Abstract:
:Reactivation of latent herpes simplex virus (HSV) type I or varicella-zoster virus (VZV) has been recognized as the most common pathomechanism underlying Bell's palsy. There is also increased reactivation of HSV or VZV in patients with immunosuppressed states and in cancer patients. The purpose of this study was to investigate the risk for cancer during a 5-year follow-up period after diagnosis of Bell's palsy by using a population-based dataset in Taiwan. We used data from the "Longitudinal Health Insurance Database". We identified 2,618 patients with Bell's palsy as the study cohort and randomly selected 13,090 patients to be used as a comparison cohort. Cox proportional hazards regression was performed to compare the 5-year risk of subsequent cancer between the study and comparison cohorts. We found that the incidence of cancer was 1.55 (95 % CI 1.35-1.78) per 100 person-years for patients with Bell's palsy and 1.09 (95 % CI 1.02-1.18) per 100 person-years for comparison patients. After censoring cases that died from non-cancer causes during the follow-up period and adjusting for urbanization, monthly income, geographic region, and diabetes, the hazard ratio (HR) for cancer during the 5-year follow-up period for patients with Bell's palsy was 1.43 times that for comparison patients (95 % CI 1.22-1.73). There was a particularly increased risk of oral cancer (HR = 2.49; 95 % CI 1.54-4.03) for patients with Bell's palsy compared with the other patients. We conclude that patients with Bell's palsy were at significant risk of cancer during a 5-year follow-up period after diagnosis.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Sheu JJ,Keller JJ,Lin HCdoi
10.1007/s11060-012-0954-9subject
Has Abstractpub_date
2012-11-01 00:00:00pages
215-20issue
2eissn
0167-594Xissn
1573-7373journal_volume
110pub_type
杂志文章abstract::The time to tumor progression (TTP), time to death (TTD) and complications were studied prospectively in a cohort of patients treated by surgery and adjuvant radio- and intensified PCV chemotherapy for astrocytomas (AIII), oligodendrogliomas (OIII) and oligoastrocytomas (OAIII) WHO grade III. The treatment was carried...
journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-020-03535-3
更新日期:2020-10-01 00:00:00
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journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-016-2300-0
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
doi:10.1007/s11060-010-0249-y
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:2007-05-01 00:00:00
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journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-014-1417-2
更新日期:2014-05-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
doi:10.1007/s11060-012-0811-x
更新日期:2012-06-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01059949
更新日期:1995-01-01 00:00:00
abstract::Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis. Its effect was evaluated on several human astrocytomas at different degrees of malignancy; a correlation was found between LDN effect on lactate production and tumor malignancy: in grade I and II astrocytomas LND stimulates lactate production, while ...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:1988-11-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1023/a:1015044012574
更新日期:2002-02-01 00:00:00
abstract:INTRODUCTION:Central nervous system hemangioblastoma is a benign tumor associated with or without von Hippel-Lindau (VHL) disease which is an autosomal dominant hereditary disease that results from a germline mutation in the VHL gene. A main axis of signaling pathways in central nervous system hemangioblastoma is VHL-H...
journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-020-03506-8
更新日期:2020-05-01 00:00:00
abstract::Steroids are beneficial in neurological illness, but have many serious side effects. Having observed several patients with severe steroid psychoses, which greatly prolonged their hospitalizations, the authors sought to improve understanding of this entity. A literature review was conducted. The incidence of severe psy...
journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-012-0919-z
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/BF00146088
更新日期:1996-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-011-0530-8
更新日期:2011-09-01 00:00:00
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更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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