Abstract：
PURPOSE:To investigate intraocular concentrations and pharmacokinetics of ranibizumab after a single intravitreal injection in humans. DESIGN:Prospective, noncomparative, interventional case series. METHODS:We included 18 nonvitrectomized eyes of 18 patients (age range, 61-85 years) that were diagnosed with both clinically significant cataract and macular edema secondary to either exudative age-related macular degeneration, diabetic maculopathy, or retinal vein occlusion. Each eye received a single intravitreal injection of 0.5 mg ranibizumab. An aqueous humor sample was obtained during cataract surgery between 1 and 37 days after injection. Concentrations of unbound ranibizumab in these samples were quantified by enzyme-linked immunosorbent assay. RESULTS:Ranibizumab concentration in aqueous humor peaked the first day after injection (range, 36.9-66.1 μg/mL) and subsequently declined in a mono-exponential fashion. Nonlinear regression analysis determined an initial peak concentration (c(max)) of 56.1 μg/mL and an elimination half-life (t(1/2)) of 7.19 days with a coefficient of determination (R(2)) of 0.90. Correction of ranibizumab concentrations for ocular volume as calculated from axial length measurements did not alter regression analysis results significantly (t(1/2), 7.15 days; R(2), 0.89). CONCLUSIONS:In human nonvitrectomized eyes, the aqueous half-life of 0.5 mg intravitreally injected ranibizumab is 7.19 days, slightly shorter than the half-life of 9.82 days previously determined for bevacizumab by comparable methods.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Krohne TU,Liu Z,Holz FG,Meyer CHdoi
10.1016/j.ajo.2012.03.047subject
Has Abstractpub_date
2012-10-01 00:00:00pages
682-686.e2issue
4eissn
0002-9394issn
1879-1891pii
S0002-9394(12)00261-9journal_volume
154pub_type
杂志文章abstract：PURPOSE:To assess the results of iris suture fixation of subluxated intraocular lenses. DESIGN:Retrospective study. METHODS:This was a nonrandomized chart review of eyes with subluxated intraocular lenses that underwent iris suture fixation at an academic institutional care center. Seventy-two eyes of 67 consecutive ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.11.009
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To identify associations between severity of sickle cell retinopathy (SCR) and other clinical, laboratory, or treatment factors relevant to sickle cell disease (SCD). DESIGN:Retrospective cohort study. METHODS:We investigated clinical, laboratory, and demographic associations with the severity of SCR in 296 p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
abstract：PURPOSE:To report the incidence and risk factors of elevated IOP following deep anterior lamellar keratoplasty (DALK). DESIGN:A retrospective case series. METHODS:A retrospective study investigating the 5-year incidence of raised IOP following DALK cases performed from 2004 to 2008 in a tertiary center. Patients with...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.07.025
更新日期：2016-10-01 00:00:00
abstract：:The transmission characteristics of a new filter combination for fluorescein angiography were selected on the basis of in vivo measurements of the excitation and emission spectra of fluorescein dye during its transit in the fundus. This combination of filters was characterized by separation of 530 nm between the spect...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90542-0
更新日期：1976-10-01 00:00:00
abstract：PURPOSE:To evaluate the repeatability of an extensive number of relevant indices with the Pentacam HR in keratoconus of varying severity and normal eyes. DESIGN:Reliability analysis. METHODS:This study was performed at Antwerp University Hospital, Belgium, and enrolled 20 healthy volunteers (20 eyes) and 69 patients ...
journal_title：American journal of ophthalmology
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更新日期：2020-11-01 00:00:00
abstract：PURPOSE:We compared the efficacy of different contact lens disinfection systems to eliminate adenovirus. METHODS:Laboratory study evaluating the elimination of adenoviral ocular isolates by contact lens disinfection systems. Hard (gas permeable) and soft contact lenses were contaminated with adenovirus serotypes 8 and...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01128-x
更新日期：2001-11-01 00:00:00
abstract：PURPOSE:To assess retinal nerve fiber layer (RNFL) and macular thickness using optical coherence tomography (OCT) on HIV-infected patients without ocular manifestations and to correlate these findings with frequency-doubling technology perimetry (FDT). DESIGN:Cross-sectional study. METHODS:setting: Single center. stu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
abstract：PURPOSE:To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA). DESIGN:Retrospective case series. METHODS:We included 21 eyes (9 males and 1...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.01.016
更新日期：2009-07-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90574-9
更新日期：1979-11-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2007-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72215-9
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.04.008
更新日期：2016-07-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1995-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1983-11-01 00:00:00
abstract：PURPOSE:To evaluate the use of disk diameter as an indicator in the identification of glaucomatous optic neuropathy. METHODS:We evaluated all available stereofundus photographs for 1,040 right eyes obtained in the Reykjavik Eye Study. Horizontal and vertical disk diameters were determined in a masked manner by a glauc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2003-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2019-04-01 00:00:00
abstract：PURPOSE:To report the phenotype and genotype of a splice site mutation at intron 2 of the peripherin/RDS gene in four half-siblings with pattern dystrophy of the retina. DESIGN:Experimental study. METHODS:In four siblings with a common mother and three separate fathers, complete ophthalmic examination, pedigree, elec...
journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：2020-03-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2013-12-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：1979-11-01 00:00:00
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更新日期：1990-04-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
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更新日期：2006-03-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1987-01-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
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更新日期：2020-12-01 00:00:00
abstract：PURPOSE:To report the clinical outcomes of penetrating keratoplasty (PK) after autologous cultivated limbal epithelial transplantation in eyes with limbal stem cell deficiency (LSCD) after ocular surface burns. DESIGN:Retrospective case series. METHODS:This study included 47 patients with unilateral LSCD treated by a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1984-10-15 00:00:00
abstract：PURPOSE:To provide additional evidence that anterior uveitis can be a manifestation of poststreptococcal syndrome. METHOD:A case report providing follow-up information on a previously described patient. RESULTS:An adolescent girl in whom anterior uveitis was the only manifestation of poststreptococcal syndrome subseq...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
