc oxidation ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12091
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To retrospectively evaluate the conditions of the peri-implant tissues in treated patients with chronic periodontitis (CP) and in patients without chronic periodontitis (noCP). MATERIALS AND METHODS:A chart review was used to evaluate 267 implants, 134 placed in 42 CP treated patients and 133 placed in 46 n...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13712
更新日期:2021-01-16 00:00:00
abstract:OBJECTIVE:In the present study, a new healing cap that could generate a pulsed electromagnetic field (PEMF) around titanium implants to stimulate peri-implant osteogenesis was tested in the rabbit model. MATERIALS AND METHODS:A total of 22 implants were inserted in the proximal tibial metaphysis of 22 rabbits. A heali...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12661
更新日期:2016-08-01 00:00:00